PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23840006-10 2013 The inhibitory activity of IgG on TLR agonist-induced IFNalpha required monocyte production of prostaglandin E2, a potent suppressor of IFNalpha production by PDCs. Dinoprostone 95-111 interferon alpha 1 Homo sapiens 54-62 23840006-10 2013 The inhibitory activity of IgG on TLR agonist-induced IFNalpha required monocyte production of prostaglandin E2, a potent suppressor of IFNalpha production by PDCs. Dinoprostone 95-111 interferon alpha 1 Homo sapiens 136-144 20201989-4 2010 CD70 expression on IFN-alpha-induced MoDCs was elicited by different categories of maturation-inducing factors (Toll-like receptor ligands, CD40 ligand and pro-inflammatory mediators), among which prostaglandin E(2) was most effective. Dinoprostone 197-215 interferon alpha 1 Homo sapiens 19-28 20018632-0 2010 Prostaglandin E2 inhibits IFN-alpha secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement. Dinoprostone 0-16 interferon alpha 1 Homo sapiens 26-35 20018632-3 2010 Although PGE2 is considered to mediate mainly proinflammatory effects, we show that PGE2 and PG analogs potently inhibit secretion of IFN-alpha by TLR-activated PDCs. Dinoprostone 9-13 interferon alpha 1 Homo sapiens 134-143 20018632-3 2010 Although PGE2 is considered to mediate mainly proinflammatory effects, we show that PGE2 and PG analogs potently inhibit secretion of IFN-alpha by TLR-activated PDCs. Dinoprostone 84-88 interferon alpha 1 Homo sapiens 134-143 20018632-5 2010 Of note, profound IFN-alpha inhibition by PGE2 is also seen in PDCs from SLE subjects, independent of age, disease activity, and therapy. Dinoprostone 42-46 interferon alpha 1 Homo sapiens 18-27 20018632-9 2010 In conclusion, our data suggest that PGE2 and certain PG analogs, some of which are already in clinical use, should be evaluated as a novel and inexpensive treatment approach for patients with SLE and other IFN-alpha-dependent, Th1-driven autoimmune diseases. Dinoprostone 37-41 interferon alpha 1 Homo sapiens 207-216 19644885-10 2009 These mediators and IL-10 suppressed IFNalpha production in PBMC cultures, with ROS and PGE2 also inhibiting IFNalpha production by purified PDCs. Dinoprostone 88-92 interferon alpha 1 Homo sapiens 109-117 20067543-2 2009 Here we demonstrate that tumour-derived prostaglandin E2 (PGE(2)) and transforming growth factor-beta (TGF-beta) increase interleukin-8 (IL-8) but synergistically inhibit interferon-alpha (IFN-alpha) and tumour necrosis factor (TNF) production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9)-stimulated PDC. Dinoprostone 40-56 interferon alpha 1 Homo sapiens 189-198 18678606-4 2008 Instead, TNF-alpha and PGE2 increased Stat1 serine phosphorylation and Stat4 tyrosine phosphorylation and activated expression of the NF-kappaB and Stat1 target gene IFN regulatory factor 1 (IRF1), which contributes to IFN responses. Dinoprostone 23-27 interferon alpha 1 Homo sapiens 166-169 1786082-2 1991 In experiment 1, all interferon molecules (bTP-1, oTP-1, bIFN-alpha and hIFN-alpha) equally inhibited secretion of PGF and PGE2 from endometrial explant cultures obtained at day 17 of the estrous cycle. Dinoprostone 123-127 interferon alpha 1 Homo sapiens 72-82 18632653-5 2008 This PGE(2)-induced overproduction of CCL22 and the resulting attraction of FOXP3(+) Tregs are counteracted by IFN alpha, a mediator of acute inflammation, which also restores the ability of the PGE(2)-exposed DC to secrete the Th1-attracting chemokines: CXCL9, CXCL10, CXCL11, and CCL5. Dinoprostone 5-11 interferon alpha 1 Homo sapiens 111-120 18632653-5 2008 This PGE(2)-induced overproduction of CCL22 and the resulting attraction of FOXP3(+) Tregs are counteracted by IFN alpha, a mediator of acute inflammation, which also restores the ability of the PGE(2)-exposed DC to secrete the Th1-attracting chemokines: CXCL9, CXCL10, CXCL11, and CCL5. Dinoprostone 195-201 interferon alpha 1 Homo sapiens 111-120 9106259-8 1997 Animals previously exposed to both IFN-alpha 2b and NLX (SQ or ICV) subsequently lost their sensitivity to this cytokine, and also showed diminished reactivity to human recombinant interleukin-1 beta (hrIL-1 beta; 10 ng) and prostaglandin E2 (PGE2; 250 ng). Dinoprostone 225-241 interferon alpha 1 Homo sapiens 35-44 9106259-8 1997 Animals previously exposed to both IFN-alpha 2b and NLX (SQ or ICV) subsequently lost their sensitivity to this cytokine, and also showed diminished reactivity to human recombinant interleukin-1 beta (hrIL-1 beta; 10 ng) and prostaglandin E2 (PGE2; 250 ng). Dinoprostone 243-247 interferon alpha 1 Homo sapiens 35-44 15465601-7 2004 It showed that IFNalpha and 129Ser-IFNalpha decreased cAMP production, induced the fever, and stimulated PGE2 to release from the hypothalamus slices, which could be blocked by naloxone, but 38Leu-IFNalpha failed. Dinoprostone 105-109 interferon alpha 1 Homo sapiens 15-23 15465601-7 2004 It showed that IFNalpha and 129Ser-IFNalpha decreased cAMP production, induced the fever, and stimulated PGE2 to release from the hypothalamus slices, which could be blocked by naloxone, but 38Leu-IFNalpha failed. Dinoprostone 105-109 interferon alpha 1 Homo sapiens 35-43 15465601-7 2004 It showed that IFNalpha and 129Ser-IFNalpha decreased cAMP production, induced the fever, and stimulated PGE2 to release from the hypothalamus slices, which could be blocked by naloxone, but 38Leu-IFNalpha failed. Dinoprostone 105-109 interferon alpha 1 Homo sapiens 35-43 1786082-8 1991 Furthermore, other interferon-alpha molecules, including bIFN-alpha, hIFN-alpha, and oTP-1, also reduced PGF and PGE2 secretion in culture. Dinoprostone 113-117 interferon alpha 1 Homo sapiens 69-79 6319493-7 1984 On the other hand, IFN or poly I:C diminished the accumulation of intracellular cAMP levels in NK cells in response to PGE2 stimulation. Dinoprostone 119-123 interferon alpha 1 Homo sapiens 19-22 3099351-6 1986 Addition of exogenous PGE1 or PGE2 into interferon production media significantly inhibited IFN-alpha yield by the PBL of both normal and low producers. Dinoprostone 30-34 interferon alpha 1 Homo sapiens 92-101 3872345-4 1985 These studies were based on recent work with recombinant human interferon (IFN)-alpha, which is intrinsically pyrogenic and capable of producing fever by inducing the synthesis of prostaglandin E2 (PGE2). Dinoprostone 180-196 interferon alpha 1 Homo sapiens 63-85 3872345-4 1985 These studies were based on recent work with recombinant human interferon (IFN)-alpha, which is intrinsically pyrogenic and capable of producing fever by inducing the synthesis of prostaglandin E2 (PGE2). Dinoprostone 198-202 interferon alpha 1 Homo sapiens 63-85 2418132-1 1985 The effect of interferon (IFN) on prostaglandin E2 (PGE2) synthesis by peripheral blood mononuclear cells of normal subjects and patients with inflammatory bowel disease was studied. Dinoprostone 34-50 interferon alpha 1 Homo sapiens 14-30 2418132-2 1985 Exposure of peripheral blood mononuclear cells, isolated from normal subjects and patients with active ulcerative colitis and Crohn"s disease, to IFN reduced the release of PGE2 in a dose-dependent manner. Dinoprostone 173-177 interferon alpha 1 Homo sapiens 146-149 2418132-4 1985 To correlate the effect of IFN on PGE2 synthesis with a known activity of IFN, the induction of (2"-5")oligoadenylate synthetase (OAS) was also studied in the same mononuclear cells. Dinoprostone 34-38 interferon alpha 1 Homo sapiens 27-30 6590569-9 1984 However, hIFN stimulated prostaglandin E2 (PGE2) release from rabbit hypothalamic tissue in vitro. Dinoprostone 25-41 interferon alpha 1 Homo sapiens 9-13 6590569-9 1984 However, hIFN stimulated prostaglandin E2 (PGE2) release from rabbit hypothalamic tissue in vitro. Dinoprostone 43-47 interferon alpha 1 Homo sapiens 9-13 6590569-10 1984 Intracerebroventricular injection of hIFN into the awake cat also produced fever and a rise in PGE2 levels in the cerebrospinal fluid; both effects were reversed by treatment with indomethacin. Dinoprostone 95-99 interferon alpha 1 Homo sapiens 37-41 6590569-11 1984 We conclude that the fever of recombinant hIFN is not due to endotoxin but that hIFN is intrinsically pyrogenic by inducing PGE2 in the hypothalamus. Dinoprostone 124-128 interferon alpha 1 Homo sapiens 80-84 6319493-3 1984 In this study we demonstrated that human NK cells activated by IFN or poly I:C were partially resistant to suppression by PGE2, PGD2, PGA2, PGI2, dibutyryl cAMP, isoproterenol, and theophylline. Dinoprostone 122-126 interferon alpha 1 Homo sapiens 63-66 6319493-9 1984 A possible mechanism for the IFN-induced unresponsiveness to PGE2 may be a compartmentalized loss of cAMP responsiveness. Dinoprostone 61-65 interferon alpha 1 Homo sapiens 29-32 6168691-5 1981 That is, if PGE2 was added during cellular processing required for full expression of NK activation induced by IFN, pre-NK lytic potential was inhibited. Dinoprostone 12-16 interferon alpha 1 Homo sapiens 111-114 6184617-6 1982 We have demonstrated that IFN-activated NK cells become resistant to PGE2-mediated suppression; moreover the suppression does not require cells other than the large granular lymphocytes, the major effector cell type for NK. Dinoprostone 69-73 interferon alpha 1 Homo sapiens 26-29 6180022-2 1982 Protective effect of interferon on NK cells from suppression by PGE2. Dinoprostone 64-68 interferon alpha 1 Homo sapiens 21-31 6180022-3 1982 Activation of human natural killer (NK) cells in vitro with interferon (IFN) and poly I:C results in a partial loss of sensitivity of these cells to suppression by PGE2. Dinoprostone 164-168 interferon alpha 1 Homo sapiens 60-76 6180022-5 1982 With K562, HSB, and CEM used as NK target cells, the IFN-induced resistance to suppression by PGE2 is observed with all three target cells. Dinoprostone 94-98 interferon alpha 1 Homo sapiens 53-56 6180022-6 1982 Furthermore, ADCC activity of IFN-activated cells against tumor (SB-TNP) and erythroid (CRC-TNP) target cells is also less susceptible to suppression by PGE2. Dinoprostone 153-157 interferon alpha 1 Homo sapiens 30-33 6180022-7 1982 The dual effect of IFN on NK cells is prompt; the augmentation of NK activity and the acquired resistance to suppression by PGE2 can be seen after 3 hr of treatment with IFN. Dinoprostone 124-128 interferon alpha 1 Homo sapiens 19-22 6180022-7 1982 The dual effect of IFN on NK cells is prompt; the augmentation of NK activity and the acquired resistance to suppression by PGE2 can be seen after 3 hr of treatment with IFN. Dinoprostone 124-128 interferon alpha 1 Homo sapiens 170-173 6180022-10 1982 Our data therefore suggest that IFN-stimulated NK cells are protected from suppression by PGE2. Dinoprostone 90-94 interferon alpha 1 Homo sapiens 32-35 6168691-6 1981 If, on the other hand, PGE2 is added after completion of full expression of the IFN-induced activated lytic process, there is enhancement of recycling capabilities of the same number of NK cells. Dinoprostone 23-27 interferon alpha 1 Homo sapiens 80-83 32667932-9 2020 In contrast, an inverse relationship exists between PGE2 and IFN-alpha expression levels; high IFN-alpha expressers were associated with low levels of PGE2 and vice-versa (Spearman"s rho = -0.563; p<0.0001). Dinoprostone 52-56 interferon alpha 1 Homo sapiens 61-70 32667932-9 2020 In contrast, an inverse relationship exists between PGE2 and IFN-alpha expression levels; high IFN-alpha expressers were associated with low levels of PGE2 and vice-versa (Spearman"s rho = -0.563; p<0.0001). Dinoprostone 151-155 interferon alpha 1 Homo sapiens 95-104 29407895-7 2018 In cultured mucosal cells (mainly epithelial), the expression of AvBD4, 10-13 and IFNalpha, beta, and lambda was upregulated following incubation with 500 nM PGE2. Dinoprostone 158-162 interferon alpha 1 Homo sapiens 65-90 28261111-5 2017 The host immune system can be modulated by PGE2, with regards to immunosuppression, inhibition of nitrogen oxide (NO) production, inhibition of interferon (IFN) and apoptotic pathways, and inhibition of viral receptor expression. Dinoprostone 43-47 interferon alpha 1 Homo sapiens 144-160