PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16777343-1	2006	Most of the inflammatory effects of the cytokine interleukin 1beta (IL-1beta) are mediated by induction of cyclooxygenase (COX)2 and the subsequent synthesis and release of prostaglandin E2.	Dinoprostone	173-189	interleukin 1 beta	Mus musculus	49-66	
17166728-6	2007	Cyclooxygenase inhibitor administration prevented the interleukin-1-beta-induced increase in the production of brain prostaglandin E(2) (a cyclooxygenase metabolite) and changes in the expression of brain interleukin-6, interleukin-18, tumor necrosis factor-alpha, and brain-derived neurotrophic factor.	Dinoprostone	117-135	interleukin 1 beta	Mus musculus	54-72	
17023389-4	2006	The results show that genetic deletion of mPGES-1 results in a dramatic decrease in PGE2 production in Het and null MEFs under basal conditions and after stimulation with interleukin (IL)-1beta, suggesting that mPGES-1 is critically important for PGE2 production.	Dinoprostone	84-88	interleukin 1 beta	Mus musculus	171-193	
17023389-4	2006	The results show that genetic deletion of mPGES-1 results in a dramatic decrease in PGE2 production in Het and null MEFs under basal conditions and after stimulation with interleukin (IL)-1beta, suggesting that mPGES-1 is critically important for PGE2 production.	Dinoprostone	247-251	interleukin 1 beta	Mus musculus	171-193	
16777343-1	2006	Most of the inflammatory effects of the cytokine interleukin 1beta (IL-1beta) are mediated by induction of cyclooxygenase (COX)2 and the subsequent synthesis and release of prostaglandin E2.	Dinoprostone	173-189	interleukin 1 beta	Mus musculus	68-76	
15135319-0	2004	PGE2 induces IL-1beta gene expression in mouse osteoblasts through a cAMP-PKA signaling pathway.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	13-21	
16513308-4	2006	Cyclooxygenase-2 (COX-2) and tyrosine kinase involve on prostaglandin E2 (PGE2) production in mouse calvarial osteoblasts stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Dinoprostone	74-78	interleukin 1 beta	Mus musculus	145-162	
16513308-6	2006	TGF-beta, YJ (100microg/ml) and their combinations of YJ+TGF-beta reduced the COX-2 mRNA level, PGE2 biosynthesis and bone resorption induced by IL-1beta, TNF-alpha, IL-6 or their combination.	Dinoprostone	96-100	interleukin 1 beta	Mus musculus	145-153	
15883739-6	2005	In the presence of IL-1beta, PGE2, 15d-PGJ2, 6-keto PGF1alpha and PGF2alpha each enhanced COX-2 protein expression between 5- to 20-fold.	Dinoprostone	29-33	interleukin 1 beta	Mus musculus	19-27	
15749024-5	2005	Recombinant mouse IL-1beta induced strong activation of ERK1/2, p38, JNK and NFkappa B, and significant release of IL-6 and PGE2, which was blocked by IL-1ra.	Dinoprostone	124-128	interleukin 1 beta	Mus musculus	18-26	
15313472-1	2004	Cyclooxygenase-2 (COX-2) and tyrosine kinase, which are involved in the biosynthesis of prostaglandin E(2) (PGE(2)) in mouse calvarial osteoblasts, are stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Dinoprostone	88-106	interleukin 1 beta	Mus musculus	175-192	
15313472-1	2004	Cyclooxygenase-2 (COX-2) and tyrosine kinase, which are involved in the biosynthesis of prostaglandin E(2) (PGE(2)) in mouse calvarial osteoblasts, are stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Dinoprostone	88-106	interleukin 1 beta	Mus musculus	194-202	
16513308-4	2006	Cyclooxygenase-2 (COX-2) and tyrosine kinase involve on prostaglandin E2 (PGE2) production in mouse calvarial osteoblasts stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Dinoprostone	56-72	interleukin 1 beta	Mus musculus	145-162	
16513308-4	2006	Cyclooxygenase-2 (COX-2) and tyrosine kinase involve on prostaglandin E2 (PGE2) production in mouse calvarial osteoblasts stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Dinoprostone	56-72	interleukin 1 beta	Mus musculus	164-172	
15986771-5	2005	However, IL-1beta enhanced the PGE2-induced increase of L-glutamate uptake.	Dinoprostone	31-35	interleukin 1 beta	Mus musculus	9-17	
15986771-7	2005	Kinetic analysis of L-glutamate uptake showed that PGE2 and PGE2 with IL-1beta increased V(max) value with no significant effect on Km value for Na(+)-dependent L-glutamate uptake.	Dinoprostone	51-55	interleukin 1 beta	Mus musculus	70-78	
15986771-7	2005	Kinetic analysis of L-glutamate uptake showed that PGE2 and PGE2 with IL-1beta increased V(max) value with no significant effect on Km value for Na(+)-dependent L-glutamate uptake.	Dinoprostone	60-64	interleukin 1 beta	Mus musculus	70-78	
15313472-6	2004	A novel Src tyrosine kinase inhibitor, Herbimycin A (HERB), reduced COX-2 mRNA levels as well as PGE(2) production induced by IL-1beta, TNF-alpha and IL-6 or a combination of IL-1beta, TNF-alpha, IL-6, whereas COX-1 mRNA levels remained unaffected.	Dinoprostone	97-103	interleukin 1 beta	Mus musculus	126-134	
15135319-3	2004	However, the issue of whether PGE2 regulates the expression of IL-1beta in mouse osteoblasts has not been resolved.	Dinoprostone	30-34	interleukin 1 beta	Mus musculus	63-71	
15135319-4	2004	In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level.	Dinoprostone	34-38	interleukin 1 beta	Mus musculus	62-70	
15135319-4	2004	In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level.	Dinoprostone	117-121	interleukin 1 beta	Mus musculus	153-161	
15135319-4	2004	In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level.	Dinoprostone	117-121	interleukin 1 beta	Mus musculus	153-161	
15135319-4	2004	In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level.	Dinoprostone	117-121	interleukin 1 beta	Mus musculus	153-161	
15135319-4	2004	In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level.	Dinoprostone	117-121	interleukin 1 beta	Mus musculus	153-161	
14975584-2	2004	To understand the consequences of its presence in brain, we carried out intraparenchymal IL-1beta injections and found significant increases in prostaglandin (PG)E2, a critical factor in inflammatory and physiological processes.	Dinoprostone	144-164	interleukin 1 beta	Mus musculus	89-97	
15135319-5	2004	PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	25-33	
15135319-5	2004	PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	154-162	
15135319-5	2004	PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2.	Dinoprostone	204-208	interleukin 1 beta	Mus musculus	25-33	
15135319-5	2004	PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2.	Dinoprostone	204-208	interleukin 1 beta	Mus musculus	154-162	
15135319-7	2004	The role of cAMP activation in PGE2-mediated IL-1beta production was examined by the effects of forskolin, an adenylyl cyclase (AC) activator and dideoxyadenosine (DDA), an AC inhibitor.	Dinoprostone	31-35	interleukin 1 beta	Mus musculus	45-53	
15135319-8	2004	Forskolin enhanced and DDA blocked the production of IL-1beta by PGE2.	Dinoprostone	65-69	interleukin 1 beta	Mus musculus	53-61	
15135319-9	2004	In addition, PGE2-mediated IL-1beta induction was completely inhibited by the cAMP antagonist, Rp-cAMP, and protein kinase A (PKA) inhibitors of KT5720 and H89.	Dinoprostone	13-17	interleukin 1 beta	Mus musculus	27-35	
15135319-10	2004	The PGE2-induced production of IL-1beta was also blocked by the PKA inhibitor PKI14-22.	Dinoprostone	4-8	interleukin 1 beta	Mus musculus	31-39	
15135319-13	2004	These findings indicate that PGE2 involves the cAMP-PKA signaling pathway in regulating IL-1beta gene expression in osteoblasts.	Dinoprostone	29-33	interleukin 1 beta	Mus musculus	88-96	
11094054-2	2001	Treatment of murine macrophages with lipopolysaccharide, interleukin-1beta, and tumor necrosis factor-alpha increased PLAA levels at early time points (2-30 min), which correlated with an up-regulation in cytosolic PLA2 and PGE2 levels.	Dinoprostone	224-228	interleukin 1 beta	Mus musculus	57-74	
12466348-0	2002	Interleukin-1beta induces phosphodiesterase 4B2 expression in human myometrial cells through a prostaglandin E2- and cyclic adenosine 3",5"-monophosphate-dependent pathway.	Dinoprostone	95-111	interleukin 1 beta	Mus musculus	0-17	
12421347-7	2002	In comparison, IL-1beta induced the release of PGE2, IL-6 and activated NF-kappaB, p38, JNK and ERK1/2 in mixed glial cultures, but failed to induce any of these responses in microglial cell cultures.	Dinoprostone	47-51	interleukin 1 beta	Mus musculus	15-23	
12198250-5	2002	In addition, IL-1beta-stimulated prostaglandin E2 production is completely inhibited by a preferential lipoxygenase inhibitor cinnaminyl-3,4-dihydroxy-alpha-cyanocinnamate.	Dinoprostone	33-49	interleukin 1 beta	Mus musculus	13-21	
12198250-6	2002	We then evaluated IL-1beta-induced PGE2 production in islets purified from control C57BL/6 mice and 12-LO knockout mice lacking cytokine-inducible 12-HETE.	Dinoprostone	35-39	interleukin 1 beta	Mus musculus	18-26	
12198250-7	2002	IL-1beta stimulated an 8-fold increase in PGE2 production in C57BL/6 islets but failed to stimulate PGE2 in 12-LO knockout islets.	Dinoprostone	42-46	interleukin 1 beta	Mus musculus	0-8	
12375736-0	2002	IL-1beta regulates cellular proliferation, prostaglandin E2 synthesis, plasminogen activator activity, osteocalcin production, and bone resorptive activity of the mouse calvarial bone cells.	Dinoprostone	43-59	interleukin 1 beta	Mus musculus	0-8	
12375736-2	2002	IL-1beta stimulated cellular proliferation and the synthesis of prostaglandin E2 in the cultured cells in a dose-dependent manner.	Dinoprostone	64-80	interleukin 1 beta	Mus musculus	0-8	
12067102-2	2002	On processing bone metabolism, PGE2 accelerated production of IL-1beta in fetal mouse osteoblast and stimulated physiological activation substance, IL-1beta.	Dinoprostone	31-35	interleukin 1 beta	Mus musculus	62-70	
12067102-2	2002	On processing bone metabolism, PGE2 accelerated production of IL-1beta in fetal mouse osteoblast and stimulated physiological activation substance, IL-1beta.	Dinoprostone	31-35	interleukin 1 beta	Mus musculus	148-156	
12067102-3	2002	The novel class of Src tyrosine kinase inhibitors, Herbimycin A (HERB) and HHI reduced COX-2 mRNA levels as well as PGE2 production induced by IL-1beta, TNF-alpha and IL-6.	Dinoprostone	116-120	interleukin 1 beta	Mus musculus	143-151	
10960082-0	2000	Induction of COX-2 and PGE(2) biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes.	Dinoprostone	23-29	interleukin 1 beta	Mus musculus	46-54	
10960082-2	2000	In the present study, we examined whether prostaglandin E(2) (PGE(2)) production after IL-1beta stimulation is dependent upon activation of protein kinases in astroglial cells.	Dinoprostone	42-60	interleukin 1 beta	Mus musculus	87-95	
10960082-2	2000	In the present study, we examined whether prostaglandin E(2) (PGE(2)) production after IL-1beta stimulation is dependent upon activation of protein kinases in astroglial cells.	Dinoprostone	62-68	interleukin 1 beta	Mus musculus	87-95	
10960082-3	2000	Astrocyte cultures stimulated with IL-1beta or the phorbol ester, PMA significantly increased PGE(2) secretion.	Dinoprostone	94-100	interleukin 1 beta	Mus musculus	35-43	
10960082-4	2000	The stimulatory action of IL-1beta on PGE(2) production was totally abolished by NS-398, a specific inhibitor of cyclo-oxygenase-2 activity, as well as by the protein synthesis inhibitor cycloheximide, and the glucocorticoid dexamethasone.	Dinoprostone	38-44	interleukin 1 beta	Mus musculus	26-34	
8895611-5	1996	PGE2 decreased in ibuprofen-treated groups (P < 0.05 versus control, IL-1beta groups).	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	72-80	
10799905-10	2000	Finally, PGE2 pretreatment synergistically stimulated LPS-induced expression of IL-1beta and IL-6 genes in mouse macrophages.	Dinoprostone	9-13	interleukin 1 beta	Mus musculus	80-88	
9242654-3	1997	Kinetic and pharmacological studies showed that delayed PGE2 generation by this cell line in response to interleukin (IL)-1beta and tumor necrosis factor alpha (TNFalpha) was dependent upon cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX)-2.	Dinoprostone	56-60	interleukin 1 beta	Mus musculus	105-127	
9242654-5	1997	Exogenous addition or enforced expression of type IIA sPLA2 significantly increased IL-1beta/TNFalpha-initiated PGE2 generation, which was accompanied by increased expression of both cPLA2 and COX-2 and suppressed by inhibitors of these enzymes.	Dinoprostone	112-116	interleukin 1 beta	Mus musculus	84-92	
8830984-2	1996	The combination of interleukin-1 beta (IL-1) and tumor necrosis factor alpha (TNF) stimulated NO production, PGE2 production, and bone resorption.	Dinoprostone	109-113	interleukin 1 beta	Mus musculus	19-37	
8852950-1	1996	Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production.	Dinoprostone	77-93	interleukin 1 beta	Mus musculus	0-18	
8632179-3	1996	In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA).	Dinoprostone	65-81	interleukin 1 beta	Mus musculus	119-137	
8632179-3	1996	In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA).	Dinoprostone	65-81	interleukin 1 beta	Mus musculus	139-148	
8632179-3	1996	In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA).	Dinoprostone	83-87	interleukin 1 beta	Mus musculus	119-137	
8632179-3	1996	In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA).	Dinoprostone	83-87	interleukin 1 beta	Mus musculus	139-148	
8632179-4	1996	This increase in PGE2 content was blocked by pretreatment with dexamethasone and correlated with increases in cyclooxygenase activity measured at 4 h. Northern blots revealed concomitant increases in PGHS-2 mRNA levels that peaked at 2 h and were dependent on the dosage of IL-1 beta.	Dinoprostone	17-21	interleukin 1 beta	Mus musculus	274-283	
8852950-1	1996	Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production.	Dinoprostone	77-93	interleukin 1 beta	Mus musculus	20-29	
8852950-1	1996	Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production.	Dinoprostone	95-99	interleukin 1 beta	Mus musculus	0-18	
8852950-1	1996	Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production.	Dinoprostone	95-99	interleukin 1 beta	Mus musculus	20-29	
8596046-0	1996	Prostaglandin E2 stimulates osteoclast formation via endogenous IL-1 beta expressed through protein kinase A.	Dinoprostone	0-16	interleukin 1 beta	Mus musculus	64-73	
8852950-4	1996	We report here that IL-1 beta induces PGE2 production in bone marrow culture induced by a PGHS-2-dependent mechanism.	Dinoprostone	38-42	interleukin 1 beta	Mus musculus	20-29	
8596046-2	1996	PGE2 induced IL-1 beta gene expression in the primed calvarial cells.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	13-22	
8852950-5	1996	IL-1 beta stimulated the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNC) and the production of PGE2 in mouse bone marrow cultures.	Dinoprostone	139-143	interleukin 1 beta	Mus musculus	0-9	
8596046-4	1996	PGE2-induced IL-1 beta gene expression was markedly inhibited by H-89, a potent inhibitor of protein kinase A.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	13-22	
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Dinoprostone	49-53	interleukin 1 beta	Mus musculus	31-40	
8596046-7	1996	The presence of the IL-1 beta gene product in the conditioned medium of 1 alpha,25-(OH)2D3-primed calvarial cells treated with PGE2 was proved by the results of an immunoprecipitation assay using anti-mouse IL-1 beta Ab.	Dinoprostone	127-131	interleukin 1 beta	Mus musculus	20-29	
8596046-8	1996	The addition of anti-mouse IL-1 beta Ab to 1 alpha,25-(OH)2D3 primed calvarial cell cultures markedly inhibited PGE2-stimulated osteoclast formation.	Dinoprostone	112-116	interleukin 1 beta	Mus musculus	27-36	
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Dinoprostone	49-53	interleukin 1 beta	Mus musculus	116-125	
8596046-9	1996	The stimulatory effect of conditioned medium of primed calvarial cells treated with PGE2 on osteoclast formation was also inhibited by anti-IL-1 beta Ab pretreatment.	Dinoprostone	84-88	interleukin 1 beta	Mus musculus	140-149	
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Dinoprostone	100-104	interleukin 1 beta	Mus musculus	31-40	
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Dinoprostone	100-104	interleukin 1 beta	Mus musculus	116-125	
8418915-6	1993	Treatment of murine decidual explants with LPS, IL-1 beta, and TNF resulted in significant increases in the production of prostaglandin E2 (PGE2) and IL-6.	Dinoprostone	122-138	interleukin 1 beta	Mus musculus	48-57	
8418915-6	1993	Treatment of murine decidual explants with LPS, IL-1 beta, and TNF resulted in significant increases in the production of prostaglandin E2 (PGE2) and IL-6.	Dinoprostone	140-144	interleukin 1 beta	Mus musculus	48-57	
1425428-10	1992	IL-1 beta also increased steady state levels of 7.5- and 0.9-kilobase IGF-I mRNA transcripts in total RNA extracted from cultured calvaria at 24 h. The cyclooxygenase inhibitor indomethacin (1 microM) inhibited IL-1 beta-induced prostaglandin E2 (PGE2) production and inhibited resorption and release of IGF-I from calvaria.	Dinoprostone	229-245	interleukin 1 beta	Mus musculus	0-9	
1425428-10	1992	IL-1 beta also increased steady state levels of 7.5- and 0.9-kilobase IGF-I mRNA transcripts in total RNA extracted from cultured calvaria at 24 h. The cyclooxygenase inhibitor indomethacin (1 microM) inhibited IL-1 beta-induced prostaglandin E2 (PGE2) production and inhibited resorption and release of IGF-I from calvaria.	Dinoprostone	247-251	interleukin 1 beta	Mus musculus	0-9	
2172382-5	1990	PGE2 and dBcAMP not only potentiated LPS-induced IL-1 beta mRNA levels but were also able to stimulate modest accumulation of IL-1 beta mRNA in the absence of LPS.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	49-58	
2025252-1	1991	Interleukin-1 (IL-1) alpha and beta dose-dependently stimulated the release of 45Ca and the formation of prostaglandin E2 (PGE2) and PGI2 in cultured mouse calvarial bones, with IL-1 beta being the most potent agonist.	Dinoprostone	105-121	interleukin 1 beta	Mus musculus	178-187	
2025252-1	1991	Interleukin-1 (IL-1) alpha and beta dose-dependently stimulated the release of 45Ca and the formation of prostaglandin E2 (PGE2) and PGI2 in cultured mouse calvarial bones, with IL-1 beta being the most potent agonist.	Dinoprostone	123-127	interleukin 1 beta	Mus musculus	178-187	
2025252-2	1991	Bradykinin (BK; 10 nmol/l) synergistically potentiated the effect of IL-1 alpha (10 pg/ml) and IL-1 beta (5 pg/ml) both on 45Ca release and on biosynthesis of PGE2 and PGI2.	Dinoprostone	159-163	interleukin 1 beta	Mus musculus	95-104	
2172382-5	1990	PGE2 and dBcAMP not only potentiated LPS-induced IL-1 beta mRNA levels but were also able to stimulate modest accumulation of IL-1 beta mRNA in the absence of LPS.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	126-135	
2129785-1	1990	Recombinant Interleukin-1 beta (rIL-1 beta) induced dose-dependent synthesis of PGE2 and activation of both cell-associated and soluble phospholipase A2 (PLA2) in cultured mouse peritoneal macrophages.	Dinoprostone	80-84	interleukin 1 beta	Mus musculus	12-30	
2967326-5	1988	Purified rM IL-1 beta exhibited biologic activity equivalent to 7.8 x 10(7) units/mg in the murine thymocyte proliferation assay and 9.9 x 10(3) units/mg in the human gingival fibroblast PGE2 production assay, indicative of species specificity.	Dinoprostone	187-191	interleukin 1 beta	Mus musculus	12-21	
2651547-4	1989	Immunoperoxidase staining for cell-associated TNF alpha, IL-1 alpha, and IL-1 beta demonstrated that PGE2 suppressed TNF, but not IL-1 alpha or -beta expression, supporting the bioassay data.	Dinoprostone	101-105	interleukin 1 beta	Mus musculus	73-82	
3141017-3	1988	Prostaglandin E2 synthesis was also stimulated dose dependently by the presence of IL-1(beta), with a maximal increase at 2.5 U/ml, at which concentration the prostaglandin E2 level in the medium was 1.61 +/- 0.10 ng/ml.	Dinoprostone	0-16	interleukin 1 beta	Mus musculus	83-93	
3141017-3	1988	Prostaglandin E2 synthesis was also stimulated dose dependently by the presence of IL-1(beta), with a maximal increase at 2.5 U/ml, at which concentration the prostaglandin E2 level in the medium was 1.61 +/- 0.10 ng/ml.	Dinoprostone	159-175	interleukin 1 beta	Mus musculus	83-93	
33878544-5	2021	In vitro cell experiments, the inflammatory response in chondrocytes is mediated via interleukin-1beta (IL-1beta), which led to abnormal secretion of pro-inflammatory factors, such as prostaglandin E2 (PGE2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cyclooxygenase-2 (COX-2), nitric oxide (NO) and inducible nitric oxide synthase (iNOS).	Dinoprostone	184-200	interleukin 1 beta	Mus musculus	85-102	
33878544-5	2021	In vitro cell experiments, the inflammatory response in chondrocytes is mediated via interleukin-1beta (IL-1beta), which led to abnormal secretion of pro-inflammatory factors, such as prostaglandin E2 (PGE2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cyclooxygenase-2 (COX-2), nitric oxide (NO) and inducible nitric oxide synthase (iNOS).	Dinoprostone	202-206	interleukin 1 beta	Mus musculus	85-102	
30160278-5	2018	Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner.	Dinoprostone	120-136	interleukin 1 beta	Mus musculus	18-35	
32918847-0	2021	NLRP3 inflammasome-derived interleukin-1beta attenuates stress-induced gastric injury via the COX-2/PGE2 axis.	Dinoprostone	100-104	interleukin 1 beta	Mus musculus	27-44	
30942801-6	2019	IL-1beta-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) were all inhibited significantly by Pm pretreatment in vitro.	Dinoprostone	50-66	interleukin 1 beta	Mus musculus	0-8	
30942801-6	2019	IL-1beta-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) were all inhibited significantly by Pm pretreatment in vitro.	Dinoprostone	68-72	interleukin 1 beta	Mus musculus	0-8	
30886580-4	2019	Macrophages sense TsV via innate immune receptors, including TLR2, TLR4, and CD14 that promote inflammation and mortality via PGE2/cAMP/PKA/NF-kappaB/IL-1beta axis.	Dinoprostone	126-130	interleukin 1 beta	Mus musculus	150-158	
30355787-5	2018	The IL-1beta-dependent induction of cyclooxygenase 2 (COX2) and the secretion of PGE2 was reduced in mouse embryonic fibroblasts and intestinal myofibroblasts (IMFs) from ABIN2[D310N] mice.	Dinoprostone	81-85	interleukin 1 beta	Mus musculus	4-12	
30355787-12	2018	USA 111: E4658-E4667), but the IL-1beta-dependent production of COX2 and PGE2 in mouse embryonic fibroblasts or IMFs was unaffected by pharmacological inhibition of Tpl2 in wild-type mice.	Dinoprostone	73-77	interleukin 1 beta	Mus musculus	31-39	
30327995-7	2018	Our results showed that NJK14047 markedly reduced the production of nitric oxide and prostaglandin E2 by downregulating the expression of various proinflammatory mediators such as nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha and interleukin-1beta in LPS-induced BV2 microglia.	Dinoprostone	85-101	interleukin 1 beta	Mus musculus	253-270	
31633177-0	2019	Prostaglandin-E2 deficiency during late pregnancy and the associated increase in interleukin-1beta derived from periaortic lymph nodes lead to abortion.	Dinoprostone	0-16	interleukin 1 beta	Mus musculus	81-98	
31633177-5	2019	Further, through RNA sequencing, we reveal that PLNs produce a large amount of interleukin-1beta (IL-1beta) when exposed to PGE2 deficiency, which causes damage to the placental labyrinth, probably via destroying the extracellular matrix.	Dinoprostone	124-128	interleukin 1 beta	Mus musculus	79-96	
31633177-5	2019	Further, through RNA sequencing, we reveal that PLNs produce a large amount of interleukin-1beta (IL-1beta) when exposed to PGE2 deficiency, which causes damage to the placental labyrinth, probably via destroying the extracellular matrix.	Dinoprostone	124-128	interleukin 1 beta	Mus musculus	98-106	
31633177-7	2019	These results suggest that high levels of PGE2 during late pregnancy protect fetuses from inflammatory damage related to IL-1beta.	Dinoprostone	42-46	interleukin 1 beta	Mus musculus	121-129	
30896805-4	2019	The data revealed that Peimine not only suppressed IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2, but also reduced the protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2).	Dinoprostone	104-120	interleukin 1 beta	Mus musculus	51-59	
30273917-8	2018	In this study, leonurine visibly inhibited the IL-1beta-induced production of NO, PGE2, IL-6 and TNF-alpha; and decreased the expression of iNOS, COX-2, MMP-3, MMP-13 and ADAMTS-5 in chondrocytes.	Dinoprostone	82-86	interleukin 1 beta	Mus musculus	47-55	
30160278-5	2018	Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner.	Dinoprostone	120-136	interleukin 1 beta	Mus musculus	37-45	
29894720-8	2018	Furthermore, we observed that treatment of THP-1 and AMJ2-C11 cell lines with exogenous PGE2 reduces MIP-1alpha production, while increasing IL-1beta production in cells stimulated by B. jararaca or B. jararacussu venoms.	Dinoprostone	88-92	interleukin 1 beta	Mus musculus	141-149	
29473075-5	2018	In vitro, monascin treatment inhibited the IL-1beta-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6).	Dinoprostone	159-175	interleukin 1 beta	Mus musculus	43-51	
29473075-5	2018	In vitro, monascin treatment inhibited the IL-1beta-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6).	Dinoprostone	177-181	interleukin 1 beta	Mus musculus	43-51	
28695367-10	2017	The results showed that pretreatment with paeonol could inhibit IL-1beta-induced NO and PGE2 production.	Dinoprostone	88-92	interleukin 1 beta	Mus musculus	64-72	
28589946-8	2018	Reducing PGE2 levels with indomethacin improved bacterial clearance and reduced IL-1beta-mediated acute lung injury in P. aeruginosa-infected BMT mice.	Dinoprostone	9-13	interleukin 1 beta	Mus musculus	80-88	
30121673-8	2018	RESULTS: LIG lowered the phosphorylation levels of p65, IkappaBalpha, and IKKalpha/beta and suppressed the IL-1beta-induced expression of MMP-3, ADAMTS-5, iNOS, and COX-2 and the inflammatory factors PGE2, TNF-alpha, and IL-6.	Dinoprostone	200-204	interleukin 1 beta	Mus musculus	107-115	
29425654-6	2018	METHODS: In IL-1beta-stimulated FLS cells derived from rheumatoid arthritis patients, the anti-inflammatory activity of ACI was examined by analyzing the expression levels of inflammatory mediators such as TNF-alpha, IL-6, IL-8, MMP-1, MMP-3, MMP-13, PGE2, and COX-2 using ELISA and RT-PCR analysis.	Dinoprostone	251-255	interleukin 1 beta	Mus musculus	12-20	
29425654-9	2018	RESULTS: The ethanolic extract (50% v/v) of ACI reduced the levels of TNF-alpha, IL-6, IL-8, MMP-1, and MMP-13 secreted by IL-1beta-stimulated FLS cells, whereas MMP-3, COX-2, and PGE2 were not significantly affected.	Dinoprostone	180-184	interleukin 1 beta	Mus musculus	123-131	
28589946-4	2018	Using a murine bone marrow transplant (BMT) model, we show that overexpression of prostaglandin E2 (PGE2) post-BMT signals via EP2 or EP4 to induce cyclic adenosine monophosphate (cAMP), which activates protein kinase A or the exchange protein activated by cAMP (Epac) to induce cAMP response element binding-dependent transcription of IL-1beta leading to exacerbated lung injury in BMT mice.	Dinoprostone	82-98	interleukin 1 beta	Mus musculus	336-344	
28589946-4	2018	Using a murine bone marrow transplant (BMT) model, we show that overexpression of prostaglandin E2 (PGE2) post-BMT signals via EP2 or EP4 to induce cyclic adenosine monophosphate (cAMP), which activates protein kinase A or the exchange protein activated by cAMP (Epac) to induce cAMP response element binding-dependent transcription of IL-1beta leading to exacerbated lung injury in BMT mice.	Dinoprostone	100-104	interleukin 1 beta	Mus musculus	336-344	
28589946-5	2018	Induction of IL-1beta by PGE2 is time and dose dependent.	Dinoprostone	25-29	interleukin 1 beta	Mus musculus	13-21	
25711428-7	2015	Moreover, in in vivo experiments, NCX 429, at the lowest dose tested, was able to significantly inhibit cell influx in response to IL-1beta administration although naproxen was found to be more potent than NCX 429 at reducing PGE2 in inflammatory exudates.	Dinoprostone	226-230	interleukin 1 beta	Mus musculus	131-139	
28684418-8	2017	Greater reductions in HO-1 expression and increase in PGE2/IL-6 production were observed in HG+IL-1beta-stimulated chondrocytes from Nrf-2-/- mice than in chondrocytes from wild-type mice.	Dinoprostone	54-58	interleukin 1 beta	Mus musculus	95-103	
27463229-8	2017	They activated Nrf2 transcription factor, abolished IL-1beta-induced NO, PGE2 , MMP-13, and HNE production as well as IL-beta-induced GSTA4-4 down-regulation.	Dinoprostone	73-77	interleukin 1 beta	Mus musculus	52-60	
27388564-12	2016	In addition, LTD4 and PGE2 treatment significantly elevated the plasma levels of cysteinyl leukotrienes and PGE2, as well as levels of IL-1beta, IL-2, IL-6, TNF-alpha and CXCL1/KC/GRO.	Dinoprostone	22-26	interleukin 1 beta	Mus musculus	135-143	
27388564-13	2016	In addition, increased mRNA expression of IL-1beta, IL-6 and IL-10 were detected in tumors from mice that had been treated with LTD4 or PGE2.	Dinoprostone	136-140	interleukin 1 beta	Mus musculus	42-50	
28298525-4	2017	We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha.	Dinoprostone	62-66	interleukin 1 beta	Mus musculus	126-134	
28298525-4	2017	We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha.	Dinoprostone	62-66	interleukin 1 beta	Mus musculus	199-207	
28213268-10	2017	We found that fisetin inhibited IL-1beta-induced expression of NO, PGE2, TNF-alpha, IL-6, COX-2, iNOS, MMP-3, MMP-13, ADAMTS-5.	Dinoprostone	67-71	interleukin 1 beta	Mus musculus	32-40	
27375005-0	2017	The involvement of prostaglandin E2 in interleukin-1beta evoked anorexia is strain dependent.	Dinoprostone	19-35	interleukin 1 beta	Mus musculus	39-56	
27375005-6	2017	We conclude that the involvement of induced PGE2 in IL-1beta evoked anorexia is strain dependent and we suggest that different routes that probably involve distinct prostanoids exist by which inflammatory stimuli may evoke an anorexic response and that these routes may be of different importance in different strains of mice.	Dinoprostone	44-48	interleukin 1 beta	Mus musculus	52-60	
27351842-7	2016	PGE2 increased Il6, Il1b, Il23 and Ccr7 mRNA while reducing Tnfa mRNA through EP4 in isolated myeloid cells.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	20-24	
26528946-5	2016	Moreover, compared to BM-MSCs, MenSCs activated with IFN-gamma and IL-1beta produced lower amounts of immunosuppressive factors such as IDO, PDL-1, PGE2, and Activin A and exhibited a substantial lower expression level of IFN-gamma receptor subunits.	Dinoprostone	148-152	interleukin 1 beta	Mus musculus	67-75	
25585625-8	2015	We demonstrate that IL-1beta-treated GPR40(-/-) chondrocytes secret more inflammatory mediators (nitric oxide, interleukin-6, prostaglandin E2) and active catabolic enzymes (metalloproteinase-2, -9 [MMP-2, MMP-9]), and show decreased anabolism (glycoaminoglycan) compared to GPR40(+/+) cells.	Dinoprostone	126-142	interleukin 1 beta	Mus musculus	20-28	
26226733-13	2015	Moreover, the expression of IL-1beta and mPGES-1 was decreased after Guizhi Fuling capsule and active complex treatment, which might contribute to the inhibitory effect of Guizhi Fuling capsule in the releasing of IL-1beta, TNF-alpha and PGE2.	Dinoprostone	238-242	interleukin 1 beta	Mus musculus	28-36	
22490780-2	2012	PGE2 is a well-established endogenous pyrogen activated by proinflammatory cytokine interleukin (IL)-1beta.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	84-106	
23938462-5	2014	The cascade involved prostaglandin E2 (PGE2) production from melanoma induced by IL-18-dependent tumor necrosis factor-alpha (TNFalpha); next, PGE2-induced IL-1beta via vascular endothelial growth factor (VEGF) secretion, which in turn induced VLA-4 activation via cyclooxygenase 2-dependent H2O2.	Dinoprostone	143-147	interleukin 1 beta	Mus musculus	156-164	
24170042-3	2013	CD200R-deficient bone marrow derived macrophages (BMMPhi) were used to demonstrate that macrophages lacking this inhibitory receptor exhibit enhanced levels of Vegfa, Arg-1 and Il-1beta when stimulated with PGE2 or RPE-conditioned (PGE2-enriched) media.	Dinoprostone	207-211	interleukin 1 beta	Mus musculus	177-185	
22789837-11	2012	Moreover, phloroglucinol inhibited the IL-1beta-induced PGE(2) production in pulp fibroblasts.	Dinoprostone	56-62	interleukin 1 beta	Mus musculus	39-47	
24192281-5	2014	In response to the addition of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma to the culture medium, primary osteoblasts showed increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) at early time points and decreases in cell viability.	Dinoprostone	222-238	interleukin 1 beta	Mus musculus	57-103	
24192281-5	2014	In response to the addition of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma to the culture medium, primary osteoblasts showed increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) at early time points and decreases in cell viability.	Dinoprostone	240-244	interleukin 1 beta	Mus musculus	57-103	
22490780-4	2012	Here we show that P2X7R activation is required for the release of PGE2 and other autacoids independent of inflammasome activation, with an ATP EC(50) for PGE2 and IL-1beta release of 1.58 and 1.23 mM, respectively.	Dinoprostone	66-70	interleukin 1 beta	Mus musculus	163-171	
24116274-4	2012	WIN-34B inhibited the level of IL-6, PGE2, and MMP-13 in IL-1beta-stimulated RA FLSs in a dose-dependent manner.	Dinoprostone	37-41	interleukin 1 beta	Mus musculus	57-65	
22803375-0	2012	[Cinnamaldehyde decreases interleukin-1beta induced PGE2 production by down-regulation of mPGES-1 and COX-2 expression in mouse macrophage RAW264.7 cells].	Dinoprostone	52-56	interleukin 1 beta	Mus musculus	26-43	
22179028-8	2012	Accordingly, IL-1beta-induced PGE2, MMP-3 and MMP-13 releases were inhibited by 86% (P<0.001), 58%(P<0.001) and 38% (P<0.01) respectively.	Dinoprostone	30-34	interleukin 1 beta	Mus musculus	13-21	
21441617-3	2011	In mouse brain cortex, interleukin-1beta at 0.3 nM and the prostaglandin E2 analogue sulprostone at 3 nM inhibited noradrenaline release by about 40% the effect of interleukin-1beta developed gradually, whereas the effect of sulprostone occurred promptly.	Dinoprostone	59-75	interleukin 1 beta	Mus musculus	164-181	
17963953-1	2007	Many of the proinflammatory effects of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha) are mediated through cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2).	Dinoprostone	162-178	interleukin 1 beta	Mus musculus	39-61	
20412387-2	2010	Downstream actions of IL-1beta include production of prostaglandin (PG) E(2) by increasing expression of cyclooxygenase (COX) enzymes and prostaglandin E synthase (PGES) isoforms.	Dinoprostone	53-76	interleukin 1 beta	Mus musculus	22-30	
20412387-5	2010	Here, we aimed to elucidate the effects of long-term IL-1beta expression on the PGE(2) synthetic pathway and to determine the effects of PGs on inflammation and memory in our model.	Dinoprostone	80-86	interleukin 1 beta	Mus musculus	53-61	
20412387-6	2010	As expected, PGE(2) levels were significantly elevated after IL-1beta up-regulation.	Dinoprostone	13-19	interleukin 1 beta	Mus musculus	61-69	
20025057-5	2010	However, in cells treated with LPS coupled with COX-2 neutralization, the mRNA expression levels of COX-2, mPGES-1, tumor necrosis factor-alpha, interleukin-1beta and inducible nitric oxide synthase were significantly suppressed; production of prostaglandin E(2) and reactive oxygen species also decreased.	Dinoprostone	244-262	interleukin 1 beta	Mus musculus	145-162	
18438860-6	2008	Finally, small interfering RNA (siRNA) was used to assess the influence of visfatin on IL-1beta-induced release of PGE2 in immature mouse articular chondrocytes.	Dinoprostone	115-119	interleukin 1 beta	Mus musculus	87-95	
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	Dinoprostone	73-77	interleukin 1 beta	Mus musculus	27-35	
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	Dinoprostone	133-137	interleukin 1 beta	Mus musculus	27-35	
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	Dinoprostone	133-137	interleukin 1 beta	Mus musculus	116-124	
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	Dinoprostone	133-137	interleukin 1 beta	Mus musculus	27-35	
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	Dinoprostone	133-137	interleukin 1 beta	Mus musculus	116-124	
17963953-1	2007	Many of the proinflammatory effects of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha) are mediated through cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2).	Dinoprostone	180-184	interleukin 1 beta	Mus musculus	39-61	
17882968-0	2007	[Structure-activity relationship of phenylallyl compounds inhibiting PGE2 release in mouse cerebral microvascular endothelial cells induced by IL-1beta].	Dinoprostone	69-73	interleukin 1 beta	Mus musculus	143-151	
17882968-3	2007	Different concentrations of phenylallyl compounds were added separately, and the content of PGE2 induced by IL-1beta in the culture media was measured by ELISA assay.	Dinoprostone	92-96	interleukin 1 beta	Mus musculus	108-116	
17535900-2	2007	To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and human neonates.	Dinoprostone	82-100	interleukin 1 beta	Mus musculus	36-44	
17535900-2	2007	To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and human neonates.	Dinoprostone	102-108	interleukin 1 beta	Mus musculus	36-44	
17535900-8	2007	We conclude that IL-1beta adversely affects breathing and its control by mPGES-1 activation and PGE(2) binding to brainstem EP3 receptors, resulting in increased apnea frequency and hypoxia-induced mortality.	Dinoprostone	96-102	interleukin 1 beta	Mus musculus	17-25