PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27916229-0	2016	Corrigendum to: "Long-term leptin treatment exerts a pro-apoptotic effect on renal tubular cells via prostaglandin E2 augmentation" [Eur.	Dinoprostone	101-117	leptin	Homo sapiens	27-33	
32820432-0	2021	Leptin reduces in vitro cementoblast mineralization and survival as well as induces PGE2 release by ERK1/2 commitment.	Dinoprostone	84-88	leptin	Homo sapiens	0-6	
32820432-10	2021	RESULTS: In vitro, when compressive forces are applied, leptin promotes ERK1/2 phosphorylation, as well as upregulates PGE2 and caspase 3 and caspase 9 on OCCM cells.	Dinoprostone	119-123	leptin	Homo sapiens	56-62	
32820432-11	2021	Blockade of ERK1/2 impairs leptin-induced PGE2 secretion and reduced caspase 3 and caspase 9 expression.	Dinoprostone	42-46	leptin	Homo sapiens	27-33	
32820432-13	2021	CLINICAL RELEVANCE: Our findings indicate that leptin exacerbates the physiological effect of compressive forces on cementoblasts promoting the release of PGE2 and increases the rate of cell apoptosis, and thus, increased levels of leptin may influence the inflammatory response during orthodontically induced tooth movement.	Dinoprostone	155-159	leptin	Homo sapiens	47-53	
28571770-8	2017	In addition, leptin induced COX-2 expression, promoter activity, and increased the production of prostaglandin E2.	Dinoprostone	97-113	leptin	Homo sapiens	13-19	
19127349-7	2009	These findings disclose an important link between leptin-induced and Src kinase-mediated EGFR transactivation and the activation of cytosolic phospholipase A(2) that leads to up-regulation in PGE2 production, thus providing new insights into the mechanism of gastric mucosal protection by leptin.	Dinoprostone	192-196	leptin	Homo sapiens	50-56	
21475828-5	2009	In this study, we demonstrated that human lung cancer A549 and H157 cells express leptin receptors Ob-Ra and Ob-Rb, and that leptin stimulation increases the production of immunoinflammatory cytokines: vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) and prostaglandin (PGE2).	Dinoprostone	285-289	leptin	Homo sapiens	125-131	
21475828-6	2009	Moreover, leptin stimulation activated the JAK/STAT3, PI3K/AKT and MEK1/2 signaling pathways, which contributed to VEGF, IL-6 and PGE2 production.	Dinoprostone	130-134	leptin	Homo sapiens	10-16	
19127349-7	2009	These findings disclose an important link between leptin-induced and Src kinase-mediated EGFR transactivation and the activation of cytosolic phospholipase A(2) that leads to up-regulation in PGE2 production, thus providing new insights into the mechanism of gastric mucosal protection by leptin.	Dinoprostone	192-196	leptin	Homo sapiens	289-295	
19688109-0	2009	Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production.	Dinoprostone	128-132	leptin	Homo sapiens	0-6	
19688109-0	2009	Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production.	Dinoprostone	128-132	leptin	Homo sapiens	113-119	
11474480-0	2001	Stimulation of leptin release by arachidonic acid and prostaglandin E(2) in adipose tissue from obese humans.	Dinoprostone	54-72	leptin	Homo sapiens	15-21	
18340408-6	2008	The leptin-induced changes in arachidonic acid release and PGE2 generation were blocked by ERK inhibitor, PD98059, but not by PI3K inhibitor, wortmannin.	Dinoprostone	59-63	leptin	Homo sapiens	4-10	
12524663-4	2003	The release of leptin was also stimulated by agonists of G(i)-coupled receptors (prostaglandin E(2) [PGE(2)], brimonidine [an alpha(2) catecholamine agonist] and cyclopentyladenosine [CPA]) in the presence of dexamethasone.	Dinoprostone	81-99	leptin	Homo sapiens	15-21	
11474480-2	2001	We found that arachidonic acid or prostaglandin E(2) (PGE(2)) stimulated leptin release by explants of subcutaneous adipose tissue from obese humans.	Dinoprostone	34-52	leptin	Homo sapiens	73-79	
11474480-2	2001	We found that arachidonic acid or prostaglandin E(2) (PGE(2)) stimulated leptin release by explants of subcutaneous adipose tissue from obese humans.	Dinoprostone	54-60	leptin	Homo sapiens	73-79	
11474480-7	2001	The level of leptin mRNA at 48 hours was reduced by 28% if PGE(2) was added in the absence of dexamethasone, while in the presence of dexamethasone, the amount of leptin mRNA was enhanced by 156%.	Dinoprostone	59-65	leptin	Homo sapiens	13-19	
11474480-8	2001	These data suggest that when upregulation of COX-2 is blocked by dexamethasone, exogenous PGE(2) enhances both leptin release and leptin mRNA accumulation by explants of human adipose tissue in primary culture.	Dinoprostone	90-96	leptin	Homo sapiens	111-117	
11474480-8	2001	These data suggest that when upregulation of COX-2 is blocked by dexamethasone, exogenous PGE(2) enhances both leptin release and leptin mRNA accumulation by explants of human adipose tissue in primary culture.	Dinoprostone	90-96	leptin	Homo sapiens	130-136	
10872609-4	2000	In addition, WISH cells, JAR cells and placental explants were treated with leptin to assess its effects on production of IL-8, IL-6 and prostaglandin E2 (PGE2).	Dinoprostone	137-153	leptin	Homo sapiens	76-82	
10872609-4	2000	In addition, WISH cells, JAR cells and placental explants were treated with leptin to assess its effects on production of IL-8, IL-6 and prostaglandin E2 (PGE2).	Dinoprostone	155-159	leptin	Homo sapiens	76-82