PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34122722-6	2021	CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO , and PGE2 inflammatory mediators.	Dinoprostone	243-247	ATP citrate lyase	Homo sapiens	177-181	
33096779-1	2020	Hydroxycitrate (HCA), a main organic acid component of the fruit rind of Garcinia cambogia, is a natural citrate analog that can inhibit the ATP citrate lyase (ACLY) enzyme with a consequent reduction of inflammatory mediators (i.e., nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E2 (PGE2)) levels.	Dinoprostone	288-304	ATP citrate lyase	Homo sapiens	141-158	
33096779-1	2020	Hydroxycitrate (HCA), a main organic acid component of the fruit rind of Garcinia cambogia, is a natural citrate analog that can inhibit the ATP citrate lyase (ACLY) enzyme with a consequent reduction of inflammatory mediators (i.e., nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E2 (PGE2)) levels.	Dinoprostone	288-304	ATP citrate lyase	Homo sapiens	160-164	
33096779-1	2020	Hydroxycitrate (HCA), a main organic acid component of the fruit rind of Garcinia cambogia, is a natural citrate analog that can inhibit the ATP citrate lyase (ACLY) enzyme with a consequent reduction of inflammatory mediators (i.e., nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E2 (PGE2)) levels.	Dinoprostone	306-310	ATP citrate lyase	Homo sapiens	141-158	
33096779-1	2020	Hydroxycitrate (HCA), a main organic acid component of the fruit rind of Garcinia cambogia, is a natural citrate analog that can inhibit the ATP citrate lyase (ACLY) enzyme with a consequent reduction of inflammatory mediators (i.e., nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E2 (PGE2)) levels.	Dinoprostone	306-310	ATP citrate lyase	Homo sapiens	160-164	
29745322-7	2019	Inhibition of CIC or ACLY by different synthetic and natural molecules results in reduction of NO, ROS and PGE2 levels suggesting that the citrate pathway can be a new target to be addressed in inflammation.	Dinoprostone	107-111	ATP citrate lyase	Homo sapiens	21-25	
24051091-5	2013	Importantly, ACLY activity inhibition as well as ACLY gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators.	Dinoprostone	127-143	ATP citrate lyase	Homo sapiens	13-17	
24051091-5	2013	Importantly, ACLY activity inhibition as well as ACLY gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators.	Dinoprostone	127-143	ATP citrate lyase	Homo sapiens	49-53