PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21294165-0 2011 Signaling pathways of ATP-induced PGE2 release in spinal cord astrocytes are EGFR transactivation-dependent. Dinoprostone 34-38 epidermal growth factor receptor Homo sapiens 77-81 21925169-6 2011 PGE2 increased the second EGFR-P and IL-8 production via binding to its Gi-protein-coupled E-prostanoid (EP)3 receptor. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 26-32 21925169-8 2011 Thus, we conclude that a positive feedback pathway involving COX-2/PGE2/EP3 receptor-dependent EGFR reactivation exaggerates IL-8 production in NCI-H292 cancer cells but not in NHBE (normal) cells. Dinoprostone 67-71 epidermal growth factor receptor Homo sapiens 95-99 20705717-6 2011 Using an in vitro model system of Ishikawa endometrial epithelial cells stably expressing PTGER2 and human first trimester decidua explants, we demonstrate that CXCR4 expression is regulated by PTGER2 via the epidermal growth factor receptor (EGFR)-phosphatidylinositol-3-kinase (PI3K)-extracellular signal-regulated kinase (ERK1/2) pathway.Taken together, our data suggest that early embryonic signals may regulate fetal-maternal crosstalk in the human endometrium by inducing CXCR4 expression via the PGE2-PTGER2-mediated induction of the EGFR, PI3K and ERK1/2 pathways. Dinoprostone 503-507 epidermal growth factor receptor Homo sapiens 209-241 20850495-0 2011 Involvement of the epidermal growth factor receptor in Pb2+-induced activation of cPLA2/COX-2 genes and PGE2 production in vascular smooth muscle cells. Dinoprostone 104-108 epidermal growth factor receptor Homo sapiens 19-51 18294142-0 2008 Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells. Dinoprostone 125-143 epidermal growth factor receptor Homo sapiens 49-81 19127349-7 2009 These findings disclose an important link between leptin-induced and Src kinase-mediated EGFR transactivation and the activation of cytosolic phospholipase A(2) that leads to up-regulation in PGE2 production, thus providing new insights into the mechanism of gastric mucosal protection by leptin. Dinoprostone 192-196 epidermal growth factor receptor Homo sapiens 89-93 19717552-10 2009 These results demonstrated that in HTSMCs, CSE-induced COX-2-dependent PGE2 generation was mediated through PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt leading to the recruitment of p300 with NF-kappaB complex. Dinoprostone 71-75 epidermal growth factor receptor Homo sapiens 123-127 19201881-0 2009 Lipopolysaccharide initiates a positive feedback of epidermal growth factor receptor signaling by prostaglandin E2 in human biliary carcinoma cells. Dinoprostone 98-114 epidermal growth factor receptor Homo sapiens 52-84 18294142-8 2008 These results demonstrate that LPA induces COX-2 expression and PGE(2) production through EGFR transactivation-independent activation of transcriptional factors NF-kappaB and c-Jun, and EGFR transactivation-dependent activation of C/EBPbeta in HBEpCs. Dinoprostone 64-70 epidermal growth factor receptor Homo sapiens 90-94 17877615-9 2007 Direct inhibition of EGFR activity with AG1478 reduced PGE(2)-stimulated motility, clearly demonstrating that PGE(2 )acts via the EGFR-signalling pathway. Dinoprostone 55-61 epidermal growth factor receptor Homo sapiens 21-25 17477350-6 2007 Furthermore, in contrast to previous studies, we found that an epidermal growth factor (EGF) receptor autocrine growth mechanism, another Raf-independent signaling mechanism, was necessary for COX-2 and PGE2 upregulation. Dinoprostone 203-207 epidermal growth factor receptor Homo sapiens 63-101 17551669-6 2007 The intracellular calcium chelator, BAPTA-AM, was shown to block PGE2-induced Erk and EGFR phosphorylation. Dinoprostone 65-69 epidermal growth factor receptor Homo sapiens 86-90 17551669-8 2007 Our findings suggest that in human cholangiocarcinoma cells, PGE2-enhanced phosphorylation of Erk is, at least in part, mediated through EP1 receptors and EGFR phosphorylation induced by increases in the intracellular concentration of calcium. Dinoprostone 61-65 epidermal growth factor receptor Homo sapiens 155-159 17805209-5 2007 The data revealed that EGF-R signaling had a bimodal positive effect on fetal enterocyte: 1) it increased cell proliferation and migration synergistically with hydrocortisone and 2) up-regulated COX-2 mRNA expression and subsequent PGE2 production. Dinoprostone 232-236 epidermal growth factor receptor Homo sapiens 23-28 17877615-9 2007 Direct inhibition of EGFR activity with AG1478 reduced PGE(2)-stimulated motility, clearly demonstrating that PGE(2 )acts via the EGFR-signalling pathway. Dinoprostone 55-61 epidermal growth factor receptor Homo sapiens 130-134 17550984-14 2007 PGE(2)-induced invasion was EGFR-dependent, confirming a link between PGE(2), EGFR, and c-Met. Dinoprostone 0-6 epidermal growth factor receptor Homo sapiens 28-32 17550984-14 2007 PGE(2)-induced invasion was EGFR-dependent, confirming a link between PGE(2), EGFR, and c-Met. Dinoprostone 0-6 epidermal growth factor receptor Homo sapiens 78-82 17604021-2 2007 Recently, we have demonstrated the rapid, epidermal growth factor receptor (EGFR)-dependent induction of COX-2 and PGE(2) synthesis in astrocytes following optic nerve injury and in culture. Dinoprostone 115-121 epidermal growth factor receptor Homo sapiens 42-74 17604021-2 2007 Recently, we have demonstrated the rapid, epidermal growth factor receptor (EGFR)-dependent induction of COX-2 and PGE(2) synthesis in astrocytes following optic nerve injury and in culture. Dinoprostone 115-121 epidermal growth factor receptor Homo sapiens 76-80 16966336-4 2006 This effect was mediated by induction of cyclooxygenase-2 (COX-2) gene expression and production of prostaglandin E2 (PGE2) that in turn transactivated epidermal growth factor receptor (EGFR) and Akt. Dinoprostone 100-116 epidermal growth factor receptor Homo sapiens 152-184 17384145-6 2007 PGE2 effects were confined to the selective stimulation of the EP2 receptor subtype, leading to epidermal growth factor receptor (EGFR) transactivation via protein kinase A (PKA) and c-Src activation. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 96-128 17384145-6 2007 PGE2 effects were confined to the selective stimulation of the EP2 receptor subtype, leading to epidermal growth factor receptor (EGFR) transactivation via protein kinase A (PKA) and c-Src activation. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 130-134 16905765-0 2007 Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway. Dinoprostone 19-35 epidermal growth factor receptor Homo sapiens 189-221 17178880-3 2006 Here, we show that GPCR ligands prostaglandin E2 (PGE2) and bradykinin (BK) activate EGFR signaling. Dinoprostone 32-48 epidermal growth factor receptor Homo sapiens 85-89 17178880-3 2006 Here, we show that GPCR ligands prostaglandin E2 (PGE2) and bradykinin (BK) activate EGFR signaling. Dinoprostone 50-54 epidermal growth factor receptor Homo sapiens 85-89 17178880-5 2006 PGE2 and BK triggered EGFR signaling by increasing selective autocrine release of transforming growth factor-alpha (TGF-alpha). Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 22-26 17178880-6 2006 Inhibition of tumor necrosis factor-alpha-converting enzyme abrogated BK- or PGE2-mediated activation of EGFR signaling. Dinoprostone 77-81 epidermal growth factor receptor Homo sapiens 105-109 17178880-7 2006 Both PGE2 and BK stimulated head and neck squamous cell carcinoma (HNSCC) invasion via EGFR. Dinoprostone 5-9 epidermal growth factor receptor Homo sapiens 87-91 16966336-4 2006 This effect was mediated by induction of cyclooxygenase-2 (COX-2) gene expression and production of prostaglandin E2 (PGE2) that in turn transactivated epidermal growth factor receptor (EGFR) and Akt. Dinoprostone 100-116 epidermal growth factor receptor Homo sapiens 186-190 16966336-4 2006 This effect was mediated by induction of cyclooxygenase-2 (COX-2) gene expression and production of prostaglandin E2 (PGE2) that in turn transactivated epidermal growth factor receptor (EGFR) and Akt. Dinoprostone 118-122 epidermal growth factor receptor Homo sapiens 152-184 16966336-4 2006 This effect was mediated by induction of cyclooxygenase-2 (COX-2) gene expression and production of prostaglandin E2 (PGE2) that in turn transactivated epidermal growth factor receptor (EGFR) and Akt. Dinoprostone 118-122 epidermal growth factor receptor Homo sapiens 186-190 16557574-10 2006 In vitro, CDCA induced the production of PGE2 and VEGF in dose- and time-dependent manners, and these effects were attenuated by a selective COX-2 inhibitor, mitogen-activated protein kinases inhibitor, or epidermal growth factor receptor inhibitor. Dinoprostone 41-45 epidermal growth factor receptor Homo sapiens 206-238 16740977-0 2006 Leptin stimulates proliferation and inhibits apoptosis in Barrett"s esophageal adenocarcinoma cells by cyclooxygenase-2-dependent, prostaglandin-E2-mediated transactivation of the epidermal growth factor receptor and c-Jun NH2-terminal kinase activation. Dinoprostone 131-147 epidermal growth factor receptor Homo sapiens 180-212 16740977-13 2006 Subsequent PGE2-mediated transactivation of the epidermal growth factor receptor and JNK activation are essential to the leptin effects. Dinoprostone 11-15 epidermal growth factor receptor Homo sapiens 48-80 15855163-0 2005 Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. Dinoprostone 25-41 epidermal growth factor receptor Homo sapiens 149-181 16331686-6 2006 The EP(1)-induced EGFR transactivation and cell invasion involves c-Src, in light of the presence of native binding complex of EP(1)/Src/EGFR and the inhibition of PGE(2)-induced EGFR phosphorylation and cell invasion by the Src siRNA and the Src inhibitor, PP2. Dinoprostone 164-170 epidermal growth factor receptor Homo sapiens 18-22 16432186-2 2006 For example, prostaglandin E(2) (PGE(2))-induced transactivation of the EGF receptor (EGFR) in colorectal carcinoma cells is mediated by means of a c-Src-dependent mechanism and regulates cell proliferation and migration. Dinoprostone 13-31 epidermal growth factor receptor Homo sapiens 72-84 16432186-2 2006 For example, prostaglandin E(2) (PGE(2))-induced transactivation of the EGF receptor (EGFR) in colorectal carcinoma cells is mediated by means of a c-Src-dependent mechanism and regulates cell proliferation and migration. Dinoprostone 13-31 epidermal growth factor receptor Homo sapiens 86-90 16432186-2 2006 For example, prostaglandin E(2) (PGE(2))-induced transactivation of the EGF receptor (EGFR) in colorectal carcinoma cells is mediated by means of a c-Src-dependent mechanism and regulates cell proliferation and migration. Dinoprostone 33-39 epidermal growth factor receptor Homo sapiens 72-84 16432186-2 2006 For example, prostaglandin E(2) (PGE(2))-induced transactivation of the EGF receptor (EGFR) in colorectal carcinoma cells is mediated by means of a c-Src-dependent mechanism and regulates cell proliferation and migration. Dinoprostone 33-39 epidermal growth factor receptor Homo sapiens 86-90 16432186-6 2006 Here we report that PGE(2) induces the association of a prostaglandin E receptor 4/beta-arrestin 1/c-Src signaling complex resulting in the transactivation of the EGFR and downstream Akt (PKB) signaling. Dinoprostone 20-26 epidermal growth factor receptor Homo sapiens 163-167 16432186-8 2006 These results show that the prostaglandin E/beta-arrestin 1/c-Src signaling complex is a crucial step in PGE(2)-mediated transactivation of the EGFR and may play a pivotal role in tumor metastasis. Dinoprostone 105-111 epidermal growth factor receptor Homo sapiens 144-148 16120814-9 2005 We conclude that PAR(2)-triggered PGE(2) formation in A549 cells involves a coordinated up-regulation of COX-2 and mPGES-1 involving cPLA(2), increased cytosolic Ca(2+), PKC, Src, MEK-ERK, p38 MAPK, Src-mediated EGF receptor trans-activation, and also metabolic products of both COX-1 and COX-2. Dinoprostone 34-40 epidermal growth factor receptor Homo sapiens 212-224 16024629-0 2005 Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. Dinoprostone 0-16 epidermal growth factor receptor Homo sapiens 147-179 16024629-10 2005 Our data indicate the presence of an EGFR-independent activation of the mitogen-activated protein kinase/Erk pathway by PGE2 in NSCLC cells. Dinoprostone 120-124 epidermal growth factor receptor Homo sapiens 37-41 16574793-8 2006 Therefore, we have demonstrated that seminal plasma and PGE(2) can promote the expression of tumorigenic and angiogenic factors, in cervical adenocarcinoma cells via the EP4 receptor, EGFR, and ERK1/2 signaling pathways. Dinoprostone 56-62 epidermal growth factor receptor Homo sapiens 184-188 16331686-5 2006 The PGE(2)-induced EGFR phosphorylation and cell invasiveness were blocked by the EP(1) receptor siRNA or antagonist ONO-8711 and by two EGFR tyrosine kinase inhibitors, AG1478 and PD153035. Dinoprostone 4-10 epidermal growth factor receptor Homo sapiens 19-23 16331686-5 2006 The PGE(2)-induced EGFR phosphorylation and cell invasiveness were blocked by the EP(1) receptor siRNA or antagonist ONO-8711 and by two EGFR tyrosine kinase inhibitors, AG1478 and PD153035. Dinoprostone 4-10 epidermal growth factor receptor Homo sapiens 137-141 15855163-5 2005 Overexpression of COX-2 or treatment with PGE2 or the EP1 receptor agonist ONO-DI-004 induced phosphorylation of EGFR and enhanced tumor cell proliferation and invasion, which were inhibited by the EP1 receptor small interfering RNA or antagonist ONO-8711. Dinoprostone 42-46 epidermal growth factor receptor Homo sapiens 113-117 15855163-6 2005 Treatment of CCLP1 cells with PGE2 or ONO-DI-004 enhanced binding of EGFR to the EP1 receptor and c-Src. Dinoprostone 30-34 epidermal growth factor receptor Homo sapiens 69-73 15855163-7 2005 Furthermore, PGE2 or ONO-DI-004 treatment also increased Akt phosphorylation, which was blocked by the EGFR tyrosine kinase inhibitors AG 1478 and PD 153035. Dinoprostone 13-17 epidermal growth factor receptor Homo sapiens 103-107 15855163-9 2005 On the other hand, activation of EGFR by its cognate ligand (EGF) increased COX-2 expression and PGE2 production, whereas blocking PGE2 synthesis or the EP1 receptor inhibited EGF-induced EGFR phosphorylation. Dinoprostone 97-101 epidermal growth factor receptor Homo sapiens 33-37 15855163-9 2005 On the other hand, activation of EGFR by its cognate ligand (EGF) increased COX-2 expression and PGE2 production, whereas blocking PGE2 synthesis or the EP1 receptor inhibited EGF-induced EGFR phosphorylation. Dinoprostone 131-135 epidermal growth factor receptor Homo sapiens 33-37 15995627-5 2005 RESULTS: PGE2 significantly up-regulated VEGF mRNA and protein expression and increased the activation of EGFR and ERK2. Dinoprostone 9-13 epidermal growth factor receptor Homo sapiens 106-110 19956499-2 2005 Our previous studies have demonstrated that prostaglandin E(2) (PGE(2)), generated by cyclooxygenase 2 (Cox-2), transactivates epidermal growth factor receptor (EGFR), c-Met and beta-catenin; thus, enhancing colon cancer cell growth and invasiveness in vitro. Dinoprostone 44-62 epidermal growth factor receptor Homo sapiens 127-159 19956499-2 2005 Our previous studies have demonstrated that prostaglandin E(2) (PGE(2)), generated by cyclooxygenase 2 (Cox-2), transactivates epidermal growth factor receptor (EGFR), c-Met and beta-catenin; thus, enhancing colon cancer cell growth and invasiveness in vitro. Dinoprostone 44-62 epidermal growth factor receptor Homo sapiens 161-165 19956499-2 2005 Our previous studies have demonstrated that prostaglandin E(2) (PGE(2)), generated by cyclooxygenase 2 (Cox-2), transactivates epidermal growth factor receptor (EGFR), c-Met and beta-catenin; thus, enhancing colon cancer cell growth and invasiveness in vitro. Dinoprostone 64-70 epidermal growth factor receptor Homo sapiens 127-159 19956499-2 2005 Our previous studies have demonstrated that prostaglandin E(2) (PGE(2)), generated by cyclooxygenase 2 (Cox-2), transactivates epidermal growth factor receptor (EGFR), c-Met and beta-catenin; thus, enhancing colon cancer cell growth and invasiveness in vitro. Dinoprostone 64-70 epidermal growth factor receptor Homo sapiens 161-165 15995627-0 2005 PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 98-130 15995627-6 2005 Incubation of MKN28 cells with AG1478 significantly reduced PGE2-induced EGFR activity, ERK2 activity, and VEGF mRNA and protein expression. Dinoprostone 60-64 epidermal growth factor receptor Homo sapiens 73-77 15995627-8 2005 CONCLUSION: Our data suggested that PGE2 up-regulates VEGF expression in gastric cancer cells via transactivation of EGFR-MAPK signaling pathways, which may be mechanisms underlying the contribution of COX-2 to tumor angiogenesis in gastric cancer. Dinoprostone 36-40 epidermal growth factor receptor Homo sapiens 117-121 15626689-0 2005 PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 107-111 15626689-9 2005 Immunoprecipitation of myocyte lysates demonstrated that the EGFR was rapidly phosphorylated by PGE2 in VMs, and the EP4 antagonist blocked this. Dinoprostone 96-100 epidermal growth factor receptor Homo sapiens 61-65 15626689-10 2005 In addition, the selective EGFR inhibitor AG-1478 completely blocked PGE2-induced protein synthesis. Dinoprostone 69-73 epidermal growth factor receptor Homo sapiens 27-31 15044590-8 2004 Therefore, we have demonstrated that elevated EP2 receptor expression may facilitate the PGE(2)-induced release of proangiogenic factors in reproductive tumor cells via intracellular cAMP-mediated transactivation of the EGFR and ERK1/2 pathways. Dinoprostone 89-95 epidermal growth factor receptor Homo sapiens 220-224 15844661-0 2004 Cyclooxygenase-2 induction and prostaglandin E2 accumulation in squamous cell carcinoma as a consequence of epidermal growth factor receptor activation by imatinib mesylate. Dinoprostone 31-47 epidermal growth factor receptor Homo sapiens 108-140 12824187-0 2003 Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. Dinoprostone 0-16 epidermal growth factor receptor Homo sapiens 82-114 14627647-0 2003 Activation of erbB-1 signaling in tanycytes of the median eminence stimulates transforming growth factor beta1 release via prostaglandin E2 production and induces cell plasticity. Dinoprostone 123-139 epidermal growth factor receptor Homo sapiens 14-20 14627647-5 2003 Blockade of either erbB-1 receptor signal transduction or prostaglandin synthesis prevented the stimulatory effect of TGFalpha on both PGE2 and TGFbeta1 release. Dinoprostone 135-139 epidermal growth factor receptor Homo sapiens 19-23 14627647-10 2003 These in vitro results identify tanycytes as targets of TGFalpha action and demonstrate that activation of erbB-1-mediated signaling in these cells results in plastic changes that, involving PGE2 and TGFbeta1 as downstream effectors, mimic the morphological plasticity displayed by tanycytes during the hours encompassing the preovulatory surge of LHRH. Dinoprostone 191-195 epidermal growth factor receptor Homo sapiens 107-111 12824187-7 2003 In the present study, we demonstrate that the PGE2-induced migration and invasion occurs via rapid transactivation and phosphorylation of the epidermal growth factor receptor (EGFR). Dinoprostone 46-50 epidermal growth factor receptor Homo sapiens 142-174 12824187-7 2003 In the present study, we demonstrate that the PGE2-induced migration and invasion occurs via rapid transactivation and phosphorylation of the epidermal growth factor receptor (EGFR). Dinoprostone 46-50 epidermal growth factor receptor Homo sapiens 176-180 12824187-12 2003 These results suggest that in developing colonic carcinomas, the early effects of cyclooxygenase-2-derived PGE2 are in part mediated by the EGFR, and this transactivation is responsible for subsequent down-stream effects including the stimulation of cell migration and invasion. Dinoprostone 107-111 epidermal growth factor receptor Homo sapiens 140-144 12958170-4 2003 Here we provide evidence that PGE2 transactivates c-Met-R (contingent upon functional EGFR), increases tyrosine phosphorylation and nuclear accumulation of beta-catenin, and induces urokinase-type plasminogen activator receptor (uPAR) mRNA expression. Dinoprostone 30-34 epidermal growth factor receptor Homo sapiens 86-90 12958170-6 2003 Inactivation of EGFR and c-Met-R significantly reduced PGE2-induced cancer cell invasiveness. Dinoprostone 55-59 epidermal growth factor receptor Homo sapiens 16-20 9062364-7 1997 Furthermore, IFN-gamma induced the expression of RNAs for a number of ligands at the EGF receptor TGF-alpha; heparin-binding EGF-like growth factor (HB-EGF); and amphiregulin in NHBECs, and when administered exogenously, these ligands increased PGE2 release from NHBECs. Dinoprostone 245-249 epidermal growth factor receptor Homo sapiens 85-97 11875501-5 2002 Here we provide evidence that prostaglandin E2 (PGE2) rapidly phosphorylates EGFR and triggers the extracellular signal-regulated kinase 2 (ERK2)--mitogenic signaling pathway in normal gastric epithelial (RGM1) and colon cancer (Caco-2, LoVo and HT-29) cell lines. Dinoprostone 30-46 epidermal growth factor receptor Homo sapiens 77-81 11875501-5 2002 Here we provide evidence that prostaglandin E2 (PGE2) rapidly phosphorylates EGFR and triggers the extracellular signal-regulated kinase 2 (ERK2)--mitogenic signaling pathway in normal gastric epithelial (RGM1) and colon cancer (Caco-2, LoVo and HT-29) cell lines. Dinoprostone 48-52 epidermal growth factor receptor Homo sapiens 77-81 11875501-6 2002 Inactivation of EGFR kinase with selective inhibitors significantly reduces PGE2-induced ERK2 activation, c-fos mRNA expression and cell proliferation. Dinoprostone 76-80 epidermal growth factor receptor Homo sapiens 16-20 11875501-7 2002 Inhibition of matrix metalloproteinases (MMPs), transforming growth factor-alpha (TGF-alpha) or c-Src blocked PGE2-mediated EGFR transactivation and downstream signaling indicating that PGE2-induced EGFR transactivation involves signaling transduced via TGF-alpha, an EGFR ligand, likely released by c-Src-activated MMP(s). Dinoprostone 110-114 epidermal growth factor receptor Homo sapiens 124-128 11875501-7 2002 Inhibition of matrix metalloproteinases (MMPs), transforming growth factor-alpha (TGF-alpha) or c-Src blocked PGE2-mediated EGFR transactivation and downstream signaling indicating that PGE2-induced EGFR transactivation involves signaling transduced via TGF-alpha, an EGFR ligand, likely released by c-Src-activated MMP(s). Dinoprostone 110-114 epidermal growth factor receptor Homo sapiens 199-203 11875501-7 2002 Inhibition of matrix metalloproteinases (MMPs), transforming growth factor-alpha (TGF-alpha) or c-Src blocked PGE2-mediated EGFR transactivation and downstream signaling indicating that PGE2-induced EGFR transactivation involves signaling transduced via TGF-alpha, an EGFR ligand, likely released by c-Src-activated MMP(s). Dinoprostone 110-114 epidermal growth factor receptor Homo sapiens 199-203 11875501-7 2002 Inhibition of matrix metalloproteinases (MMPs), transforming growth factor-alpha (TGF-alpha) or c-Src blocked PGE2-mediated EGFR transactivation and downstream signaling indicating that PGE2-induced EGFR transactivation involves signaling transduced via TGF-alpha, an EGFR ligand, likely released by c-Src-activated MMP(s). Dinoprostone 186-190 epidermal growth factor receptor Homo sapiens 124-128 11875501-7 2002 Inhibition of matrix metalloproteinases (MMPs), transforming growth factor-alpha (TGF-alpha) or c-Src blocked PGE2-mediated EGFR transactivation and downstream signaling indicating that PGE2-induced EGFR transactivation involves signaling transduced via TGF-alpha, an EGFR ligand, likely released by c-Src-activated MMP(s). Dinoprostone 186-190 epidermal growth factor receptor Homo sapiens 199-203 11875501-7 2002 Inhibition of matrix metalloproteinases (MMPs), transforming growth factor-alpha (TGF-alpha) or c-Src blocked PGE2-mediated EGFR transactivation and downstream signaling indicating that PGE2-induced EGFR transactivation involves signaling transduced via TGF-alpha, an EGFR ligand, likely released by c-Src-activated MMP(s). Dinoprostone 186-190 epidermal growth factor receptor Homo sapiens 199-203 11875501-8 2002 Our findings that PGE2 transactivates EGFR reveal a previously unknown mechanism by which PGE2 mediates trophic actions resulting in gastric and intestinal hypertrophy as well as growth of colonic polyps and cancers. Dinoprostone 18-22 epidermal growth factor receptor Homo sapiens 38-42 11875501-8 2002 Our findings that PGE2 transactivates EGFR reveal a previously unknown mechanism by which PGE2 mediates trophic actions resulting in gastric and intestinal hypertrophy as well as growth of colonic polyps and cancers. Dinoprostone 90-94 epidermal growth factor receptor Homo sapiens 38-42 9062364-9 1997 These data are consistent with the presence of an autocrine growth factor/EGF receptor loop regulating PGHS-2 expression and PGE2 synthesis in bronchial epithelial cells. Dinoprostone 125-129 epidermal growth factor receptor Homo sapiens 74-86 32982722-8 2020 Additionally, HPV elevates COX-2 levels through the EGFR pathway and HIV promotes elevated COX-2 levels in cervical tissue as well as increases PGE2 levels eliciting inflammation and progression of cancer. Dinoprostone 144-148 epidermal growth factor receptor Homo sapiens 52-56 35242277-0 2022 Sphingosine 1-Phosphate-Upregulated COX-2/PGE2 System Contributes to Human Cardiac Fibroblast Apoptosis: Involvement of MMP-9-Dependent Transactivation of EGFR Cascade. Dinoprostone 42-46 epidermal growth factor receptor Homo sapiens 155-159 35242277-8 2022 Our results showed that S1PR1/3 activated by S1P coupled to Gq- and Gi-mediated MMP9 activity to stimulate EGFR/PI3K/Akt/MAPKs/AP-1-dependent activity of transcription to upregulate COX-2 accompanied with PGE2 production, leading to stimulation of caspase-3 activity and apoptosis. Dinoprostone 205-209 epidermal growth factor receptor Homo sapiens 107-111 35242277-10 2022 These results concluded that transactivation of MMP9/EGFR-mediated PI3K/Akt/MAPKs-dependent AP-1 activity was involved in the upregulation of the COX-2/PGE2 system induced by S1P, in turn leading to apoptosis in HCFs. Dinoprostone 152-156 epidermal growth factor receptor Homo sapiens 53-57 33609510-9 2021 In addition, AH23848 treatment attenuated PGE2-or cay10598-induced proliferation and migration by repressing the EGF receptor (EGFR)/Growth factor receptor bound protein 2-associated binder protein 1 (Gab1)/Akt/NF-kappaB/VEGF-A signaling network in human retinal microvascular endothelial cells (hRMECs). Dinoprostone 42-46 epidermal growth factor receptor Homo sapiens 113-125 33609510-9 2021 In addition, AH23848 treatment attenuated PGE2-or cay10598-induced proliferation and migration by repressing the EGF receptor (EGFR)/Growth factor receptor bound protein 2-associated binder protein 1 (Gab1)/Akt/NF-kappaB/VEGF-A signaling network in human retinal microvascular endothelial cells (hRMECs). Dinoprostone 42-46 epidermal growth factor receptor Homo sapiens 127-131 29599917-0 2018 PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 14-18 32546278-16 2020 Co-IP results showed DIM could modulate AHR to reverse EMT directly through inhibition of interaction between AHR and EGFR (epidermal growth factor receptor) so as to block RhoA/ROCK1-mediated COX2/PGE2 pathway which was connected by NF-kappaB. Dinoprostone 198-202 epidermal growth factor receptor Homo sapiens 118-122 32546278-16 2020 Co-IP results showed DIM could modulate AHR to reverse EMT directly through inhibition of interaction between AHR and EGFR (epidermal growth factor receptor) so as to block RhoA/ROCK1-mediated COX2/PGE2 pathway which was connected by NF-kappaB. Dinoprostone 198-202 epidermal growth factor receptor Homo sapiens 124-156 29936588-8 2018 In this review, we delineate the contribution of HB-EGF, an important EGFR ligand, to the cardiac dysfunction related to decreased shedding of HB-EGF after COX-2/PGE2 inhibition. Dinoprostone 162-166 epidermal growth factor receptor Homo sapiens 70-74 29599917-6 2018 The combination of EGF and PGE2 prolongs nuclear EGFR transcriptional activity manifested by the upregulation of CCND1, PTGS2, MYC and NOS2 mRNA levels and potentiates nuclear EGFR-induced NSCLC cell proliferation. Dinoprostone 27-31 epidermal growth factor receptor Homo sapiens 176-180 29599917-8 2018 Together, our findings indicate a complex mechanism underlying PGE2-induced EGF/EGFR signaling and transcriptional control, which plays a key role in cancer progression. Dinoprostone 63-67 epidermal growth factor receptor Homo sapiens 80-84 31207300-3 2019 Overexpression of mPGES-1/prostaglandin E-2 (PGE-2) signaling in GR cells was associated with acquisition of mesenchymal and stem-like cell properties, nuclear EGFR translocation and tolerance to cisplatin. Dinoprostone 26-43 epidermal growth factor receptor Homo sapiens 160-164 30367494-6 2019 PGE2 -induced increase in COX-2 expression and, thereby, in transcriptional increase in HIF-1alpha expression was due to EGFR activation, leading to the activation of Phosphoinositide 3-kinase/Akt, Extracellular signal -regulated kinases 1/2, p38 and Mitogen- and stress-activated protein kinase-1 (PI3K/Akt, Erk1/2, p38 and MSK-1). Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 121-125 30367494-7 2019 Collectively, the data suggest that EGFR-dependent COX-2 upregulation by a novel positive feedback loop triggered by iPGE2 underlies the intracrine pro-tumoral effects of PGE2 in PC3 cells. Dinoprostone 118-122 epidermal growth factor receptor Homo sapiens 36-40 29514844-6 2018 More importantly, COX-2-specific inhibitors synergistically enhanced the antitumor activity of sorafenib treatment.Conclusions: Our data obtained demonstrate that the COX/PGE2 axis acts as a regulator of HIF2alpha expression and activity to promote HCC development and reduce sorafenib sensitivity by constitutively activating the TGFalpha/EGFR pathway. Dinoprostone 171-175 epidermal growth factor receptor Homo sapiens 340-344 29447132-5 2018 The EGFR inhibitor, tyrphostin AG 1478, prevented the induction of prolonged PGE2-induced hyperalgesia, but not OIH, when tested out to 30 days after DAMGO. Dinoprostone 77-81 epidermal growth factor receptor Homo sapiens 4-8 29447132-10 2018 Thus, although the induction of prolongation of PGE2-induced hyperalgesia at the peripheral terminal of peptidergic nociceptor is dependent on Src, FAK, EGFR, and MAPK signaling, Src, FAK, and MAPK signaling is only partially involved in the induction of OIH. Dinoprostone 48-52 epidermal growth factor receptor Homo sapiens 153-157 29154474-6 2018 Interestingly, iPGE2 also mediates the effects of PGE2 on prostate cancer PC3 cells through the axis iPGE2 -iEP receptors-EGFR-HIF-1alpha. Dinoprostone 16-20 epidermal growth factor receptor Homo sapiens 122-126 29599917-2 2018 PGE2 has been reported to transactivate and internalize into the nucleus receptor tyrosine kinases such as Epidermal growth factor receptor (EGFR), thereby supporting tumor progression. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 107-139 29599917-2 2018 PGE2 has been reported to transactivate and internalize into the nucleus receptor tyrosine kinases such as Epidermal growth factor receptor (EGFR), thereby supporting tumor progression. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 141-145 29599917-3 2018 Here we demonstrate that in non-small cell lung carcinoma (NSCLC) cells, PGE2 induces EGFR nuclear translocation via different dynamin-dependent endocytic pathways, promotes the formation of an EGFR-STAT3 complex, affects nuclear EGFR target gene expression and mediates tumor cell proliferation. Dinoprostone 73-77 epidermal growth factor receptor Homo sapiens 86-90 29599917-3 2018 Here we demonstrate that in non-small cell lung carcinoma (NSCLC) cells, PGE2 induces EGFR nuclear translocation via different dynamin-dependent endocytic pathways, promotes the formation of an EGFR-STAT3 complex, affects nuclear EGFR target gene expression and mediates tumor cell proliferation. Dinoprostone 73-77 epidermal growth factor receptor Homo sapiens 194-198 29599917-3 2018 Here we demonstrate that in non-small cell lung carcinoma (NSCLC) cells, PGE2 induces EGFR nuclear translocation via different dynamin-dependent endocytic pathways, promotes the formation of an EGFR-STAT3 complex, affects nuclear EGFR target gene expression and mediates tumor cell proliferation. Dinoprostone 73-77 epidermal growth factor receptor Homo sapiens 194-198 29599917-4 2018 Indeed, we find that PGE2 induces EGFR internalization and consequent nuclear import through Clathrin- and Caveolin-mediated endocytosis and through the interaction of EGFR with Importin beta1. Dinoprostone 21-25 epidermal growth factor receptor Homo sapiens 34-38 29599917-4 2018 Indeed, we find that PGE2 induces EGFR internalization and consequent nuclear import through Clathrin- and Caveolin-mediated endocytosis and through the interaction of EGFR with Importin beta1. Dinoprostone 21-25 epidermal growth factor receptor Homo sapiens 168-172 29599917-6 2018 The combination of EGF and PGE2 prolongs nuclear EGFR transcriptional activity manifested by the upregulation of CCND1, PTGS2, MYC and NOS2 mRNA levels and potentiates nuclear EGFR-induced NSCLC cell proliferation. Dinoprostone 27-31 epidermal growth factor receptor Homo sapiens 49-53 29272001-1 2017 OBJECTIVE: To determine whether the combination of prostaglandin E2 (PGE2) and EP2, the subtype receptor of PGE2, could trans-activate the epidermal growth factor receptor (EGFR). Dinoprostone 69-73 epidermal growth factor receptor Homo sapiens 139-171 29180467-7 2018 Additional investigations suggested that activation of the COX2/PGE2 and YAP1 pathways also promoted acquired resistance to EGFR inhibitors in basal-type UCB. Dinoprostone 64-68 epidermal growth factor receptor Homo sapiens 124-128 29272001-0 2017 Investigation on the regulatory effect of PGE2 on ESCC cells through the trans-activation of EGFR by EP2 and the relevant mechanism. Dinoprostone 42-46 epidermal growth factor receptor Homo sapiens 93-97 29272001-1 2017 OBJECTIVE: To determine whether the combination of prostaglandin E2 (PGE2) and EP2, the subtype receptor of PGE2, could trans-activate the epidermal growth factor receptor (EGFR). Dinoprostone 69-73 epidermal growth factor receptor Homo sapiens 173-177 29272001-1 2017 OBJECTIVE: To determine whether the combination of prostaglandin E2 (PGE2) and EP2, the subtype receptor of PGE2, could trans-activate the epidermal growth factor receptor (EGFR). Dinoprostone 51-67 epidermal growth factor receptor Homo sapiens 139-171 29272001-1 2017 OBJECTIVE: To determine whether the combination of prostaglandin E2 (PGE2) and EP2, the subtype receptor of PGE2, could trans-activate the epidermal growth factor receptor (EGFR). Dinoprostone 108-112 epidermal growth factor receptor Homo sapiens 139-171 29272001-1 2017 OBJECTIVE: To determine whether the combination of prostaglandin E2 (PGE2) and EP2, the subtype receptor of PGE2, could trans-activate the epidermal growth factor receptor (EGFR). Dinoprostone 51-67 epidermal growth factor receptor Homo sapiens 173-177 29272001-1 2017 OBJECTIVE: To determine whether the combination of prostaglandin E2 (PGE2) and EP2, the subtype receptor of PGE2, could trans-activate the epidermal growth factor receptor (EGFR). Dinoprostone 108-112 epidermal growth factor receptor Homo sapiens 173-177 29272001-9 2017 After the intervention of PGE2, EP2 expression was decreased and the p-EGFR expression was increased (p < 0.05). Dinoprostone 26-30 epidermal growth factor receptor Homo sapiens 71-75 29272001-15 2017 ESCC cells can highly express the receptor subtype EP2 of PGE2 that can transactivate the EGFR, through which PGE2 is involved in the transition mechanism from inflammation to cancer. Dinoprostone 58-62 epidermal growth factor receptor Homo sapiens 90-94 29272001-15 2017 ESCC cells can highly express the receptor subtype EP2 of PGE2 that can transactivate the EGFR, through which PGE2 is involved in the transition mechanism from inflammation to cancer. Dinoprostone 110-114 epidermal growth factor receptor Homo sapiens 90-94 28094049-4 2017 It is known that PGE2-induced EP4 activation can transactivate the intracellular signaling pathway of the epidermal growth factor receptor (EGFR). Dinoprostone 17-21 epidermal growth factor receptor Homo sapiens 106-138 28415726-0 2017 PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 31-35 28415726-0 2017 PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 77-81 28415726-2 2017 Here we demonstrate that in non-small cell lung carcinoma (NSCLC) cells, A549 and GLC82, PGE2 promotes nuclear translocation of epidermal growth factor receptor (nEGFR), affects gene expression and induces cell growth. Dinoprostone 89-93 epidermal growth factor receptor Homo sapiens 128-160 28415726-4 2017 The nuclear localization sequence (NLS) of EGFR as well as its tyrosine kinase activity are required for the effect of PGE2 on nEGFR and downstream signaling activities. Dinoprostone 119-123 epidermal growth factor receptor Homo sapiens 43-47 28415726-5 2017 PGE2 binds its bona fide receptor EP3 which by activating SRC family kinases, induces ADAMs activation which, in turn, releases EGFR-ligands from the cell membrane and promotes nEGFR. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 128-132 28415726-7 2017 Pharmacological inhibition or silencing of the PGE2/EP3/SRC-ADAMs signaling axis or EGFR ligands i.e. AREG and EREG expression abolishes nEGFR induced by PGE2. Dinoprostone 154-158 epidermal growth factor receptor Homo sapiens 84-88 28415726-8 2017 In conclusion, PGE2 induces NSCLC cell proliferation by EP3 receptor, SRC-ADAMs activation, EGFR ligands shedding and finally, phosphorylation and nEGFR. Dinoprostone 15-19 epidermal growth factor receptor Homo sapiens 92-96 28415726-9 2017 Since nuclear EGFR is a hallmark of cancer aggressiveness, our findings reveal a novel mechanism for the contribution of PGE2 to tumor progression. Dinoprostone 121-125 epidermal growth factor receptor Homo sapiens 14-18 28213942-0 2017 PGE2 /EP4 receptor attenuated mucosal injury via beta-arrestin1/Src/EGFR-mediated proliferation in portal hypertensive gastropathy. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 68-72 28213942-5 2017 The aim of the study was to investigate whether beta-arr1 participated in PGE2 /EP4 receptor-mediated mucosal proliferation by recruiting the Src/EGF receptor (EGFR) complex to activate Akt/proliferating cell nuclear antigen (PCNA) signalling in PHG. Dinoprostone 74-78 epidermal growth factor receptor Homo sapiens 146-158 28213942-5 2017 The aim of the study was to investigate whether beta-arr1 participated in PGE2 /EP4 receptor-mediated mucosal proliferation by recruiting the Src/EGF receptor (EGFR) complex to activate Akt/proliferating cell nuclear antigen (PCNA) signalling in PHG. Dinoprostone 74-78 epidermal growth factor receptor Homo sapiens 160-164 28094049-4 2017 It is known that PGE2-induced EP4 activation can transactivate the intracellular signaling pathway of the epidermal growth factor receptor (EGFR). Dinoprostone 17-21 epidermal growth factor receptor Homo sapiens 140-144 27506158-3 2017 This study identifies a previously unknown mechanism by which PGE2 /prostaglandin E receptor 4 (EP4 ) signaling regulates multiple signaling pathways (e.g., PI3K/Akt signaling, TGFbeta signaling, Wnt signaling, EGFR signaling) which maintain the basal mammary stem cell phenotype. Dinoprostone 62-66 epidermal growth factor receptor Homo sapiens 211-215 27377703-6 2017 Specific inhibitor and mutagenesis studies showed that Src, EGFR, JNK1/2, and Erk1/2 are involved in PGE2 -induced uPAR expression. Dinoprostone 101-105 epidermal growth factor receptor Homo sapiens 60-64 27377703-11 2017 To the best of our knowledge, this is the first report that PGE2 -induced uPAR expression, which stimulates invasiveness of human gastric cancer AGS cells, is mediated by the EP2 receptor-dependent Src/EGFR/JNK1/2, Erk1/2/AP-1, and Src/EGFR/JNK1/2, Erk1/2/NF-kappaB cascades. Dinoprostone 60-64 epidermal growth factor receptor Homo sapiens 202-206 27377703-11 2017 To the best of our knowledge, this is the first report that PGE2 -induced uPAR expression, which stimulates invasiveness of human gastric cancer AGS cells, is mediated by the EP2 receptor-dependent Src/EGFR/JNK1/2, Erk1/2/AP-1, and Src/EGFR/JNK1/2, Erk1/2/NF-kappaB cascades. Dinoprostone 60-64 epidermal growth factor receptor Homo sapiens 236-240 27377703-5 2017 PGE2 induced the activation of Src, epidermal growth factor receptor (EGFR), c-Jun NH2 -terminal kinase (JNK), extracellular signal-regulated kinase (Erk), and p38 mitogen activated protein kinase (p38 MAPK). Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 36-68 27377703-5 2017 PGE2 induced the activation of Src, epidermal growth factor receptor (EGFR), c-Jun NH2 -terminal kinase (JNK), extracellular signal-regulated kinase (Erk), and p38 mitogen activated protein kinase (p38 MAPK). Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 70-74 27216189-5 2016 Both AREG and prostaglandin E2 converge to activate signaling through EGFR. Dinoprostone 14-30 epidermal growth factor receptor Homo sapiens 70-74 25103627-9 2014 These experiments demonstrated that the regulation of CCR5 expression by SP occurs via the epidermal growth factor receptor (EGFR)-COX-1-PGE2 pathway. Dinoprostone 137-141 epidermal growth factor receptor Homo sapiens 91-123 26113609-3 2015 In PCa, overexpression of EGFR promotes metastatic invasion and correlates with a high Gleason score, while prostaglandin E2 (PGE2) has been reported to modulate oncogenic EGFR-driven oncogenicity. Dinoprostone 108-124 epidermal growth factor receptor Homo sapiens 172-176 26113609-3 2015 In PCa, overexpression of EGFR promotes metastatic invasion and correlates with a high Gleason score, while prostaglandin E2 (PGE2) has been reported to modulate oncogenic EGFR-driven oncogenicity. Dinoprostone 126-130 epidermal growth factor receptor Homo sapiens 172-176 26113609-9 2015 Although EGFR inhibition reduces mPGES-1(SC) and mPGES-1(KD) cell xenograft tumour growth, we show that mPGES-1/PGE2 signalling sensitizes tumour cells to EGFR inhibitors. Dinoprostone 112-116 epidermal growth factor receptor Homo sapiens 155-159 27010855-10 2016 Reduced activity of EGFR resulted in enhanced expression of 15-hydroxyprostaglandin dehydrogenase increasing PGE2 degradation thereby blocking a positive feedback loop. Dinoprostone 109-113 epidermal growth factor receptor Homo sapiens 20-24 26033830-2 2015 This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) by prostaglandin E2 (PGE2). Dinoprostone 154-170 epidermal growth factor receptor Homo sapiens 36-40 26033830-2 2015 This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) by prostaglandin E2 (PGE2). Dinoprostone 172-176 epidermal growth factor receptor Homo sapiens 36-40 25828575-9 2015 These results suggest that PGE2-EP2 dependent intracrine mechanisms involving EGFR and HIF-1alpha play a role in PC. Dinoprostone 27-31 epidermal growth factor receptor Homo sapiens 78-82 26058972-8 2015 These findings reveal that PGE2 upregulated the cholangiocarcinoma cell beta-catenin protein through the EP3-4R/Src/EGFR/PI3K/AKT/GSK-3beta pathway. Dinoprostone 27-31 epidermal growth factor receptor Homo sapiens 116-120 25749386-7 2015 We demonstrate that the addition of PGE2 enhances cell survival and proliferation though its ability to trans-activate the Epithelial Growth Factor receptor (EGFR) and to activate beta-catenin. Dinoprostone 36-40 epidermal growth factor receptor Homo sapiens 123-156 25749386-7 2015 We demonstrate that the addition of PGE2 enhances cell survival and proliferation though its ability to trans-activate the Epithelial Growth Factor receptor (EGFR) and to activate beta-catenin. Dinoprostone 36-40 epidermal growth factor receptor Homo sapiens 158-162 25103627-9 2014 These experiments demonstrated that the regulation of CCR5 expression by SP occurs via the epidermal growth factor receptor (EGFR)-COX-1-PGE2 pathway. Dinoprostone 137-141 epidermal growth factor receptor Homo sapiens 125-129 24953041-2 2014 In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1alpha and VEGF-A through epidermal growth factor receptor (EGFR)-dependent up-regulation of retinoic acid receptor-beta (RARbeta). Dinoprostone 43-59 epidermal growth factor receptor Homo sapiens 110-142 25240937-11 2014 CONCLUSIONS: Targeting TGF-beta and prostaglandin E2 may allow for improved outcomes for cancer patients treated with combination immunotherapy and EGFR inhibitors. Dinoprostone 36-52 epidermal growth factor receptor Homo sapiens 148-152 25240937-0 2014 Tumor-derived TGF-beta and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor. Dinoprostone 27-43 epidermal growth factor receptor Homo sapiens 136-140 25240937-9 2014 Conversely, production of transforming growth factor beta (TGF-beta) and prostaglandin E2 was increased by EGFR inhibition, indicating that these immunosuppressive molecules were involved in diminishing tumor recognition by T cells. Dinoprostone 73-89 epidermal growth factor receptor Homo sapiens 107-111 24953041-2 2014 In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1alpha and VEGF-A through epidermal growth factor receptor (EGFR)-dependent up-regulation of retinoic acid receptor-beta (RARbeta). Dinoprostone 43-59 epidermal growth factor receptor Homo sapiens 144-148 24953041-2 2014 In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1alpha and VEGF-A through epidermal growth factor receptor (EGFR)-dependent up-regulation of retinoic acid receptor-beta (RARbeta). Dinoprostone 61-65 epidermal growth factor receptor Homo sapiens 110-142 24953041-2 2014 In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1alpha and VEGF-A through epidermal growth factor receptor (EGFR)-dependent up-regulation of retinoic acid receptor-beta (RARbeta). Dinoprostone 61-65 epidermal growth factor receptor Homo sapiens 144-148 24953041-4 2014 Treatment of HK2 cells with PGE2 resulted in increased phosphorylation of EGFR, the three studied kinases and the histone H3 (Ser10) at the RARbeta gene promoter (the latter has been proposed as a molecular signature of the activated RARbeta gene promoter). Dinoprostone 28-32 epidermal growth factor receptor Homo sapiens 74-78 24953041-5 2014 Prevention of the phosphorylation of EGFR, ERK1/2, p38 MAPK or MSK1 is by incubating, respectively, with AG1478, PD98059, SB203580 or H89 allowed to elucidate the precise phosphorylation order in the signaling cascade triggered by PGE2: first, EGFR; then, ERK1/2 and p38 MAPK and, finally, MSK1. Dinoprostone 231-235 epidermal growth factor receptor Homo sapiens 37-41 24378923-9 2014 These findings reveal that PGE2 upregulated YB-1 expression through the EP1/Src/EGFR/p44/42 MAPK/mTOR pathway, which greatly enhanced HCC cell invasion. Dinoprostone 27-31 epidermal growth factor receptor Homo sapiens 80-84 24760275-21 2014 In conclusion, PGE2 activates Akt/NF-kappaB signaling and then upregulates Snail via the EP4R/EGFR to promote migration and invasion in hepatoma cells. Dinoprostone 15-19 epidermal growth factor receptor Homo sapiens 94-98 24378923-5 2014 Src and EGFR were both activated by PGE2, which in turn increased the phosphorylation levels of p44/42 MAPK. Dinoprostone 36-40 epidermal growth factor receptor Homo sapiens 8-12 24378923-6 2014 Src, EGFR and p44/42 MAPK were all involved in PGE2-induced YB-1 expression. Dinoprostone 47-51 epidermal growth factor receptor Homo sapiens 5-9 24626807-7 2014 Our findings suggest that PGE2 could upregulate the expression level of Snail protein through the EP2/Src/EGFR/Akt/mTOR pathway in Huh-7 cells, which promotes HCC cell invasion and migration. Dinoprostone 26-30 epidermal growth factor receptor Homo sapiens 106-110 23644172-0 2013 Epidermal growth factor receptor transactivation by intracellular prostaglandin E2-activated prostaglandin E2 receptors. Dinoprostone 66-82 epidermal growth factor receptor Homo sapiens 0-32 24092824-10 2013 Knockdown of EGF receptor (EGFR) attenuated LH-induced COX-2 expression and PGE2 production. Dinoprostone 76-80 epidermal growth factor receptor Homo sapiens 13-25 24092824-10 2013 Knockdown of EGF receptor (EGFR) attenuated LH-induced COX-2 expression and PGE2 production. Dinoprostone 76-80 epidermal growth factor receptor Homo sapiens 27-31 24092824-12 2013 The stimulatory effects of AREG, BTC, and EREG on COX-2 expression and PGE2 production were blocked by inhibition of EGFR activity and expression. Dinoprostone 71-75 epidermal growth factor receptor Homo sapiens 117-121 23973650-0 2013 Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Galphai and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. Dinoprostone 44-60 epidermal growth factor receptor Homo sapiens 155-187 23644172-7 2013 We found that EGFR inhibitor AG1478 prevented the increase in VEGF-A production induced by PGE2- and all-trans retinoic acid. Dinoprostone 91-95 epidermal growth factor receptor Homo sapiens 14-18 23644172-9 2013 PGE2 and all-trans retinoic acid also increased EGFR phosphorylation and this effect was sensitive to antagonists of EP receptors. Dinoprostone 0-4 epidermal growth factor receptor Homo sapiens 48-52 23644172-10 2013 The role of intracellular PGE2 was indicated by two facts; i) PGE2-induced EGFR phosphorylation was substantially prevented by inhibitor of prostaglandin uptake transporter bromocresol green and ii) all-trans retinoic acid treatment, which enhanced intracellular but not extracellular PGE2, had lower effect on EGFR phosphorylation upon pre-treatment with cyclooxygenase inhibitor diclofenac. Dinoprostone 26-30 epidermal growth factor receptor Homo sapiens 75-79 23644172-10 2013 The role of intracellular PGE2 was indicated by two facts; i) PGE2-induced EGFR phosphorylation was substantially prevented by inhibitor of prostaglandin uptake transporter bromocresol green and ii) all-trans retinoic acid treatment, which enhanced intracellular but not extracellular PGE2, had lower effect on EGFR phosphorylation upon pre-treatment with cyclooxygenase inhibitor diclofenac. Dinoprostone 26-30 epidermal growth factor receptor Homo sapiens 311-315 23644172-10 2013 The role of intracellular PGE2 was indicated by two facts; i) PGE2-induced EGFR phosphorylation was substantially prevented by inhibitor of prostaglandin uptake transporter bromocresol green and ii) all-trans retinoic acid treatment, which enhanced intracellular but not extracellular PGE2, had lower effect on EGFR phosphorylation upon pre-treatment with cyclooxygenase inhibitor diclofenac. Dinoprostone 62-66 epidermal growth factor receptor Homo sapiens 75-79 23644172-10 2013 The role of intracellular PGE2 was indicated by two facts; i) PGE2-induced EGFR phosphorylation was substantially prevented by inhibitor of prostaglandin uptake transporter bromocresol green and ii) all-trans retinoic acid treatment, which enhanced intracellular but not extracellular PGE2, had lower effect on EGFR phosphorylation upon pre-treatment with cyclooxygenase inhibitor diclofenac. Dinoprostone 62-66 epidermal growth factor receptor Homo sapiens 311-315 23644172-10 2013 The role of intracellular PGE2 was indicated by two facts; i) PGE2-induced EGFR phosphorylation was substantially prevented by inhibitor of prostaglandin uptake transporter bromocresol green and ii) all-trans retinoic acid treatment, which enhanced intracellular but not extracellular PGE2, had lower effect on EGFR phosphorylation upon pre-treatment with cyclooxygenase inhibitor diclofenac. Dinoprostone 62-66 epidermal growth factor receptor Homo sapiens 75-79 23644172-10 2013 The role of intracellular PGE2 was indicated by two facts; i) PGE2-induced EGFR phosphorylation was substantially prevented by inhibitor of prostaglandin uptake transporter bromocresol green and ii) all-trans retinoic acid treatment, which enhanced intracellular but not extracellular PGE2, had lower effect on EGFR phosphorylation upon pre-treatment with cyclooxygenase inhibitor diclofenac. Dinoprostone 62-66 epidermal growth factor receptor Homo sapiens 311-315 23644172-11 2013 Thus, EGFR transactivation by intracellular PGE2-activated EP receptors results in the sequential activation of RARbeta and HIF-1alpha leading to increased production of VEGF-A and it may be a target for the therapeutic modulation of HIF-1alpha/VEGF-A. Dinoprostone 44-48 epidermal growth factor receptor Homo sapiens 6-10 23394575-0 2013 Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway. Dinoprostone 148-152 epidermal growth factor receptor Homo sapiens 34-38 23525457-14 2013 The EGF receptor (EGFR) inhibitor also suppressed 17-PT-PGE2-upregulated FAK phosphorylation. Dinoprostone 56-60 epidermal growth factor receptor Homo sapiens 4-16 23525457-14 2013 The EGF receptor (EGFR) inhibitor also suppressed 17-PT-PGE2-upregulated FAK phosphorylation. Dinoprostone 56-60 epidermal growth factor receptor Homo sapiens 18-22 22815767-10 2012 CONCLUSION: Our work demonstrates that the pharmacological inhibition of mPGES-1 reduces squamous carcinoma growth by suppressing PGE(2) mediated-EGFR signalling and by impairing tumor associated angiogenesis. Dinoprostone 130-136 epidermal growth factor receptor Homo sapiens 146-150 22791816-12 2012 Coculture increased Caco-2 phospho-active ERBB (pERBB2), whereas DN-EGFR in Caco-2 cells suppressed fibroblast PTGS2 and prostaglandin E2 (PGE2). Dinoprostone 121-137 epidermal growth factor receptor Homo sapiens 68-72 22791816-12 2012 Coculture increased Caco-2 phospho-active ERBB (pERBB2), whereas DN-EGFR in Caco-2 cells suppressed fibroblast PTGS2 and prostaglandin E2 (PGE2). Dinoprostone 139-143 epidermal growth factor receptor Homo sapiens 68-72