PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24378735-6 2014 Furthermore, okadaic acid, a protein phosphatase (PP) 1/2A inhibitor, suppressed the progression of adipogenesis by preventing PP1/2A-mediated suppression of CREB-dependent COX-2 expression, thus resulting in increased production of anti-adipogenic PGE2 and PGF2alpha. Dinoprostone 249-253 cAMP responsive element binding protein 1 Mus musculus 158-162 22775220-11 2012 In the PGE(2)-stimulated melanocytes, mRNA expressions of EP-1, Tyr and Tyrp1 and phosphorylation of CREB protein were suppressed. Dinoprostone 7-13 cAMP responsive element binding protein 1 Mus musculus 101-105 33329572-8 2020 Mechanistic studies showed that exosomal prostaglandin E2 (PGE2) produced by G-MDSCs upregulated the phosphorylation levels of GSK-3beta and CREB, which play a key role in the production of IL-10+ B cells. Dinoprostone 41-57 cAMP responsive element binding protein 1 Mus musculus 141-145 18567804-3 2008 In primary mouse keratinocyte cultures, PGE2 activated the epidermal growth factor receptor (EGFR) and its downstream signaling pathways as well as increased cyclic AMP (cAMP) production and activated the cAMP response element binding protein (CREB). Dinoprostone 40-44 cAMP responsive element binding protein 1 Mus musculus 205-242 18567804-3 2008 In primary mouse keratinocyte cultures, PGE2 activated the epidermal growth factor receptor (EGFR) and its downstream signaling pathways as well as increased cyclic AMP (cAMP) production and activated the cAMP response element binding protein (CREB). Dinoprostone 40-44 cAMP responsive element binding protein 1 Mus musculus 244-248 18567804-6 2008 In addition, these inhibitors attenuated the PGE2-induced proliferation, nuclear factor-kappa B, activator protein-1 (AP-1), and CREB binding to the promoter regions of the cyclin D1 and vascular endothelial growth factor (VEGF) genes and expression of cyclin D1 and VEGF in primary mouse keratinocytes. Dinoprostone 45-49 cAMP responsive element binding protein 1 Mus musculus 129-133 17277233-7 2007 Cyclic AMP response element-binding protein (CREB) phosphorylation was elevated to a greater extent in keratinocytes from EP2 transgenic mice compared with those of WT mice following PGE2 treatment. Dinoprostone 183-187 cAMP responsive element binding protein 1 Mus musculus 0-43 17277233-7 2007 Cyclic AMP response element-binding protein (CREB) phosphorylation was elevated to a greater extent in keratinocytes from EP2 transgenic mice compared with those of WT mice following PGE2 treatment. Dinoprostone 183-187 cAMP responsive element binding protein 1 Mus musculus 45-49 17277233-8 2007 A protein kinase A (PKA) inhibitor reduced PGE2-mediated CREB phosphorylation in keratinocytes from EP2 transgenic mice. Dinoprostone 43-47 cAMP responsive element binding protein 1 Mus musculus 57-61 18567804-7 2008 Similarly, in vivo, we found that WT mice treated with PGE2 and untreated cyclooxygenase-2-overexpressing transgenic mice had higher levels of cell proliferation and expression of cyclin D1 and VEGF, as well as higher levels of activated EGFR, nuclear factor-kappa B, AP-1, and CREB, than vehicle-treated WT mice. Dinoprostone 55-59 cAMP responsive element binding protein 1 Mus musculus 278-282 33329572-8 2020 Mechanistic studies showed that exosomal prostaglandin E2 (PGE2) produced by G-MDSCs upregulated the phosphorylation levels of GSK-3beta and CREB, which play a key role in the production of IL-10+ B cells. Dinoprostone 59-63 cAMP responsive element binding protein 1 Mus musculus 141-145 31818003-7 2019 PGE2 stimulated M2 polarization via the EP4-cAMP-CREB in normal mice, while failed to promote M2 polarization in the PMs of CIA mice. Dinoprostone 0-4 cAMP responsive element binding protein 1 Mus musculus 49-53 32350920-0 2020 Prostaglandin E2 confers protection against diabetic coronary atherosclerosis by stimulating M2 macrophage polarization via the activation of the CREB/BDNF/TrkB signaling pathway. Dinoprostone 0-16 cAMP responsive element binding protein 1 Mus musculus 146-150 32350920-11 2020 PGE2 stimulated M2 macrophage polarization by inducing KLF4 via the activation of the CREB/BDNF/TrkB signaling pathway. Dinoprostone 0-4 cAMP responsive element binding protein 1 Mus musculus 86-90 32350920-12 2020 This study demonstrates that PGE2 promotes M2 macrophage polarization by activating the CREB/BDNF/TrkB signaling pathway, thus alleviating DMAS. Dinoprostone 29-33 cAMP responsive element binding protein 1 Mus musculus 88-92 31818003-8 2019 Further, we found the EP4 over-desensitization stimulated by PGE2 induced abnormal PGE2-cAMP-CREB signaling as well as the imbalance of macrophage polarization. Dinoprostone 61-65 cAMP responsive element binding protein 1 Mus musculus 93-97 29935220-6 2019 RESULTS: IL-23 induces Ptgs2, encoding COX2 in TH17 cells, and produces PGE2, which acts back on the PGE receptors EP2 and EP4 in these cells and enhances IL-23-induced expression of an IL-23 receptor subunit gene, Il23r, by activating signal transducer and activator of transcription (STAT) 3, cAMP-responsive element binding protein 1, and nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) through cyclic AMP-protein kinase A signaling. Dinoprostone 72-76 cAMP responsive element binding protein 1 Mus musculus 295-336 29108246-0 2017 MRP4 regulates ENaC-dependent CREB/COX-2/PGE2 signaling during embryo implantation. Dinoprostone 41-45 cAMP responsive element binding protein 1 Mus musculus 30-34 30503586-0 2019 Alternariol induced proliferation in primary mouse keratinocytes and inflammation in mouse skin is regulated via PGE2/EP2/cAMP/p-CREB signaling pathway. Dinoprostone 113-117 cAMP responsive element binding protein 1 Mus musculus 129-133 29108246-5 2017 These results in together have revealed a previously undefined role of MRP4 in mediating ENaC-dependent CREB/COX-2/PGE2 signaling essential to embryo implantation with implication in cancer progression as well. Dinoprostone 115-119 cAMP responsive element binding protein 1 Mus musculus 104-108 26118414-0 2015 Endogenous prostaglandin E2 potentiates anti-inflammatory phenotype of macrophage through the CREB-C/EBP-beta cascade. Dinoprostone 11-27 cAMP responsive element binding protein 1 Mus musculus 94-98 26348574-6 2015 By contrast, the induction of ID1 by prostaglandin E2 was mediated by cAMP response element-binding protein (CREB). Dinoprostone 37-53 cAMP responsive element binding protein 1 Mus musculus 70-107 26348574-6 2015 By contrast, the induction of ID1 by prostaglandin E2 was mediated by cAMP response element-binding protein (CREB). Dinoprostone 37-53 cAMP responsive element binding protein 1 Mus musculus 109-113 28245593-8 2017 TNFalpha and PGE2 increased the expression of RANKL, NFAT cytoplasmic-1 (NFATc1), cAMP response element-binding protein (CREB), and cyclooxygenase 2 (COX2); which increment was suppressed by indomethacin, a COX inhibitor. Dinoprostone 13-17 cAMP responsive element binding protein 1 Mus musculus 82-119 28245593-8 2017 TNFalpha and PGE2 increased the expression of RANKL, NFAT cytoplasmic-1 (NFATc1), cAMP response element-binding protein (CREB), and cyclooxygenase 2 (COX2); which increment was suppressed by indomethacin, a COX inhibitor. Dinoprostone 13-17 cAMP responsive element binding protein 1 Mus musculus 121-125 28245593-10 2017 PGE2 induced the binding of CREB to the RANKL promoter, whereas TNFalpha increased the binding of both CREB and NFATc1 to this promoter through a process blocked by indomethacin. Dinoprostone 0-4 cAMP responsive element binding protein 1 Mus musculus 28-32 26118414-4 2015 Of note, PGE2 phosphorylates CREB via EP2 and EP4 receptor ligation, thereby transcriptionally increasing C/EBP-beta expression in BALB/c bone marrow derived macrophages. Dinoprostone 9-13 cAMP responsive element binding protein 1 Mus musculus 29-33 26118414-5 2015 Activated CREB directly binds to the CREB-responsive element of the C/EBP-beta promoter, such that PGE2 ultimately reinforces arg1, IL10 and Mrc1 gene expression. Dinoprostone 99-103 cAMP responsive element binding protein 1 Mus musculus 10-14 26118414-5 2015 Activated CREB directly binds to the CREB-responsive element of the C/EBP-beta promoter, such that PGE2 ultimately reinforces arg1, IL10 and Mrc1 gene expression. Dinoprostone 99-103 cAMP responsive element binding protein 1 Mus musculus 37-41 26031354-4 2015 Here we show that PGE2 enhances Th17 cell differentiation via the activation of the CREB co-activator CRTC2. Dinoprostone 18-22 cAMP responsive element binding protein 1 Mus musculus 84-88