PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17855089-2	2007	The amino(methyl) pyrrolidine scaffolds were designed based on the proposed bioisosterism to the piperazine core in known FXa inhibitors.	Piperazine	97-107	coagulation factor X	Homo sapiens	122-125	
17555959-1	2007	This paper describes the synthesis of orally available potent fXa inhibitors 2 and 3 by modification of the piperazine part of lead compound 1.	Piperazine	108-118	coagulation factor X	Homo sapiens	62-65	
12593649-3	2003	The scaffold comprising the sulfonyl keto piperazine moiety might play a pivotal role in the orientation of substituents, since there is a strong hydrogen bond between Gly219 of fXa and the carbonyl oxygen of the piperazine.	Piperazine	42-52	coagulation factor X	Homo sapiens	178-181