PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23938462-5 2014 The cascade involved prostaglandin E2 (PGE2) production from melanoma induced by IL-18-dependent tumor necrosis factor-alpha (TNFalpha); next, PGE2-induced IL-1beta via vascular endothelial growth factor (VEGF) secretion, which in turn induced VLA-4 activation via cyclooxygenase 2-dependent H2O2. Dinoprostone 143-147 interleukin 1 beta Mus musculus 156-164 24192281-5 2014 In response to the addition of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma to the culture medium, primary osteoblasts showed increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) at early time points and decreases in cell viability. Dinoprostone 222-238 interleukin 1 beta Mus musculus 57-103 24192281-5 2014 In response to the addition of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma to the culture medium, primary osteoblasts showed increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) at early time points and decreases in cell viability. Dinoprostone 240-244 interleukin 1 beta Mus musculus 57-103 22789837-11 2012 Moreover, phloroglucinol inhibited the IL-1beta-induced PGE(2) production in pulp fibroblasts. Dinoprostone 56-62 interleukin 1 beta Mus musculus 39-47 24170042-3 2013 CD200R-deficient bone marrow derived macrophages (BMMPhi) were used to demonstrate that macrophages lacking this inhibitory receptor exhibit enhanced levels of Vegfa, Arg-1 and Il-1beta when stimulated with PGE2 or RPE-conditioned (PGE2-enriched) media. Dinoprostone 207-211 interleukin 1 beta Mus musculus 177-185 22490780-2 2012 PGE2 is a well-established endogenous pyrogen activated by proinflammatory cytokine interleukin (IL)-1beta. Dinoprostone 0-4 interleukin 1 beta Mus musculus 84-106 22490780-4 2012 Here we show that P2X7R activation is required for the release of PGE2 and other autacoids independent of inflammasome activation, with an ATP EC(50) for PGE2 and IL-1beta release of 1.58 and 1.23 mM, respectively. Dinoprostone 66-70 interleukin 1 beta Mus musculus 163-171 21441617-3 2011 In mouse brain cortex, interleukin-1beta at 0.3 nM and the prostaglandin E2 analogue sulprostone at 3 nM inhibited noradrenaline release by about 40% the effect of interleukin-1beta developed gradually, whereas the effect of sulprostone occurred promptly. Dinoprostone 59-75 interleukin 1 beta Mus musculus 164-181 22803375-0 2012 [Cinnamaldehyde decreases interleukin-1beta induced PGE2 production by down-regulation of mPGES-1 and COX-2 expression in mouse macrophage RAW264.7 cells]. Dinoprostone 52-56 interleukin 1 beta Mus musculus 26-43 24116274-4 2012 WIN-34B inhibited the level of IL-6, PGE2, and MMP-13 in IL-1beta-stimulated RA FLSs in a dose-dependent manner. Dinoprostone 37-41 interleukin 1 beta Mus musculus 57-65 22179028-8 2012 Accordingly, IL-1beta-induced PGE2, MMP-3 and MMP-13 releases were inhibited by 86% (P<0.001), 58%(P<0.001) and 38% (P<0.01) respectively. Dinoprostone 30-34 interleukin 1 beta Mus musculus 13-21 17023389-4 2006 The results show that genetic deletion of mPGES-1 results in a dramatic decrease in PGE2 production in Het and null MEFs under basal conditions and after stimulation with interleukin (IL)-1beta, suggesting that mPGES-1 is critically important for PGE2 production. Dinoprostone 84-88 interleukin 1 beta Mus musculus 171-193 20412387-2 2010 Downstream actions of IL-1beta include production of prostaglandin (PG) E(2) by increasing expression of cyclooxygenase (COX) enzymes and prostaglandin E synthase (PGES) isoforms. Dinoprostone 53-76 interleukin 1 beta Mus musculus 22-30 20412387-5 2010 Here, we aimed to elucidate the effects of long-term IL-1beta expression on the PGE(2) synthetic pathway and to determine the effects of PGs on inflammation and memory in our model. Dinoprostone 80-86 interleukin 1 beta Mus musculus 53-61 20412387-6 2010 As expected, PGE(2) levels were significantly elevated after IL-1beta up-regulation. Dinoprostone 13-19 interleukin 1 beta Mus musculus 61-69 18310904-5 2008 The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production. Dinoprostone 73-77 interleukin 1 beta Mus musculus 27-35 18310904-5 2008 The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production. Dinoprostone 133-137 interleukin 1 beta Mus musculus 27-35 18310904-5 2008 The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production. Dinoprostone 133-137 interleukin 1 beta Mus musculus 116-124 18310904-5 2008 The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production. Dinoprostone 133-137 interleukin 1 beta Mus musculus 27-35 18310904-5 2008 The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production. Dinoprostone 133-137 interleukin 1 beta Mus musculus 116-124 17882968-0 2007 [Structure-activity relationship of phenylallyl compounds inhibiting PGE2 release in mouse cerebral microvascular endothelial cells induced by IL-1beta]. Dinoprostone 69-73 interleukin 1 beta Mus musculus 143-151 17882968-3 2007 Different concentrations of phenylallyl compounds were added separately, and the content of PGE2 induced by IL-1beta in the culture media was measured by ELISA assay. Dinoprostone 92-96 interleukin 1 beta Mus musculus 108-116 17535900-2 2007 To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and human neonates. Dinoprostone 82-100 interleukin 1 beta Mus musculus 36-44 17535900-2 2007 To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and human neonates. Dinoprostone 102-108 interleukin 1 beta Mus musculus 36-44 17535900-8 2007 We conclude that IL-1beta adversely affects breathing and its control by mPGES-1 activation and PGE(2) binding to brainstem EP3 receptors, resulting in increased apnea frequency and hypoxia-induced mortality. Dinoprostone 96-102 interleukin 1 beta Mus musculus 17-25 17166728-6 2007 Cyclooxygenase inhibitor administration prevented the interleukin-1-beta-induced increase in the production of brain prostaglandin E(2) (a cyclooxygenase metabolite) and changes in the expression of brain interleukin-6, interleukin-18, tumor necrosis factor-alpha, and brain-derived neurotrophic factor. Dinoprostone 117-135 interleukin 1 beta Mus musculus 54-72 20025057-5 2010 However, in cells treated with LPS coupled with COX-2 neutralization, the mRNA expression levels of COX-2, mPGES-1, tumor necrosis factor-alpha, interleukin-1beta and inducible nitric oxide synthase were significantly suppressed; production of prostaglandin E(2) and reactive oxygen species also decreased. Dinoprostone 244-262 interleukin 1 beta Mus musculus 145-162 18438860-6 2008 Finally, small interfering RNA (siRNA) was used to assess the influence of visfatin on IL-1beta-induced release of PGE2 in immature mouse articular chondrocytes. Dinoprostone 115-119 interleukin 1 beta Mus musculus 87-95 17963953-1 2007 Many of the proinflammatory effects of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha) are mediated through cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2). Dinoprostone 162-178 interleukin 1 beta Mus musculus 39-61 17963953-1 2007 Many of the proinflammatory effects of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha) are mediated through cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2). Dinoprostone 180-184 interleukin 1 beta Mus musculus 39-61 17023389-4 2006 The results show that genetic deletion of mPGES-1 results in a dramatic decrease in PGE2 production in Het and null MEFs under basal conditions and after stimulation with interleukin (IL)-1beta, suggesting that mPGES-1 is critically important for PGE2 production. Dinoprostone 247-251 interleukin 1 beta Mus musculus 171-193 15986771-5 2005 However, IL-1beta enhanced the PGE2-induced increase of L-glutamate uptake. Dinoprostone 31-35 interleukin 1 beta Mus musculus 9-17 16513308-4 2006 Cyclooxygenase-2 (COX-2) and tyrosine kinase involve on prostaglandin E2 (PGE2) production in mouse calvarial osteoblasts stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6). Dinoprostone 56-72 interleukin 1 beta Mus musculus 145-162 16513308-4 2006 Cyclooxygenase-2 (COX-2) and tyrosine kinase involve on prostaglandin E2 (PGE2) production in mouse calvarial osteoblasts stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6). Dinoprostone 56-72 interleukin 1 beta Mus musculus 164-172 16777343-1 2006 Most of the inflammatory effects of the cytokine interleukin 1beta (IL-1beta) are mediated by induction of cyclooxygenase (COX)2 and the subsequent synthesis and release of prostaglandin E2. Dinoprostone 173-189 interleukin 1 beta Mus musculus 49-66 16777343-1 2006 Most of the inflammatory effects of the cytokine interleukin 1beta (IL-1beta) are mediated by induction of cyclooxygenase (COX)2 and the subsequent synthesis and release of prostaglandin E2. Dinoprostone 173-189 interleukin 1 beta Mus musculus 68-76 16513308-4 2006 Cyclooxygenase-2 (COX-2) and tyrosine kinase involve on prostaglandin E2 (PGE2) production in mouse calvarial osteoblasts stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6). Dinoprostone 74-78 interleukin 1 beta Mus musculus 145-162 16513308-6 2006 TGF-beta, YJ (100microg/ml) and their combinations of YJ+TGF-beta reduced the COX-2 mRNA level, PGE2 biosynthesis and bone resorption induced by IL-1beta, TNF-alpha, IL-6 or their combination. Dinoprostone 96-100 interleukin 1 beta Mus musculus 145-153 15986771-7 2005 Kinetic analysis of L-glutamate uptake showed that PGE2 and PGE2 with IL-1beta increased V(max) value with no significant effect on Km value for Na(+)-dependent L-glutamate uptake. Dinoprostone 51-55 interleukin 1 beta Mus musculus 70-78 15986771-7 2005 Kinetic analysis of L-glutamate uptake showed that PGE2 and PGE2 with IL-1beta increased V(max) value with no significant effect on Km value for Na(+)-dependent L-glutamate uptake. Dinoprostone 60-64 interleukin 1 beta Mus musculus 70-78 15883739-6 2005 In the presence of IL-1beta, PGE2, 15d-PGJ2, 6-keto PGF1alpha and PGF2alpha each enhanced COX-2 protein expression between 5- to 20-fold. Dinoprostone 29-33 interleukin 1 beta Mus musculus 19-27 15749024-5 2005 Recombinant mouse IL-1beta induced strong activation of ERK1/2, p38, JNK and NFkappa B, and significant release of IL-6 and PGE2, which was blocked by IL-1ra. Dinoprostone 124-128 interleukin 1 beta Mus musculus 18-26 15313472-1 2004 Cyclooxygenase-2 (COX-2) and tyrosine kinase, which are involved in the biosynthesis of prostaglandin E(2) (PGE(2)) in mouse calvarial osteoblasts, are stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6). Dinoprostone 88-106 interleukin 1 beta Mus musculus 175-192 15313472-1 2004 Cyclooxygenase-2 (COX-2) and tyrosine kinase, which are involved in the biosynthesis of prostaglandin E(2) (PGE(2)) in mouse calvarial osteoblasts, are stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6). Dinoprostone 88-106 interleukin 1 beta Mus musculus 194-202 15313472-6 2004 A novel Src tyrosine kinase inhibitor, Herbimycin A (HERB), reduced COX-2 mRNA levels as well as PGE(2) production induced by IL-1beta, TNF-alpha and IL-6 or a combination of IL-1beta, TNF-alpha, IL-6, whereas COX-1 mRNA levels remained unaffected. Dinoprostone 97-103 interleukin 1 beta Mus musculus 126-134 12421347-7 2002 In comparison, IL-1beta induced the release of PGE2, IL-6 and activated NF-kappaB, p38, JNK and ERK1/2 in mixed glial cultures, but failed to induce any of these responses in microglial cell cultures. Dinoprostone 47-51 interleukin 1 beta Mus musculus 15-23 15135319-3 2004 However, the issue of whether PGE2 regulates the expression of IL-1beta in mouse osteoblasts has not been resolved. Dinoprostone 30-34 interleukin 1 beta Mus musculus 63-71 15135319-4 2004 In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level. Dinoprostone 34-38 interleukin 1 beta Mus musculus 62-70 15135319-4 2004 In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level. Dinoprostone 117-121 interleukin 1 beta Mus musculus 153-161 15135319-4 2004 In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level. Dinoprostone 117-121 interleukin 1 beta Mus musculus 153-161 15135319-4 2004 In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level. Dinoprostone 117-121 interleukin 1 beta Mus musculus 153-161 15135319-4 2004 In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level. Dinoprostone 117-121 interleukin 1 beta Mus musculus 153-161 15135319-5 2004 PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2. Dinoprostone 0-4 interleukin 1 beta Mus musculus 25-33 15135319-5 2004 PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2. Dinoprostone 0-4 interleukin 1 beta Mus musculus 154-162 15135319-5 2004 PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2. Dinoprostone 204-208 interleukin 1 beta Mus musculus 25-33 15135319-5 2004 PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2. Dinoprostone 204-208 interleukin 1 beta Mus musculus 154-162 15135319-7 2004 The role of cAMP activation in PGE2-mediated IL-1beta production was examined by the effects of forskolin, an adenylyl cyclase (AC) activator and dideoxyadenosine (DDA), an AC inhibitor. Dinoprostone 31-35 interleukin 1 beta Mus musculus 45-53 15135319-8 2004 Forskolin enhanced and DDA blocked the production of IL-1beta by PGE2. Dinoprostone 65-69 interleukin 1 beta Mus musculus 53-61 15135319-9 2004 In addition, PGE2-mediated IL-1beta induction was completely inhibited by the cAMP antagonist, Rp-cAMP, and protein kinase A (PKA) inhibitors of KT5720 and H89. Dinoprostone 13-17 interleukin 1 beta Mus musculus 27-35 15135319-10 2004 The PGE2-induced production of IL-1beta was also blocked by the PKA inhibitor PKI14-22. Dinoprostone 4-8 interleukin 1 beta Mus musculus 31-39 15135319-13 2004 These findings indicate that PGE2 involves the cAMP-PKA signaling pathway in regulating IL-1beta gene expression in osteoblasts. Dinoprostone 29-33 interleukin 1 beta Mus musculus 88-96 14975584-2 2004 To understand the consequences of its presence in brain, we carried out intraparenchymal IL-1beta injections and found significant increases in prostaglandin (PG)E2, a critical factor in inflammatory and physiological processes. Dinoprostone 144-164 interleukin 1 beta Mus musculus 89-97 15135319-0 2004 PGE2 induces IL-1beta gene expression in mouse osteoblasts through a cAMP-PKA signaling pathway. Dinoprostone 0-4 interleukin 1 beta Mus musculus 13-21 12466348-0 2002 Interleukin-1beta induces phosphodiesterase 4B2 expression in human myometrial cells through a prostaglandin E2- and cyclic adenosine 3",5"-monophosphate-dependent pathway. Dinoprostone 95-111 interleukin 1 beta Mus musculus 0-17 12375736-0 2002 IL-1beta regulates cellular proliferation, prostaglandin E2 synthesis, plasminogen activator activity, osteocalcin production, and bone resorptive activity of the mouse calvarial bone cells. Dinoprostone 43-59 interleukin 1 beta Mus musculus 0-8 12198250-5 2002 In addition, IL-1beta-stimulated prostaglandin E2 production is completely inhibited by a preferential lipoxygenase inhibitor cinnaminyl-3,4-dihydroxy-alpha-cyanocinnamate. Dinoprostone 33-49 interleukin 1 beta Mus musculus 13-21 12198250-6 2002 We then evaluated IL-1beta-induced PGE2 production in islets purified from control C57BL/6 mice and 12-LO knockout mice lacking cytokine-inducible 12-HETE. Dinoprostone 35-39 interleukin 1 beta Mus musculus 18-26 12198250-7 2002 IL-1beta stimulated an 8-fold increase in PGE2 production in C57BL/6 islets but failed to stimulate PGE2 in 12-LO knockout islets. Dinoprostone 42-46 interleukin 1 beta Mus musculus 0-8 12375736-2 2002 IL-1beta stimulated cellular proliferation and the synthesis of prostaglandin E2 in the cultured cells in a dose-dependent manner. Dinoprostone 64-80 interleukin 1 beta Mus musculus 0-8 8632179-3 1996 In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA). Dinoprostone 65-81 interleukin 1 beta Mus musculus 119-137 12067102-2 2002 On processing bone metabolism, PGE2 accelerated production of IL-1beta in fetal mouse osteoblast and stimulated physiological activation substance, IL-1beta. Dinoprostone 31-35 interleukin 1 beta Mus musculus 62-70 12067102-2 2002 On processing bone metabolism, PGE2 accelerated production of IL-1beta in fetal mouse osteoblast and stimulated physiological activation substance, IL-1beta. Dinoprostone 31-35 interleukin 1 beta Mus musculus 148-156 12067102-3 2002 The novel class of Src tyrosine kinase inhibitors, Herbimycin A (HERB) and HHI reduced COX-2 mRNA levels as well as PGE2 production induced by IL-1beta, TNF-alpha and IL-6. Dinoprostone 116-120 interleukin 1 beta Mus musculus 143-151 11094054-2 2001 Treatment of murine macrophages with lipopolysaccharide, interleukin-1beta, and tumor necrosis factor-alpha increased PLAA levels at early time points (2-30 min), which correlated with an up-regulation in cytosolic PLA2 and PGE2 levels. Dinoprostone 224-228 interleukin 1 beta Mus musculus 57-74 10960082-0 2000 Induction of COX-2 and PGE(2) biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes. Dinoprostone 23-29 interleukin 1 beta Mus musculus 46-54 10960082-2 2000 In the present study, we examined whether prostaglandin E(2) (PGE(2)) production after IL-1beta stimulation is dependent upon activation of protein kinases in astroglial cells. Dinoprostone 42-60 interleukin 1 beta Mus musculus 87-95 10960082-2 2000 In the present study, we examined whether prostaglandin E(2) (PGE(2)) production after IL-1beta stimulation is dependent upon activation of protein kinases in astroglial cells. Dinoprostone 62-68 interleukin 1 beta Mus musculus 87-95 10960082-3 2000 Astrocyte cultures stimulated with IL-1beta or the phorbol ester, PMA significantly increased PGE(2) secretion. Dinoprostone 94-100 interleukin 1 beta Mus musculus 35-43 10960082-4 2000 The stimulatory action of IL-1beta on PGE(2) production was totally abolished by NS-398, a specific inhibitor of cyclo-oxygenase-2 activity, as well as by the protein synthesis inhibitor cycloheximide, and the glucocorticoid dexamethasone. Dinoprostone 38-44 interleukin 1 beta Mus musculus 26-34 9242654-5 1997 Exogenous addition or enforced expression of type IIA sPLA2 significantly increased IL-1beta/TNFalpha-initiated PGE2 generation, which was accompanied by increased expression of both cPLA2 and COX-2 and suppressed by inhibitors of these enzymes. Dinoprostone 112-116 interleukin 1 beta Mus musculus 84-92 8895611-5 1996 PGE2 decreased in ibuprofen-treated groups (P < 0.05 versus control, IL-1beta groups). Dinoprostone 0-4 interleukin 1 beta Mus musculus 72-80 8830984-2 1996 The combination of interleukin-1 beta (IL-1) and tumor necrosis factor alpha (TNF) stimulated NO production, PGE2 production, and bone resorption. Dinoprostone 109-113 interleukin 1 beta Mus musculus 19-37 10799905-10 2000 Finally, PGE2 pretreatment synergistically stimulated LPS-induced expression of IL-1beta and IL-6 genes in mouse macrophages. Dinoprostone 9-13 interleukin 1 beta Mus musculus 80-88 9242654-3 1997 Kinetic and pharmacological studies showed that delayed PGE2 generation by this cell line in response to interleukin (IL)-1beta and tumor necrosis factor alpha (TNFalpha) was dependent upon cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX)-2. Dinoprostone 56-60 interleukin 1 beta Mus musculus 105-127 8632179-3 1996 In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA). Dinoprostone 65-81 interleukin 1 beta Mus musculus 139-148 8632179-3 1996 In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA). Dinoprostone 83-87 interleukin 1 beta Mus musculus 119-137 8632179-3 1996 In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA). Dinoprostone 83-87 interleukin 1 beta Mus musculus 139-148 8632179-4 1996 This increase in PGE2 content was blocked by pretreatment with dexamethasone and correlated with increases in cyclooxygenase activity measured at 4 h. Northern blots revealed concomitant increases in PGHS-2 mRNA levels that peaked at 2 h and were dependent on the dosage of IL-1 beta. Dinoprostone 17-21 interleukin 1 beta Mus musculus 274-283 8418915-6 1993 Treatment of murine decidual explants with LPS, IL-1 beta, and TNF resulted in significant increases in the production of prostaglandin E2 (PGE2) and IL-6. Dinoprostone 122-138 interleukin 1 beta Mus musculus 48-57 8596046-0 1996 Prostaglandin E2 stimulates osteoclast formation via endogenous IL-1 beta expressed through protein kinase A. Dinoprostone 0-16 interleukin 1 beta Mus musculus 64-73 8596046-2 1996 PGE2 induced IL-1 beta gene expression in the primed calvarial cells. Dinoprostone 0-4 interleukin 1 beta Mus musculus 13-22 8596046-4 1996 PGE2-induced IL-1 beta gene expression was markedly inhibited by H-89, a potent inhibitor of protein kinase A. Dinoprostone 0-4 interleukin 1 beta Mus musculus 13-22 8596046-7 1996 The presence of the IL-1 beta gene product in the conditioned medium of 1 alpha,25-(OH)2D3-primed calvarial cells treated with PGE2 was proved by the results of an immunoprecipitation assay using anti-mouse IL-1 beta Ab. Dinoprostone 127-131 interleukin 1 beta Mus musculus 20-29 8596046-8 1996 The addition of anti-mouse IL-1 beta Ab to 1 alpha,25-(OH)2D3 primed calvarial cell cultures markedly inhibited PGE2-stimulated osteoclast formation. Dinoprostone 112-116 interleukin 1 beta Mus musculus 27-36 8596046-9 1996 The stimulatory effect of conditioned medium of primed calvarial cells treated with PGE2 on osteoclast formation was also inhibited by anti-IL-1 beta Ab pretreatment. Dinoprostone 84-88 interleukin 1 beta Mus musculus 140-149 8852950-1 1996 Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production. Dinoprostone 77-93 interleukin 1 beta Mus musculus 0-18 8852950-1 1996 Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production. Dinoprostone 77-93 interleukin 1 beta Mus musculus 20-29 8852950-1 1996 Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production. Dinoprostone 95-99 interleukin 1 beta Mus musculus 0-18 8852950-1 1996 Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production. Dinoprostone 95-99 interleukin 1 beta Mus musculus 20-29 8852950-4 1996 We report here that IL-1 beta induces PGE2 production in bone marrow culture induced by a PGHS-2-dependent mechanism. Dinoprostone 38-42 interleukin 1 beta Mus musculus 20-29 8852950-5 1996 IL-1 beta stimulated the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNC) and the production of PGE2 in mouse bone marrow cultures. Dinoprostone 139-143 interleukin 1 beta Mus musculus 0-9 8852950-7 1996 Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis. Dinoprostone 49-53 interleukin 1 beta Mus musculus 31-40 8852950-7 1996 Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis. Dinoprostone 49-53 interleukin 1 beta Mus musculus 116-125 8852950-7 1996 Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis. Dinoprostone 100-104 interleukin 1 beta Mus musculus 31-40 8852950-7 1996 Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis. Dinoprostone 100-104 interleukin 1 beta Mus musculus 116-125 8418915-6 1993 Treatment of murine decidual explants with LPS, IL-1 beta, and TNF resulted in significant increases in the production of prostaglandin E2 (PGE2) and IL-6. Dinoprostone 140-144 interleukin 1 beta Mus musculus 48-57 2025252-1 1991 Interleukin-1 (IL-1) alpha and beta dose-dependently stimulated the release of 45Ca and the formation of prostaglandin E2 (PGE2) and PGI2 in cultured mouse calvarial bones, with IL-1 beta being the most potent agonist. Dinoprostone 105-121 interleukin 1 beta Mus musculus 178-187 1425428-10 1992 IL-1 beta also increased steady state levels of 7.5- and 0.9-kilobase IGF-I mRNA transcripts in total RNA extracted from cultured calvaria at 24 h. The cyclooxygenase inhibitor indomethacin (1 microM) inhibited IL-1 beta-induced prostaglandin E2 (PGE2) production and inhibited resorption and release of IGF-I from calvaria. Dinoprostone 229-245 interleukin 1 beta Mus musculus 0-9 1425428-10 1992 IL-1 beta also increased steady state levels of 7.5- and 0.9-kilobase IGF-I mRNA transcripts in total RNA extracted from cultured calvaria at 24 h. The cyclooxygenase inhibitor indomethacin (1 microM) inhibited IL-1 beta-induced prostaglandin E2 (PGE2) production and inhibited resorption and release of IGF-I from calvaria. Dinoprostone 247-251 interleukin 1 beta Mus musculus 0-9 2025252-1 1991 Interleukin-1 (IL-1) alpha and beta dose-dependently stimulated the release of 45Ca and the formation of prostaglandin E2 (PGE2) and PGI2 in cultured mouse calvarial bones, with IL-1 beta being the most potent agonist. Dinoprostone 123-127 interleukin 1 beta Mus musculus 178-187 2025252-2 1991 Bradykinin (BK; 10 nmol/l) synergistically potentiated the effect of IL-1 alpha (10 pg/ml) and IL-1 beta (5 pg/ml) both on 45Ca release and on biosynthesis of PGE2 and PGI2. Dinoprostone 159-163 interleukin 1 beta Mus musculus 95-104 2651547-4 1989 Immunoperoxidase staining for cell-associated TNF alpha, IL-1 alpha, and IL-1 beta demonstrated that PGE2 suppressed TNF, but not IL-1 alpha or -beta expression, supporting the bioassay data. Dinoprostone 101-105 interleukin 1 beta Mus musculus 73-82 2172382-5 1990 PGE2 and dBcAMP not only potentiated LPS-induced IL-1 beta mRNA levels but were also able to stimulate modest accumulation of IL-1 beta mRNA in the absence of LPS. Dinoprostone 0-4 interleukin 1 beta Mus musculus 126-135 2129785-1 1990 Recombinant Interleukin-1 beta (rIL-1 beta) induced dose-dependent synthesis of PGE2 and activation of both cell-associated and soluble phospholipase A2 (PLA2) in cultured mouse peritoneal macrophages. Dinoprostone 80-84 interleukin 1 beta Mus musculus 12-30 2172382-5 1990 PGE2 and dBcAMP not only potentiated LPS-induced IL-1 beta mRNA levels but were also able to stimulate modest accumulation of IL-1 beta mRNA in the absence of LPS. Dinoprostone 0-4 interleukin 1 beta Mus musculus 49-58 3141017-3 1988 Prostaglandin E2 synthesis was also stimulated dose dependently by the presence of IL-1(beta), with a maximal increase at 2.5 U/ml, at which concentration the prostaglandin E2 level in the medium was 1.61 +/- 0.10 ng/ml. Dinoprostone 0-16 interleukin 1 beta Mus musculus 83-93 3141017-3 1988 Prostaglandin E2 synthesis was also stimulated dose dependently by the presence of IL-1(beta), with a maximal increase at 2.5 U/ml, at which concentration the prostaglandin E2 level in the medium was 1.61 +/- 0.10 ng/ml. Dinoprostone 159-175 interleukin 1 beta Mus musculus 83-93 33878544-5 2021 In vitro cell experiments, the inflammatory response in chondrocytes is mediated via interleukin-1beta (IL-1beta), which led to abnormal secretion of pro-inflammatory factors, such as prostaglandin E2 (PGE2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cyclooxygenase-2 (COX-2), nitric oxide (NO) and inducible nitric oxide synthase (iNOS). Dinoprostone 184-200 interleukin 1 beta Mus musculus 85-102 2967326-5 1988 Purified rM IL-1 beta exhibited biologic activity equivalent to 7.8 x 10(7) units/mg in the murine thymocyte proliferation assay and 9.9 x 10(3) units/mg in the human gingival fibroblast PGE2 production assay, indicative of species specificity. Dinoprostone 187-191 interleukin 1 beta Mus musculus 12-21 33878544-5 2021 In vitro cell experiments, the inflammatory response in chondrocytes is mediated via interleukin-1beta (IL-1beta), which led to abnormal secretion of pro-inflammatory factors, such as prostaglandin E2 (PGE2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cyclooxygenase-2 (COX-2), nitric oxide (NO) and inducible nitric oxide synthase (iNOS). Dinoprostone 202-206 interleukin 1 beta Mus musculus 85-102 30355787-5 2018 The IL-1beta-dependent induction of cyclooxygenase 2 (COX2) and the secretion of PGE2 was reduced in mouse embryonic fibroblasts and intestinal myofibroblasts (IMFs) from ABIN2[D310N] mice. Dinoprostone 81-85 interleukin 1 beta Mus musculus 4-12 32918847-0 2021 NLRP3 inflammasome-derived interleukin-1beta attenuates stress-induced gastric injury via the COX-2/PGE2 axis. Dinoprostone 100-104 interleukin 1 beta Mus musculus 27-44 30896805-4 2019 The data revealed that Peimine not only suppressed IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2, but also reduced the protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). Dinoprostone 104-120 interleukin 1 beta Mus musculus 51-59 30942801-6 2019 IL-1beta-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) were all inhibited significantly by Pm pretreatment in vitro. Dinoprostone 50-66 interleukin 1 beta Mus musculus 0-8 30942801-6 2019 IL-1beta-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) were all inhibited significantly by Pm pretreatment in vitro. Dinoprostone 68-72 interleukin 1 beta Mus musculus 0-8 30886580-4 2019 Macrophages sense TsV via innate immune receptors, including TLR2, TLR4, and CD14 that promote inflammation and mortality via PGE2/cAMP/PKA/NF-kappaB/IL-1beta axis. Dinoprostone 126-130 interleukin 1 beta Mus musculus 150-158 30273917-8 2018 In this study, leonurine visibly inhibited the IL-1beta-induced production of NO, PGE2, IL-6 and TNF-alpha; and decreased the expression of iNOS, COX-2, MMP-3, MMP-13 and ADAMTS-5 in chondrocytes. Dinoprostone 82-86 interleukin 1 beta Mus musculus 47-55 31633177-0 2019 Prostaglandin-E2 deficiency during late pregnancy and the associated increase in interleukin-1beta derived from periaortic lymph nodes lead to abortion. Dinoprostone 0-16 interleukin 1 beta Mus musculus 81-98 31633177-5 2019 Further, through RNA sequencing, we reveal that PLNs produce a large amount of interleukin-1beta (IL-1beta) when exposed to PGE2 deficiency, which causes damage to the placental labyrinth, probably via destroying the extracellular matrix. Dinoprostone 124-128 interleukin 1 beta Mus musculus 79-96 31633177-5 2019 Further, through RNA sequencing, we reveal that PLNs produce a large amount of interleukin-1beta (IL-1beta) when exposed to PGE2 deficiency, which causes damage to the placental labyrinth, probably via destroying the extracellular matrix. Dinoprostone 124-128 interleukin 1 beta Mus musculus 98-106 31633177-7 2019 These results suggest that high levels of PGE2 during late pregnancy protect fetuses from inflammatory damage related to IL-1beta. Dinoprostone 42-46 interleukin 1 beta Mus musculus 121-129 30355787-12 2018 USA 111: E4658-E4667), but the IL-1beta-dependent production of COX2 and PGE2 in mouse embryonic fibroblasts or IMFs was unaffected by pharmacological inhibition of Tpl2 in wild-type mice. Dinoprostone 73-77 interleukin 1 beta Mus musculus 31-39 28589946-8 2018 Reducing PGE2 levels with indomethacin improved bacterial clearance and reduced IL-1beta-mediated acute lung injury in P. aeruginosa-infected BMT mice. Dinoprostone 9-13 interleukin 1 beta Mus musculus 80-88 30160278-5 2018 Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner. Dinoprostone 120-136 interleukin 1 beta Mus musculus 18-35 30160278-5 2018 Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner. Dinoprostone 120-136 interleukin 1 beta Mus musculus 37-45 29473075-5 2018 In vitro, monascin treatment inhibited the IL-1beta-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6). Dinoprostone 159-175 interleukin 1 beta Mus musculus 43-51 29473075-5 2018 In vitro, monascin treatment inhibited the IL-1beta-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6). Dinoprostone 177-181 interleukin 1 beta Mus musculus 43-51 30327995-7 2018 Our results showed that NJK14047 markedly reduced the production of nitric oxide and prostaglandin E2 by downregulating the expression of various proinflammatory mediators such as nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha and interleukin-1beta in LPS-induced BV2 microglia. Dinoprostone 85-101 interleukin 1 beta Mus musculus 253-270 29894720-8 2018 Furthermore, we observed that treatment of THP-1 and AMJ2-C11 cell lines with exogenous PGE2 reduces MIP-1alpha production, while increasing IL-1beta production in cells stimulated by B. jararaca or B. jararacussu venoms. Dinoprostone 88-92 interleukin 1 beta Mus musculus 141-149 28589946-4 2018 Using a murine bone marrow transplant (BMT) model, we show that overexpression of prostaglandin E2 (PGE2) post-BMT signals via EP2 or EP4 to induce cyclic adenosine monophosphate (cAMP), which activates protein kinase A or the exchange protein activated by cAMP (Epac) to induce cAMP response element binding-dependent transcription of IL-1beta leading to exacerbated lung injury in BMT mice. Dinoprostone 82-98 interleukin 1 beta Mus musculus 336-344 28589946-4 2018 Using a murine bone marrow transplant (BMT) model, we show that overexpression of prostaglandin E2 (PGE2) post-BMT signals via EP2 or EP4 to induce cyclic adenosine monophosphate (cAMP), which activates protein kinase A or the exchange protein activated by cAMP (Epac) to induce cAMP response element binding-dependent transcription of IL-1beta leading to exacerbated lung injury in BMT mice. Dinoprostone 100-104 interleukin 1 beta Mus musculus 336-344 28589946-5 2018 Induction of IL-1beta by PGE2 is time and dose dependent. Dinoprostone 25-29 interleukin 1 beta Mus musculus 13-21 30121673-8 2018 RESULTS: LIG lowered the phosphorylation levels of p65, IkappaBalpha, and IKKalpha/beta and suppressed the IL-1beta-induced expression of MMP-3, ADAMTS-5, iNOS, and COX-2 and the inflammatory factors PGE2, TNF-alpha, and IL-6. Dinoprostone 200-204 interleukin 1 beta Mus musculus 107-115 28695367-10 2017 The results showed that pretreatment with paeonol could inhibit IL-1beta-induced NO and PGE2 production. Dinoprostone 88-92 interleukin 1 beta Mus musculus 64-72 29425654-6 2018 METHODS: In IL-1beta-stimulated FLS cells derived from rheumatoid arthritis patients, the anti-inflammatory activity of ACI was examined by analyzing the expression levels of inflammatory mediators such as TNF-alpha, IL-6, IL-8, MMP-1, MMP-3, MMP-13, PGE2, and COX-2 using ELISA and RT-PCR analysis. Dinoprostone 251-255 interleukin 1 beta Mus musculus 12-20 29425654-9 2018 RESULTS: The ethanolic extract (50% v/v) of ACI reduced the levels of TNF-alpha, IL-6, IL-8, MMP-1, and MMP-13 secreted by IL-1beta-stimulated FLS cells, whereas MMP-3, COX-2, and PGE2 were not significantly affected. Dinoprostone 180-184 interleukin 1 beta Mus musculus 123-131 28298525-4 2017 We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha. Dinoprostone 62-66 interleukin 1 beta Mus musculus 126-134 27463229-8 2017 They activated Nrf2 transcription factor, abolished IL-1beta-induced NO, PGE2 , MMP-13, and HNE production as well as IL-beta-induced GSTA4-4 down-regulation. Dinoprostone 73-77 interleukin 1 beta Mus musculus 52-60 28684418-8 2017 Greater reductions in HO-1 expression and increase in PGE2/IL-6 production were observed in HG+IL-1beta-stimulated chondrocytes from Nrf-2-/- mice than in chondrocytes from wild-type mice. Dinoprostone 54-58 interleukin 1 beta Mus musculus 95-103 28298525-4 2017 We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha. Dinoprostone 62-66 interleukin 1 beta Mus musculus 199-207 28213268-10 2017 We found that fisetin inhibited IL-1beta-induced expression of NO, PGE2, TNF-alpha, IL-6, COX-2, iNOS, MMP-3, MMP-13, ADAMTS-5. Dinoprostone 67-71 interleukin 1 beta Mus musculus 32-40 26226733-13 2015 Moreover, the expression of IL-1beta and mPGES-1 was decreased after Guizhi Fuling capsule and active complex treatment, which might contribute to the inhibitory effect of Guizhi Fuling capsule in the releasing of IL-1beta, TNF-alpha and PGE2. Dinoprostone 238-242 interleukin 1 beta Mus musculus 28-36 27375005-0 2017 The involvement of prostaglandin E2 in interleukin-1beta evoked anorexia is strain dependent. Dinoprostone 19-35 interleukin 1 beta Mus musculus 39-56 27375005-6 2017 We conclude that the involvement of induced PGE2 in IL-1beta evoked anorexia is strain dependent and we suggest that different routes that probably involve distinct prostanoids exist by which inflammatory stimuli may evoke an anorexic response and that these routes may be of different importance in different strains of mice. Dinoprostone 44-48 interleukin 1 beta Mus musculus 52-60 27388564-12 2016 In addition, LTD4 and PGE2 treatment significantly elevated the plasma levels of cysteinyl leukotrienes and PGE2, as well as levels of IL-1beta, IL-2, IL-6, TNF-alpha and CXCL1/KC/GRO. Dinoprostone 22-26 interleukin 1 beta Mus musculus 135-143 27388564-13 2016 In addition, increased mRNA expression of IL-1beta, IL-6 and IL-10 were detected in tumors from mice that had been treated with LTD4 or PGE2. Dinoprostone 136-140 interleukin 1 beta Mus musculus 42-50 25585625-8 2015 We demonstrate that IL-1beta-treated GPR40(-/-) chondrocytes secret more inflammatory mediators (nitric oxide, interleukin-6, prostaglandin E2) and active catabolic enzymes (metalloproteinase-2, -9 [MMP-2, MMP-9]), and show decreased anabolism (glycoaminoglycan) compared to GPR40(+/+) cells. Dinoprostone 126-142 interleukin 1 beta Mus musculus 20-28 25711428-7 2015 Moreover, in in vivo experiments, NCX 429, at the lowest dose tested, was able to significantly inhibit cell influx in response to IL-1beta administration although naproxen was found to be more potent than NCX 429 at reducing PGE2 in inflammatory exudates. Dinoprostone 226-230 interleukin 1 beta Mus musculus 131-139 27351842-7 2016 PGE2 increased Il6, Il1b, Il23 and Ccr7 mRNA while reducing Tnfa mRNA through EP4 in isolated myeloid cells. Dinoprostone 0-4 interleukin 1 beta Mus musculus 20-24 26528946-5 2016 Moreover, compared to BM-MSCs, MenSCs activated with IFN-gamma and IL-1beta produced lower amounts of immunosuppressive factors such as IDO, PDL-1, PGE2, and Activin A and exhibited a substantial lower expression level of IFN-gamma receptor subunits. Dinoprostone 148-152 interleukin 1 beta Mus musculus 67-75