PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16751012-1 2006 BACKGROUND: Levels of COX-2 and downstream products, such as prostaglandin (PG) E2, are increased in inflammatory settings after stimulation by IL-1beta, LPS, and other innate factors. Dinoprostone 61-82 interleukin 1 beta Homo sapiens 144-152 16525037-10 2006 ML120B also blocked IL-1beta-induced prostaglandin E2 production. Dinoprostone 37-53 interleukin 1 beta Homo sapiens 20-28 16183115-10 2006 We conclude that mPGES-1 is not involved in the inducible COX-2 mediated pathway for PGE2 biosynthesis at the transcriptional level, however, the treatment with IL-1beta results in a higher degree of co-ordination of the mPGES-1 and COX-2 protein immunolocalization, eliciting PGE2 synthesis. Dinoprostone 277-281 interleukin 1 beta Homo sapiens 161-169 16487663-7 2006 IL-1beta-induced PGE2 production and effects of PGE2 on the synthesis of procollagen by culture-derived fibroblasts were determined by using enzyme-linked immunosorbant assay (ELISA) kits. Dinoprostone 17-21 interleukin 1 beta Homo sapiens 0-8 16487663-11 2006 IL-1beta (1 ng/ml and 10 ng/ml) stimulated statistically significant production (p<0.01) of PGE2 by both normal and keloid-derived fibroblasts. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 0-8 16529823-3 2006 In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Dinoprostone 114-118 interleukin 1 beta Homo sapiens 76-93 16529823-3 2006 In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Dinoprostone 114-118 interleukin 1 beta Homo sapiens 95-103 16529823-6 2006 The inhibition of IL-1beta-mediated PGE2 synthesis by ascorbic acid was not due to the inhibition of the expression of COX-2 or microsomal prostaglandin E synthase (mPGES-1). Dinoprostone 36-40 interleukin 1 beta Homo sapiens 18-26 16529823-7 2006 Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress. Dinoprostone 282-286 interleukin 1 beta Homo sapiens 92-100 16491333-4 2006 As an example, released inflammatory cytokines (e.g., interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)), activated in up-stream macrophages, flow through a microfluidic mixing system, generating linear concentration gradients in down-stream wells and inducing down-stream osteoblasts to release prostaglandin E2 (PGE2), a well-known bone resorption marker. Dinoprostone 321-337 interleukin 1 beta Homo sapiens 54-72 16299051-0 2006 Regulatory features of interleukin-1beta-mediated prostaglandin E2 synthesis in airway smooth muscle. Dinoprostone 50-66 interleukin 1 beta Homo sapiens 23-40 16299051-1 2006 Exposure of airway smooth muscle (ASM) cells to the cytokine IL-1beta results in an induction of PGE2 synthesis that affects numerous cell functions. Dinoprostone 97-101 interleukin 1 beta Homo sapiens 61-69 16299051-3 2006 To explore other putative regulatory features we examined the role of phospholipase A2 (PLA2) and PGE synthase (PGES) enzymes in IL-1beta-induced PGE2 production. Dinoprostone 146-150 interleukin 1 beta Homo sapiens 129-137 16299051-7 2006 SB-202474, an SB-203580 analog lacking the ability to inhibit p38 but capable of inhibiting IL-1beta-induced PGE2 production, was effective in inhibiting mPGES but not COX-2 or cPLA2 induction. Dinoprostone 109-113 interleukin 1 beta Homo sapiens 92-100 16299051-9 2006 mPGES induction and, possibly, cPLA2 induction appear to cooperate with COX-2 to determine IL-1beta-mediated PGE2 production in human ASM cells. Dinoprostone 109-113 interleukin 1 beta Homo sapiens 91-99 16508938-5 2006 We investigated the effects of S1P on proliferation by WST-1 assay, and its effects on tumor necrosis factor alpha (TNFalpha)- or interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production in RA synoviocytes and MH7A cells by Western blotting and enzyme-linked immunosorbent assay, respectively. Dinoprostone 207-223 interleukin 1 beta Homo sapiens 130-147 16508938-5 2006 We investigated the effects of S1P on proliferation by WST-1 assay, and its effects on tumor necrosis factor alpha (TNFalpha)- or interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production in RA synoviocytes and MH7A cells by Western blotting and enzyme-linked immunosorbent assay, respectively. Dinoprostone 207-223 interleukin 1 beta Homo sapiens 149-157 16508938-5 2006 We investigated the effects of S1P on proliferation by WST-1 assay, and its effects on tumor necrosis factor alpha (TNFalpha)- or interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production in RA synoviocytes and MH7A cells by Western blotting and enzyme-linked immunosorbent assay, respectively. Dinoprostone 225-229 interleukin 1 beta Homo sapiens 130-147 16491333-4 2006 As an example, released inflammatory cytokines (e.g., interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)), activated in up-stream macrophages, flow through a microfluidic mixing system, generating linear concentration gradients in down-stream wells and inducing down-stream osteoblasts to release prostaglandin E2 (PGE2), a well-known bone resorption marker. Dinoprostone 321-337 interleukin 1 beta Homo sapiens 74-83 16508938-5 2006 We investigated the effects of S1P on proliferation by WST-1 assay, and its effects on tumor necrosis factor alpha (TNFalpha)- or interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production in RA synoviocytes and MH7A cells by Western blotting and enzyme-linked immunosorbent assay, respectively. Dinoprostone 225-229 interleukin 1 beta Homo sapiens 149-157 16508938-11 2006 Moreover, S1P enhanced expression of COX-2 and production of PGE2 induced by stimulation with TNFalpha or IL-1beta in RA synoviocytes and MH7A cells. Dinoprostone 61-65 interleukin 1 beta Homo sapiens 106-114 16477014-2 2006 It acts by inducing synthesis of prostaglandin E2, which mediates the late phase of IL-1beta-induced fever. Dinoprostone 33-49 interleukin 1 beta Homo sapiens 84-92 16452236-11 2006 Taken together, the data suggest that CDK2 activity may play an important event in the IL-1beta-induced COX-2 expression and prostaglandin E(2) synthesis and might represent a novel target for BMS-387032. Dinoprostone 125-143 interleukin 1 beta Homo sapiens 87-95 16251433-8 2005 In addition, the frequency of mEPSCs was enhanced in neurons pretreated with interleukin-1beta or lipopolysaccharide, which elevated expression of COX-2 and mPGES-1 and produced PGE2, and this enhancement was inhibited by a COX-2 inhibitor that inhibited production of PGE2. Dinoprostone 178-182 interleukin 1 beta Homo sapiens 77-94 16399619-2 2006 In human primary chondrocytes, the production of matrix metalloproteinase-13 and -1 (MMP-13 and -1) and prostaglandin E2 (PGE2) was induced by interleukin-1beta. Dinoprostone 104-120 interleukin 1 beta Homo sapiens 143-160 16399619-2 2006 In human primary chondrocytes, the production of matrix metalloproteinase-13 and -1 (MMP-13 and -1) and prostaglandin E2 (PGE2) was induced by interleukin-1beta. Dinoprostone 122-126 interleukin 1 beta Homo sapiens 143-160 16405508-8 2006 Our data suggest that PGE2 signaling in the brain may be altered after IL-1beta release due to up-regulation of EP3 receptors. Dinoprostone 22-26 interleukin 1 beta Homo sapiens 71-79 16405508-9 2006 This might play an important role in acute and chronic conditions such as cerebral ischemia, traumatic brain injury, HIV-encephalitis, Alzheimer"s disease and prion diseases in which a marked up-regulation of IL-1beta is followed by a prolonged increase of PGE2 levels in the brain. Dinoprostone 257-261 interleukin 1 beta Homo sapiens 209-217 16338461-4 2006 RESULTS: Both dexamethasone and IL-1beta caused a significant increase in prostaglandin E(2) output, cPLA(2) mRNA and protein expression in cultured human amnion fibroblasts. Dinoprostone 74-92 interleukin 1 beta Homo sapiens 32-40 16297873-1 2006 Mechanical loading can counteract inflammatory pathways induced by IL-1beta by inhibiting *NO and PGE2, catabolic mediators known to be involved in cartilage degradation. Dinoprostone 98-102 interleukin 1 beta Homo sapiens 67-75 16297873-3 2006 The data presented demonstrate that IL-4 alone can inhibit nitrite release in the presence and absence of IL-1beta and partially reverse the IL-1beta induced PGE2 release. Dinoprostone 158-162 interleukin 1 beta Homo sapiens 141-149 16297873-4 2006 When provided in combination, IL-4 and dynamic compression could further abrogate the IL-1beta induced nitrite and PGE2 release. Dinoprostone 115-119 interleukin 1 beta Homo sapiens 86-94 16912414-4 2006 The current data demonstrate that IL-1beta induced nitrite and PGE2 release and inhibited [3H]-thymidine and 35SO4 incorporation. Dinoprostone 63-67 interleukin 1 beta Homo sapiens 34-42 16912414-5 2006 Inhibitor experiments indicate that 1400W and NS-398 either partially reversed or abolished IL-1beta induced nitrite and PGE2 release. Dinoprostone 121-125 interleukin 1 beta Homo sapiens 92-100 16912414-9 2006 The data obtained using human chondrocytes demonstrate that IL-1beta induced *NO and PGE2 release via an iNOS-driven-COX-2 inter-dependent pathway. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 60-68 16210363-0 2006 T helper type 1 and type 2 cytokines exert divergent influence on the induction of prostaglandin E2 and hyaluronan synthesis by interleukin-1beta in orbital fibroblasts: implications for the pathogenesis of thyroid-associated ophthalmopathy. Dinoprostone 83-99 interleukin 1 beta Homo sapiens 128-145 16210363-2 2006 At the heart of orbital susceptibility to Graves" disease appears to be the peculiar phenotype of orbital fibroblasts that, when activated by IL-1beta and other proinflammatory cytokines, produce excess prostaglandin E2 (PGE2) and hyaluronan. Dinoprostone 203-219 interleukin 1 beta Homo sapiens 142-150 16210363-5 2006 We report here that interferon-gamma and IL-4, representative of these respective classes of cytokines, attenuate IL-1beta-provoked PGE2 production. Dinoprostone 132-136 interleukin 1 beta Homo sapiens 114-122 16244114-14 2006 IL-1beta and tumor necrosis factor alpha were also found to potentiate PGE-2 action. Dinoprostone 71-76 interleukin 1 beta Homo sapiens 0-8 16226404-0 2005 Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts. Dinoprostone 89-93 interleukin 1 beta Homo sapiens 43-51 16226404-7 2005 In the absence of stretching, it was found that 10 pM of IL-1beta markedly induced higher levels of COX-2, MMP-1 gene expression, and PGE2 production than non-treated cells. Dinoprostone 134-138 interleukin 1 beta Homo sapiens 57-65 16226404-8 2005 Furthermore, cells with 4% stretching decreased the COX-2 and MMP-1 gene expression and PGE2 production that were stimulated by IL-1beta, whereas cells with 8% stretching further increased these gene products and/or expression levels in addition to the effects of IL-1beta stimulation. Dinoprostone 88-92 interleukin 1 beta Homo sapiens 128-136 16354411-10 2005 Furthermore, it appears that the inhibitory effect of licochalcone A on PGE2 production in response to IL-1beta is quite different from that of the steroid. Dinoprostone 72-76 interleukin 1 beta Homo sapiens 103-111 16491333-4 2006 As an example, released inflammatory cytokines (e.g., interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)), activated in up-stream macrophages, flow through a microfluidic mixing system, generating linear concentration gradients in down-stream wells and inducing down-stream osteoblasts to release prostaglandin E2 (PGE2), a well-known bone resorption marker. Dinoprostone 339-343 interleukin 1 beta Homo sapiens 54-72 16491333-4 2006 As an example, released inflammatory cytokines (e.g., interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)), activated in up-stream macrophages, flow through a microfluidic mixing system, generating linear concentration gradients in down-stream wells and inducing down-stream osteoblasts to release prostaglandin E2 (PGE2), a well-known bone resorption marker. Dinoprostone 339-343 interleukin 1 beta Homo sapiens 74-83 16912414-2 2006 Both mechanical loading and IL-1beta will influence the release of *NO and PGE2. Dinoprostone 75-79 interleukin 1 beta Homo sapiens 28-36 16354411-0 2005 Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts. Dinoprostone 98-102 interleukin 1 beta Homo sapiens 81-89 16354411-2 2005 In this study, we examined the effect of licochalcone A on the production of chemical mediators such as prostaglandin (PG)E2 and cytokines by interleukin (IL)-1beta in human skin fibroblasts. Dinoprostone 104-124 interleukin 1 beta Homo sapiens 142-164 16354411-3 2005 Licochalcone A (IC50 15.0 nM) inhibited PGE2 production, but not IL-6 and IL-8 production, in response to IL-1beta. Dinoprostone 40-44 interleukin 1 beta Homo sapiens 106-114 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. Dinoprostone 0-4 interleukin 1 beta Homo sapiens 18-26 16081677-3 2005 In this study and other reports, curcumin suppresses interleukin-1beta-induced formation of prostaglandin E(2) in a concentration-dependent manner. Dinoprostone 92-110 interleukin 1 beta Homo sapiens 53-70 16251433-8 2005 In addition, the frequency of mEPSCs was enhanced in neurons pretreated with interleukin-1beta or lipopolysaccharide, which elevated expression of COX-2 and mPGES-1 and produced PGE2, and this enhancement was inhibited by a COX-2 inhibitor that inhibited production of PGE2. Dinoprostone 269-273 interleukin 1 beta Homo sapiens 77-94 15833737-0 2005 Interleukin-1beta differentially regulates beta2 adrenoreceptor and prostaglandin E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells. Dinoprostone 68-84 interleukin 1 beta Homo sapiens 0-17 16253096-5 2005 RESULTS: PGE2 biosynthesis was dose dependently inhibited by both triclosan and triclosan and CPC when challenged by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta. Dinoprostone 9-13 interleukin 1 beta Homo sapiens 154-176 16253096-6 2005 At pharmacologically relevant concentrations, triclosan and CPC inhibited IL-1beta-induced PGE2 production to a greater extent than triclosan alone (P = 0.02). Dinoprostone 91-95 interleukin 1 beta Homo sapiens 74-82 15890711-5 2005 Normal muscle incubated (2 h) in IL-1beta and IL-6 had increases in H2O2, PGE2, and PAF levels. Dinoprostone 74-78 interleukin 1 beta Homo sapiens 33-41 15890711-10 2005 We conclude that IL-1beta-induced production of H2O2 causes formation of PGE2 and PAF that inhibit ACh release from esophageal cholinergic neurons without affecting ACh-induced contraction of esophageal circular muscle. Dinoprostone 73-77 interleukin 1 beta Homo sapiens 17-25 16141576-0 2005 Synthesis and inhibitory effect of novel glycyrrhetinic acid derivatives on IL-1 beta-induced prostaglandin E(2) production in normal human dermal fibroblasts. Dinoprostone 94-112 interleukin 1 beta Homo sapiens 76-85 16141576-3 2005 These were screened for their inhibitory activity against interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production in normal human dermal fibroblasts (NHDF). Dinoprostone 97-115 interleukin 1 beta Homo sapiens 58-76 16141576-3 2005 These were screened for their inhibitory activity against interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production in normal human dermal fibroblasts (NHDF). Dinoprostone 97-115 interleukin 1 beta Homo sapiens 78-87 16018763-0 2005 Interleukin-1beta-induced prostaglandin E2 production by human gingival fibroblasts is upregulated by glycine. Dinoprostone 26-42 interleukin 1 beta Homo sapiens 0-17 16018763-5 2005 RESULTS: The PGE(2) production by IL-1beta-stimulated GFB was significantly upregulated by glycine. Dinoprostone 13-19 interleukin 1 beta Homo sapiens 34-42 16018763-9 2005 The IL-1beta-driven PGE(2) synthesis was blocked by indomethacin, a COX-1/COX-2 inhibitor, and by COX-2 inhibitor NS-398. Dinoprostone 20-26 interleukin 1 beta Homo sapiens 4-12 15833737-4 2005 In contrast, interleukin-1beta significantly impaired prostaglandin E2-induced cAMP accumulation by induction of cyclo-oxygenase-2, prostaglandin E2 production, and a resulting down-regulation of adenylyl cyclase. Dinoprostone 54-70 interleukin 1 beta Homo sapiens 13-30 15833737-4 2005 In contrast, interleukin-1beta significantly impaired prostaglandin E2-induced cAMP accumulation by induction of cyclo-oxygenase-2, prostaglandin E2 production, and a resulting down-regulation of adenylyl cyclase. Dinoprostone 132-148 interleukin 1 beta Homo sapiens 13-30 15833737-5 2005 The cAMP changes were all mirrored by alterations in chloride efflux assessed using the fluorescent chloride probe N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide with interleukin-1beta increasing chloride efflux in response to isoprenaline and reducing the response to prostaglandin E2. Dinoprostone 276-292 interleukin 1 beta Homo sapiens 174-191 15950779-5 2005 We report that IL-1beta induced cPLA2 and COX-2 mRNA and protein expression and subsequent prostaglandin E2 (PGE2) release in a time-dependent manner in H4 neuroglioma cells. Dinoprostone 91-107 interleukin 1 beta Homo sapiens 15-23 15950779-5 2005 We report that IL-1beta induced cPLA2 and COX-2 mRNA and protein expression and subsequent prostaglandin E2 (PGE2) release in a time-dependent manner in H4 neuroglioma cells. Dinoprostone 109-113 interleukin 1 beta Homo sapiens 15-23 15950779-6 2005 Both SB203580 and PD98059 [p38 and p42/44 mitogen-activated protein kinase (MAPKs) inhibitors, respectively] reduced IL-1beta-induced PGE2 production, while only SB203580 reduced both cPLA2 and COX-2 expression. Dinoprostone 134-138 interleukin 1 beta Homo sapiens 117-125 15862289-6 2005 In conclusion, IL-1beta increases VEGF-A secretion by COX-2 derived PGE(2) production whereas TGFbeta uses COX-independent pathways. Dinoprostone 68-74 interleukin 1 beta Homo sapiens 15-23 15950779-7 2005 Similarly, in SKNSH neuroblastoma cells, both SB203580 and PD98059 reduced IL-1beta-induced PGE2 release, with no detectable COX-2 and cPLA2 protein expression in these cells. Dinoprostone 92-96 interleukin 1 beta Homo sapiens 75-83 15950779-8 2005 Our results indicate that the signaling mechanisms of p38 and p42/44 MAPKs play a role in IL-1beta-mediated PGE2 release in both of these cell lines, with differences upstream at the level of cPLA(2)/COX-2 expression. Dinoprostone 108-112 interleukin 1 beta Homo sapiens 90-98 15868626-12 2005 Peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-delta(12,14)-prostaglandin J2 and troglitazone, inhibited IL-1beta-induced mPGES-1 protein expression, an effect that was reversed by exogenous PGE2. Dinoprostone 211-215 interleukin 1 beta Homo sapiens 125-133 15862289-2 2005 IL-1beta and TGFbeta induced cyclo-oxygenase (COX)-2 protein and increased prostaglandin E(2) (PGE(2)). Dinoprostone 75-93 interleukin 1 beta Homo sapiens 0-8 15838249-5 2005 A potential role for prostaglandin E2 in downregulating interleukin-1beta-induced inflammatory responses has also been described. Dinoprostone 21-37 interleukin 1 beta Homo sapiens 56-73 15685372-5 2005 IL-1beta stimulated the formation of NO and PGE2 by pancreatic beta-cells. Dinoprostone 44-48 interleukin 1 beta Homo sapiens 0-8 15458923-3 2005 Thus we examined IL-1beta-stimulated mPGES-1 and cPGES mRNA and protein expression in gastric fibroblasts by quantitative PCR and Western blot analysis, respectively, and studied both their relationship to COX-1 and -2 and their roles in PGE2 and VEGF production in vitro. Dinoprostone 238-242 interleukin 1 beta Homo sapiens 17-25 15458923-10 2005 These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway. Dinoprostone 131-135 interleukin 1 beta Homo sapiens 27-35 15458923-10 2005 These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway. Dinoprostone 391-395 interleukin 1 beta Homo sapiens 27-35 15458923-10 2005 These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway. Dinoprostone 391-395 interleukin 1 beta Homo sapiens 156-164 15619239-5 2005 Moreover, the production of prostaglandin E2 was partially controlled by interleukin-1beta and tumor necrosis factor alpha. Dinoprostone 28-44 interleukin 1 beta Homo sapiens 73-122 15183150-4 2004 Human recombinant IL-1beta stimulated PGE(2) production and shifted the cilomilast concentration-dependence curve to the left in both assay systems, indicating increased sensitivity to cilomilast. Dinoprostone 38-44 interleukin 1 beta Homo sapiens 18-26 15621371-8 2005 IL-1beta and TNFalpha treatment for 24 h enhanced prostaglandin E2 (PGE2) production 2-4-fold, which was blocked by pretreatment with the COX-2 inhibitor, NS-398. Dinoprostone 50-66 interleukin 1 beta Homo sapiens 0-8 15621371-8 2005 IL-1beta and TNFalpha treatment for 24 h enhanced prostaglandin E2 (PGE2) production 2-4-fold, which was blocked by pretreatment with the COX-2 inhibitor, NS-398. Dinoprostone 68-72 interleukin 1 beta Homo sapiens 0-8 15180965-8 2004 Although PGE2 also induces IL-1beta and IL-6 expression in non-stimulated DCs, the stimulatory effect of PGE2 on IL-23 production is not mediated through IL-1beta or IL-6. Dinoprostone 9-13 interleukin 1 beta Homo sapiens 27-35 15266025-3 2004 We found that IL-1beta increased cyclooxygenase-2 (COX-2) mRNA expression and prostaglandin (PG) E(2) production and that the COX-2 inhibitor celecoxib suppressed IL-1beta-induced MUC5AC production. Dinoprostone 78-101 interleukin 1 beta Homo sapiens 14-22 15272234-0 2004 Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes. Dinoprostone 73-89 interleukin 1 beta Homo sapiens 0-17 15272234-4 2004 IL-1beta-related MMP-2 expression was found to be dependent on prostaglandin E2 (PGE2) production. Dinoprostone 63-79 interleukin 1 beta Homo sapiens 0-8 15272234-4 2004 IL-1beta-related MMP-2 expression was found to be dependent on prostaglandin E2 (PGE2) production. Dinoprostone 81-85 interleukin 1 beta Homo sapiens 0-8 15272234-7 2004 Taken together, these results demonstrated that IL-1beta induces MMP-2 expression through the PGE2-dependent mechanism in human chondrocytes. Dinoprostone 94-98 interleukin 1 beta Homo sapiens 48-56 15479233-1 2004 In A549 pulmonary cells, the dexamethasone- and budesonide-dependent repression of interleukin-1beta-induced prostaglandin E2 release was mimicked by the steroid antagonist, RU486. Dinoprostone 109-125 interleukin 1 beta Homo sapiens 83-100 15156569-0 2004 Platelet-derived growth factor-induced arachidonic acid release for enhancement of prostaglandin E(2) synthesis in human gingival fibroblasts pretreated with interleukin-1beta. Dinoprostone 83-101 interleukin 1 beta Homo sapiens 158-175 15023995-0 2004 Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. Dinoprostone 118-134 interleukin 1 beta Homo sapiens 72-89 14872092-1 2004 Prostaglandin (PG) E(2) induces dendritic cell maturation in cooperation with proinflammatory cytokines [such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta]. Dinoprostone 0-23 interleukin 1 beta Homo sapiens 151-173 15146435-12 2004 CONCLUSION: These findings indicate that BCP crystals may be an important amplifier of PGE(2) production through induction of the COX enzymes and the proinflammatory cytokine IL-1beta. Dinoprostone 87-93 interleukin 1 beta Homo sapiens 175-183 15067222-2 2004 However, the mechanisms underlying IL-1beta-induced cyclooxygenase (COX) expression and PGE(2) synthesis via activation of p42/p44 and p38 mitogen-activated protein kinases (MAPKs) in human tracheal smooth muscle cells (HTSMCs) are not completely understood. Dinoprostone 88-94 interleukin 1 beta Homo sapiens 35-43 15067222-3 2004 We found that IL-1beta increased COX-2 expression and PGE(2) synthesis in time- and concentration-dependent manners. Dinoprostone 54-60 interleukin 1 beta Homo sapiens 14-22 14996278-0 2004 Interleukin-1beta induces matrix metalloproteinase-1 expression in cultured human gingival fibroblasts: role of cyclooxygenase-2 and prostaglandin E2. Dinoprostone 133-149 interleukin 1 beta Homo sapiens 0-17 15077295-3 2004 CRH- and interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production from 10 fresh rheumatoid arthritis (RA) synovial tissue (ST) explants was quantified using a competitive enzyme-linked immunosorbent assay. Dinoprostone 48-66 interleukin 1 beta Homo sapiens 9-27 15077295-3 2004 CRH- and interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production from 10 fresh rheumatoid arthritis (RA) synovial tissue (ST) explants was quantified using a competitive enzyme-linked immunosorbent assay. Dinoprostone 48-66 interleukin 1 beta Homo sapiens 29-38 15077295-3 2004 CRH- and interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production from 10 fresh rheumatoid arthritis (RA) synovial tissue (ST) explants was quantified using a competitive enzyme-linked immunosorbent assay. Dinoprostone 68-74 interleukin 1 beta Homo sapiens 9-27 15077295-3 2004 CRH- and interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production from 10 fresh rheumatoid arthritis (RA) synovial tissue (ST) explants was quantified using a competitive enzyme-linked immunosorbent assay. Dinoprostone 68-74 interleukin 1 beta Homo sapiens 29-38 15077295-8 2004 Costimulation of RA ST with CRH and IL-1 beta significantly augmented (P = 0.036) the effects on PGE(2) production additively over 24 hours. Dinoprostone 97-103 interleukin 1 beta Homo sapiens 36-45 15379214-4 2004 The results showed that IL-1beta as well as TNFalpha induced mPGES-1 mRNA and protein expression accompanied by enhanced PGE2 production in gingival fibroblasts. Dinoprostone 121-125 interleukin 1 beta Homo sapiens 24-32 15379214-5 2004 The anti-inflammatory steroid dexamethasone (DEX) inhibited mPGES-1 mRNA and protein expression as well as PGE2 production induced by IL-1beta or TNFalpha. Dinoprostone 107-111 interleukin 1 beta Homo sapiens 134-142 15379214-7 2004 The results demonstrate that mPGES-1 regulates PGE2 production in gingival fibroblasts stimulated by inflammatory mediators IL-1beta and TNFa. Dinoprostone 47-51 interleukin 1 beta Homo sapiens 124-132 14981131-3 2004 In HGF from healthy gingiva, PGE2 down-regulated IL-1beta-induced MMP-3 production, whereas in HGF from periodontitis patients, PGE2 enhanced it. Dinoprostone 29-33 interleukin 1 beta Homo sapiens 49-57 14981131-5 2004 Analysis of these data suggests that, in HGF from healthy tissue, IL-1beta-induced MMP-3 production is down-regulated by PGE2 via EP2 and EP4 receptors, whereas in cells from periodontally diseased tissue, IL-1beta-induced MMP-3 production is up-regulated via EP1 receptors. Dinoprostone 121-125 interleukin 1 beta Homo sapiens 66-74 14981131-6 2004 Different regulation of IL-1beta-induced MMP-3 production by PGE2 between healthy and periodontally diseased tissues may be involved in the pathogenesis of periodontal disease. Dinoprostone 61-65 interleukin 1 beta Homo sapiens 24-32 14996278-10 2004 CONCLUSION: The IL-1beta-induced MMP-1 expression in gingival fibroblasts may be mediated, at least in part, by COX-2 and its product PGE2. Dinoprostone 134-138 interleukin 1 beta Homo sapiens 16-24 14670842-8 2004 Consistent with this, IL-1beta, BK, and TGF-beta1 all induced COX-2 and PGE2 release. Dinoprostone 72-76 interleukin 1 beta Homo sapiens 22-30 14670842-0 2004 Interleukin-1beta, transforming growth factor-beta1, and bradykinin attenuate cyclic AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin E2 by cyclooxygenase-2 induction and downregulation of adenylyl cyclase isoforms 1, 2, and 4. Dinoprostone 188-204 interleukin 1 beta Homo sapiens 0-17 14670842-3 2004 In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin. Dinoprostone 273-289 interleukin 1 beta Homo sapiens 71-88 14670842-3 2004 In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin. Dinoprostone 273-289 interleukin 1 beta Homo sapiens 90-98 14670842-3 2004 In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin. Dinoprostone 291-295 interleukin 1 beta Homo sapiens 71-88 14670842-3 2004 In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin. Dinoprostone 291-295 interleukin 1 beta Homo sapiens 90-98 14757123-3 2004 Recombinant human interleukin-1 beta increased prostaglandin E(2) synthesis in fibroblasts about sixfold. Dinoprostone 47-65 interleukin 1 beta Homo sapiens 18-36 14757123-4 2004 The prostaglandin E(2) response to interleukin-1 beta was attenuated by lower concentrations of vasopressin (10(-10)-10(-9) M). Dinoprostone 4-22 interleukin 1 beta Homo sapiens 35-53 14757123-5 2004 By contrast, higher concentrations (10(-8)-10(-7) M) of vasopressin effected significant enhancement of the interleukin-1 beta-induced prostaglandin E(2) synthesis. Dinoprostone 135-153 interleukin 1 beta Homo sapiens 108-126 15016032-2 2004 MATERIAL AND METHODS: Human embryo palatal mesenchyme (HEPM) cells were used for testing the inhibition of IL-1beta-stimulated PGE2-production in vitro by different concentrations of oxybenzone. Dinoprostone 127-131 interleukin 1 beta Homo sapiens 107-115 15068113-8 2004 Endogenous PGE2 partially mediated the IL-1beta-induced RANKL mRNA expression. Dinoprostone 11-15 interleukin 1 beta Homo sapiens 39-47 15379214-2 2004 Previously we have reported that the inflammatory mediators interleukin-1beta, (IL-1beta) and tumor necrosis factor alpha (TNFalpha) stimulate PGE2 synthesis by inducing mRNA expression of cyclooxygenase-2 (COX-2) in human gingival fibroblasts. Dinoprostone 143-147 interleukin 1 beta Homo sapiens 60-78 15379214-2 2004 Previously we have reported that the inflammatory mediators interleukin-1beta, (IL-1beta) and tumor necrosis factor alpha (TNFalpha) stimulate PGE2 synthesis by inducing mRNA expression of cyclooxygenase-2 (COX-2) in human gingival fibroblasts. Dinoprostone 143-147 interleukin 1 beta Homo sapiens 80-88 14757123-8 2004 The effects of vasopressin on basal and interleukin-1 beta-induced prostaglandin E(2) synthesis were antagonized by selective vasopressin receptor antagonists. Dinoprostone 67-85 interleukin 1 beta Homo sapiens 40-58 15225371-12 2004 In comparison with 6-keto-PGF1alpha and thromboxane B2, the production of PGE2 was greater after chondrocytes were stimulated by IL-1beta or TNF-alpha. Dinoprostone 74-78 interleukin 1 beta Homo sapiens 129-137 15225371-13 2004 Conversion of PGH2 to PGE2 (PGES activity) was significantly increased in the lysate from IL-1beta-stimulated chondrocytes and it was inhibited by MK-886, which has an inhibitory effect on mPGES-1 activity. Dinoprostone 22-26 interleukin 1 beta Homo sapiens 90-98 14664905-1 2003 In previous studies performed to elucidate acetaminophen mechanism of action, we demonstrated that acetaminophen inhibits prostaglandin E2 production by interleukin (IL)-1beta-stimulated T98G human astrocytic cells, without affecting cyclooxygenase-2 enzymatic activity. Dinoprostone 122-138 interleukin 1 beta Homo sapiens 153-175 14673370-5 2003 Human nucleus pulposus has been shown to synthesize increased amounts of interleukin (IL)-6, prostaglandin E2 (PGE2), and nitric oxide in response to stimulation with IL-1beta. Dinoprostone 93-109 interleukin 1 beta Homo sapiens 167-175 14673370-5 2003 Human nucleus pulposus has been shown to synthesize increased amounts of interleukin (IL)-6, prostaglandin E2 (PGE2), and nitric oxide in response to stimulation with IL-1beta. Dinoprostone 111-115 interleukin 1 beta Homo sapiens 167-175 14676104-10 2003 Moreover, both plasma and bronchoalveolar lavage fluid obtained from treated subjects significantly reduced the production of PGE2 that resulted when a lung cancer cell line, A549, was stimulated with IL-1beta or A23187. Dinoprostone 126-130 interleukin 1 beta Homo sapiens 201-209 12794822-7 2003 Upon stimulation with IL-1beta, elevation of COX-2, but not COX-1, mRNA and protein preceded the enhancement of PGE(2) synthesis. Dinoprostone 112-118 interleukin 1 beta Homo sapiens 22-30 29539078-5 2003 Little is known about IL-1beta-stimulated AgP fibroblast IL-6 and PGE2 production and their regulation by COX inhibitors. Dinoprostone 66-70 interleukin 1 beta Homo sapiens 22-30 29539078-6 2003 The objective of this study was to determine the effects of COX-2 inhibitors on amounts of PGE2 and IL-6 made by IL-1beta-stimulated gingival fibroblasts. Dinoprostone 91-95 interleukin 1 beta Homo sapiens 113-121 29539078-10 2003 When exogenous PGE2 was added concurrently with COX-2 inhibitors before addition of IL-1beta, IL-6 production returned to levels at or approaching that produced by cells exposed only to IL-1beta (P <=0.04). Dinoprostone 15-19 interleukin 1 beta Homo sapiens 186-194 14645533-6 2003 We also revealed that endogenous prostaglandin E(2) was critical in bradykinin-induced COX-2 transcription initiation and involved in IL-1beta-induced COX-2 transcription at a latter stage. Dinoprostone 33-51 interleukin 1 beta Homo sapiens 134-142 14558087-0 2003 Prostaglandin E2 is an enhancer of interleukin-1beta-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 35-52 14568676-4 2003 In particular, we demonstrate that exogenous NO inhibits PGE2 release evoked by IL-1beta whereas high levels of the prostanoid, in the presence of proinflammatory agents, exert a negative feed-back control on iNOS mRNA expression, possibly through a cAMP-dependent mechanism. Dinoprostone 57-61 interleukin 1 beta Homo sapiens 80-88 12954240-0 2003 Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs. Dinoprostone 78-82 interleukin 1 beta Homo sapiens 32-41 12954240-1 2003 OBJECTIVE: To examine the effect of IL-1 beta-induced *NO and PGE(2)release by stimulated superficial and deep chondrocyte/agarose constructs subjected to mechanical compression. Dinoprostone 62-68 interleukin 1 beta Homo sapiens 36-45 12954240-5 2003 RESULTS: The current data reveal that IL-1 beta significantly enhanced *NO and PGE(2)release for superficial chondrocytes, an effect reversed with L-NIO. Dinoprostone 79-85 interleukin 1 beta Homo sapiens 38-47 12954240-12 2003 CONCLUSION: The present findings suggest that dynamic compression inhibits *NO and PGE(2)release in IL-1 beta-stimulated superficial cells via distinct pathways, a significant finding that may contribute to the development of intervention strategies for the treatment of inflammatory joint disorders. Dinoprostone 83-89 interleukin 1 beta Homo sapiens 100-109 12952251-7 2003 Prostaglandin E2, known as an activator of the prostanoid receptors EP2 and EP4, which are positively coupled to adenylyl cyclase, also decreased the IL-1beta-induced eotaxin and MCP-1 production by 57+/-17 and 53+/-4%, respectively. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 150-158 12860389-1 2003 Prostaglandin (PG) E2 release is induced in pulmonary A549 cells by the NF-kappaB-activating stimuli interleukin-1beta (IL-1beta) and phorbol 12-myristate 13-acetate (PMA). Dinoprostone 0-21 interleukin 1 beta Homo sapiens 120-128 12860389-4 2003 These data conclusively demonstrate a substantial role for NF-kappaB in the co-ordinate induction of COX-2, mPGES and in the corresponding release of PGE2 by IL-1beta. Dinoprostone 150-154 interleukin 1 beta Homo sapiens 158-166 14974816-5 2003 Little is known about IL-1beta-stimulated AgP fibroblast IL-6 and PGE2 production and their regulation by COX inhibitors. Dinoprostone 66-70 interleukin 1 beta Homo sapiens 22-30 14974816-6 2003 The objective of this study was to determine the effects of COX-2 inhibitors on amounts of PGE2 and IL-6 made by IL-1beta-stimulated gingival fibroblasts. Dinoprostone 91-95 interleukin 1 beta Homo sapiens 113-121 14974816-10 2003 When exogenous PGE2 was added concurrently with COX-2 inhibitors before addition of IL-1beta, IL-6 production returned to levels at or approaching that produced by cells exposed only to IL-1beta (P < or = 0.04). Dinoprostone 15-19 interleukin 1 beta Homo sapiens 186-194 12810931-0 2003 Ciprofloxacin reduces the stimulation of prostaglandin E(2) output by interleukin-1beta in human tendon-derived cells. Dinoprostone 41-59 interleukin 1 beta Homo sapiens 70-87 12810931-5 2003 RESULTS: IL-1beta stimulated a substantial and prolonged increase in the output of PGE2. Dinoprostone 83-87 interleukin 1 beta Homo sapiens 9-17 12810931-6 2003 Preincubation with ciprofloxacin reduced IL-1beta-induced PGE2 output at all times tested; the reduction at 48 h was 69% (99% confidence interval 59-79%; 15 experiments). Dinoprostone 58-62 interleukin 1 beta Homo sapiens 41-49 12810931-8 2003 However, ciprofloxacin did not affect the induction of COX-2 by IL-1beta, measured at 4 or 48 h. CONCLUSIONS: Ciprofloxacin reduces IL-1beta-induced PGE2 output in tendon-derived cells. Dinoprostone 149-153 interleukin 1 beta Homo sapiens 132-140 12810931-9 2003 The reduction in PGE2 output could modulate various cellular activities of IL-1beta, and may be implicated in fluoroquinolone-induced tendinopathy. Dinoprostone 17-21 interleukin 1 beta Homo sapiens 75-83 12860389-0 2003 IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 0-8 12860389-1 2003 Prostaglandin (PG) E2 release is induced in pulmonary A549 cells by the NF-kappaB-activating stimuli interleukin-1beta (IL-1beta) and phorbol 12-myristate 13-acetate (PMA). Dinoprostone 0-21 interleukin 1 beta Homo sapiens 101-118 12672669-7 2003 In postlabor amnion cells, IL-1beta increased IL-8 and PGE2 synthesis and COX-2 expression, but progesterone did not attenuate the effect of IL-1beta upon IL-8 synthesis. Dinoprostone 55-59 interleukin 1 beta Homo sapiens 27-35 12730964-4 2003 More importantly, in combination with the inflammatory mediators IL-1beta, tumor necrosis factor-alpha, and lipopolysaccharide, OSM exhibits a striking synergy, resulting in up to 50-fold higher PGE(2) production by astrocytes, astroglioma, and neuroblastoma cell lines. Dinoprostone 195-201 interleukin 1 beta Homo sapiens 65-102 12730964-6 2003 Of the enzymes involved in PGE(2) biosynthesis, only COX-2 mRNA and protein levels are synergistically amplified by OSM and IL-1beta. Dinoprostone 27-33 interleukin 1 beta Homo sapiens 124-132 12932294-3 2003 In this study, using prostaglandin E2 production as a measure of stimulation, we quantitatively compared the ability of anakinra, as well as that of IL-1Ra delivered by gene transfer, to inhibit the biologic actions of IL-1beta. Dinoprostone 21-37 interleukin 1 beta Homo sapiens 219-227 12672669-5 2003 In LSF cells, IL-1beta significantly increased IL-8 and PGE2 synthesis and COX-2 and IL-8 mRNA expression, but progesterone significantly attenuated these effects. Dinoprostone 56-60 interleukin 1 beta Homo sapiens 14-22 12672669-6 2003 In prelabor amnion cells, IL-1beta also increased IL-8 and PGE2 synthesis and both COX-2 and IL-8 mRNA and promoter expression; however, progesterone significantly attenuated these effects on IL-8 and PGE2 synthesis and COX-2 expression. Dinoprostone 59-63 interleukin 1 beta Homo sapiens 26-34 12672669-6 2003 In prelabor amnion cells, IL-1beta also increased IL-8 and PGE2 synthesis and both COX-2 and IL-8 mRNA and promoter expression; however, progesterone significantly attenuated these effects on IL-8 and PGE2 synthesis and COX-2 expression. Dinoprostone 201-205 interleukin 1 beta Homo sapiens 26-34 12639911-0 2003 Prostaglandin (PG) FP and EP1 receptors mediate PGF2alpha and PGE2 regulation of interleukin-1beta expression in Leydig cell progenitors. Dinoprostone 62-66 interleukin 1 beta Homo sapiens 81-98 12957788-8 2003 These results indicate that IL-1beta reduces the expression of ATPase independently of NFkB but, through a major pathway involving p38 and COX-2/PGE2, and another pathway involving JNK/AP1. Dinoprostone 145-149 interleukin 1 beta Homo sapiens 28-36 12681956-8 2003 GS also inhibited the release of PGE2 to conditioned media of HOC stimulated with IL-1beta. Dinoprostone 33-37 interleukin 1 beta Homo sapiens 82-90 12568957-10 2003 The IL-1 beta-treated tendon cells released prostaglandin E(2) (PGE(2)) in the medium, suggesting that the inducible COX2 catalyzed this synthesis. Dinoprostone 44-62 interleukin 1 beta Homo sapiens 4-13 12568957-10 2003 The IL-1 beta-treated tendon cells released prostaglandin E(2) (PGE(2)) in the medium, suggesting that the inducible COX2 catalyzed this synthesis. Dinoprostone 64-70 interleukin 1 beta Homo sapiens 4-13 12543811-4 2003 In group I strains, mean basal and peak PGE2 levels after 24 h of interleukin (IL)-1beta stimulation were 5.4 +/- 1.1 and 32.8 +/- 4.9 ng/mg protein, respectively. Dinoprostone 40-44 interleukin 1 beta Homo sapiens 66-88 12543811-6 2003 IL-1beta-mediated stimulation of PGE2 was fully blocked in the presence of a nonselective COX inhibitor (indomethacin) or a selective COX-2 inhibitor (NS-398). Dinoprostone 33-37 interleukin 1 beta Homo sapiens 0-8 12492578-5 2003 Expression of CD80, CD83, CD86, and major histocompatibility complex class I and class II antigens were reduced on lipopolysaccharide (LPS)-matured leukaemic DC but were enhanced by a mixture of interleukin 1beta (IL-1beta), IL-6, tumour necrosis factor-alpha (TNF-alpha) and prostaglandin E2 (PGE2). Dinoprostone 276-292 interleukin 1 beta Homo sapiens 195-212 12492578-5 2003 Expression of CD80, CD83, CD86, and major histocompatibility complex class I and class II antigens were reduced on lipopolysaccharide (LPS)-matured leukaemic DC but were enhanced by a mixture of interleukin 1beta (IL-1beta), IL-6, tumour necrosis factor-alpha (TNF-alpha) and prostaglandin E2 (PGE2). Dinoprostone 294-298 interleukin 1 beta Homo sapiens 195-212 12496396-7 2003 Immunoneutralization studies indicated that TNF-alpha was a primary regulator of IL-1beta, IL-10, and PGE2 production, while IL-1beta stimulated only PGE2 production. Dinoprostone 150-154 interleukin 1 beta Homo sapiens 125-133 12529415-0 2003 Interleukin-1beta induces glycosaminoglycan synthesis via the prostaglandin E2 pathway in cultured human cervical fibroblasts. Dinoprostone 62-78 interleukin 1 beta Homo sapiens 0-17 12529415-1 2003 The aim of this study was to identify, in cultured human cervical fibroblasts, the mechanisms by which interleukin (IL)-1beta induces the synthesis of glycosaminoglycans (GAG) and to explore the putative role of prostaglandin E(2) (PGE(2)) in this process. Dinoprostone 232-238 interleukin 1 beta Homo sapiens 103-125 12417253-1 2002 Recently, under large-scale screening experiments, we found that sphondin, a furanocoumarin derivative isolated from Heracleum laciniatum, possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells. Dinoprostone 233-239 interleukin 1 beta Homo sapiens 173-181 12543811-9 2003 However, incubation of fibroblasts with PGE2 after IL-1beta stimulation prolonged COX-2 mRNA half-life from approximately 1 to 9 h. Our results strengthen the evidence that fibroblasts and other mesenchymal cells are the source of COX-2 expression in normal and premalignant colorectal tissue. Dinoprostone 40-44 interleukin 1 beta Homo sapiens 51-59 12466348-2 2002 They trigger an increase in proinflammatory cytokines, in particular IL-1beta, that induces a cascade of events resulting in the production of potent effectors of myometrial contractility, such as the prostaglandin E(2) (PGE(2)). Dinoprostone 201-219 interleukin 1 beta Homo sapiens 69-77 12466348-5 2002 The IL-1beta-induced PDE4 activity occurs after an increase in PGE(2) production and subsequent cAMP augmentation. Dinoprostone 63-69 interleukin 1 beta Homo sapiens 4-12 12466348-6 2002 Pretreatment with indomethacin or NS 398 completely blocked this long-term effect of IL-1beta, revealing a PGE(2)-dependent pathway. Dinoprostone 107-113 interleukin 1 beta Homo sapiens 85-93 12512699-11 2002 It means that IL-1beta-triggered-PGE2 biosynthesis in endothelial cells is probably regulated by induction of both COX-2 and PGE-S. Dinoprostone 33-37 interleukin 1 beta Homo sapiens 14-22 12417253-9 2002 Taken together, we demonstrate that sphondin inhibits IL-1beta-induced PGE(2) release in A549 cells; this inhibition is mediated by suppressing of COX-2 expression, rather than by inhibiting COX-2 enzyme activity. Dinoprostone 71-77 interleukin 1 beta Homo sapiens 54-62 12107235-2 2002 We found that cyclooxygenase-2 (COX-2) mRNA and protein levels and PGE(2) production in ESC were significantly increased by IL-1beta. Dinoprostone 67-73 interleukin 1 beta Homo sapiens 124-132 12215436-5 2002 PGE(2) also inhibited the tumor necrosis factor-alpha-, interferon-gamma-, and interleukin-1beta-mediated expression of these chemokines. Dinoprostone 0-5 interleukin 1 beta Homo sapiens 79-96 12356282-1 2002 We examined the inhibitory mechanism of byakangelicol, isolated from Angelica dahurica, on interleukin-1beta (IL-1beta)-induced cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) release in human pulmonary epithelial cell line (A549). Dinoprostone 186-190 interleukin 1 beta Homo sapiens 110-118 12356282-2 2002 Byakangelicol (10-50 microM) concentration-dependently attenuated IL-1beta-induced COX-2 expression and PGE2 release. Dinoprostone 104-108 interleukin 1 beta Homo sapiens 66-74 12356282-7 2002 Taken together, we have demonstrated that byakangelicol inhibits IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expression and the activity of COX-2 enzyme. Dinoprostone 82-86 interleukin 1 beta Homo sapiens 65-73 12391274-8 2002 The inhibition of both MAPKs reduced IL-1beta-induced COX-2 expression and PGE(2) synthesis. Dinoprostone 75-81 interleukin 1 beta Homo sapiens 37-45 12374621-3 2002 Stimulation of human chondrocytes with IL-1 beta (5 ng/ml) for 24 h resulted in significantly enhanced production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) when compared to untreated controls (p <.001). Dinoprostone 139-157 interleukin 1 beta Homo sapiens 39-48 12374621-7 2002 Overall, the study suggests that EGCG affords protection against IL-1 beta-induced production of catabolic mediators NO and PGE(2) in human chondrocytes by regulating the expression and catalytic activity of their respective enzymes. Dinoprostone 124-130 interleukin 1 beta Homo sapiens 65-74 12371761-11 2002 CONCLUSIONS AND CLINICAL RELEVANCE: Human recombinant IL-1beta resulted in loss of cell viability, alterations in extracellular matrix components, and production of PG and MMP Carprofen and dexamethasone had little effect on cell and matrix variables but did decrease PGE2 concentrations and primarily affected the inflammatory pathway of osteoarthritis. Dinoprostone 268-272 interleukin 1 beta Homo sapiens 54-62 12233875-9 2002 Conversion of PGH2 to PGE2 increased by IL-1beta and was correlated with mPGES expression. Dinoprostone 22-26 interleukin 1 beta Homo sapiens 40-48 12130681-9 2002 Both (-)-Syn and (-)-Anti enantiomers of A276575 were potent inhibitors of IL-1beta-stimulated PGE2 production in A549 lung epithelial cells; unexpectedly, however, only the (-)-Anti enantiomer inhibited regulated on T-cell activation, normal T-cell expressed and secreted (RANTES) production in A549 cells. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 75-83 12113880-0 2002 Interferon gamma antagonizes interleukin-1beta-induced cyclooxygenase-2 expression and prostaglandin E(2) production in human myometrial cells. Dinoprostone 87-105 interleukin 1 beta Homo sapiens 29-46 12115742-6 2002 In response to IL-1beta (0.1 ng/ml), NO and PGE(2) release was maximal on Day 2 or 3 and then declined to near basal level by Day 14. Dinoprostone 44-50 interleukin 1 beta Homo sapiens 15-23 12115742-13 2002 Like the OA, IL-1beta-induced NO and PGE(2) release decreased over time. Dinoprostone 37-43 interleukin 1 beta Homo sapiens 13-21 12115742-14 2002 In conclusion, with prolonged exposure to IL-1beta, human chondrocytes develop selective tolerance involving NO and PGE(2) release but not MMP-13 production, metabolic activity, or matrix metabolism. Dinoprostone 116-122 interleukin 1 beta Homo sapiens 42-50 11847219-0 2002 Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression. Dinoprostone 17-33 interleukin 1 beta Homo sapiens 47-64 12136890-8 2002 IL-15 production stimulated by interferon-gamma (IFN-gamma), IL-1beta, or lipopolysaccharide were also strongly inhibited by PGE2. Dinoprostone 125-129 interleukin 1 beta Homo sapiens 61-69 11847219-11 2002 These results indicate that the induction of PGHS-2 and mPGES by IL-1beta underlies robust PGE(2) production in orbital fibroblasts. Dinoprostone 91-97 interleukin 1 beta Homo sapiens 65-73 12126649-3 2002 IL-1beta also increases prostaglandin E(2) (PGE(2)) production and stimulates bone resorption. Dinoprostone 24-42 interleukin 1 beta Homo sapiens 0-8 12126649-3 2002 IL-1beta also increases prostaglandin E(2) (PGE(2)) production and stimulates bone resorption. Dinoprostone 44-50 interleukin 1 beta Homo sapiens 0-8 11882577-1 2002 Interleukin-1beta (IL-1beta), a proinflammatory cytokine, induces cyclooxygenase-2 (COX-2) in cultured neonatal ventricular myocytes (NVMs), resulting in the preferential production of prostaglandin E(2) (PGE(2)). Dinoprostone 185-203 interleukin 1 beta Homo sapiens 0-17 11834608-4 2002 IL-1beta-induced chondrocyte products (nitric oxide and prostaglandin E(2)) were measured in culture supernatants after 48 h incubation time. Dinoprostone 56-74 interleukin 1 beta Homo sapiens 0-8 11834608-9 2002 It was shown that autocrine prostaglandin E(2) (PGE(2)) enabled PDE4 inhibitors to reduce IL-1beta-induced NO in this experimental setting. Dinoprostone 28-46 interleukin 1 beta Homo sapiens 90-98 11834608-9 2002 It was shown that autocrine prostaglandin E(2) (PGE(2)) enabled PDE4 inhibitors to reduce IL-1beta-induced NO in this experimental setting. Dinoprostone 48-54 interleukin 1 beta Homo sapiens 90-98 12010778-5 2002 Exogenous PGE(2) completely abolished the effects of NS-398 on the production of each mediator by OA fibroblasts stimulated with IL-1beta. Dinoprostone 10-16 interleukin 1 beta Homo sapiens 129-137 11936556-5 2002 Antipyretic drugs such as acetylsalicylic acid, dexamethasone, and lipocortin 5-(204-212) peptide counteract IL-1beta-induced fever and abolish changes in Ca2+ and PGE2 concentrations in CSF. Dinoprostone 164-168 interleukin 1 beta Homo sapiens 109-117 11882577-1 2002 Interleukin-1beta (IL-1beta), a proinflammatory cytokine, induces cyclooxygenase-2 (COX-2) in cultured neonatal ventricular myocytes (NVMs), resulting in the preferential production of prostaglandin E(2) (PGE(2)). Dinoprostone 185-203 interleukin 1 beta Homo sapiens 19-27 11980586-5 2002 PGE2 was the predominant COX product in IL-1beta-stimulated cells with no significant difference between HF-IPF and HF-NL (28.35 [9.09-89.09] vs. 17.12 [8.58-29.33] ng/10(6) cells/30 min, respectively; P = 0.25). Dinoprostone 0-4 interleukin 1 beta Homo sapiens 40-48 11842936-3 2002 Indomethacin, a cyclooxygenase inhibitor, significantly enhanced IL-1beta-induced IL-6 production by HGF, although it completely inhibited IL-1beta-induced PGE2 production. Dinoprostone 156-160 interleukin 1 beta Homo sapiens 139-147 11842936-4 2002 Exogenous PGE2 suppressed the IL-1beta-induced IL-6 production. Dinoprostone 10-14 interleukin 1 beta Homo sapiens 30-38 11842936-8 2002 Based on these data, we suggest that PGE2 can up- or downregulate IL-1beta-induced IL-6 production via EP1 receptors or via EP2/EP4 receptors in HGF, respectively. Dinoprostone 37-41 interleukin 1 beta Homo sapiens 66-74 11686835-8 2001 RESULTS: Interleukin-1beta treatment dose- and time-dependently increased COX-2 mRNA and protein expression levels, and enhanced PGE2 production/secretion in AGS cells. Dinoprostone 129-133 interleukin 1 beta Homo sapiens 9-26 11879548-3 2002 In combination with TNF or IL-1beta, hTWEAK further stimulated the secretion of prostaglandin E2, MMP-1, IL-6 and IL-8 up to fourfold, and IP-10 and RANTES up to 70-fold compared to TNF or IL-1beta alone. Dinoprostone 80-96 interleukin 1 beta Homo sapiens 27-35 11686835-11 2001 To demonstrate the cause-effect relationship, we showed that inhibition of MEK and p38 MAP kinase with specific inhibitors suppressed IL-1beta-mediated increases in COX-2 mRNA and protein levels, and the PGE2 production. Dinoprostone 204-208 interleukin 1 beta Homo sapiens 134-142 11423555-0 2001 Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts. Dinoprostone 0-18 interleukin 1 beta Homo sapiens 140-158 11592370-9 2001 IL-1beta significantly increased PGE2 production. Dinoprostone 33-37 interleukin 1 beta Homo sapiens 0-8 11592370-10 2001 The combination of IL-1beta and TNFalpha had an additive effect on PGE2 production, while addition of IL-17 to TNFalpha or IL-1beta synergistically enhanced PGE2 production. Dinoprostone 67-71 interleukin 1 beta Homo sapiens 19-27 11592370-10 2001 The combination of IL-1beta and TNFalpha had an additive effect on PGE2 production, while addition of IL-17 to TNFalpha or IL-1beta synergistically enhanced PGE2 production. Dinoprostone 157-161 interleukin 1 beta Homo sapiens 123-131 11592370-11 2001 Inhibition of NO production by 1400W significantly increased IL-1beta-stimulated PGE2 production, and inhibition of PGE2 production by the COX-2 inhibitor N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide significantly increased IL-17-stimulated NO production. Dinoprostone 81-85 interleukin 1 beta Homo sapiens 61-69 11423555-2 2001 We explored a positive feedback, prostaglandin E(2) (PGE(2))-dependent stabilization of COX-2 mRNA mediated by the p38 MAPK cascade in IL-1 beta-stimulated human synovial fibroblasts. Dinoprostone 33-51 interleukin 1 beta Homo sapiens 135-144 11423555-2 2001 We explored a positive feedback, prostaglandin E(2) (PGE(2))-dependent stabilization of COX-2 mRNA mediated by the p38 MAPK cascade in IL-1 beta-stimulated human synovial fibroblasts. Dinoprostone 53-59 interleukin 1 beta Homo sapiens 135-144 11401841-6 2001 Addition of interleukin-1beta to serum enhanced COX-2 expression and PGE2 synthesis over that by serum alone but had no effect on the progression of these cells into S phase. Dinoprostone 69-73 interleukin 1 beta Homo sapiens 12-29 11570587-6 2001 Our studies on the regulation of IL-10 secretion in OVCAR-3 revealed that (1) proinflammatory stimuli IL-1beta and TNF-alpha, but not LPS, enhance IL-10 secretion, (2) IL-6 has no influence on the release of IL-10, (3) prostaglandin E2 influences neither the spontaneous nor the TNF-alpha- or IL-1beta-stimulated IL-10 production and (4) interferon-gamma inhibits IL-10 secretion. Dinoprostone 219-235 interleukin 1 beta Homo sapiens 102-110 11469463-6 2001 RESULTS: Constitutive PGE2 production was significantly upregulated and IL-1beta induced PGE2 production was increased by the enhancing expression of both COX-2 mRNA and protein in fibroblasts from scleroderma involved skin; PGE2 production and COX-2 expression were inhibited by UVA irradiation. Dinoprostone 89-93 interleukin 1 beta Homo sapiens 72-80 11469463-6 2001 RESULTS: Constitutive PGE2 production was significantly upregulated and IL-1beta induced PGE2 production was increased by the enhancing expression of both COX-2 mRNA and protein in fibroblasts from scleroderma involved skin; PGE2 production and COX-2 expression were inhibited by UVA irradiation. Dinoprostone 89-93 interleukin 1 beta Homo sapiens 72-80 11453112-0 2001 Prostaglandin E2 secretion from gingival fibroblasts treated with interleukin-1beta: effects of lipid extracts from Porphyromonas gingivalis or calculus. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 66-83 11350802-7 2001 However, OSM caused dose-dependent augmentation of COX-2 expression and prostaglandin (PG) E(2) release induced by IL-1beta. Dinoprostone 72-95 interleukin 1 beta Homo sapiens 115-123 11352510-1 2001 We have previously demonstrated that bradykinin potentiates prostaglandin E(2)release in human gingival fibroblasts pretreated with interleukin-1 beta (priming). Dinoprostone 60-78 interleukin 1 beta Homo sapiens 132-150 11352510-7 2001 These results suggest that bradykinin-induced prostaglandin E2 synthesis is regulated at the level of the transcription of cyclooxygenase-2 mRNA via Ca2+ mobilization in the interleukin-1 beta-primed human gingival fibroblasts. Dinoprostone 46-62 interleukin 1 beta Homo sapiens 174-192 11270638-0 2001 Interleukin-1beta-induced prostaglandin E2 production in human myometrial cells: role of a pertussis toxin-sensitive component. Dinoprostone 26-42 interleukin 1 beta Homo sapiens 0-17 11171589-5 2001 Interleukin (IL)-1beta (10 ng/ml) induces PGHS-2 expression and PGE(2) production in primary thyrocytes. Dinoprostone 64-70 interleukin 1 beta Homo sapiens 0-22 11270638-4 2001 RESULTS: IL-1 increased PGE2 output during an 18-hr long incubation by 21.7-fold (n = 5 experiments). Dinoprostone 24-28 interleukin 1 beta Homo sapiens 9-13 11282781-5 2001 IL-1beta has been demonstrated to induce cox-2 expression and PGE(2) synthesis. Dinoprostone 62-68 interleukin 1 beta Homo sapiens 0-8 11250126-0 2001 Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer"s disease. Dinoprostone 58-74 interleukin 1 beta Homo sapiens 0-17 11263775-8 2001 Concomitant application of CTS abrogated the catabolic effects of IL-1beta on TMJ chondrocytes by inhibiting iNOS, COX-2, and MMP-1 mRNA production and NO, PGE2, and MMP-1 synthesis. Dinoprostone 156-160 interleukin 1 beta Homo sapiens 66-74 11194936-8 2001 PGE2 synthesis by astrocytes and SK-N-SH cells was stimulated by interleukin-1beta. Dinoprostone 0-4 interleukin 1 beta Homo sapiens 65-82 11289656-5 2001 However, there was no difference in spontaneous levels of soluble factors between OA and RA fibroblasts, though medium concentrations of IL-1beta-released VEGF, MMP-1, and PGE2, but not cytokines, in RA were slightly higher than those in OA. Dinoprostone 172-176 interleukin 1 beta Homo sapiens 137-145 11289656-7 2001 But PGE2 prevented proliferation of RA fibroblasts when added to medium up to 3 h after IL-1beta stimulation. Dinoprostone 4-8 interleukin 1 beta Homo sapiens 88-96 11289656-8 2001 Dexamethasone also inhibited the release of IL-6, IL-8, and PGE2 induced by IL-1beta in both OA and RA fibroblasts. Dinoprostone 60-64 interleukin 1 beta Homo sapiens 76-84 11289656-12 2001 CONCLUSION: The present results indicate that the activation of NF-kappaB plays an important role in the proliferative response to IL-1beta in human fibroblasts, and suggest that PGE2 acts as a modulator of cell proliferation in inflamed synovial tissue. Dinoprostone 179-183 interleukin 1 beta Homo sapiens 131-139 11152649-4 2001 Cells stimulated with a combination of proinflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha each at 10 ng/ml) for 24 h released significant amounts of PGE2 (measured by radioimmunoassay) and GM-CSF (measured by enzyme-linked immunosorbent assay). Dinoprostone 175-179 interleukin 1 beta Homo sapiens 66-115 11247321-8 2001 IL-1 beta significantly decreased the proliferation rate of chondrocytes in co-cultures and slightly increased prostaglandin-E2 release. Dinoprostone 111-127 interleukin 1 beta Homo sapiens 0-9 11189028-3 2000 A difficulty, however, is that (1) IL-1beta is not expressed constitutively in mononuclear phagocytes, their presumed cell source upon stimulation by exogenous pyrogens, e.g. endotoxin, and (2) similarly, the isoform of the enzyme that selectively mediates the production and release of PGE2 by endotoxin-stimulated macrophages, COX-2, is also not constitutively expressed in these cells. Dinoprostone 287-291 interleukin 1 beta Homo sapiens 35-43 11296546-2 2001 Nimesulide or NS-398 inhibited IL-1 beta-induced PGE2 production at all concentrations tested, and in addition they suppressed IL-1 beta-induced COX-2 mRNA expression and protein synthesis. Dinoprostone 49-53 interleukin 1 beta Homo sapiens 31-40 11201045-2 2000 We have previously demonstrated that PGE2 down-regulates intercellular adhesion molecule-1 (ICAM-1) expression in interleukin-1beta (IL-1beta)-stimulated human gingival fibroblasts (HGF). Dinoprostone 37-41 interleukin 1 beta Homo sapiens 114-131 11112151-0 2000 Effect of endogenous and exogenous prostaglandin E(2) on interleukin-1 beta-induced cyclooxygenase-2 expression in human airway smooth-muscle cells. Dinoprostone 35-53 interleukin 1 beta Homo sapiens 57-75 11112151-1 2000 We studied the effect of endogenous and exogenous prostaglandin E(2) (PGE(2)), a metabolite of arachidonic acid through the cyclooxygenase (COX) pathway, on interleukin (IL)-1 beta-induced COX-2 expression, using primary cultures of human bronchial smooth-muscle cells (HBSMC). Dinoprostone 50-68 interleukin 1 beta Homo sapiens 157-180 11112151-3 2000 Inhibition of PGE(2) production with a nonselective COX inhibitor (flurbiprofen, 10 microM) resulted in a significant reduction in IL-1 beta- induced COX-2 expression, supporting a role of endogenous COX metabolites in the modulation of COX-2 expression. Dinoprostone 14-20 interleukin 1 beta Homo sapiens 131-140 11201045-0 2000 Cyclooxygenase-2-dependent prostaglandin E2 down-regulates intercellular adhesion molecule-1 expression via EP2/EP4 receptors in interleukin-1beta-stimulated human gingival fibroblasts. Dinoprostone 27-43 interleukin 1 beta Homo sapiens 129-146 11053030-9 2000 These results are consistent with the hypothesis that p38 is involved in the signal transduction pathway through which IL-1 beta induces COX-2 expression, PGE(2) release, and beta-adrenergic hyporesponsiveness. Dinoprostone 155-160 interleukin 1 beta Homo sapiens 119-128 11063815-8 2000 Indeed endogenous IL-1beta appears to inhibit LPS-induced PGE(2) release. Dinoprostone 58-64 interleukin 1 beta Homo sapiens 18-26 11039768-6 2000 Human interleukin-1beta (5-10 ng/mL) induced nitric oxide, prostaglandin E2 and matrix metalloprotease production in bovine or human chondrocytes, which could be inhibited by 500 pg/mL of Type II interleukin-1 receptor. Dinoprostone 59-75 interleukin 1 beta Homo sapiens 6-23 11201045-9 2000 AH-23848B, an EP4 antagonist, antagonized the inhibitory effect of IL-1beta-elicited ICAM-1 expression by PGE2. Dinoprostone 106-110 interleukin 1 beta Homo sapiens 67-75 11201045-11 2000 Analysis of these data suggests that COX-2-derived PGE2 down-regulates ICAM-1 expression via EP2/EP4 receptors in IL-1beta-stimulated HGF. Dinoprostone 51-55 interleukin 1 beta Homo sapiens 114-122 11032891-0 2000 Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB. Dinoprostone 47-65 interleukin 1 beta Homo sapiens 0-17 11032891-5 2000 Here we show that interleukin (IL)-1beta induces COX-2 mRNA and protein synthesis and the release of PGE(2) in the human neuroblastoma cell line SK-N-SH. Dinoprostone 101-107 interleukin 1 beta Homo sapiens 18-40 11201045-2 2000 We have previously demonstrated that PGE2 down-regulates intercellular adhesion molecule-1 (ICAM-1) expression in interleukin-1beta (IL-1beta)-stimulated human gingival fibroblasts (HGF). Dinoprostone 37-41 interleukin 1 beta Homo sapiens 133-141 11201045-3 2000 In the present study, we investigated which COX was involved in down-regulation of ICAM-1 expression by PGE2 in IL-1beta-stimulated HGF and which subtypes of EP receptors modulated the ICAM-1 expression. Dinoprostone 104-108 interleukin 1 beta Homo sapiens 112-120 11201045-4 2000 NS-398, a specific COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated HGF, as did indomethacin, a COX-1/COX-2 inhibitor. Dinoprostone 57-61 interleukin 1 beta Homo sapiens 76-84 11201045-8 2000 PGE2, 11-deoxy-PGE1 (a selective EP2/EP4 agonist), and Butaprost (a selective EP2 agonist) attenuated IL-1beta-elicited ICAM-1 expression, although Butaprost was less potent than PGE2 and 11-deoxy-PGE1. Dinoprostone 0-4 interleukin 1 beta Homo sapiens 102-110 10976994-8 2000 Interleukin-1beta (IL-1beta and prostaglandin E2 (PGE2) were identified as candidate molecules for the transferable factor as both were shown to induce HBC hyperpolarization by opening of small conductance calcium-activated potassium channels, the means by which 0.33 Hz PIS causes HBC hyperpolarization. Dinoprostone 50-54 interleukin 1 beta Homo sapiens 0-17 10896792-9 2000 We also discovered that induction of PGE(2) biosynthesis in response to IL-1 or IL-1/FGF-1 was affected by the density of MG-63 cells in culture. Dinoprostone 37-43 interleukin 1 beta Homo sapiens 72-76 10924071-4 2000 In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production. Dinoprostone 99-105 interleukin 1 beta Homo sapiens 45-62 10924071-4 2000 In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production. Dinoprostone 99-105 interleukin 1 beta Homo sapiens 64-72 10896792-9 2000 We also discovered that induction of PGE(2) biosynthesis in response to IL-1 or IL-1/FGF-1 was affected by the density of MG-63 cells in culture. Dinoprostone 37-43 interleukin 1 beta Homo sapiens 80-84 10896792-12 2000 We conclude that the signaling pathways resulting in PGE(2) biosynthesis in response to proinflammatory agents like IL-1 are subject to complex regulation by additional soluble mediators as well as cell-cell or cell-extracellular matrix interactions. Dinoprostone 53-59 interleukin 1 beta Homo sapiens 116-120 10843735-1 2000 Interleukin (IL-)1 stimulates prostaglandin E(2)(PGE(2)) generation in fibroblasts, and preferential couplings between particular phospholipase A(2)(PLA(2)) and cyclooxygenase (COX) isozymes are implicated with IL-1-induced delayed PGE(2)generation. Dinoprostone 30-48 interleukin 1 beta Homo sapiens 0-18 10903976-0 2000 The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes. Dinoprostone 84-90 interleukin 1 beta Homo sapiens 65-73 10942208-3 2000 Since pro-inflammatory cytokine IL-1beta has been shown to induce prostaglandin E2 (PGE2) release in human gingival fibroblasts (HGF), here we analyzed the effect of IL-1beta on the expression of COX-2 and the activation of NFkappaB in HGF. Dinoprostone 66-82 interleukin 1 beta Homo sapiens 32-40 12515149-1 2000 This study was designed to investigate the local changes in the levels of placental estradiol and progesterone and their ratio during term labor and to determine whether the PGE2-generating ability of the fetal membrane in response to IL-1 beta at term labor is greater than that at term not-in-labor. Dinoprostone 174-178 interleukin 1 beta Homo sapiens 235-244 12515149-6 2000 IL-1 beta stimulated fetal membrane to produce more PGE2 at term labor, and at term not-in-labor, too. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 0-9 10942208-3 2000 Since pro-inflammatory cytokine IL-1beta has been shown to induce prostaglandin E2 (PGE2) release in human gingival fibroblasts (HGF), here we analyzed the effect of IL-1beta on the expression of COX-2 and the activation of NFkappaB in HGF. Dinoprostone 66-82 interleukin 1 beta Homo sapiens 166-174 10942208-3 2000 Since pro-inflammatory cytokine IL-1beta has been shown to induce prostaglandin E2 (PGE2) release in human gingival fibroblasts (HGF), here we analyzed the effect of IL-1beta on the expression of COX-2 and the activation of NFkappaB in HGF. Dinoprostone 84-88 interleukin 1 beta Homo sapiens 32-40 10942208-6 2000 IL-1beta-induced PGE2 release was blocked by the tyrosine kinase inhibitor and increased by the tyrosine phosphatase inhibitor. Dinoprostone 17-21 interleukin 1 beta Homo sapiens 0-8 10812056-8 2000 These results suggest that interleukin-1beta- and bradykinin-induced prostaglandin E(2) release is dependent on cyclooxygenase-2 and the potentiated effect of bradykinin in the human gingival fibroblasts primed with interleukin-1beta is caused by Ca(2+) mobilization. Dinoprostone 69-87 interleukin 1 beta Homo sapiens 27-44 10812056-0 2000 Bradykinin potentiates prostaglandin E(2) release in the human gingival fibroblasts pretreated with interleukin-1beta via Ca(2+) mobilization. Dinoprostone 23-41 interleukin 1 beta Homo sapiens 100-117 10857767-3 2000 Their cell-associated IL-1beta levels are elevated after stimulation with tumour necrosis factor (TNF-)alpha but not with cytokines such as IL-1alpha, IL-3, IL-4, IL-6, IL-7, IL-10, SCF, G-CSF, M-CSF and TGF-beta or lipid mediators such as PGE2, LTB4, LXA4, LXB4, 12-HETE, 15-HETE and PAF. Dinoprostone 240-244 interleukin 1 beta Homo sapiens 22-30 10812056-1 2000 Interleukin-1beta, a proinflammatory cytokine, causes a slow increase in prostaglandin E(2) release. Dinoprostone 73-91 interleukin 1 beta Homo sapiens 0-17 10812056-3 2000 Simultaneous stimulation with interleukin-1beta (200 pg/ml) and bradykinin (1 microM) evoked a moderately synergistic increase in prostaglandin E(2) release in human gingival fibroblasts. Dinoprostone 130-148 interleukin 1 beta Homo sapiens 30-47 10812056-4 2000 However, in the human gingival fibroblasts pretreated with interleukin-1beta, bradykinin drastically enhanced prostaglandin E(2) release. Dinoprostone 110-128 interleukin 1 beta Homo sapiens 59-76 10858012-4 2000 RESULTS: In response to IL-1beta and TNF-alpha combined cells of the thyroid epithelial cell line Nthy-ori3-1 secreted marked amounts of PGE2 in a time-dependent fashion. Dinoprostone 137-141 interleukin 1 beta Homo sapiens 24-32 10896792-0 2000 The regulation of PGE(2) biosynthesis in MG-63 osteosarcoma cells by IL-1 and FGF is cell density-dependent. Dinoprostone 18-24 interleukin 1 beta Homo sapiens 69-73 10731036-3 2000 Our experiments demonstrate that the rapid prostaglandin E2 (PGE2) synthesis induced by IL-1beta is abolished by cycloheximide, suggesting the involvement of protein synthesis. Dinoprostone 43-59 interleukin 1 beta Homo sapiens 88-96 10699967-2 2000 We found that IL-1beta induced a large decrease in MeAIB uptake by human osteoarthritic synovial cells and a concomitant increase in prostaglandin E(2) (PGE(2)) synthesis. Dinoprostone 133-151 interleukin 1 beta Homo sapiens 14-22 11193500-6 2000 COX-2 has been focused as a key enzyme to regulate PGE2 synthesis and plays an important role in inflammation, because COX-2 was induced in many types of cells by the stimulation of inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha). Dinoprostone 51-55 interleukin 1 beta Homo sapiens 213-231 11193500-6 2000 COX-2 has been focused as a key enzyme to regulate PGE2 synthesis and plays an important role in inflammation, because COX-2 was induced in many types of cells by the stimulation of inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha). Dinoprostone 51-55 interleukin 1 beta Homo sapiens 233-242 10807502-5 2000 RESULTS: 4"-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1beta-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs. Dinoprostone 193-197 interleukin 1 beta Homo sapiens 98-106 10675243-10 2000 In contrast, only inhibition of cytosolic phospholipase A2 led to a decrease in interleukin-1beta-stimulated prostaglandin E2 release. Dinoprostone 109-125 interleukin 1 beta Homo sapiens 80-97 10675243-12 2000 Interleukin-1beta-stimulated prostaglandin E2 release appears to be dependent on the activity of cytosolic phospholipase A2. Dinoprostone 29-45 interleukin 1 beta Homo sapiens 0-17 10736970-16 2000 Both PGE2 and DBcAMP also attenuated the IL-1 beta-stimulated migration of monocytes. Dinoprostone 5-9 interleukin 1 beta Homo sapiens 41-50 10731036-3 2000 Our experiments demonstrate that the rapid prostaglandin E2 (PGE2) synthesis induced by IL-1beta is abolished by cycloheximide, suggesting the involvement of protein synthesis. Dinoprostone 61-65 interleukin 1 beta Homo sapiens 88-96 10731036-7 2000 These data demonstrate that the activation of p38 MAP kinase elicited by IL-1beta leads to the phosphorylation of cPLA2 and Cox-2 overexpression, allowing rapid synthesis of PGE2 as a prerequisite for bradykinin B2 gene expression in human bronchial smooth muscle cells which could explain the hyperresponsiveness of asthmatic patients to bradykinin. Dinoprostone 174-178 interleukin 1 beta Homo sapiens 73-81 11268335-4 2000 Our behavioral and electrophysiological studies have revealed that IL-1 beta in the brain induces hyperalgesia through the actions of prostaglandin E2 (PGE2) on EP3 receptors in the preoptic area and its neighboring basal forebrain, whereas the IL-1 beta-induced analgesia is produced by the actions of PGE2 on EP1 receptors in the ventromedial hypothalamus. Dinoprostone 134-150 interleukin 1 beta Homo sapiens 67-76 10681439-2 2000 Because of these similarities, IL-18 was investigated for its ability to induce prostaglandin E(2) (PGE(2)) synthesis in human peripheral blood mononuclear cells (PBMC), a prominent, proinflammatory property of IL-1. Dinoprostone 80-98 interleukin 1 beta Homo sapiens 31-35 10681439-2 2000 Because of these similarities, IL-18 was investigated for its ability to induce prostaglandin E(2) (PGE(2)) synthesis in human peripheral blood mononuclear cells (PBMC), a prominent, proinflammatory property of IL-1. Dinoprostone 100-106 interleukin 1 beta Homo sapiens 31-35 10681439-10 2000 PGE(2) production was also increased by the addition of IL-18BP to PBMC stimulated with either IL-1beta or IL-12 and also in whole blood cultures stimulated with Staphylococcus epidermidis. Dinoprostone 0-6 interleukin 1 beta Homo sapiens 95-103 11268335-4 2000 Our behavioral and electrophysiological studies have revealed that IL-1 beta in the brain induces hyperalgesia through the actions of prostaglandin E2 (PGE2) on EP3 receptors in the preoptic area and its neighboring basal forebrain, whereas the IL-1 beta-induced analgesia is produced by the actions of PGE2 on EP1 receptors in the ventromedial hypothalamus. Dinoprostone 152-156 interleukin 1 beta Homo sapiens 67-76 11268335-4 2000 Our behavioral and electrophysiological studies have revealed that IL-1 beta in the brain induces hyperalgesia through the actions of prostaglandin E2 (PGE2) on EP3 receptors in the preoptic area and its neighboring basal forebrain, whereas the IL-1 beta-induced analgesia is produced by the actions of PGE2 on EP1 receptors in the ventromedial hypothalamus. Dinoprostone 152-156 interleukin 1 beta Homo sapiens 245-254 11268335-4 2000 Our behavioral and electrophysiological studies have revealed that IL-1 beta in the brain induces hyperalgesia through the actions of prostaglandin E2 (PGE2) on EP3 receptors in the preoptic area and its neighboring basal forebrain, whereas the IL-1 beta-induced analgesia is produced by the actions of PGE2 on EP1 receptors in the ventromedial hypothalamus. Dinoprostone 303-307 interleukin 1 beta Homo sapiens 67-76 11729854-10 2000 PGE2 production by the human cell line was increased by LPS, IL-1 and Ca Ion. Dinoprostone 0-4 interleukin 1 beta Homo sapiens 61-65 10651950-7 2000 Combinations of TGF-beta1 with IL-1beta also increased PGE2 output and caused appropriate changes in prostaglandin pathway enzymes, whereas TGF-beta1 and IL-1alpha had more limited effects. Dinoprostone 55-59 interleukin 1 beta Homo sapiens 31-39 11729854-11 2000 IL-1 and Ca Ion stimulated PGE2 formation was inhibited by the cPLA2 enzyme inhibitors while LPS stimulated PGE2 production was not inhibited by the cPLA2 inhibitor; but was inhibited by the sPLA2 enzyme inhibitor. Dinoprostone 27-31 interleukin 1 beta Homo sapiens 0-4 11132768-8 2000 DEX but not annexin I peptide inhibited IL-1beta-induced PGE2 release. Dinoprostone 57-61 interleukin 1 beta Homo sapiens 40-48 10559138-0 1999 Increase in prostaglandin E(2) production by interleukin-1beta in arterial smooth muscle cells derived from patients with moyamoya disease. Dinoprostone 12-30 interleukin 1 beta Homo sapiens 45-62 10617676-3 2000 The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect. Dinoprostone 149-167 interleukin 1 beta Homo sapiens 132-140 10599732-8 1999 IL-1beta increased PGHS-2 mRNA and PGE2 output from villous and chorion trophoblasts and decreased PGDH mRNA in villous trophoblasts (all P < 0.05). Dinoprostone 35-39 interleukin 1 beta Homo sapiens 0-8 10594346-7 1999 Auranofin attenuated interleukin-1beta-induced prostaglandin E(2) production of the cells in a dose-dependent fashion. Dinoprostone 47-65 interleukin 1 beta Homo sapiens 21-38 10594346-11 1999 Our data indicate that auranofin inhibits interleukin-1beta-induced prostaglandin E(2) synthesis and cyclooxygenase-2 expression via suppression of nuclear factor-kappa B activation on synoviocytes. Dinoprostone 68-86 interleukin 1 beta Homo sapiens 42-59 10559138-6 1999 When the cells were stimulated with interleukin-1beta (IL-1beta), prostaglandin E(2) (PGE(2)) release into the medium was significantly greater from moyamoya SMCs than from control SMCs, whereas the amounts of prostacyclin and thromboxane B(2) did not differ. Dinoprostone 66-84 interleukin 1 beta Homo sapiens 36-53 10559138-6 1999 When the cells were stimulated with interleukin-1beta (IL-1beta), prostaglandin E(2) (PGE(2)) release into the medium was significantly greater from moyamoya SMCs than from control SMCs, whereas the amounts of prostacyclin and thromboxane B(2) did not differ. Dinoprostone 66-84 interleukin 1 beta Homo sapiens 55-63 10564178-6 1999 Dex and FP also prevented IL-1beta-induced hyporesponsiveness to PGE(2) stimulation. Dinoprostone 65-71 interleukin 1 beta Homo sapiens 26-34 10523409-6 1999 IL-1beta-induced COX-2 expression was accompanied by a 3-fold increase of prostaglandin E2 release into the culture medium. Dinoprostone 74-90 interleukin 1 beta Homo sapiens 0-8 10685373-7 1999 These results reveal that PGE2 at different concentrations exerts a biphasic effect on BMP-2-stimulated osteoblastic differentiation in HPLC, BMP-2 inhibits IL-1 beta-induced PGE2 production through suppressing COX-2 expression, and the BMP-2-stimulated osteoblastic differentiation may be enhanced by the endogenous PGE2 induced by BMP-2 and IL-1 beta. Dinoprostone 26-30 interleukin 1 beta Homo sapiens 157-166 10685373-7 1999 These results reveal that PGE2 at different concentrations exerts a biphasic effect on BMP-2-stimulated osteoblastic differentiation in HPLC, BMP-2 inhibits IL-1 beta-induced PGE2 production through suppressing COX-2 expression, and the BMP-2-stimulated osteoblastic differentiation may be enhanced by the endogenous PGE2 induced by BMP-2 and IL-1 beta. Dinoprostone 26-30 interleukin 1 beta Homo sapiens 343-352 10685373-7 1999 These results reveal that PGE2 at different concentrations exerts a biphasic effect on BMP-2-stimulated osteoblastic differentiation in HPLC, BMP-2 inhibits IL-1 beta-induced PGE2 production through suppressing COX-2 expression, and the BMP-2-stimulated osteoblastic differentiation may be enhanced by the endogenous PGE2 induced by BMP-2 and IL-1 beta. Dinoprostone 175-179 interleukin 1 beta Homo sapiens 157-166 10685373-7 1999 These results reveal that PGE2 at different concentrations exerts a biphasic effect on BMP-2-stimulated osteoblastic differentiation in HPLC, BMP-2 inhibits IL-1 beta-induced PGE2 production through suppressing COX-2 expression, and the BMP-2-stimulated osteoblastic differentiation may be enhanced by the endogenous PGE2 induced by BMP-2 and IL-1 beta. Dinoprostone 175-179 interleukin 1 beta Homo sapiens 157-166 10198245-6 1999 Furthermore, the COX-2 specific inhibitor, NS-398, abolished the PGE2 production induced by IL-1beta, EGF, or the combination. Dinoprostone 65-69 interleukin 1 beta Homo sapiens 92-100 11729854-14 2000 In human intestinal epithelial cells, LPS production of PGE2 proceeds through a pathway associated with sPLA2 generated arachidonic acid while IL-1 stimulated PGE2 is produced by arachidonic acid generated by cPLA2. Dinoprostone 159-163 interleukin 1 beta Homo sapiens 143-147 10467171-0 1999 Interleukin-1beta induces interleukin-6 production through the production of prostaglandin E(2) in human osteoblasts, MG-63 cells. Dinoprostone 77-95 interleukin 1 beta Homo sapiens 0-17 10455314-9 1999 In A549 cells treated for 24 h with interleukin-1beta, to induce COX-2, A771726 potently inhibited PGE2 synthesis (IC50 0.13 microg ml-1). Dinoprostone 99-103 interleukin 1 beta Homo sapiens 36-53 10447739-3 1999 An antibody to IL-1beta was without effect after 4 hr of culture, inhibited endotoxin-stimulated prostaglandin E2 (PGE2) production after 8 hr of culture, and caused a parallel decrease in the expression of mRNA for COX-2. Dinoprostone 97-113 interleukin 1 beta Homo sapiens 15-23 10447739-3 1999 An antibody to IL-1beta was without effect after 4 hr of culture, inhibited endotoxin-stimulated prostaglandin E2 (PGE2) production after 8 hr of culture, and caused a parallel decrease in the expression of mRNA for COX-2. Dinoprostone 115-119 interleukin 1 beta Homo sapiens 15-23 10198245-0 1999 Involvement of tyrosine kinases on cyclooxygenase expression and prostaglandin E2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor. Dinoprostone 65-81 interleukin 1 beta Homo sapiens 139-156 10198245-3 1999 Simultaneous treatment with EGF and IL-1beta resulted in enhanced COX-2 mRNA levels accompanied by a synergistic stimulation of PGE2 biosynthesis compared to the cells treated with IL-1beta or EGF alone. Dinoprostone 128-132 interleukin 1 beta Homo sapiens 36-44 10198245-5 1999 The tyrosine kinase inhibitors, Herbimycin A and PD 153035 hydrochloride, reduced COX-2 mRNA levels as well as PGE2 production induced by IL-1beta or the combination of IL-1beta and EGF whereas COX-1 mRNA levels were not affected. Dinoprostone 111-115 interleukin 1 beta Homo sapiens 138-146 10198245-7 1999 These results indicate that the synergy between IL-1beta and EGF on PGE2 production is due to an enhanced gene expression of COX-2 and that tyrosine kinase(s) are involved in the signal transduction of COX-2 in gingival fibroblasts. Dinoprostone 68-72 interleukin 1 beta Homo sapiens 48-56 10209072-7 1999 IL- 1beta (100 U/ml) was as active as IL-1alpha in triggering release of PGI2 from endothelial cells and PGE2 from fibroblasts. Dinoprostone 105-109 interleukin 1 beta Homo sapiens 0-9 10195945-12 1999 The product of cyclooxygenase, prostaglandin E2, has been shown to inhibit IL-1 beta activity in some systems. Dinoprostone 31-47 interleukin 1 beta Homo sapiens 75-84 10223396-6 1999 Additionally, OAS-1000 was tested for it"s ability inhibit 1 ng/ml IL-1beta stimulated PGE2 production in a cell culture system. Dinoprostone 87-91 interleukin 1 beta Homo sapiens 67-75 10076187-3 1999 Treatment with IL-1beta enhanced media accumulation of nitrites (4.8-fold), prostaglandin E2 (PGE2, 3. Dinoprostone 76-92 interleukin 1 beta Homo sapiens 15-23 10076187-3 1999 Treatment with IL-1beta enhanced media accumulation of nitrites (4.8-fold), prostaglandin E2 (PGE2, 3. Dinoprostone 94-98 interleukin 1 beta Homo sapiens 15-23 10076187-7 1999 However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner. Dinoprostone 80-84 interleukin 1 beta Homo sapiens 44-52 10027847-3 1999 We addressed this question by using radioimmunoassay to measure PGE2 release by human cells (A549) induced to express cyclooxygenase-2 (measured by Western blot analysis) by interleukin-1beta. Dinoprostone 64-68 interleukin 1 beta Homo sapiens 174-191 10207535-4 1999 When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P < 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts. Dinoprostone 213-217 interleukin 1 beta Homo sapiens 78-87 10082276-12 1999 Interleukin-1beta dramatically increased prostaglandin E2 production and significantly stimulated hepatocyte growth factor synthesis. Dinoprostone 41-57 interleukin 1 beta Homo sapiens 0-17 10082276-14 1999 Indomethacin significantly reduced interleukin-1beta-induced prostaglandin E2 release and hepatocyte growth factor production. Dinoprostone 61-77 interleukin 1 beta Homo sapiens 35-52 10207535-4 1999 When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P < 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts. Dinoprostone 213-217 interleukin 1 beta Homo sapiens 172-181 10207838-9 1999 These results suggest that PGE2 and PGI2 downregulate ICAM-1 expression in IL-1 beta-stimulated HGF through a cAMP-dependent mechanism and that intracellular cAMP elevation in HGF may control inflammatory and immune responses in periodontal disease. Dinoprostone 27-31 interleukin 1 beta Homo sapiens 75-84 10091607-4 1999 HMC released increased amounts of prostaglandin E2 (PGE2) after treatment with several combinations of IL-1 beta, tumor necrosis factor (TNF)-alpha and/or lipopolysaccharide. Dinoprostone 34-50 interleukin 1 beta Homo sapiens 103-112 10091607-4 1999 HMC released increased amounts of prostaglandin E2 (PGE2) after treatment with several combinations of IL-1 beta, tumor necrosis factor (TNF)-alpha and/or lipopolysaccharide. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 103-112 10091607-6 1999 The accumulation of PGE2 elicited by a combination of IL-1 beta/TNF-alpha correlated closely with the temporal pattern of COX-2 protein expression, which reflected the induction of COX-2 mRNA. Dinoprostone 20-24 interleukin 1 beta Homo sapiens 54-63 10091607-7 1999 IL-13 inhibited IL-1 beta/TNF-alpha-elicited PGE2 production, as well as COX-2 protein and mRNA expression in a concentration-dependent fashion. Dinoprostone 45-49 interleukin 1 beta Homo sapiens 16-25 10065757-2 1999 IL-1beta-stimulated PDL fibroblasts produced prostaglandin E2 (PGE2) in a time-dependent manner. Dinoprostone 45-61 interleukin 1 beta Homo sapiens 0-8 10065757-2 1999 IL-1beta-stimulated PDL fibroblasts produced prostaglandin E2 (PGE2) in a time-dependent manner. Dinoprostone 63-67 interleukin 1 beta Homo sapiens 0-8 10065757-3 1999 Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated cells. Dinoprostone 115-119 interleukin 1 beta Homo sapiens 134-142 10065757-5 1999 Dexamethasone inhibited COX-2 mRNA expression, COX activity and PGE2 production in IL-1beta-stimulated cells. Dinoprostone 64-68 interleukin 1 beta Homo sapiens 83-91 10065757-6 1999 IL-4 and IFN-gamma suppressed PGE2 production by IL-1beta-stimulated PDL fibroblasts, but COX activity enhanced by IL-1beta treatment was significantly inhibited by IL-4, not by IFN-gamma. Dinoprostone 30-34 interleukin 1 beta Homo sapiens 49-57 10065757-9 1999 These data suggest that COX-2 is primarily responsible for PGE2 production by IL-1beta-stimulated human PDL fibroblasts and that IL-4 inhibited PGE2 production by IL-1beta-stimulated PDL fibroblasts through down-regulation of COX-2 expression, while IFN-gamma suppressed the PGE2 production with no effect on COX-2 expression. Dinoprostone 59-63 interleukin 1 beta Homo sapiens 78-86 10065757-9 1999 These data suggest that COX-2 is primarily responsible for PGE2 production by IL-1beta-stimulated human PDL fibroblasts and that IL-4 inhibited PGE2 production by IL-1beta-stimulated PDL fibroblasts through down-regulation of COX-2 expression, while IFN-gamma suppressed the PGE2 production with no effect on COX-2 expression. Dinoprostone 144-148 interleukin 1 beta Homo sapiens 163-171 10065757-9 1999 These data suggest that COX-2 is primarily responsible for PGE2 production by IL-1beta-stimulated human PDL fibroblasts and that IL-4 inhibited PGE2 production by IL-1beta-stimulated PDL fibroblasts through down-regulation of COX-2 expression, while IFN-gamma suppressed the PGE2 production with no effect on COX-2 expression. Dinoprostone 144-148 interleukin 1 beta Homo sapiens 163-171 10207838-0 1999 Prostaglandin E2 and I2 regulate intercellular adhesion molecule-1 expression in interleukin-1 beta-stimulated human gingival fibroblasts. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 81-99 10207838-1 1999 The present study investigated the effect of prostaglandin (PG) E2 and PGI2 on intercellular adhesion molecule-1 (ICAM-1) expression in interleukin-1 beta (IL-1 beta)-stimulated human gingival fibroblasts (HGF). Dinoprostone 45-66 interleukin 1 beta Homo sapiens 136-154 10207838-1 1999 The present study investigated the effect of prostaglandin (PG) E2 and PGI2 on intercellular adhesion molecule-1 (ICAM-1) expression in interleukin-1 beta (IL-1 beta)-stimulated human gingival fibroblasts (HGF). Dinoprostone 45-66 interleukin 1 beta Homo sapiens 156-165 10207838-4 1999 IL-1 beta significantly increased the levels of PGE2 and, to a lesser extent, those of 6-keto-PGF1 alpha (a stable metabolite of PGI2) in the culture media of HGF. Dinoprostone 48-52 interleukin 1 beta Homo sapiens 0-9 10207838-5 1999 Indomethacin completely inhibited the production of PGE2 and 6-keto-PGF1 alpha in IL-1 beta-stimulated HGF. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 82-91 10207838-6 1999 Exogenous PGE2 and carbacyclin (a stable derivative of PGI2) in the presence of indomethacin dose-dependently suppressed ICAM-1 expression in IL-1 beta-challenged HGF. Dinoprostone 10-14 interleukin 1 beta Homo sapiens 142-151 9918155-9 1999 RESULTS: Carprofen significantly decreased PGE2 production by unstimulated chondrocytes and antagonized an IL-1-induced increase in PGE2 production. Dinoprostone 132-136 interleukin 1 beta Homo sapiens 107-111 9918155-15 1999 Carprofen also inhibited PGE2 production by unstimulated and IL-1-stimulated chondrocytes. Dinoprostone 25-29 interleukin 1 beta Homo sapiens 61-65 11056661-30 1999 The 1alpha,25(OH)2D3 had little effect on basal PGE2 production by RSF, but the enhanced PGE2 production observed following IL-1beta stimulation of these cells was markedly suppressed by the concomitant addition of 1alpha,25(OH)2D3. Dinoprostone 89-93 interleukin 1 beta Homo sapiens 124-132 11056661-31 1999 As with MMP production, there are disparate effects of 1alpha,25(OH)2D3 on IL-1beta stimulated PGE2 production by the two cell types; 1alpha,25(OH)2D3 added concomitantly with IL-1beta had no effect on PGE2 production by HACs. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 75-83 10065947-3 1999 The cytokines IL-1beta and TNFalpha stimulated prostaglandin E2 (PGE2) and prostacyclin (PGI2) production in gingival fibroblasts. Dinoprostone 47-63 interleukin 1 beta Homo sapiens 14-22 10065947-3 1999 The cytokines IL-1beta and TNFalpha stimulated prostaglandin E2 (PGE2) and prostacyclin (PGI2) production in gingival fibroblasts. Dinoprostone 65-69 interleukin 1 beta Homo sapiens 14-22 10065947-4 1999 Simultaneous treatment of the cells with IL-1beta and TNFalpha resulted in a synergistic stimulation of PGE2 and PGI2 formation. Dinoprostone 104-108 interleukin 1 beta Homo sapiens 41-49 10065947-7 1999 Simultaneous addition of IL-1beta and TNFalpha synergistically enhanced COX-2 mRNA levels, accompanied by a corresponding stimulation of PGE2 synthesis. Dinoprostone 137-141 interleukin 1 beta Homo sapiens 25-33 10065947-9 1999 PMA, known to activate protein kinase C (PKC), enhanced the stimulatory effect of IL-1beta, TNFalpha, and the combination on COX-2 mRNA levels accompanied by a corresponding increase in PGE2 production. Dinoprostone 186-190 interleukin 1 beta Homo sapiens 82-90 10815617-0 1999 The induction of cyclooxygenase-2 in IL-1beta-treated endothelial cells is inhibited by prostaglandin E2 through cAMP. Dinoprostone 88-104 interleukin 1 beta Homo sapiens 37-45 10815617-10 1999 Interestingly, PGE2 (3 microM for 24h) can inhibit COX-2 protein, but not COX-1 protein, expressed in HUVEC treated with IL-1beta. Dinoprostone 15-19 interleukin 1 beta Homo sapiens 121-129 10815617-12 1999 The increased COX activity in HUVEC treated with IL-1beta was also inhibited by PGE2 (0.03, 0.3 and 3 microM for 24h) in a dose-dependent manner. Dinoprostone 80-84 interleukin 1 beta Homo sapiens 49-57 10815617-13 1999 Similarly, forskolin (10, 50 or 100 microM) can also reverse the inhibition of PGE2 on increased COX activity in IL-1beta treated HUVEC. Dinoprostone 79-83 interleukin 1 beta Homo sapiens 113-121 9916962-8 1999 EP1 receptor levels also increased approximately fourfold in response to IL-1beta incubation even in the presence of high agonist (PGE2) concentrations (P < .01). Dinoprostone 131-135 interleukin 1 beta Homo sapiens 73-81 9916962-9 1999 CONCLUSION: The results of this study show that IL-1beta might be involved in infection-induced preterm labor by interfering with the normal regulation of EP1 receptor levels and with the promotion of increased PGE2 production in amnion tissue. Dinoprostone 211-215 interleukin 1 beta Homo sapiens 48-56 9886334-6 1998 We demonstrated that IL-1 was mainly responsible for IL-6 production in the tumoural environment through a PGE2 loop. Dinoprostone 107-111 interleukin 1 beta Homo sapiens 21-25 10070275-5 1998 RESULTS: The production of PGE2 by the synovial fibroblasts was increased by stimulation with IL1 beta at all concentrations tested. Dinoprostone 27-31 interleukin 1 beta Homo sapiens 94-102 10070275-7 1998 Fe-citrate inhibited the spontaneous PGE2 production by the cells in a dose dependent manner, and a maximum inhibition by Fe-citrate was observed at the concentration of 0.1 mM with IL1 beta stimulation. Dinoprostone 37-41 interleukin 1 beta Homo sapiens 182-190 9834469-3 1998 It was found that, after 4 h of culture, IL-1beta increased prostaglandin E2 (PGE2) output approximately twofold. Dinoprostone 60-76 interleukin 1 beta Homo sapiens 41-49 10815617-14 1999 The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles. Dinoprostone 31-35 interleukin 1 beta Homo sapiens 116-124 10815617-14 1999 The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles. Dinoprostone 31-35 interleukin 1 beta Homo sapiens 208-216 10815617-14 1999 The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles. Dinoprostone 170-174 interleukin 1 beta Homo sapiens 208-216 10815617-14 1999 The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles. Dinoprostone 170-174 interleukin 1 beta Homo sapiens 208-216 9834469-3 1998 It was found that, after 4 h of culture, IL-1beta increased prostaglandin E2 (PGE2) output approximately twofold. Dinoprostone 78-82 interleukin 1 beta Homo sapiens 41-49 9834469-5 1998 IL-1alpha was less effective than IL-1beta at stimulating PGE2 production through similar mechanisms. Dinoprostone 58-62 interleukin 1 beta Homo sapiens 34-42 9822711-3 1998 In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2. Dinoprostone 70-86 interleukin 1 beta Homo sapiens 31-48 9845672-10 1998 Increased production of prostaglandin E2 (PGE2) in response to TNF-alpha and IL-1beta treatment was attenuated by IL-4 pretreatment, by 52% and 72%, respectively. Dinoprostone 24-40 interleukin 1 beta Homo sapiens 77-85 9845672-10 1998 Increased production of prostaglandin E2 (PGE2) in response to TNF-alpha and IL-1beta treatment was attenuated by IL-4 pretreatment, by 52% and 72%, respectively. Dinoprostone 42-46 interleukin 1 beta Homo sapiens 77-85 9822711-3 1998 In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2. Dinoprostone 70-86 interleukin 1 beta Homo sapiens 50-58 9822711-3 1998 In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2. Dinoprostone 88-92 interleukin 1 beta Homo sapiens 31-48 9822711-3 1998 In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2. Dinoprostone 88-92 interleukin 1 beta Homo sapiens 50-58 9822711-8 1998 Repression of IL-1beta-induced PGE2 release, COX activity, and COX-2 protein by actinomycin D was only effective within the first hour following IL-1beta treatment, while dexamethasone was effective when added up to 10 h later, suggesting a functional role for post-transcriptional mechanisms of repression. Dinoprostone 31-35 interleukin 1 beta Homo sapiens 14-22 9870074-4 1998 RESULTS: Both IL-10 and IL-4 inhibited IL-1 beta- and TNF-alpha-induced PGE2 production but had no significant effects on the production of PGE2 under basal conditions. Dinoprostone 72-76 interleukin 1 beta Homo sapiens 39-48 9870076-7 1998 The maximal inhibition of IL-1 beta-stimulated PGE2 production (to 28% +/- 10% of control) was seen at 10 ng/ml of IL-4 or IL-13. Dinoprostone 47-51 interleukin 1 beta Homo sapiens 26-35 9779823-1 1998 In a recent communication, we demonstrated that prostaglandin E2 (PGE2) lowers basal while it ablates interleukin-1beta((IL-1beta) and transforming growth factor-beta (TGFbeta) upregulated lysyl oxidase (LO) mRNA levels. Dinoprostone 48-64 interleukin 1 beta Homo sapiens 102-119 9863663-3 1998 We have reported that IL-1beta induces cyclo-oxygenase-2 (COX-2) in human ASM cells and results in a marked increase in prostanoid generation with PGE2 and PGI2 as the major products. Dinoprostone 147-151 interleukin 1 beta Homo sapiens 22-30 9863663-4 1998 We investigated the role of COX-2 induction and prostanoid release (measured as PGE2) in IL-1beta induced attenuation of cyclic AMP generation in response to the beta-adrenoceptor agonist isoprenaline (ISO). Dinoprostone 80-84 interleukin 1 beta Homo sapiens 89-97 9779823-1 1998 In a recent communication, we demonstrated that prostaglandin E2 (PGE2) lowers basal while it ablates interleukin-1beta((IL-1beta) and transforming growth factor-beta (TGFbeta) upregulated lysyl oxidase (LO) mRNA levels. Dinoprostone 48-64 interleukin 1 beta Homo sapiens 121-129 9779823-1 1998 In a recent communication, we demonstrated that prostaglandin E2 (PGE2) lowers basal while it ablates interleukin-1beta((IL-1beta) and transforming growth factor-beta (TGFbeta) upregulated lysyl oxidase (LO) mRNA levels. Dinoprostone 66-70 interleukin 1 beta Homo sapiens 102-119 9779823-1 1998 In a recent communication, we demonstrated that prostaglandin E2 (PGE2) lowers basal while it ablates interleukin-1beta((IL-1beta) and transforming growth factor-beta (TGFbeta) upregulated lysyl oxidase (LO) mRNA levels. Dinoprostone 66-70 interleukin 1 beta Homo sapiens 121-129 9859867-0 1998 Interleukin-1beta and bacterial endotoxin change the metabolism of prostaglandins E2 and F2alpha in intact term fetal membranes. Dinoprostone 67-84 interleukin 1 beta Homo sapiens 0-17 9859867-2 1998 This study used an intact fetal membrane disk model to investigate the regulation of PGE2 and PGF2alpha metabolism by interleukin-1 beta (IL-1beta) and bacterial endotoxin [lipopolysaccharide (LPS)]. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 118-136 9859867-2 1998 This study used an intact fetal membrane disk model to investigate the regulation of PGE2 and PGF2alpha metabolism by interleukin-1 beta (IL-1beta) and bacterial endotoxin [lipopolysaccharide (LPS)]. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 138-146 9755052-5 1998 Treatment for 24 h with interleukin-1beta (IL-1beta; 10 ng/ml) or tumor necrosis factor-alpha (50 ng/ml), respectively, elicited maximal 25- and 6-fold inductions of PGE2 synthesis in CCD-18Co cultures and similar results in primary fibroblast cultures; maximal inductions with IL-1beta in colonic epithelial cell lines were from zero to fivefold. Dinoprostone 166-170 interleukin 1 beta Homo sapiens 24-41 9755052-5 1998 Treatment for 24 h with interleukin-1beta (IL-1beta; 10 ng/ml) or tumor necrosis factor-alpha (50 ng/ml), respectively, elicited maximal 25- and 6-fold inductions of PGE2 synthesis in CCD-18Co cultures and similar results in primary fibroblast cultures; maximal inductions with IL-1beta in colonic epithelial cell lines were from zero to fivefold. Dinoprostone 166-170 interleukin 1 beta Homo sapiens 43-51 9755052-5 1998 Treatment for 24 h with interleukin-1beta (IL-1beta; 10 ng/ml) or tumor necrosis factor-alpha (50 ng/ml), respectively, elicited maximal 25- and 6-fold inductions of PGE2 synthesis in CCD-18Co cultures and similar results in primary fibroblast cultures; maximal inductions with IL-1beta in colonic epithelial cell lines were from zero to fivefold. Dinoprostone 166-170 interleukin 1 beta Homo sapiens 278-286 9721692-3 1998 HUVECs exposed to IL-1beta produced prostaglandin (PG) I2 for no longer than 30 seconds after the substrate was added irrespective of the cyclooxygenase (COX) activity, whereas the time course of PGE2 and PGD2 formation was parallel to the COX activity. Dinoprostone 196-200 interleukin 1 beta Homo sapiens 18-26 9751081-0 1998 Induction by interleukin-1beta peptide of prostaglandin E2 formation via enhanced prostaglandin H synthase-2 expression in 3T6 fibroblasts. Dinoprostone 42-58 interleukin 1 beta Homo sapiens 13-30 9751081-2 1998 Only the IL-1beta fragment (208-240) enhanced body temperature, although both IL-1beta (208-240) and IL-1alpha (223-250) stimulated prostaglandin E2 (PGE2) production in vitro. Dinoprostone 132-148 interleukin 1 beta Homo sapiens 78-86 9751081-2 1998 Only the IL-1beta fragment (208-240) enhanced body temperature, although both IL-1beta (208-240) and IL-1alpha (223-250) stimulated prostaglandin E2 (PGE2) production in vitro. Dinoprostone 150-154 interleukin 1 beta Homo sapiens 78-86 9743339-4 1998 Here we show that PGE2, although it does not induce final DC maturation by itself, synergizes with IL-1beta and TNF-alpha, and allows their effectiveness at 100-fold lower concentrations. Dinoprostone 18-22 interleukin 1 beta Homo sapiens 99-107 9728043-7 1998 IL-1beta (20 ng/ml for 22 h) caused an increase in both basal (15-fold) and arachidonic acid (AA)-stimulated (10-fold) PGE2 release. Dinoprostone 119-123 interleukin 1 beta Homo sapiens 0-8 9728043-8 1998 Indo blocked basal and AA-stimulated PGE2 release in both control and IL-1beta-treated cells. Dinoprostone 37-41 interleukin 1 beta Homo sapiens 70-78 9728043-9 1998 NS-398 also markedly reduced basal and AA-stimulated PGE2 release in IL-1beta-treated cells but had no significant effect on AA-stimulated PGE2 release in control cells. Dinoprostone 53-57 interleukin 1 beta Homo sapiens 69-77 9728043-11 1998 Exogenously administered PGE2 (10(-7) M, 22 h) caused a significant reduction in the ability of Iso to decrease cell stiffness, mimicking the effects of IL-1beta. Dinoprostone 25-29 interleukin 1 beta Homo sapiens 153-161 9721692-6 1998 PGF2alpha was the main prostanoid released into the medium during exposure to IL-1beta, whereas when HUVECs treated with IL-1beta were stimulated with histamine or exogenous AA, PGE2 was released in a higher quantity than PGF2alpha. Dinoprostone 178-182 interleukin 1 beta Homo sapiens 121-129 9712106-0 1998 Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes. Dinoprostone 83-99 interleukin 1 beta Homo sapiens 27-44 9721692-11 1998 The concept that a high ratio of PGH2 was released by the IL-1beta-treated HUVECs and isomerized outside the cell into PGE2 and PGD2 was supported by the biosynthesis of thromboxane B2 by COX-inactivated platelets, indicating the uptake by platelets of HUVEC-derived PGH2. Dinoprostone 119-123 interleukin 1 beta Homo sapiens 58-66 9705828-6 1998 Inhibition of IL-1 beta induced COX-2 and elevated ICAM-1 expression, an effect reversed by exogenous PGE2. Dinoprostone 102-106 interleukin 1 beta Homo sapiens 14-23 9704780-1 1998 OBJECTIVE: The purpose of this study was to determine the inhibitory effects of anti-interleukin-1beta and transforming growth factor-beta2 on the production of interleukin-1beta and prostaglandin E2 by human decidual cells. Dinoprostone 183-199 interleukin 1 beta Homo sapiens 85-139 9990676-11 1998 IL-1 beta-stimulated PGE2 and PGE2 alpha formation was significantly decreased by both COX-1 and COX-2 inhibitors. Dinoprostone 21-25 interleukin 1 beta Homo sapiens 0-9 9990676-11 1998 IL-1 beta-stimulated PGE2 and PGE2 alpha formation was significantly decreased by both COX-1 and COX-2 inhibitors. Dinoprostone 30-34 interleukin 1 beta Homo sapiens 0-9 9990676-12 1998 VSA, in a dose-dependent manner, significantly decreased IL-1 beta-stimulated PGE2 and PGF2 alpha production. Dinoprostone 78-82 interleukin 1 beta Homo sapiens 57-66 9704780-1 1998 OBJECTIVE: The purpose of this study was to determine the inhibitory effects of anti-interleukin-1beta and transforming growth factor-beta2 on the production of interleukin-1beta and prostaglandin E2 by human decidual cells. Dinoprostone 183-199 interleukin 1 beta Homo sapiens 85-102 9704780-8 1998 CONCLUSIONS: Lipopolysaccharide-induced prostaglandin E2 production by human decidual cells in vitro may be prevented by anti-interleukin-1beta and transforming growth factor-beta2, and interleukin-1beta production may be prevented by anti-interleukin-1beta. Dinoprostone 40-56 interleukin 1 beta Homo sapiens 126-180 9704780-8 1998 CONCLUSIONS: Lipopolysaccharide-induced prostaglandin E2 production by human decidual cells in vitro may be prevented by anti-interleukin-1beta and transforming growth factor-beta2, and interleukin-1beta production may be prevented by anti-interleukin-1beta. Dinoprostone 40-56 interleukin 1 beta Homo sapiens 126-143 9704780-8 1998 CONCLUSIONS: Lipopolysaccharide-induced prostaglandin E2 production by human decidual cells in vitro may be prevented by anti-interleukin-1beta and transforming growth factor-beta2, and interleukin-1beta production may be prevented by anti-interleukin-1beta. Dinoprostone 40-56 interleukin 1 beta Homo sapiens 186-203 9690866-14 1998 The present experiments demonstrated that the release of PGE2 by astroglial cells pretreated with IL-1beta and TNF-alpha is due to enhanced COX-2 activity via activation of the L-arginine-NO pathway, and this may be relevant to the understanding of the pathophysiological mechanisms underlying neuroimmune disorders. Dinoprostone 57-61 interleukin 1 beta Homo sapiens 98-106 9722717-21 1998 In addition, IL-1 is a strong enhancer of tissue levels of PGE2 and TNF-alpha. Dinoprostone 59-63 interleukin 1 beta Homo sapiens 13-17 9758209-1 1998 Interleukin-1beta (IL-1beta) stimulated PGE2 synthesis in human amnion derived WISH cells, whereas dexamethasone blocked IL-1beta-mediated stimulation of PGE2 production. Dinoprostone 40-44 interleukin 1 beta Homo sapiens 0-17 9758209-1 1998 Interleukin-1beta (IL-1beta) stimulated PGE2 synthesis in human amnion derived WISH cells, whereas dexamethasone blocked IL-1beta-mediated stimulation of PGE2 production. Dinoprostone 40-44 interleukin 1 beta Homo sapiens 19-27 9758209-1 1998 Interleukin-1beta (IL-1beta) stimulated PGE2 synthesis in human amnion derived WISH cells, whereas dexamethasone blocked IL-1beta-mediated stimulation of PGE2 production. Dinoprostone 154-158 interleukin 1 beta Homo sapiens 121-129 9758210-6 1998 HPASMC treated with 200 U/ml of IL-1beta and 500 U/ml of TNF alpha produced more COX metabolites such as 6-keto-PGF1alpha, thromboxane B2, PGF2alpha and PGE2 than control cells. Dinoprostone 153-157 interleukin 1 beta Homo sapiens 32-40 9712106-0 1998 Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes. Dinoprostone 83-99 interleukin 1 beta Homo sapiens 46-54 9712106-9 1998 Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA. Dinoprostone 130-134 interleukin 1 beta Homo sapiens 167-175 9712106-10 1998 CONCLUSION: LPS and IL-1beta stimulated IL-6, IL-8, and PGE2 production are downregulated by endogenously produced NO, which could limit the inflammatory reaction occurring in arthritis. Dinoprostone 56-60 interleukin 1 beta Homo sapiens 20-28 9582321-2 1998 Previously we reported that interleukin-1beta induces activation of JNK/SAPK and p38 MAPK with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 (PGE2) synthesis. Dinoprostone 162-178 interleukin 1 beta Homo sapiens 28-45 9693584-7 1998 Results suggest that the inhibitory effect on pulp cell proliferation is dependent upon IL-1 beta-induced prostaglandin E2 synthesis and that IL-1 beta is a potent mediator of prostaglandin E2 synthesis in dental pulp. Dinoprostone 106-122 interleukin 1 beta Homo sapiens 88-97 9693584-7 1998 Results suggest that the inhibitory effect on pulp cell proliferation is dependent upon IL-1 beta-induced prostaglandin E2 synthesis and that IL-1 beta is a potent mediator of prostaglandin E2 synthesis in dental pulp. Dinoprostone 176-192 interleukin 1 beta Homo sapiens 142-151 9582321-2 1998 Previously we reported that interleukin-1beta induces activation of JNK/SAPK and p38 MAPK with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 (PGE2) synthesis. Dinoprostone 180-184 interleukin 1 beta Homo sapiens 28-45 9659298-1 1998 Fetal membranes from term human pregnancies produce prostaglandins, and may respond to bacterial endotoxin or interleukin-1 beta (IL-1 beta) with increased prostaglandin E2 (PGE2) production. Dinoprostone 174-178 interleukin 1 beta Homo sapiens 130-139 9633531-1 1998 In the present studies we found that incubation of human lung fibroblasts with transforming growth factor-beta 1 (TGF-beta 1) potentiated the interleukin-1 beta (IL-1 beta) and/or tumor necrosis factor-alpha (TNF-alpha)-stimulated production of prostaglandin E2 (PGE2). Dinoprostone 245-261 interleukin 1 beta Homo sapiens 142-160 9633531-1 1998 In the present studies we found that incubation of human lung fibroblasts with transforming growth factor-beta 1 (TGF-beta 1) potentiated the interleukin-1 beta (IL-1 beta) and/or tumor necrosis factor-alpha (TNF-alpha)-stimulated production of prostaglandin E2 (PGE2). Dinoprostone 263-267 interleukin 1 beta Homo sapiens 142-160 9633531-9 1998 In summary, we demonstrate that the potentiation of PGE2 production by TGF-beta 1 in IL-1 beta and TNF-alpha-treated fibroblasts is the result of transcriptional stimulation of the Cox-2 gene by IL-1 beta and TNF-alpha and the stabilization of the resulting transcripts by TGF-beta 1. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 85-94 9633531-9 1998 In summary, we demonstrate that the potentiation of PGE2 production by TGF-beta 1 in IL-1 beta and TNF-alpha-treated fibroblasts is the result of transcriptional stimulation of the Cox-2 gene by IL-1 beta and TNF-alpha and the stabilization of the resulting transcripts by TGF-beta 1. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 195-204 9659298-1 1998 Fetal membranes from term human pregnancies produce prostaglandins, and may respond to bacterial endotoxin or interleukin-1 beta (IL-1 beta) with increased prostaglandin E2 (PGE2) production. Dinoprostone 156-172 interleukin 1 beta Homo sapiens 110-128 9659298-1 1998 Fetal membranes from term human pregnancies produce prostaglandins, and may respond to bacterial endotoxin or interleukin-1 beta (IL-1 beta) with increased prostaglandin E2 (PGE2) production. Dinoprostone 156-172 interleukin 1 beta Homo sapiens 130-139 9659298-8 1998 Both endotoxin and IL-1 beta increased PGE2 production from the activated aspirin-pretreated membranes during this culture time, but this was transient as after 12 h of culture basal PGE2 production rose to over 200 pg/ml despite aspirin pretreatment. Dinoprostone 39-43 interleukin 1 beta Homo sapiens 19-28 9659298-8 1998 Both endotoxin and IL-1 beta increased PGE2 production from the activated aspirin-pretreated membranes during this culture time, but this was transient as after 12 h of culture basal PGE2 production rose to over 200 pg/ml despite aspirin pretreatment. Dinoprostone 183-187 interleukin 1 beta Homo sapiens 19-28 9575890-2 1998 In our current studies, we determine whether insulin and IGF-I are involved in the signal transduction mechanisms resulting in IL-1 beta-induced NO and PGE2 biosynthesis in renal mesangial cells. Dinoprostone 152-156 interleukin 1 beta Homo sapiens 127-136 9682786-5 1998 IL-1 beta decreased PG and coll-II productions and increased PGE2 synthesis. Dinoprostone 61-65 interleukin 1 beta Homo sapiens 0-9 9682786-6 1998 During the first period (0-16 days), while the cluster is forming, ACS counteracted the IL-1 beta-induced effects on PG (500-1000 micrograms ACS/ml), coll-II (100-1000 micrograms ACS/ml) and PGE2 (500-1000 micrograms ACS/ml) productions. Dinoprostone 191-195 interleukin 1 beta Homo sapiens 88-97 9682786-7 1998 During the second period (16-32 days), when the cluster is already formed, ACS counteracted the IL-1 beta-induced effects on total PG (100-1000 micrograms ACS/ml), coll-II (1000 micrograms ACS/ml) and PGE2 (1000 micrograms ACS/ml) productions. Dinoprostone 201-205 interleukin 1 beta Homo sapiens 96-105 9571196-5 1998 Among various potential stimulants tested, interleukin-1 beta (IL-1 beta) dramatically increased PGE2 production and significantly stimulated HGF production. Dinoprostone 97-101 interleukin 1 beta Homo sapiens 43-61 9571196-5 1998 Among various potential stimulants tested, interleukin-1 beta (IL-1 beta) dramatically increased PGE2 production and significantly stimulated HGF production. Dinoprostone 97-101 interleukin 1 beta Homo sapiens 63-72 9571196-7 1998 IND significantly reduced both basal and IL-1 beta-induced PGE2 release and HGF production. Dinoprostone 59-63 interleukin 1 beta Homo sapiens 41-50 9575890-3 1998 We demonstrate that both insulin and IGF-I increase IL-1 beta-induced Cox-2 and iNOS protein expression, which in turn enhance PGE2 and NO production. Dinoprostone 127-131 interleukin 1 beta Homo sapiens 52-61 9531313-3 1998 IL-1beta and TNF-alpha expression and synthesis were up-regulated by rhIL-17 in a dose (ED50 was 50 +/- 9 ng/ml)- and time-dependent fashion, with cytokine accumulation reaching a zenith after 9 h. Release of IL-6, PGE2, IL-10, IL-12, IL-1R antagonist, and stromelysin was also stimulated by rhIL-17. Dinoprostone 215-219 interleukin 1 beta Homo sapiens 0-8 9562240-9 1998 IL-1, but not ceramide induced cPLA2 mRNA and protein expression which corresponded with the initiation of PGE2 synthesis. Dinoprostone 107-111 interleukin 1 beta Homo sapiens 0-4 9515807-3 1998 We found that PGE2 production by A549 non-small cell lung cancer (NSCLC) cells was elevated up to 50-fold in response to interleukin (IL)-1beta. Dinoprostone 14-18 interleukin 1 beta Homo sapiens 121-143 9690866-2 1998 The role of the L-arginine-nitric oxide (NO) pathway on the formation of prostaglandin E2 (PGE2) by human cultured astroglial cells incubated with interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) was investigated. Dinoprostone 73-89 interleukin 1 beta Homo sapiens 147-164 9690866-2 1998 The role of the L-arginine-nitric oxide (NO) pathway on the formation of prostaglandin E2 (PGE2) by human cultured astroglial cells incubated with interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) was investigated. Dinoprostone 73-89 interleukin 1 beta Homo sapiens 166-174 9690866-2 1998 The role of the L-arginine-nitric oxide (NO) pathway on the formation of prostaglandin E2 (PGE2) by human cultured astroglial cells incubated with interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) was investigated. Dinoprostone 91-95 interleukin 1 beta Homo sapiens 147-164 9515807-4 1998 Reversal of IL-1beta-induced PGE2 production in A549 cells was achieved by specific pharmacological or antisense oligonucleotide inhibition of COX-2 activity or expression. Dinoprostone 29-33 interleukin 1 beta Homo sapiens 12-20 9517759-16 1998 CONCLUSION: MTX has an inhibitory effect on IL-1beta stimulated production of PGE2 by cultured human rheumatoid synoviocytes, without affecting either COX mRNA expression. Dinoprostone 78-82 interleukin 1 beta Homo sapiens 44-52 9596483-6 1998 Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively. Dinoprostone 83-87 interleukin 1 beta Homo sapiens 0-17 9596483-6 1998 Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively. Dinoprostone 83-87 interleukin 1 beta Homo sapiens 19-27 9517759-13 1998 EIA showed that MTX decreased IL-1beta induced PGE2 production by synoviocytes in a dose dependent manner. Dinoprostone 47-51 interleukin 1 beta Homo sapiens 30-38 9562240-1 1998 Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis. Dinoprostone 48-64 interleukin 1 beta Homo sapiens 0-17 9562240-1 1998 Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis. Dinoprostone 48-64 interleukin 1 beta Homo sapiens 19-23 9562240-1 1998 Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis. Dinoprostone 66-70 interleukin 1 beta Homo sapiens 0-17 9562240-1 1998 Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis. Dinoprostone 66-70 interleukin 1 beta Homo sapiens 19-23 9562240-2 1998 We previously showed that ceramide accumulates in fibroblasts treated with IL-1 and that it enhances IL-1-induced PGE2 production. Dinoprostone 114-118 interleukin 1 beta Homo sapiens 101-105 9562240-3 1998 The present study was undertaken to determine the mechanism(s) by which ceramide and IL-1 interact to enhance PGE2 production by examining their respective effects on the rate-limiting enzymes in PGE2 synthesis, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2). Dinoprostone 110-114 interleukin 1 beta Homo sapiens 85-89 9562240-3 1998 The present study was undertaken to determine the mechanism(s) by which ceramide and IL-1 interact to enhance PGE2 production by examining their respective effects on the rate-limiting enzymes in PGE2 synthesis, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2). Dinoprostone 196-200 interleukin 1 beta Homo sapiens 85-89 9562240-4 1998 IL-1-induced PGE2 synthesis required approximately 8 h even though COX-1 was constitutively expressed (both mRNA and protein) and enzymatically active in untreated cells. Dinoprostone 13-17 interleukin 1 beta Homo sapiens 0-4 9586676-9 1998 As anticipated, IL-1beta induced a marked release of collagenase, stromelysin, IL-6, IL-8 and PGE2. Dinoprostone 94-98 interleukin 1 beta Homo sapiens 16-24 9457465-10 1998 TNF-alpha, IL-1 beta, IL-6, and IL-10 were each synergistic or additive with PGE2 in upregulating the promoter. Dinoprostone 77-81 interleukin 1 beta Homo sapiens 11-20 9375864-11 1997 IL-1beta, alone or in combinations, was dominant with respect to stimulation of PGE2 synthesis. Dinoprostone 80-84 interleukin 1 beta Homo sapiens 0-8 9353419-0 1997 Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine. Dinoprostone 61-77 interleukin 1 beta Homo sapiens 32-49 9353419-1 1997 Exposure of human rheumatoid synovial fibroblasts (RSF) to interleukin 1beta (IL-1beta) results in the coordinate up-regulation of 85-kDa phospholipase A2 (PLA2) and mitogen-inducible cyclooxygenase (COX II) and subsequent biosynthesis of prostaglandin E2 (PGE2). Dinoprostone 239-255 interleukin 1 beta Homo sapiens 59-76 9353419-1 1997 Exposure of human rheumatoid synovial fibroblasts (RSF) to interleukin 1beta (IL-1beta) results in the coordinate up-regulation of 85-kDa phospholipase A2 (PLA2) and mitogen-inducible cyclooxygenase (COX II) and subsequent biosynthesis of prostaglandin E2 (PGE2). Dinoprostone 239-255 interleukin 1 beta Homo sapiens 78-86 9627083-3 1998 Indomethacin and indo-Phe inhibited the PGE2 synthesis in treated and untreated IL-1beta or LPS-treated monocytes. Dinoprostone 40-44 interleukin 1 beta Homo sapiens 80-88 9836494-9 1998 Indomethacin at 20 microM concentration, and VSA inhibited lipopolysaccharide and interleukin 1beta stimulated prostaglandin E2, but not 6-keto prostaglandin F1alpha formation. Dinoprostone 111-127 interleukin 1 beta Homo sapiens 82-99 9927229-10 1998 IL-1beta and LPS increased both PGE2 and 6-keto-PGF1alpha in a dose dependent fashion with enhanced production detected two hours following exposure. Dinoprostone 32-36 interleukin 1 beta Homo sapiens 0-8 9460084-5 1998 The autocrine IL-1 beta released by the OA-affected cartilage (for at least 72 hr in ex vivo conditions) is present in sufficient quantities to modulate NO and PGE2 production because addition of recombinant soluble IL-1 beta receptor (but not soluble tumor necrosis factor-alpha receptor) and cytokine-suppressive antiinflammatory drugs (CSAIDs) significantly attenuates the spontaneous release of NO and PGE2. Dinoprostone 160-164 interleukin 1 beta Homo sapiens 14-23 9460084-5 1998 The autocrine IL-1 beta released by the OA-affected cartilage (for at least 72 hr in ex vivo conditions) is present in sufficient quantities to modulate NO and PGE2 production because addition of recombinant soluble IL-1 beta receptor (but not soluble tumor necrosis factor-alpha receptor) and cytokine-suppressive antiinflammatory drugs (CSAIDs) significantly attenuates the spontaneous release of NO and PGE2. Dinoprostone 406-410 interleukin 1 beta Homo sapiens 14-23 9460084-8 1998 These experiments demonstrate that the human OA-affected cartilage itself releases sufficient amounts of functionally active autocrine IL-1 beta that can modulate endogenous NO, PGE2, and IL-6, but not IL-8, all of which are known to be stimulated by IL-1 beta in vitro. Dinoprostone 178-182 interleukin 1 beta Homo sapiens 135-144 9389546-11 1997 IL-1beta treatment up-regulates the expression of IL-1alpha, IL-1beta, and PGE2. Dinoprostone 75-79 interleukin 1 beta Homo sapiens 0-8 9469643-3 1997 Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells. Dinoprostone 47-68 interleukin 1 beta Homo sapiens 127-144 9469643-3 1997 Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells. Dinoprostone 47-68 interleukin 1 beta Homo sapiens 146-154 9449430-7 1997 This post-mortem astrocyte culture was found to produce large amounts of PGE2 upon stimulation with IL-1beta, whereas in the supernatants of the postmortem astrocyte culture A295 and the astroglioma cell lines, low PGE2 concentrations were detected. Dinoprostone 73-77 interleukin 1 beta Homo sapiens 100-108 9449430-8 1997 Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested. Dinoprostone 22-26 interleukin 1 beta Homo sapiens 92-100 9449430-8 1997 Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested. Dinoprostone 22-26 interleukin 1 beta Homo sapiens 92-96 9449430-9 1997 Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells, however the inhibitory effect of dexamethasone on the IL-1beta-activated IL-6 release could not be prevented by the addition of PGE2. Dinoprostone 217-221 interleukin 1 beta Homo sapiens 143-151 9393919-9 1997 Both IL-1beta and TNFalpha stimulated IL-6 and PGE2 release from the osteoblast-like cells. Dinoprostone 47-51 interleukin 1 beta Homo sapiens 5-13 9353419-1 1997 Exposure of human rheumatoid synovial fibroblasts (RSF) to interleukin 1beta (IL-1beta) results in the coordinate up-regulation of 85-kDa phospholipase A2 (PLA2) and mitogen-inducible cyclooxygenase (COX II) and subsequent biosynthesis of prostaglandin E2 (PGE2). Dinoprostone 257-261 interleukin 1 beta Homo sapiens 59-76 9353419-1 1997 Exposure of human rheumatoid synovial fibroblasts (RSF) to interleukin 1beta (IL-1beta) results in the coordinate up-regulation of 85-kDa phospholipase A2 (PLA2) and mitogen-inducible cyclooxygenase (COX II) and subsequent biosynthesis of prostaglandin E2 (PGE2). Dinoprostone 257-261 interleukin 1 beta Homo sapiens 78-86 9353419-3 1997 Hymenialdisine, a marine natural product has recently been characterized as an inhibitor of NFkappaB activation and exposure of IL-1-stimulated RSF-inhibited PGE2 production in a concentration-dependent manner (IC50 approximately 1 microM). Dinoprostone 158-162 interleukin 1 beta Homo sapiens 128-132 9353419-9 1997 Taken together, hymenialdisine inhibits IL-1-stimulated-RSF PGE2 formation acting predominately through modulation of NFkappaB activation and offers an interesting novel tool to evaluate the role of NFkappaB in inflammatory disease. Dinoprostone 60-64 interleukin 1 beta Homo sapiens 40-44 9375864-16 1997 This effect was profoundly reduced by the antagonistic effect of IL-1beta, mediated in part by PGE2. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 65-73 9401927-5 1997 This result suggests that endogenous prostaglandin E2 (PGE2) partially inhibits IL-1 or TNF-alpha-induced IL-6 production and that the enhancement of IL-6 production by IL-1 or TNF-alpha may not be caused through endogenous PGE2-induced cAMP-dependent pathway. Dinoprostone 37-53 interleukin 1 beta Homo sapiens 80-84 9408881-5 1997 However, PGE2 production induced by IL-1 beta was significantly more than with ceramide alone, and there was no potentiation of PGE2 production with coincubation of ceramide and IL-1 beta. Dinoprostone 9-13 interleukin 1 beta Homo sapiens 36-45 9352015-6 1997 IL-1 beta and IL-4 also caused six- and two-fold increases, respectively, in culture fluid PGE2 concentrations. Dinoprostone 91-95 interleukin 1 beta Homo sapiens 0-9 9352015-8 1997 CONCLUSIONS: Based on these results, it is proposed that IL-1 beta and IL-4 may be involved in the initiation and promotion of labor by inducing EP1 levels and PGE2 production in amnion. Dinoprostone 160-164 interleukin 1 beta Homo sapiens 57-66 9336233-6 1997 Interestingly, however, SP selectively potentiated the inducing effect of IL-1beta on IL-6 and PGE2 secretion by spinal cord astrocytes without affecting the IL-1-beta-evoked secretion of other cytokines. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 74-82 9401927-5 1997 This result suggests that endogenous prostaglandin E2 (PGE2) partially inhibits IL-1 or TNF-alpha-induced IL-6 production and that the enhancement of IL-6 production by IL-1 or TNF-alpha may not be caused through endogenous PGE2-induced cAMP-dependent pathway. Dinoprostone 55-59 interleukin 1 beta Homo sapiens 80-84 9401927-10 1997 Accordingly, in inflamed periodontal tissues, gingival fibroblasts and periodontal ligament fibroblasts stimulated with pro-inflammatory cytokines such as IL-1 or TNF-alpha, may produce IL-6, and this production can be differentially modulated by endogenous PGE2, IL-6sR, T cell-derived cytokines such as IFN-gamma or IL-4, and glucocorticoids. Dinoprostone 258-262 interleukin 1 beta Homo sapiens 155-159 9325192-0 1997 Spontaneous induction of nitric oxide- and prostaglandin E2-release by hypoxic astroglial cells is modulated by interleukin 1 beta. Dinoprostone 43-59 interleukin 1 beta Homo sapiens 112-130 9322624-5 1997 RESULTS: When endometrial cells were incubated with interleukin-1 alpha or interleukin-1 beta, each cytokine was shown to stimulate the production of prostaglandin E2 and prostaglandin F2 alpha in a time- and dose-dependent fashion, with interleukin-1 alpha being far more potent than interleukin-1 beta. Dinoprostone 150-166 interleukin 1 beta Homo sapiens 75-93 9322624-5 1997 RESULTS: When endometrial cells were incubated with interleukin-1 alpha or interleukin-1 beta, each cytokine was shown to stimulate the production of prostaglandin E2 and prostaglandin F2 alpha in a time- and dose-dependent fashion, with interleukin-1 alpha being far more potent than interleukin-1 beta. Dinoprostone 150-166 interleukin 1 beta Homo sapiens 285-303 9284101-7 1997 The main soluble fraction in the keratinocyte-conditioned medium contained a precursor of interleukin-1 alpha (proIL-1alpha) by western blot analysis, and PGE2 production was inhibited by anti-IL-1alpha antibody, but not by anti-IL-1beta or by anti-tumor necrosis factor-alpha antibody. Dinoprostone 155-159 interleukin 1 beta Homo sapiens 229-237 9266823-2 1997 Interleukin-1beta (IL-1beta) treatment of type II A549 cells increases PGE2 synthesis via transcription- and translation-dependent induction of COX-2. Dinoprostone 71-75 interleukin 1 beta Homo sapiens 0-17 9266823-2 1997 Interleukin-1beta (IL-1beta) treatment of type II A549 cells increases PGE2 synthesis via transcription- and translation-dependent induction of COX-2. Dinoprostone 71-75 interleukin 1 beta Homo sapiens 19-27 9257931-10 1997 IL-1beta alone (1-50 u ml(-1) induced PGE2 formation without significant nitrite formation, a response which was inhibited by the COX-2 specific inhibitor nimesulide. Dinoprostone 38-42 interleukin 1 beta Homo sapiens 0-8 9263137-3 1997 RESULTS: In MNC and synovial fibroblast cultures dexamethasone, GSTM, and PGE2 most markedly downregulated spontaneous and/or cytokine stimulated production of IL-1 beta, IL-14a, IL-8, and MCP-1, whereas sTNFR shedding was not affected. Dinoprostone 74-78 interleukin 1 beta Homo sapiens 160-169 9274933-2 1997 Varying amounts of prostaglandin E2 were induced in WISH cells using either interleukin-1beta, tumor necrosis factor-alpha or phorbol 12-myristate 13-acetate, alone or in combination, or with okadaic acid as stimulants. Dinoprostone 19-35 interleukin 1 beta Homo sapiens 76-122 9179403-8 1997 IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products. Dinoprostone 208-212 interleukin 1 beta Homo sapiens 0-9 9226412-3 1997 Aceclofenac inhibited interleukin-1beta-induced prostaglandin E2 production by human rheumatoid synovial cells, but had no inhibitory effect on cyclooxygenase-1 or cyclooxygenase-2 activities by itself. Dinoprostone 48-64 interleukin 1 beta Homo sapiens 22-39 9256170-2 1997 IL-1beta enhanced PGE2 production in cultured fibroblasts. Dinoprostone 18-22 interleukin 1 beta Homo sapiens 0-8 9191472-9 1997 IL-1 beta also significantly attenuated the ability of prostaglandin E2 (PGE2) to decrease cell stiffness. Dinoprostone 55-71 interleukin 1 beta Homo sapiens 0-9 9191472-9 1997 IL-1 beta also significantly attenuated the ability of prostaglandin E2 (PGE2) to decrease cell stiffness. Dinoprostone 73-77 interleukin 1 beta Homo sapiens 0-9 9191472-11 1997 IL-1 beta (20 ng/ml for 40 h) caused a small (30%) but significant (P < 0.02) increase in basal cAMP, but also resulted in a 2-3-fold decrease in the changes in cAMP formation induced by either ISO or PGE2. Dinoprostone 204-208 interleukin 1 beta Homo sapiens 0-9 9179403-8 1997 IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products. Dinoprostone 101-105 interleukin 1 beta Homo sapiens 0-9 9138096-8 1997 Cyclic AMP mimetics and PKA activators, IBMX, and Sp-cAMP, inhibited the expression of the binding protein as did the PGE2 secretagogue, interleukin-1 beta (IL-beta). Dinoprostone 118-122 interleukin 1 beta Homo sapiens 137-155 9179403-14 1997 Pretreatment with the conventional non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, and the selective COX-2 inhibitors, NS-398 and nimesulide, completely blocked IL-1 beta-induced PGE2 release and COX activity. Dinoprostone 207-211 interleukin 1 beta Homo sapiens 189-198 9179403-15 1997 The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction. Dinoprostone 154-158 interleukin 1 beta Homo sapiens 133-142 9187256-7 1997 Sodium salicylate inhibited prostaglandin E2 release when added together with interleukin 1beta for 24 hr with an IC50 value of 5 microg/ml, an effect that was independent of NF-kappaB activation or COX-2 transcription or translation. Dinoprostone 28-44 interleukin 1 beta Homo sapiens 78-95 9160463-13 1997 RESULTS: Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2 in response to interleukin-1 beta. Dinoprostone 144-160 interleukin 1 beta Homo sapiens 176-194 9160463-14 1997 Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide, interleukin-6, and prostaglandin E2 in response to interleukin-1 beta. Dinoprostone 189-205 interleukin 1 beta Homo sapiens 221-239 9160463-16 1997 CONCLUSIONS: Cells of the intervertebral discs are biologically responsive and increase their production of matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2 when stimulated by interleukin-1 beta. Dinoprostone 168-184 interleukin 1 beta Homo sapiens 204-222 9168911-5 1997 In endothelium-denuded segments of pulmonary artery, the inflammatory agennts tumor necrosis factor alpha, interleukin-1 beta, interferon gamma, and lipopolysaccharide stimulated the release of PGE2 and 8-iso PGF2 alpha, which were attenuated in both cases by the cyclo-oxygenase inhibitor indomethacin. Dinoprostone 194-198 interleukin 1 beta Homo sapiens 107-125 9003059-5 1997 Furthermore, PGE2 potentiated IL-1 beta-induced IL-6 mRNA synthesis. Dinoprostone 13-17 interleukin 1 beta Homo sapiens 30-39 9065483-0 1997 p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta. Dinoprostone 82-98 interleukin 1 beta Homo sapiens 126-143 9100898-2 1997 These results imply that circulating IL-1 beta acts on its receptor on the endothelial cells of the brain vasculature to induce COX-2 mRNA, which is possibly responsible for the elevated level of PGE2 seen during fever. Dinoprostone 196-200 interleukin 1 beta Homo sapiens 37-46 9093911-8 1997 However, the increased production of PGE2 resulting from TNF stimulation was blocked by the addition of an interleukin-1 beta (IL-1 beta) neutralizing antibody, suggesting that TNF regulation of hOB cell PG synthesis was secondary to its capacity to increase hOB cell IL-1 beta production. Dinoprostone 37-41 interleukin 1 beta Homo sapiens 107-125 9093911-8 1997 However, the increased production of PGE2 resulting from TNF stimulation was blocked by the addition of an interleukin-1 beta (IL-1 beta) neutralizing antibody, suggesting that TNF regulation of hOB cell PG synthesis was secondary to its capacity to increase hOB cell IL-1 beta production. Dinoprostone 37-41 interleukin 1 beta Homo sapiens 127-136 9093911-8 1997 However, the increased production of PGE2 resulting from TNF stimulation was blocked by the addition of an interleukin-1 beta (IL-1 beta) neutralizing antibody, suggesting that TNF regulation of hOB cell PG synthesis was secondary to its capacity to increase hOB cell IL-1 beta production. Dinoprostone 37-41 interleukin 1 beta Homo sapiens 268-277 9117018-3 1997 IL-1 beta enhanced PGE2 formation in a concentration- and time-dependent manner, reaching its peak at 6 to 8 h and fading at 18 to 24 h. Immunoblot analysis showed that the inducible cyclooxygenase enzyme (COX-2) was expressed only in IL-1 beta treated cells, whereas the constitutive isoform of cyclooxygenase (COX-1) remained unaltered. Dinoprostone 19-23 interleukin 1 beta Homo sapiens 0-9 9117018-3 1997 IL-1 beta enhanced PGE2 formation in a concentration- and time-dependent manner, reaching its peak at 6 to 8 h and fading at 18 to 24 h. Immunoblot analysis showed that the inducible cyclooxygenase enzyme (COX-2) was expressed only in IL-1 beta treated cells, whereas the constitutive isoform of cyclooxygenase (COX-1) remained unaltered. Dinoprostone 19-23 interleukin 1 beta Homo sapiens 235-244 9117018-6 1997 The close parallelism between the kinetics of COX-2 protein expression and PGE2 accumulation, as well as the constitutive nature of COX-1 isoform, indicate that IL-1 beta-driven PGE2 formation in human bronchial smooth-muscle cells is mediated by de novo expression of COX-2 enzyme. Dinoprostone 75-79 interleukin 1 beta Homo sapiens 161-170 9117018-6 1997 The close parallelism between the kinetics of COX-2 protein expression and PGE2 accumulation, as well as the constitutive nature of COX-1 isoform, indicate that IL-1 beta-driven PGE2 formation in human bronchial smooth-muscle cells is mediated by de novo expression of COX-2 enzyme. Dinoprostone 178-182 interleukin 1 beta Homo sapiens 161-170 9138698-17 1997 Incubation of the cells with the cytokine mixture (IL-1 beta, TNF alpha, IFN gamma each at 10 ng ml-1 for 24 h) caused the accumulation of PGE2 and 6-keto-PGF1 alpha. Dinoprostone 139-143 interleukin 1 beta Homo sapiens 51-60 9138698-19 1997 In experiments where COX-2 metabolized endogenous stores of arachidonic acid, treatment of HASM cells with IL-1 beta in combination with TNF alpha caused a similar release of PGE2 to that when the three cytokines were given in combination. Dinoprostone 175-179 interleukin 1 beta Homo sapiens 107-116 9257931-19 1997 Cells incubated with IL-1beta 3 u ml(-1) for 6 h in the presence of dibutyryl cyclic guanylate monophosphate (0 to 10(-3) M) also demonstrated an increased PGE2 response (2.56 +/- 0.21 to 4.53 +/- 0.64 pg/10(4) cells; P<0.05). Dinoprostone 156-160 interleukin 1 beta Homo sapiens 21-29 9023325-1 1997 These studies examined the signal transduction mechanisms by which prostaglandin (PG) E2 production can occur in human amnionic WISH cells in response to the stimuli okadaic acid, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, phorbol-12-myristate-13-acetate (PMA) or combinations of PMA with IL-1beta or TNF-alpha. Dinoprostone 67-88 interleukin 1 beta Homo sapiens 180-202 9023325-1 1997 These studies examined the signal transduction mechanisms by which prostaglandin (PG) E2 production can occur in human amnionic WISH cells in response to the stimuli okadaic acid, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, phorbol-12-myristate-13-acetate (PMA) or combinations of PMA with IL-1beta or TNF-alpha. Dinoprostone 67-88 interleukin 1 beta Homo sapiens 305-313 9023325-4 1997 PMA or IL-1beta induced PGE2 production 2 to 4 hr after treatment, whereas the combination of these agents produced the most rapid induction 2 hr after treatment. Dinoprostone 24-28 interleukin 1 beta Homo sapiens 7-15 9023325-9 1997 The ability of IL-1ra to reduce PGE2 production caused by all stimuli used suggests an autocrine role for IL-1 in PGHS-2 induction in these cells. Dinoprostone 32-36 interleukin 1 beta Homo sapiens 15-19 9051715-2 1997 Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC. Dinoprostone 133-137 interleukin 1 beta Homo sapiens 24-42 9051715-2 1997 Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC. Dinoprostone 133-137 interleukin 1 beta Homo sapiens 44-53 9051715-4 1997 Furthermore, TXB2 was produced in large quantities during co-incubation of IL-1 beta-stimulated SMC with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids (PGE2, PGF2 alpha and PGD2) compared with control (P < 0.01). Dinoprostone 209-213 interleukin 1 beta Homo sapiens 75-84 9048452-7 1997 This study found greater detection frequencies of P. nigrescens, P. micros, F. nucleatum ss vincentii, and F. nucleatum ss nucleatum, as well as significant elevations in GCF levels of PGE2, IL-1 beta, and PDGF in mouths with failing implant sites as compared to mouths with healthy control implants. Dinoprostone 185-189 interleukin 1 beta Homo sapiens 191-200 9561158-2 1997 In the previous study, we demonstrated that osteoclast formation induced by IL-1 beta was mediated by PGE2 produced by induced prostaglandin endoperoxide H synthase-2 (PGHS-2) in osteoclastic cells. Dinoprostone 102-106 interleukin 1 beta Homo sapiens 76-85 8977210-1 1997 Synthesis of TNF-alpha and IL-1beta, by monocytes/macrophages can be partially regulated by the eicosanoid, PGE2. Dinoprostone 108-112 interleukin 1 beta Homo sapiens 27-35 9315512-3 1997 Interleukin-1beta (IL-1) enhanced PGE2 production in cultured normal fibroblasts and CRL-1475 cells. Dinoprostone 34-38 interleukin 1 beta Homo sapiens 0-17 9315512-3 1997 Interleukin-1beta (IL-1) enhanced PGE2 production in cultured normal fibroblasts and CRL-1475 cells. Dinoprostone 34-38 interleukin 1 beta Homo sapiens 19-23 9315512-4 1997 10(-6) M azelastine inhibited PGE2 production in these IL-1-stimulated fibroblasts. Dinoprostone 30-34 interleukin 1 beta Homo sapiens 55-59 8940164-0 1996 Manipulation of distinct NFkappaB proteins alters interleukin-1beta-induced human rheumatoid synovial fibroblast prostaglandin E2 formation. Dinoprostone 113-129 interleukin 1 beta Homo sapiens 50-67 8940164-6 1996 An NFkappaB classical oligonucleotide decoy produced a concentration-dependent decrease in IL-1-stimulated PGE2 production (IC50 = approximately 2 microM), indicating a role of NFkappaB. Dinoprostone 107-111 interleukin 1 beta Homo sapiens 91-95 8940164-7 1996 Utilization of antisense technology showed that p65 but not p50 or c-Rel mediated IL-1beta-stimulated PGE2 formation. Dinoprostone 102-106 interleukin 1 beta Homo sapiens 82-90 8913883-7 1996 The PGE2 secretagogue, IL-1 beta, down-regulated control levels of IGFBP-3 which could be completely abrogated by pre-incubation with the tyrosine kinase inhibitor, erbstatin, and partially reversed (50 +/- 8%) by KT-5720, a PKA inhibitor. Dinoprostone 4-8 interleukin 1 beta Homo sapiens 23-32 8982097-4 1996 Among these cytokines, only IL-1 beta significantly stimulated production of prostaglandins E2 and F2 alpha but not PGD2, thromboxane B2 and 6-keto-PGF1 alpha. Dinoprostone 77-94 interleukin 1 beta Homo sapiens 28-37 8958057-8 1996 Induced PGE2 production by monocyte cultures treated with lipopolysaccharide (LPS) or interleukin-1 beta (IL-1 beta) was strongly inhibited in the presence of hrIL-1ra (500 ng/ml). Dinoprostone 8-12 interleukin 1 beta Homo sapiens 86-104 8958057-8 1996 Induced PGE2 production by monocyte cultures treated with lipopolysaccharide (LPS) or interleukin-1 beta (IL-1 beta) was strongly inhibited in the presence of hrIL-1ra (500 ng/ml). Dinoprostone 8-12 interleukin 1 beta Homo sapiens 106-115 8858138-4 1996 In addition wortmannin partially inhibited IL-1 beta induced PGE2 production and potentiated IL-1 beta induced nitric oxide production. Dinoprostone 61-65 interleukin 1 beta Homo sapiens 43-52 8971655-4 1996 In combination with IL-1 beta, PHT potentiated the inhibitory effect of IL-1 beta on alpha 1 (I) procollagen mRNA level that was accompanied by an increased PGE2 formation. Dinoprostone 157-161 interleukin 1 beta Homo sapiens 72-81 8915021-2 1996 When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan. Dinoprostone 121-137 interleukin 1 beta Homo sapiens 73-81 8915021-2 1996 When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan. Dinoprostone 121-137 interleukin 1 beta Homo sapiens 109-117 8915021-2 1996 When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan. Dinoprostone 139-143 interleukin 1 beta Homo sapiens 73-81 8915021-2 1996 When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan. Dinoprostone 139-143 interleukin 1 beta Homo sapiens 109-117 8915021-6 1996 The upregulation of the metabolism of AA to PGE2 induced by IL-1beta, was markedly reduced in the presence of triclosan. Dinoprostone 44-48 interleukin 1 beta Homo sapiens 60-68 8915021-7 1996 The study indicates that the stimulatory effect of IL-1beta on prostanoid formation (PGE2, PGI2) in human gingival fibroblasts was diminished in the presence of triclosan partly at the level of phospholipase A2 and partly at the level of cyclooxygenase. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 51-59 8891757-3 1996 In the human osteoblastic cell line MG-63, IL-1 alpha (10-1000 pg/ml), IL-1 beta (3-300 pg/ml) and TNF-alpha (1-30 ng/ml) stimulated prostaglandin E2 (PGE2) formation and inhibited 1,25(OH)2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of type I collagen. Dinoprostone 133-149 interleukin 1 beta Homo sapiens 71-80 8891757-3 1996 In the human osteoblastic cell line MG-63, IL-1 alpha (10-1000 pg/ml), IL-1 beta (3-300 pg/ml) and TNF-alpha (1-30 ng/ml) stimulated prostaglandin E2 (PGE2) formation and inhibited 1,25(OH)2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of type I collagen. Dinoprostone 151-155 interleukin 1 beta Homo sapiens 71-80 8891757-5 1996 Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation. Dinoprostone 156-160 interleukin 1 beta Homo sapiens 120-129 8891757-5 1996 Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation. Dinoprostone 156-160 interleukin 1 beta Homo sapiens 208-217 8891757-6 1996 In isolated, non-transformed, human osteoblast-like cells, IL-1 beta and TNF-alpha stimulated PGE2 formation and concomitantly inhibited 1,25(OH)2-vitamin D3-stimulated osteocalcin biosynthesis, without affecting type I collagen formation. Dinoprostone 94-98 interleukin 1 beta Homo sapiens 59-68 8908619-8 1996 Interleukin-1 beta enhanced PGE2 secretion (P < 0.01) in both POGC and NC, while lipopolysaccharide increased prostaglandin release only by the NC cells. Dinoprostone 28-32 interleukin 1 beta Homo sapiens 0-18 8908620-5 1996 The NVD cells produced significantly more amount of PGE2 than the ECS cells and the both cells responded to the addition of IL-1 beta to increase PGE2 production. Dinoprostone 146-150 interleukin 1 beta Homo sapiens 124-133 8931118-2 1996 We have previously shown that interleukin 1 beta (IL-1 beta) induces PGE2 production in synovial fibroblast cultures and that this effect is suppressed by the active metabolite of vitamin D3, 1,25-(OH)2D3. Dinoprostone 69-73 interleukin 1 beta Homo sapiens 30-48 8931118-2 1996 We have previously shown that interleukin 1 beta (IL-1 beta) induces PGE2 production in synovial fibroblast cultures and that this effect is suppressed by the active metabolite of vitamin D3, 1,25-(OH)2D3. Dinoprostone 69-73 interleukin 1 beta Homo sapiens 50-59 8931118-5 1996 In comparison, dexamethasone, which also inhibits IL-1 beta induction of PGE2, had inhibitory effects on both parameters. Dinoprostone 73-77 interleukin 1 beta Homo sapiens 50-59 8663336-2 1996 Protein kinase C (PKC) plays a role in signal transduction mediated by interleukin-1beta (IL-1beta) leading to the increase in prostaglandin E2 (PGE2) production. Dinoprostone 127-143 interleukin 1 beta Homo sapiens 71-88 8663336-2 1996 Protein kinase C (PKC) plays a role in signal transduction mediated by interleukin-1beta (IL-1beta) leading to the increase in prostaglandin E2 (PGE2) production. Dinoprostone 127-143 interleukin 1 beta Homo sapiens 90-98 8663336-2 1996 Protein kinase C (PKC) plays a role in signal transduction mediated by interleukin-1beta (IL-1beta) leading to the increase in prostaglandin E2 (PGE2) production. Dinoprostone 145-149 interleukin 1 beta Homo sapiens 71-88 8663336-2 1996 Protein kinase C (PKC) plays a role in signal transduction mediated by interleukin-1beta (IL-1beta) leading to the increase in prostaglandin E2 (PGE2) production. Dinoprostone 145-149 interleukin 1 beta Homo sapiens 90-98 8663336-8 1996 Finally, antisense oligonucleotides to PKCzeta partially inhibited the IL-1beta-induced PGE2 formation while control sense oligonucleotides were without effect. Dinoprostone 88-92 interleukin 1 beta Homo sapiens 71-79 8858138-5 1996 These experiments suggest that IL-1 beta can activate PI 3-kinase in renal mesangial cells and that the enzyme plays a role in IL-1 beta induced PGE2 and NO formation in the renal mesangial cell. Dinoprostone 145-149 interleukin 1 beta Homo sapiens 31-40 8858138-5 1996 These experiments suggest that IL-1 beta can activate PI 3-kinase in renal mesangial cells and that the enzyme plays a role in IL-1 beta induced PGE2 and NO formation in the renal mesangial cell. Dinoprostone 145-149 interleukin 1 beta Homo sapiens 127-136 8875637-7 1996 IL-1 beta, PMA and ionomycin all stimulated amnion cell PGE2 production as expected. Dinoprostone 56-60 interleukin 1 beta Homo sapiens 0-9 8841895-0 1996 Prostaglandin E2 potentiates interleukin-1 beta induced interleukin-6 production by human gingival fibroblasts. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 29-47 8841895-4 1996 Therefore, the purpose of this study was to determine if PGE2 induced by IL-1 beta could potentiate the IL-6 response by HGF. Dinoprostone 57-61 interleukin 1 beta Homo sapiens 73-82 8841895-6 1996 These concentrations of IL-1 beta also induced a small, but significant increase in PGE2 production by HGF. Dinoprostone 84-88 interleukin 1 beta Homo sapiens 24-33 8841895-10 1996 These results suggest the endogenous PGE2 induced by IL-1 beta plays an important regulatory role in IL 6 production by HGF. Dinoprostone 37-41 interleukin 1 beta Homo sapiens 53-62 8681939-1 1996 The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression. Dinoprostone 195-211 interleukin 1 beta Homo sapiens 83-101 8764139-8 1996 We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets. Dinoprostone 171-175 interleukin 1 beta Homo sapiens 87-96 8641202-7 1996 Although the effect on PGHS-2 messenger RNA may account for the facilitatory role of ceramide on IL1 beta-induced PGE2 biosynthesis, neither SMase nor the membrane-permeant ceramide analogue were able to augment prostaglandin accumulation in the presence of exogenously added arachidonate precursor. Dinoprostone 114-118 interleukin 1 beta Homo sapiens 97-105 8641202-8 1996 Collectively, whereas these results show that ceramide triggers a negative-effector pathway that is both necessary and sufficient to reproduce the inhibitory effect of IL1 beta on FSH-stimulated granulosa cell steroidogenesis, they also support the notion that sphingomyelin hydrolysis may be important for cytokine-induced PGHS-2 expression but not sufficient to reproduce IL1 beta-stimulated PGE2 biosynthesis. Dinoprostone 394-398 interleukin 1 beta Homo sapiens 168-176 8681939-1 1996 The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression. Dinoprostone 195-211 interleukin 1 beta Homo sapiens 103-112 8681939-1 1996 The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression. Dinoprostone 213-217 interleukin 1 beta Homo sapiens 83-101 8681939-1 1996 The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression. Dinoprostone 213-217 interleukin 1 beta Homo sapiens 103-112 8630267-4 1996 Because PGE2 is reported to inhibit interleukin 1 (IL-1) and tumor necrosis factor (TNF), it is likely that hypoxia, through changes in PGE2, will alter IL-1 and TNF release from the human alveolar macrophage. Dinoprostone 8-12 interleukin 1 beta Homo sapiens 51-55 8602840-7 1996 A549 cells treated with IL-1beta (0.01 to 10 ng/ml) contained COX-2 protein and released greater amounts of PGE2. Dinoprostone 108-112 interleukin 1 beta Homo sapiens 24-32 8536613-11 1996 Il-1 beta also stimulates PGE2 release, and this effect was inhibited by both NGF antibodies and a trk receptor blocker, NGF antibodies administered in vivo attenuated the increase in ovarian PGE2 synthesis that antedates ovulation. Dinoprostone 26-30 interleukin 1 beta Homo sapiens 0-9 8832976-0 1996 Suppression of human synovial fibroblast 85 kDa phospholipase A2 by antisense reduces interleukin-1 beta induced prostaglandin E2. Dinoprostone 113-129 interleukin 1 beta Homo sapiens 86-104 8832976-1 1996 OBJECTIVE: To evaluate the relative roles of rheumatoid synovial fibroblast phospholipases A2 (PLA2) in interleukin- 1beta (IL-1 beta) stimulated prostaglandin E2 (PGE2) production. Dinoprostone 146-162 interleukin 1 beta Homo sapiens 104-122 8832976-1 1996 OBJECTIVE: To evaluate the relative roles of rheumatoid synovial fibroblast phospholipases A2 (PLA2) in interleukin- 1beta (IL-1 beta) stimulated prostaglandin E2 (PGE2) production. Dinoprostone 146-162 interleukin 1 beta Homo sapiens 124-133 8832976-1 1996 OBJECTIVE: To evaluate the relative roles of rheumatoid synovial fibroblast phospholipases A2 (PLA2) in interleukin- 1beta (IL-1 beta) stimulated prostaglandin E2 (PGE2) production. Dinoprostone 164-168 interleukin 1 beta Homo sapiens 104-122 8832976-1 1996 OBJECTIVE: To evaluate the relative roles of rheumatoid synovial fibroblast phospholipases A2 (PLA2) in interleukin- 1beta (IL-1 beta) stimulated prostaglandin E2 (PGE2) production. Dinoprostone 164-168 interleukin 1 beta Homo sapiens 124-133 8832976-2 1996 METHODS: The role of the cytosolic 85 kDa PLA2 in IL-1beta induced human rheumatoid synovial fibroblast PGE2 formation was directly evaluated using an antisense phosphorothioate oligonucleotide to the initiation site of the 85 kDa PLA2 mRNA. Dinoprostone 104-108 interleukin 1 beta Homo sapiens 50-58 8832976-8 1996 CONCLUSION: These data directly support a role for the 85 kDa PLA2, but not the 14 kDa PLA2, in IL- 1beta stimulated PGE2 production from human rheumatoid synovial fibroblast. Dinoprostone 117-121 interleukin 1 beta Homo sapiens 96-105 8630267-16 1996 Because PGE2 is reported to inhibit the expression of IL-1 and TNF genes, we inhibited PGE2 synthesis with indomethacin during culture in room air; the result was an increase in the release of IL-1 and TNF. Dinoprostone 8-12 interleukin 1 beta Homo sapiens 54-58 8630267-16 1996 Because PGE2 is reported to inhibit the expression of IL-1 and TNF genes, we inhibited PGE2 synthesis with indomethacin during culture in room air; the result was an increase in the release of IL-1 and TNF. Dinoprostone 8-12 interleukin 1 beta Homo sapiens 54-66 8630267-16 1996 Because PGE2 is reported to inhibit the expression of IL-1 and TNF genes, we inhibited PGE2 synthesis with indomethacin during culture in room air; the result was an increase in the release of IL-1 and TNF. Dinoprostone 87-91 interleukin 1 beta Homo sapiens 54-58 8630267-16 1996 Because PGE2 is reported to inhibit the expression of IL-1 and TNF genes, we inhibited PGE2 synthesis with indomethacin during culture in room air; the result was an increase in the release of IL-1 and TNF. Dinoprostone 87-91 interleukin 1 beta Homo sapiens 54-66 8777276-2 1996 IL-1 alpha, IL-1 beta, TNF-alpha and TNF-beta caused a time- and concentration-dependent enhancement of prostaglandin E2 (PGE2) formation in the fibroblasts. Dinoprostone 104-120 interleukin 1 beta Homo sapiens 12-21 8777276-2 1996 IL-1 alpha, IL-1 beta, TNF-alpha and TNF-beta caused a time- and concentration-dependent enhancement of prostaglandin E2 (PGE2) formation in the fibroblasts. Dinoprostone 122-126 interleukin 1 beta Homo sapiens 12-21 8777276-4 1996 BK (1 microM) and thrombin (3 U/ml) synergistically potentiated IL-1 alpha and IL-1 beta stimulated PGE2 formation in 24 h cultures. Dinoprostone 100-104 interleukin 1 beta Homo sapiens 79-88 8777276-5 1996 The effect of BK and thrombin on IL-1 beta enhanced PGE2 formation was seen both at suboptimal and optimal concentrations of IL-1 beta without affecting the sensitivity to IL-1 beta. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 33-42 8777276-5 1996 The effect of BK and thrombin on IL-1 beta enhanced PGE2 formation was seen both at suboptimal and optimal concentrations of IL-1 beta without affecting the sensitivity to IL-1 beta. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 125-134 8777276-5 1996 The effect of BK and thrombin on IL-1 beta enhanced PGE2 formation was seen both at suboptimal and optimal concentrations of IL-1 beta without affecting the sensitivity to IL-1 beta. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 125-134 8777276-10 1996 Preincubation with IL-1 beta and TNF-alpha for 24 h resulted in a substantial amplification of the PGE2 response to a subsequent 24 h challenge with BK in the absence of cytokine. Dinoprostone 99-103 interleukin 1 beta Homo sapiens 19-28 8777276-11 1996 Similarly, when the pulp fibroblasts were preincubated with or without IL-1 beta or TNF-alpha for 24 h and then challenged with exogenous arachidonic acid for 60 min, PGE2 formation was significantly enhanced in cytokine pretreated cells. Dinoprostone 167-171 interleukin 1 beta Homo sapiens 71-80 8653494-3 1996 The stimulatory effect of TNF alpha on IL-1 beta production was accompanied by enhanced PGE2 formation. Dinoprostone 88-92 interleukin 1 beta Homo sapiens 39-48 8711133-1 1996 In previous studies we have shown that IL-1 beta induced both PGE2 release and total cellular cPLA2 activity and cPLA2 protein synthesis in human amnion-derived WISH cells. Dinoprostone 62-66 interleukin 1 beta Homo sapiens 39-48 8711133-4 1996 The synthetic glucocorticoid dexamethasone (10(-10)-10(-6)M) inhibited IL-1 beta-induced cPLA2 and PGHS-2 mRNA expression activity and protein synthesis and PGE2 release in a concentration dependent manner. Dinoprostone 157-161 interleukin 1 beta Homo sapiens 71-80 9244174-0 1996 Stimulation of prostaglandin E2 synthesis by interleukin-1beta is amplified by interferons but inhibited by interleukin-4 in human amnion-derived WISH cells. Dinoprostone 15-31 interleukin 1 beta Homo sapiens 45-62 9244174-2 1996 However, the cells were stimulated greatly to synthesize prostaglandin E2 by interleukin-1beta in a dose-dependent manner. Dinoprostone 57-73 interleukin 1 beta Homo sapiens 77-94 9244174-10 1996 These results indicate that regulation of interleukin-1beta-stimulated prostaglandin E2 synthesis by interferons and interleukin-4 is controlled at the m-RNA level of cyclooxygenase-2. Dinoprostone 71-87 interleukin 1 beta Homo sapiens 42-59 8790842-29 1996 This effect may be partly due to IL-1 stimulated secretion of PGE2. Dinoprostone 62-66 interleukin 1 beta Homo sapiens 33-37 8630267-4 1996 Because PGE2 is reported to inhibit interleukin 1 (IL-1) and tumor necrosis factor (TNF), it is likely that hypoxia, through changes in PGE2, will alter IL-1 and TNF release from the human alveolar macrophage. Dinoprostone 8-12 interleukin 1 beta Homo sapiens 153-157 8630267-4 1996 Because PGE2 is reported to inhibit interleukin 1 (IL-1) and tumor necrosis factor (TNF), it is likely that hypoxia, through changes in PGE2, will alter IL-1 and TNF release from the human alveolar macrophage. Dinoprostone 136-140 interleukin 1 beta Homo sapiens 51-55 8630267-4 1996 Because PGE2 is reported to inhibit interleukin 1 (IL-1) and tumor necrosis factor (TNF), it is likely that hypoxia, through changes in PGE2, will alter IL-1 and TNF release from the human alveolar macrophage. Dinoprostone 136-140 interleukin 1 beta Homo sapiens 153-157 8519653-6 1995 Interleukin 1 beta (IL-1 beta) also induced PGE2 production in breast fibroblasts in the presence of excess substrate, consistent with cyclo-oxygenase induction by the cytokine. Dinoprostone 44-48 interleukin 1 beta Homo sapiens 0-18 18475751-5 1996 Both LPS and IL-1(beta) exposure were noted to stimulate cellular PGE(2) release, a response which was significantly inhibited by IL-1ra treatment. Dinoprostone 66-72 interleukin 1 beta Homo sapiens 13-23 8519653-6 1995 Interleukin 1 beta (IL-1 beta) also induced PGE2 production in breast fibroblasts in the presence of excess substrate, consistent with cyclo-oxygenase induction by the cytokine. Dinoprostone 44-48 interleukin 1 beta Homo sapiens 20-29 8519653-7 1995 Under these conditions only Hs578T cells and MDA-MB-231 cells demonstrated large increases in PGE2 in response to IL-1 beta or phorbol ester; no such responses were seen in MCF-7, T47-D, ZR-75-1, BT-20 or CLF-90-1 cells. Dinoprostone 94-98 interleukin 1 beta Homo sapiens 114-123 8519653-8 1995 In the absence of added arachidonate, bradykinin (BK) and endothelin-1 (ET-1), potentiated PGE2 production in IL-1 beta-treated fibroblasts, possibly by mobilising endogenous substrate. Dinoprostone 91-95 interleukin 1 beta Homo sapiens 110-119 8751285-4 1995 Intravenous bolus injection of recombinant human IL-1beta (3 mu g/kg) caused a prompt and robust rise in plasma ACTH (peak, 748 +/- 183 (-x +/- SE) pg/ml at 20 min), but this was not associated with a significant change in plasma PGE2 up to 120 min postadministration. Dinoprostone 230-234 interleukin 1 beta Homo sapiens 49-57 7488646-4 1995 Inhibition of IL-1 beta-stimulated PGE2 synthesis by indomethacin and direct addition of PGE2 had no effect on cyclic AMP levels, indicating that PGE2 did not increase cyclic AMP production by human decidual cells and confirming the independent synthesis of cyclic AMP and PGE2. Dinoprostone 35-39 interleukin 1 beta Homo sapiens 14-23 7488646-0 1995 Interleukin-1 beta independently stimulates production of prostaglandin E2 and cyclic AMP from human decidual cells. Dinoprostone 58-74 interleukin 1 beta Homo sapiens 0-18 7488646-10 1995 It is clear that IL-1 beta increased decidual PGE2 production independently of cyclic AMP, and that other second messenger must mediate the action of this cytokine. Dinoprostone 46-50 interleukin 1 beta Homo sapiens 17-26 7488646-1 1995 Interleukin-1 beta (IL-1 beta) increased the production of cyclic AMP and prostaglandin E2 (PGE2) by cultured human decidual cells during 24 h of stimulation, but not over short incubation times (< 6 h). Dinoprostone 74-90 interleukin 1 beta Homo sapiens 0-18 7488646-1 1995 Interleukin-1 beta (IL-1 beta) increased the production of cyclic AMP and prostaglandin E2 (PGE2) by cultured human decidual cells during 24 h of stimulation, but not over short incubation times (< 6 h). Dinoprostone 74-90 interleukin 1 beta Homo sapiens 20-29 7564267-11 1995 A blocking Ab against the type I IL-1R completely inhibited, in both normal and OA cells, the receptor binding and IL-1 beta stimulated PGE2 production, whereas the treatment with anti-type II IL-1R was ineffective. Dinoprostone 136-140 interleukin 1 beta Homo sapiens 115-124 7488646-1 1995 Interleukin-1 beta (IL-1 beta) increased the production of cyclic AMP and prostaglandin E2 (PGE2) by cultured human decidual cells during 24 h of stimulation, but not over short incubation times (< 6 h). Dinoprostone 92-96 interleukin 1 beta Homo sapiens 0-18 7488646-1 1995 Interleukin-1 beta (IL-1 beta) increased the production of cyclic AMP and prostaglandin E2 (PGE2) by cultured human decidual cells during 24 h of stimulation, but not over short incubation times (< 6 h). Dinoprostone 92-96 interleukin 1 beta Homo sapiens 20-29 7488646-2 1995 At concentrations of IL-1 beta ranging from 1 to 100 pg/ml, there were parallel changes in cyclic AMP and PGE2 levels, but 1000 pg of IL-1 beta/ml inhibited cyclic AMP production while still stimulating PGE2 synthesis. Dinoprostone 106-110 interleukin 1 beta Homo sapiens 21-30 8543370-1 1995 The effect of interleukin-1 beta (IL-1 beta) on the expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) mRNA and its relation to prostaglandin E2 (PGE2) biosynthesis in human gingival fibroblasts was studied. Dinoprostone 133-149 interleukin 1 beta Homo sapiens 14-32 8543370-1 1995 The effect of interleukin-1 beta (IL-1 beta) on the expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) mRNA and its relation to prostaglandin E2 (PGE2) biosynthesis in human gingival fibroblasts was studied. Dinoprostone 133-149 interleukin 1 beta Homo sapiens 34-43 8543370-1 1995 The effect of interleukin-1 beta (IL-1 beta) on the expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) mRNA and its relation to prostaglandin E2 (PGE2) biosynthesis in human gingival fibroblasts was studied. Dinoprostone 151-155 interleukin 1 beta Homo sapiens 14-32 8543370-1 1995 The effect of interleukin-1 beta (IL-1 beta) on the expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) mRNA and its relation to prostaglandin E2 (PGE2) biosynthesis in human gingival fibroblasts was studied. Dinoprostone 151-155 interleukin 1 beta Homo sapiens 34-43 8543370-5 1995 When gingival fibroblasts were treated simultaneously with IL-1 beta and PMA, the cytokine IL-1 beta synergistically increased levels of COX-2 mRNA, accompanied by a corresponding increase in PGE2 biosynthesis. Dinoprostone 192-196 interleukin 1 beta Homo sapiens 59-68 8543370-5 1995 When gingival fibroblasts were treated simultaneously with IL-1 beta and PMA, the cytokine IL-1 beta synergistically increased levels of COX-2 mRNA, accompanied by a corresponding increase in PGE2 biosynthesis. Dinoprostone 192-196 interleukin 1 beta Homo sapiens 91-100 8543370-6 1995 The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA. Dinoprostone 110-114 interleukin 1 beta Homo sapiens 136-145 8543370-6 1995 The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA. Dinoprostone 110-114 interleukin 1 beta Homo sapiens 173-182 8543370-7 1995 The study indicates that the IL-1 beta induced PGE2 formation is mediated by an enhanced gene expression of COX-2 in gingival fibroblasts suggesting that the enzyme COX-2 may play an important role in the regulation of prostanoid formation at inflammatory lesions in gingival tissue. Dinoprostone 47-51 interleukin 1 beta Homo sapiens 29-38 7544757-11 1995 Thus, we conclude that AFP downregulates TNF-alpha and IL-1 beta production via a PGE2-dependent mechanism. Dinoprostone 82-86 interleukin 1 beta Homo sapiens 55-64 8526991-1 1995 PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2). Dinoprostone 132-148 interleukin 1 beta Homo sapiens 70-88 8785034-5 1996 Exogenous and endogenous prostaglandin E2 (PGE2) was found to inhibit the release of TNF alpha rather than IL-1 beta from peritoneal macrophages, indicating that the synthesis and secretion of these cytokines is distinctly regulated by PGE2. Dinoprostone 25-41 interleukin 1 beta Homo sapiens 107-116 8785034-5 1996 Exogenous and endogenous prostaglandin E2 (PGE2) was found to inhibit the release of TNF alpha rather than IL-1 beta from peritoneal macrophages, indicating that the synthesis and secretion of these cytokines is distinctly regulated by PGE2. Dinoprostone 43-47 interleukin 1 beta Homo sapiens 107-116 8526991-1 1995 PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2). Dinoprostone 132-148 interleukin 1 beta Homo sapiens 90-99 8526991-1 1995 PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2). Dinoprostone 163-167 interleukin 1 beta Homo sapiens 70-88 8526991-1 1995 PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2). Dinoprostone 163-167 interleukin 1 beta Homo sapiens 90-99 8526991-4 1995 RESULTS: IL-1 beta stimulated a time-dependent enhancement in PGE2 and PGF2 alpha production, with PGF2 alpha synthesis predominating over PGE2. Dinoprostone 62-66 interleukin 1 beta Homo sapiens 9-18 8526991-4 1995 RESULTS: IL-1 beta stimulated a time-dependent enhancement in PGE2 and PGF2 alpha production, with PGF2 alpha synthesis predominating over PGE2. Dinoprostone 139-143 interleukin 1 beta Homo sapiens 9-18 7560228-11 1995 In cell culture experiments, it was found that triclosan inhibited IL-1 beta induced prostaglandin E2 production by human gingival fibroblasts in a concentration dependent manner, and at relatively low concentrations. Dinoprostone 85-101 interleukin 1 beta Homo sapiens 67-76 7629516-1 1995 We previously reported that ceramide, the immediate product of sphingomyelin hydrolysis, increases in response to interleukin (IL)-1 beta and plays a role in modulating IL-1 beta-mediated prostaglandin E2 production and cyclooxygenase gene expression in human fibroblasts (Ballou, L. R., C. P. Chao, M. A. Holness, S. C. Barker, and R. Raghow. Dinoprostone 188-204 interleukin 1 beta Homo sapiens 169-178 7582491-14 1995 These data suggest that IL-10 limits the inflammatory hyperalgesia evoked by carrageenin and bradykinin by two mechanisms: inhibition of cytokine production and inhibition of IL-1 beta evoked PGE2 production. Dinoprostone 192-196 interleukin 1 beta Homo sapiens 175-184 7537695-0 1995 IL-1-induced nitric oxide inhibits chondrocyte proliferation via PGE2. Dinoprostone 65-69 interleukin 1 beta Homo sapiens 0-4 7480804-0 1995 Interleukin-1 beta induces the synthesis and activity of cytosolic phospholipase A2 and the release of prostaglandin E2 in human amnion-derived WISH cells. Dinoprostone 103-119 interleukin 1 beta Homo sapiens 0-18 7480804-3 1995 Treatment of WISH cells with IL-1 beta (0.01-1 ng/mL) for up to 24 h resulted in a significant increase in PGE2 release in a concentration- and time-dependent manner accompanied by increases both in total cellular cPLA2 activity and in cPLA2 protein levels detected by Western blot analysis. Dinoprostone 107-111 interleukin 1 beta Homo sapiens 29-38 7480804-5 1995 Incubation of the cells with 10 microM AACOCF3 for 24 h significantly inhibited IL-1 beta-induced PGE2 production strongly suggesting that cPLA2 mediates IL-1 beta-induced PGE2 formation. Dinoprostone 98-102 interleukin 1 beta Homo sapiens 80-89 7480804-5 1995 Incubation of the cells with 10 microM AACOCF3 for 24 h significantly inhibited IL-1 beta-induced PGE2 production strongly suggesting that cPLA2 mediates IL-1 beta-induced PGE2 formation. Dinoprostone 172-176 interleukin 1 beta Homo sapiens 80-89 7480804-5 1995 Incubation of the cells with 10 microM AACOCF3 for 24 h significantly inhibited IL-1 beta-induced PGE2 production strongly suggesting that cPLA2 mediates IL-1 beta-induced PGE2 formation. Dinoprostone 172-176 interleukin 1 beta Homo sapiens 154-163 7537695-6 1995 However, SNP induced high levels of PGE2, and NMA reduced IL-1-induced PGE2. Dinoprostone 71-75 interleukin 1 beta Homo sapiens 58-62 7537695-9 1995 These results suggest that the chondrocyte growth inhibition by IL-1 in chondrocytes is due to the induction of NO, which stimulates the production of PGE2 as a mediator of its antiproliferative effects. Dinoprostone 151-155 interleukin 1 beta Homo sapiens 64-68 7615646-0 1995 Interleukin-1 beta induction of tissue inhibitor of metalloproteinase (TIMP-1) is functionally antagonized by prostaglandin E2 in human synovial fibroblasts. Dinoprostone 110-126 interleukin 1 beta Homo sapiens 0-18 7783414-6 1995 Increased IL-1 beta secretion coincided with a suppression in PGE2 synthesis (P < 0.02). Dinoprostone 62-66 interleukin 1 beta Homo sapiens 10-19 7783414-7 1995 Similarly, blockade of endogenous PGE2 by indomethacin increased LPS-induced IL-1 beta secretion (P < 0.01) but did not enhance total IL-1 beta production in PBMC from controls and patients on Cuprophan hemodialysis. Dinoprostone 34-38 interleukin 1 beta Homo sapiens 77-86 7873203-0 1995 Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts. Dinoprostone 78-94 interleukin 1 beta Homo sapiens 49-67 7783414-11 1995 Hemodialysis with AN 69 suppresses endogenous PGE2 synthesis in PBMC which is associated with increased LPS-induced IL-1 beta secretion in the presence of unchanged total IL-1 beta production. Dinoprostone 46-50 interleukin 1 beta Homo sapiens 116-125 7783414-12 1995 We speculate that PGE2 could inactivate the IL-1 beta converting enzyme which is essential for processing and secretion of mature IL-1 beta. Dinoprostone 18-22 interleukin 1 beta Homo sapiens 44-53 7783414-12 1995 We speculate that PGE2 could inactivate the IL-1 beta converting enzyme which is essential for processing and secretion of mature IL-1 beta. Dinoprostone 18-22 interleukin 1 beta Homo sapiens 130-139 7873203-1 1995 Because interleukin-1 beta (IL-1 beta) increases the synthesis of prostaglandin E2 (PGE2) in human lung fibroblasts, the effect of IL-1 beta on the expression of two isozymes of cyclooxygenase (cyclooxygenase-1 and -2) in human embryonic lung fibroblasts (IMR-90) was investigated in terms of three parameters (PGE2 release, cyclooxygenase activity, and mRNA). Dinoprostone 66-82 interleukin 1 beta Homo sapiens 8-26 7873203-1 1995 Because interleukin-1 beta (IL-1 beta) increases the synthesis of prostaglandin E2 (PGE2) in human lung fibroblasts, the effect of IL-1 beta on the expression of two isozymes of cyclooxygenase (cyclooxygenase-1 and -2) in human embryonic lung fibroblasts (IMR-90) was investigated in terms of three parameters (PGE2 release, cyclooxygenase activity, and mRNA). Dinoprostone 66-82 interleukin 1 beta Homo sapiens 28-37 7873203-1 1995 Because interleukin-1 beta (IL-1 beta) increases the synthesis of prostaglandin E2 (PGE2) in human lung fibroblasts, the effect of IL-1 beta on the expression of two isozymes of cyclooxygenase (cyclooxygenase-1 and -2) in human embryonic lung fibroblasts (IMR-90) was investigated in terms of three parameters (PGE2 release, cyclooxygenase activity, and mRNA). Dinoprostone 84-88 interleukin 1 beta Homo sapiens 8-26 7873203-1 1995 Because interleukin-1 beta (IL-1 beta) increases the synthesis of prostaglandin E2 (PGE2) in human lung fibroblasts, the effect of IL-1 beta on the expression of two isozymes of cyclooxygenase (cyclooxygenase-1 and -2) in human embryonic lung fibroblasts (IMR-90) was investigated in terms of three parameters (PGE2 release, cyclooxygenase activity, and mRNA). Dinoprostone 84-88 interleukin 1 beta Homo sapiens 28-37 7873203-2 1995 When the cells were incubated with IL-1 beta, both the PGE2 release to the culture medium and the cyclooxygenase activity in the cell lysate increased in a dose- and time-dependent manner, and both were inhibited by NS-398 (a cyclooxygenase-2-specific inhibitor). Dinoprostone 55-59 interleukin 1 beta Homo sapiens 35-44 7873203-3 1995 Dexamethasone and interleukin-4 (IL-4) inhibited the IL-1 beta-induced PGE2 synthesis; the former inhibited the IL-1 beta-induced cyclooxygenase activity whereas the latter failed. Dinoprostone 71-75 interleukin 1 beta Homo sapiens 53-62 7873203-3 1995 Dexamethasone and interleukin-4 (IL-4) inhibited the IL-1 beta-induced PGE2 synthesis; the former inhibited the IL-1 beta-induced cyclooxygenase activity whereas the latter failed. Dinoprostone 71-75 interleukin 1 beta Homo sapiens 112-121 7790046-5 1995 The most accredited mechanism of action of IL-1 in inflammatory diseases is the stimulation of PGE2 release, which is highly dependent on the concentration of IL-1. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 43-47 7790046-5 1995 The most accredited mechanism of action of IL-1 in inflammatory diseases is the stimulation of PGE2 release, which is highly dependent on the concentration of IL-1. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 159-163 7790046-9 1995 In fact, the cell cultures treated with hrIL-6 plus hrIL-1 caused a higher release approximately 1.5-4-fold of SAA protein than the cells treated with IL-6 plus PGE2 5 microM or IL-1 + PGE2 5 microM, respectively. Dinoprostone 185-189 interleukin 1 beta Homo sapiens 54-58 7652185-6 1995 PGE2 synthesis was increased by 24 h culture with IL-1 beta in all the cell preparations, indicating that the cells were biologically active, and that the lack of effect of changes in cyclic AMP synthesis on PGE2 levels could not be attributed to a defect in the prostaglandin synthetic pathway. Dinoprostone 0-4 interleukin 1 beta Homo sapiens 50-59 7792388-0 1995 Interleukin-1 beta-stimulated PGE2 production from early first trimester human decidual cells is inhibited by dexamethasone and progesterone. Dinoprostone 30-34 interleukin 1 beta Homo sapiens 0-18 7480798-0 1995 Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis. Dinoprostone 120-136 interleukin 1 beta Homo sapiens 0-18 7480798-0 1995 Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis. Dinoprostone 138-142 interleukin 1 beta Homo sapiens 0-18 7480798-0 1995 Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis. Dinoprostone 357-361 interleukin 1 beta Homo sapiens 0-18 7480798-2 1995 Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms. Dinoprostone 42-46 interleukin 1 beta Homo sapiens 0-18 7480798-2 1995 Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms. Dinoprostone 42-46 interleukin 1 beta Homo sapiens 20-29 7480798-2 1995 Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms. Dinoprostone 42-46 interleukin 1 beta Homo sapiens 132-141 7480798-2 1995 Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms. Dinoprostone 181-185 interleukin 1 beta Homo sapiens 0-18 7480798-2 1995 Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms. Dinoprostone 181-185 interleukin 1 beta Homo sapiens 20-29 7480798-2 1995 Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms. Dinoprostone 181-185 interleukin 1 beta Homo sapiens 132-141 7792388-4 1995 Interleukin-1 beta stimulated the production of prostaglandins E2 and F2 alpha dose-dependently, and this was associated with increased numbers of COX-2 positive cells. Dinoprostone 48-65 interleukin 1 beta Homo sapiens 0-18 7873203-7 1995 These results indicate that IL-1 beta induces cyclooxygenase-2 rather than cyclooxygenase-1 in IMR-90 cells and this induction is responsible for the augmentation of PGE2 production stimulated with IL-1 beta. Dinoprostone 166-170 interleukin 1 beta Homo sapiens 28-37 7873203-7 1995 These results indicate that IL-1 beta induces cyclooxygenase-2 rather than cyclooxygenase-1 in IMR-90 cells and this induction is responsible for the augmentation of PGE2 production stimulated with IL-1 beta. Dinoprostone 166-170 interleukin 1 beta Homo sapiens 198-207 7873203-8 1995 However, the inhibition of the IL-1 beta-induced PGE2 synthesis by IL-4 was not mediated by the down-regulation of cyclooxygenase-2. Dinoprostone 49-53 interleukin 1 beta Homo sapiens 31-40 7877083-2 1994 The purpose of this study was to examine whether prostaglandin E2 (PGE2), which is produced in abundance from HGF after stimulation with interleukin (IL)-1 beta or tumor necrosis factor-alpha (TNF-alpha), could regulate IL-6 production by HGF. Dinoprostone 49-65 interleukin 1 beta Homo sapiens 137-160 7877083-2 1994 The purpose of this study was to examine whether prostaglandin E2 (PGE2), which is produced in abundance from HGF after stimulation with interleukin (IL)-1 beta or tumor necrosis factor-alpha (TNF-alpha), could regulate IL-6 production by HGF. Dinoprostone 67-71 interleukin 1 beta Homo sapiens 137-160 7877083-4 1994 IL-6 secretion from either IL-1 beta- or TNF-alpha-stimulated HGF was enhanced by the inhibition of PGE2 synthesis with indomethacin. Dinoprostone 100-104 interleukin 1 beta Homo sapiens 27-36 7892511-4 1994 IL-1 beta enhanced the production of PGE2 in a dose- and time-dependent manner with enhanced production detectable by 2 h following exposure. Dinoprostone 37-41 interleukin 1 beta Homo sapiens 0-9 7536063-5 1994 IL-1 beta, at and above 0.3 pM, dose dependently stimulated PGE2 formation in isolated human osteoblasts, with half maximal stimulation, EC50, at 3 pM. Dinoprostone 60-64 interleukin 1 beta Homo sapiens 0-9 7536063-7 1994 The time-course for IL-1 beta-induced PGE2 formation was similar to that of forskolin, with a significant increase in the formation of PGE2 seen after 1 h. In contrast, A23187-induced PGE2 formation was seen within minutes. Dinoprostone 135-139 interleukin 1 beta Homo sapiens 20-29 7892510-9 1994 The activity present in one of these was synergistic with interleukin-1 beta (IL-1 beta) in stimulating amnion cell PGE2 production and was found to contain mainly transforming growth factor-alpha (TGF-alpha) immunoreactivity. Dinoprostone 116-120 interleukin 1 beta Homo sapiens 58-76 7892510-9 1994 The activity present in one of these was synergistic with interleukin-1 beta (IL-1 beta) in stimulating amnion cell PGE2 production and was found to contain mainly transforming growth factor-alpha (TGF-alpha) immunoreactivity. Dinoprostone 116-120 interleukin 1 beta Homo sapiens 78-87 7892510-11 1994 The PGE2-stimulatory activity present in the other peak contained IL-1 beta, epidermal growth factor (EGF), and tumor necrosis factor-alpha (TNF-alpha). Dinoprostone 4-8 interleukin 1 beta Homo sapiens 66-75 7536063-7 1994 The time-course for IL-1 beta-induced PGE2 formation was similar to that of forskolin, with a significant increase in the formation of PGE2 seen after 1 h. In contrast, A23187-induced PGE2 formation was seen within minutes. Dinoprostone 38-42 interleukin 1 beta Homo sapiens 20-29 7536063-11 1994 We conclude that IL-1 beta enhances the formation of cyclic AMP as well as PGE2 in primary cultures of isolated human osteoblasts. Dinoprostone 75-79 interleukin 1 beta Homo sapiens 17-26 7536063-7 1994 The time-course for IL-1 beta-induced PGE2 formation was similar to that of forskolin, with a significant increase in the formation of PGE2 seen after 1 h. In contrast, A23187-induced PGE2 formation was seen within minutes. Dinoprostone 135-139 interleukin 1 beta Homo sapiens 20-29 7536063-13 1994 The findings implicate that both cyclic AMP- and PGE2-formation in osteoblasts might be involved as independent mediators of IL-1 beta-induced bone resorption. Dinoprostone 49-53 interleukin 1 beta Homo sapiens 125-134 8176221-0 1994 IL-1 beta amplifies bradykinin-induced prostaglandin E2 production via a phospholipase D-linked mechanism. Dinoprostone 39-55 interleukin 1 beta Homo sapiens 0-9 8090286-1 1994 Utilizing the push-pull perfusion technique, we examined the effect of an intravenous bolus injection of recombinant human interleukin (IL)-1 beta on the release of prostaglandin E2 (PGE2), CRF, and AVP in several hypothalamic areas of freely moving rats, simultaneously monitoring plasma ACTH levels. Dinoprostone 165-181 interleukin 1 beta Homo sapiens 123-146 8090286-1 1994 Utilizing the push-pull perfusion technique, we examined the effect of an intravenous bolus injection of recombinant human interleukin (IL)-1 beta on the release of prostaglandin E2 (PGE2), CRF, and AVP in several hypothalamic areas of freely moving rats, simultaneously monitoring plasma ACTH levels. Dinoprostone 183-187 interleukin 1 beta Homo sapiens 123-146 7858842-14 1994 This release was enhanced by treatment of either cell type with the mixture of cytokines (interleukin-1 beta , tumour necrosis factors- and interferon-gamma, 10 ng ml-1 for all).PGE2 was the principal COX metabolite released by cytokine-activated epithelial cells. Dinoprostone 178-182 interleukin 1 beta Homo sapiens 90-156 8077670-3 1994 Extending this hypothesis, it follows that the relative potency of an agonist in inducing PGE2 production from IL-1-treated cells should be dependent on its ability to raise [Ca2+]i. Dinoprostone 90-94 interleukin 1 beta Homo sapiens 111-115 8077670-6 1994 Furthermore, the relative specificity and potency of the PGE2 response of bradykinin in IL-1-treated cells was paralleled, in resting cells, by a similar pattern in the [Ca2+]i response. Dinoprostone 57-61 interleukin 1 beta Homo sapiens 88-92 7948430-1 1994 We have shown that interleukin-1 (IL-1) up-regulates transcription of its own receptor and number of cell surface IL-1 receptor (IL-1R) type I molecule through induction of prostaglandin E2 (PGE2) synthesis and subsequent intracellular cAMP accumulation in a human lung fibroblast cell line (TIG-1). Dinoprostone 173-189 interleukin 1 beta Homo sapiens 34-38 7948430-1 1994 We have shown that interleukin-1 (IL-1) up-regulates transcription of its own receptor and number of cell surface IL-1 receptor (IL-1R) type I molecule through induction of prostaglandin E2 (PGE2) synthesis and subsequent intracellular cAMP accumulation in a human lung fibroblast cell line (TIG-1). Dinoprostone 173-189 interleukin 1 beta Homo sapiens 114-118 7948430-1 1994 We have shown that interleukin-1 (IL-1) up-regulates transcription of its own receptor and number of cell surface IL-1 receptor (IL-1R) type I molecule through induction of prostaglandin E2 (PGE2) synthesis and subsequent intracellular cAMP accumulation in a human lung fibroblast cell line (TIG-1). Dinoprostone 191-195 interleukin 1 beta Homo sapiens 34-38 7948430-1 1994 We have shown that interleukin-1 (IL-1) up-regulates transcription of its own receptor and number of cell surface IL-1 receptor (IL-1R) type I molecule through induction of prostaglandin E2 (PGE2) synthesis and subsequent intracellular cAMP accumulation in a human lung fibroblast cell line (TIG-1). Dinoprostone 191-195 interleukin 1 beta Homo sapiens 114-118 8176221-10 1994 Finally, we demonstrated that the IL-1-mediated amplification of PGE2 release in response to BK was reduced by the presence of ethanol in the culture medium, suggesting that part of the synergistic action of IL-1 and BK on prostanoid production was dependent on the activation of the PC-specific PLD pathway. Dinoprostone 65-69 interleukin 1 beta Homo sapiens 34-38 8176221-10 1994 Finally, we demonstrated that the IL-1-mediated amplification of PGE2 release in response to BK was reduced by the presence of ethanol in the culture medium, suggesting that part of the synergistic action of IL-1 and BK on prostanoid production was dependent on the activation of the PC-specific PLD pathway. Dinoprostone 65-69 interleukin 1 beta Homo sapiens 208-219 8126141-4 1994 However, prostaglandin E2 levels peaked on day 4 in EEC treated with progesterone, epidermal growth factor, and IL-1 beta (208.7 +/- 92 ng/10(7) cells), whereas no prostaglandin E2 was detectable in cells not treated with IL-1 beta, indicating that these cells responded to IL-1 beta. Dinoprostone 9-25 interleukin 1 beta Homo sapiens 112-121 8185692-2 1994 OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF. Dinoprostone 99-115 interleukin 1 beta Homo sapiens 126-144 8185692-2 1994 OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF. Dinoprostone 99-115 interleukin 1 beta Homo sapiens 146-155 8185692-2 1994 OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF. Dinoprostone 117-121 interleukin 1 beta Homo sapiens 126-144 8185692-2 1994 OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF. Dinoprostone 117-121 interleukin 1 beta Homo sapiens 146-155 8185692-2 1994 OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF. Dinoprostone 353-357 interleukin 1 beta Homo sapiens 146-155 8185692-7 1994 The IL-1 receptor antagonist completely abolished the induction of these two enzymes and the stimulation of PGE2 production by IL-1 beta in RSF. Dinoprostone 108-112 interleukin 1 beta Homo sapiens 127-136 7511596-14 1994 Our results indicate that cAMP-increasing agents, such as histamine or prostaglandin E2, fail to induce IL-6 synthesis but rather enhance IL-1-induced IL-6 synthesis. Dinoprostone 71-87 interleukin 1 beta Homo sapiens 138-142 8126141-4 1994 However, prostaglandin E2 levels peaked on day 4 in EEC treated with progesterone, epidermal growth factor, and IL-1 beta (208.7 +/- 92 ng/10(7) cells), whereas no prostaglandin E2 was detectable in cells not treated with IL-1 beta, indicating that these cells responded to IL-1 beta. Dinoprostone 9-25 interleukin 1 beta Homo sapiens 222-231 8126141-4 1994 However, prostaglandin E2 levels peaked on day 4 in EEC treated with progesterone, epidermal growth factor, and IL-1 beta (208.7 +/- 92 ng/10(7) cells), whereas no prostaglandin E2 was detectable in cells not treated with IL-1 beta, indicating that these cells responded to IL-1 beta. Dinoprostone 9-25 interleukin 1 beta Homo sapiens 222-231 8195358-4 1994 Positive significant correlations were seen between IL-1 beta and prostaglandin E2 (PGE2) (r = 0.47, P < 0.001), and between IL-1 beta and prostaglandin F2 alpha (PGF2 alpha) (r = 0.22, P < 0.05) in pre-ovulatory follicular fluid, but not between IL-1 beta and oestradiol, or between IL-1 beta and progesterone. Dinoprostone 66-82 interleukin 1 beta Homo sapiens 52-61 8299714-6 1994 Prostaglandin E2 is induced in rheumatoid synovial fibroblasts by interleukin-1 beta, not altered by transforming growth factor-alpha, and is synergistically released by the combination of the two cytokines. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 66-84 8016387-4 1994 Interleukin-1 beta (IL-1 beta), EGF, ionomycin (iono), and PMA are known to stimulate prostaglandin E2 production in human chorion and decidual cells. Dinoprostone 86-102 interleukin 1 beta Homo sapiens 0-18 8016387-4 1994 Interleukin-1 beta (IL-1 beta), EGF, ionomycin (iono), and PMA are known to stimulate prostaglandin E2 production in human chorion and decidual cells. Dinoprostone 86-102 interleukin 1 beta Homo sapiens 20-29 8195358-0 1994 Concentration of interleukin-1 beta correlates with prostaglandin E2 and F2 alpha in human pre-ovulatory follicular fluid. Dinoprostone 52-68 interleukin 1 beta Homo sapiens 17-35 8208752-3 1994 Hence we have evaluated the effects of staurosporine and H7 (inhibitors of protein kinase C) on IL-1 beta stimulation of amnion, chorion and decidual prostaglandin E2 (PGE2) production. Dinoprostone 150-166 interleukin 1 beta Homo sapiens 96-105 8208752-5 1994 However with minor exceptions both protein kinase C inhibitors enhanced the stimulatory actions of IL-1 beta on PGE2 production by all three cell types. Dinoprostone 112-116 interleukin 1 beta Homo sapiens 99-108 8195358-4 1994 Positive significant correlations were seen between IL-1 beta and prostaglandin E2 (PGE2) (r = 0.47, P < 0.001), and between IL-1 beta and prostaglandin F2 alpha (PGF2 alpha) (r = 0.22, P < 0.05) in pre-ovulatory follicular fluid, but not between IL-1 beta and oestradiol, or between IL-1 beta and progesterone. Dinoprostone 84-88 interleukin 1 beta Homo sapiens 52-61 7507098-2 1993 In the present study we compared PGE2 with prostacyclin (PGI2) analogs in their potency to influence LPS-stimulated production of interleukin-1 beta (IL-1 beta) and TNF-alpha by human mononuclear cells (MNC). Dinoprostone 33-37 interleukin 1 beta Homo sapiens 130-148 9419743-5 1994 RESULTS: The concentration-related stimulation of decidual PGE2 production by IL-1 beta and TNF alpha was completely abrogated by cycloheximide and actinomycin D treatment. Dinoprostone 59-63 interleukin 1 beta Homo sapiens 78-87 8280164-12 1993 In these experiments IL-1 beta increases PGE2 synthesis 8 fold in IMR90 while IL-1 beta and TGF-beta added simultaneously increases PGE2 synthesis 25 fold. Dinoprostone 41-45 interleukin 1 beta Homo sapiens 21-30 8280164-12 1993 In these experiments IL-1 beta increases PGE2 synthesis 8 fold in IMR90 while IL-1 beta and TGF-beta added simultaneously increases PGE2 synthesis 25 fold. Dinoprostone 132-136 interleukin 1 beta Homo sapiens 78-87 8140124-6 1993 Moreover, IL-2 also attenuated, in a concentration-related fashion, the stimulatory actions of IL-1 beta on PGE2 production by amnion cells. Dinoprostone 108-112 interleukin 1 beta Homo sapiens 95-104 8140125-0 1993 Interleukin-1 beta stimulates prostaglandin E2 and F2 alpha synthesis in human ovarian granulosa cells in culture. Dinoprostone 30-46 interleukin 1 beta Homo sapiens 0-18 8140125-3 1993 IL-1 beta increased immunoreactive concentrations of PGE2 and PGF2 alpha in culture medium in time- and dose-dependent manners. Dinoprostone 53-57 interleukin 1 beta Homo sapiens 0-9 8140125-4 1993 Concentration of PGE2 was significantly higher after 24 h incubation with 5 or more units/ml of IL-1 beta, when compared to the control value obtained without IL-1 beta (P < 0.05). Dinoprostone 17-21 interleukin 1 beta Homo sapiens 96-105 8140125-4 1993 Concentration of PGE2 was significantly higher after 24 h incubation with 5 or more units/ml of IL-1 beta, when compared to the control value obtained without IL-1 beta (P < 0.05). Dinoprostone 17-21 interleukin 1 beta Homo sapiens 159-168 8295979-3 1993 Very high levels of interleukin-1 receptor antagonist (> 1000 pg/ml) had limited inhibitory effects on IL-1 beta-stimulated PGE2 synthesis, and lower levels of antagonist (< 1000 pg/ml) increased the effects of IL-1 beta. Dinoprostone 127-131 interleukin 1 beta Homo sapiens 106-115 7507098-2 1993 In the present study we compared PGE2 with prostacyclin (PGI2) analogs in their potency to influence LPS-stimulated production of interleukin-1 beta (IL-1 beta) and TNF-alpha by human mononuclear cells (MNC). Dinoprostone 33-37 interleukin 1 beta Homo sapiens 150-159 8302918-0 1993 Prostaglandin E2 antagonizes gingival fibroblast proliferation stimulated by interleukin-1 beta. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 77-95 8153084-1 1993 We have evaluated the mechanism by which interleukin-1 beta (IL-1 beta) increases amnion cell PGE2 production in a concentration-dependent manner. Dinoprostone 94-98 interleukin 1 beta Homo sapiens 41-59 8153084-1 1993 We have evaluated the mechanism by which interleukin-1 beta (IL-1 beta) increases amnion cell PGE2 production in a concentration-dependent manner. Dinoprostone 94-98 interleukin 1 beta Homo sapiens 61-70 8153084-2 1993 IL-1 beta-stimulated amnion cell PGE2 biosynthesis was time-dependent, and significant stimulation occurred within 2 h of incubation. Dinoprostone 33-37 interleukin 1 beta Homo sapiens 0-9 8302918-2 1993 Addition of PGE2 to culture media containing IL-1 beta and INDO caused a significant concentration-dependent reduction in IL-1 beta- and INDO-induced stimulation of DNA synthesis. Dinoprostone 12-16 interleukin 1 beta Homo sapiens 45-54 8302918-2 1993 Addition of PGE2 to culture media containing IL-1 beta and INDO caused a significant concentration-dependent reduction in IL-1 beta- and INDO-induced stimulation of DNA synthesis. Dinoprostone 12-16 interleukin 1 beta Homo sapiens 122-131 8302918-1 1993 Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis. Dinoprostone 45-61 interleukin 1 beta Homo sapiens 226-244 8302918-1 1993 Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis. Dinoprostone 45-61 interleukin 1 beta Homo sapiens 246-255 8302918-1 1993 Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis. Dinoprostone 45-61 interleukin 1 beta Homo sapiens 260-269 8302918-1 1993 Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis. Dinoprostone 63-67 interleukin 1 beta Homo sapiens 226-244 8302918-1 1993 Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis. Dinoprostone 63-67 interleukin 1 beta Homo sapiens 246-255 8302918-1 1993 Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis. Dinoprostone 63-67 interleukin 1 beta Homo sapiens 260-269 8311923-2 1993 METHODS: IL-1 beta, TNF alpha, and EGF induced a concentration-related stimulation of prostaglandin E2 (PGE2) biosynthesis in human chorion cells, and this stimulation was enhanced by the addition of exogenous arachidonic acid. Dinoprostone 86-102 interleukin 1 beta Homo sapiens 9-18 8311923-2 1993 METHODS: IL-1 beta, TNF alpha, and EGF induced a concentration-related stimulation of prostaglandin E2 (PGE2) biosynthesis in human chorion cells, and this stimulation was enhanced by the addition of exogenous arachidonic acid. Dinoprostone 104-108 interleukin 1 beta Homo sapiens 9-18 8311924-5 1993 RESULTS: IL-1 beta, PMA, and ionomycin all stimulated decidual PGE2 and TXB2 production as expected. Dinoprostone 63-67 interleukin 1 beta Homo sapiens 9-18 8311923-3 1993 RESULTS: Protein synthesis inhibition with cycloheximide or actinomycin D resulted in complete abrogation of the stimulation of PGE2 production by IL-1 beta, TNF alpha, and EGF. Dinoprostone 128-132 interleukin 1 beta Homo sapiens 147-156 8311923-5 1993 CONCLUSIONS: It is suggested that IL-1 beta, TNF alpha, and EGF all act to stimulate human chorion PGE2 production primarily via induction of prostaglandin endoperoxide synthase activity. Dinoprostone 99-103 interleukin 1 beta Homo sapiens 34-43 8102321-3 1993 The inhibition is strong in cancer patients, because PGE2 is formed in many cancer cells and its formation is stimulated by IL-1 beta. Dinoprostone 53-57 interleukin 1 beta Homo sapiens 124-133 8218931-2 1993 IL-1 alpha, IL-1 beta and TNF-alpha, but not EGF nor TGF-alpha, stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts. Dinoprostone 75-91 interleukin 1 beta Homo sapiens 12-21 7683676-2 1993 TNF alpha (100 units/ml) and IL-1 beta (100 units/ml) stimulated the production of PGE2 and caused a dose-dependent inhibition of up to 54 and 66%, respectively, of the production of type I procollagen. Dinoprostone 83-87 interleukin 1 beta Homo sapiens 29-38 7683676-8 1993 These results indicate that TNF alpha and IL-1 beta inhibit the expression of the alpha 1(I) procollagen gene in human lung fibroblasts at the transcriptional level by a PGE2-independent effect as well as through the effect of endogenous fibroblast PGE2 released under the stimulus of the cytokines. Dinoprostone 170-174 interleukin 1 beta Homo sapiens 42-51 7683676-8 1993 These results indicate that TNF alpha and IL-1 beta inhibit the expression of the alpha 1(I) procollagen gene in human lung fibroblasts at the transcriptional level by a PGE2-independent effect as well as through the effect of endogenous fibroblast PGE2 released under the stimulus of the cytokines. Dinoprostone 249-253 interleukin 1 beta Homo sapiens 42-51 8378543-4 1993 Low levels of IL-1 beta (0.1-1.0 ng/ml) increased PGE2 levels on the fetal side of the membrane, and also increased the production of PGE2 metabolites and PGF2 alpha, suggesting that this cytokine stimulated the decidua as well as the amnion. Dinoprostone 50-54 interleukin 1 beta Homo sapiens 14-23 8378543-4 1993 Low levels of IL-1 beta (0.1-1.0 ng/ml) increased PGE2 levels on the fetal side of the membrane, and also increased the production of PGE2 metabolites and PGF2 alpha, suggesting that this cytokine stimulated the decidua as well as the amnion. Dinoprostone 134-138 interleukin 1 beta Homo sapiens 14-23 8218931-2 1993 IL-1 alpha, IL-1 beta and TNF-alpha, but not EGF nor TGF-alpha, stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts. Dinoprostone 93-97 interleukin 1 beta Homo sapiens 12-21 8218931-3 1993 The effect of IL-1 alpha, IL-1 beta and TNF-alpha on PGE2 formation was significantly potentiated by EGF in a dose-dependent manner. Dinoprostone 53-57 interleukin 1 beta Homo sapiens 26-35 8218931-4 1993 Similarly, TGF-alpha synergistically potentiated IL-1 beta stimulated PGE2 formation. Dinoprostone 70-74 interleukin 1 beta Homo sapiens 49-58 8218931-9 1993 Data indicates that EGF potentiates the IL-1 and TNF-alpha induced PGE2 formation at the level of prostaglandin endoperoxide synthase (cyclooxygenase). Dinoprostone 67-71 interleukin 1 beta Homo sapiens 40-44 8457602-11 1993 IL-1 receptor antagonist (IL-1ra) inhibited the stimulation of amnion cell PGE2 production by IL-1 beta, but not by TNF-alpha. Dinoprostone 75-79 interleukin 1 beta Homo sapiens 94-103 8386101-7 1993 In fact, interleukin-1 beta significantly inhibited the synthesis of prostaglandin E2 in iris-ciliary body. Dinoprostone 69-85 interleukin 1 beta Homo sapiens 9-27 8427707-2 1993 We have previously shown that AM produce a specific interleukin-1 (IL-1) inhibitor of 20 to 25 kD that blocks biologic activities of IL-1 alpha and IL-1 beta such as prostaglandin E2 production by fibroblasts. Dinoprostone 166-182 interleukin 1 beta Homo sapiens 148-157 7506004-6 1993 In contrast, PGE2, which significantly elevated intracellular cAMP levels, inhibited TNF but not IL-1 production at the transcriptional level. Dinoprostone 13-17 interleukin 1 beta Homo sapiens 97-101 8422241-2 1993 The minimal IL-1 beta concentrations for stimulation of IL-6 and PGE2 production by SSc fibroblasts were 10-fold and 100-fold lower, respectively, than those for normal fibroblasts. Dinoprostone 65-69 interleukin 1 beta Homo sapiens 12-21 8480532-1 1993 Effects of hyaluronan (HA) on the prostaglandin E2 (PGE2) production induced by recombinant human interleukin-1 beta (rhIL-1 beta) in rabbit articular chondrocytes were studied in vitro. Dinoprostone 34-50 interleukin 1 beta Homo sapiens 98-116 8273584-0 1993 Interleukin-1 beta induces cytosolic PLA2 in parallel with prostaglandin E2 in rheumatoid synovial fibroblasts. Dinoprostone 59-75 interleukin 1 beta Homo sapiens 0-18 8273584-4 1993 These findings support that an augmentation of CPLA2 activity, caused by an induction of cPLA2 protein, rather than sPLA2, is temporally associated with increased PGE2 production in IL-1 beta-treated RSF. Dinoprostone 163-167 interleukin 1 beta Homo sapiens 182-191 8480532-1 1993 Effects of hyaluronan (HA) on the prostaglandin E2 (PGE2) production induced by recombinant human interleukin-1 beta (rhIL-1 beta) in rabbit articular chondrocytes were studied in vitro. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 98-116 7679950-5 1993 The level of IL-6 activity in the CF and RF consistently increased; beginning 2 h after TNF alpha injection and reaching the maximum between 8 h and 12 h. It returned to the basal level within 48 h. IL-1 beta was detected in the CF of three patients, its level peaking at 8 h. Prostaglandin E2 also increased after injection of TNF alpha, peaking between 4 h and 12 h and then gradually decreasing. Dinoprostone 277-293 interleukin 1 beta Homo sapiens 199-208 8341137-2 1993 IL-1 alpha, IL-1 beta and TNF alpha, dose-dependently, stimulated PGE2 formation in gingival fibroblasts. Dinoprostone 66-70 interleukin 1 beta Homo sapiens 12-21 8341137-3 1993 The metabolite, p-HPPH (1.2-2.4 micrograms/ml), did not induce PGE2 formation itself but potentiated IL-1 alpha and IL1 beta induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentration of both IL-1 and p-HPPH. Dinoprostone 133-137 interleukin 1 beta Homo sapiens 116-124 1315688-2 1992 After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation. Dinoprostone 217-233 interleukin 1 beta Homo sapiens 62-71 8392688-2 1993 Massive liberation of bacterial cell wall components (Lipopolysaccharide, acid teichoic polymers) induce a cascade of reactions including the secretion of many cytokines (such as TNF alpha and IL-1 beta) and prostaglandins (such as PAF and PGE2) which in turn leads to the development of cerebral oedema, intracranial hypertension and cerebral blood flow reduction. Dinoprostone 240-244 interleukin 1 beta Homo sapiens 193-202 8372524-10 1993 Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level. Dinoprostone 6-22 interleukin 1 beta Homo sapiens 78-87 8372524-10 1993 Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level. Dinoprostone 6-22 interleukin 1 beta Homo sapiens 204-213 8372524-10 1993 Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level. Dinoprostone 24-28 interleukin 1 beta Homo sapiens 78-87 8372524-10 1993 Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level. Dinoprostone 24-28 interleukin 1 beta Homo sapiens 204-213 8372524-10 1993 Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level. Dinoprostone 150-154 interleukin 1 beta Homo sapiens 78-87 8372524-10 1993 Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level. Dinoprostone 150-154 interleukin 1 beta Homo sapiens 204-213 1471697-7 1992 Endometrial explants responded to treatment with interleukin-1 beta and tumor necrosis factor by a concentration-dependent increase in the production of prostaglandin E2. Dinoprostone 153-169 interleukin 1 beta Homo sapiens 49-67 1471697-8 1992 Costimulation of late luteal endometrial explants with interleukin-1 beta (10 ng/ml) and progesterone (10(-6) mol/L) resulted in variable production of prostaglandin E2, suggesting that the histologic examination of the endometrium does not necessarily reflect the functional properties of the endometrium. Dinoprostone 152-168 interleukin 1 beta Homo sapiens 55-73 1451738-2 1992 The addition of IL-1 from 1.2 x 10(-8) to 10(-10) M increased insulin secretion in the 0-4-h period after IL-1 administration and prostaglandin E2 (PGE2) production was suppressed by IL-1 from 1.2 x 10(-8) to 10(-12) M. At all doses used, IL-1 inhibited insulin secretion in the 4-24-h period after IL-1 administration and PGE2 levels were increased in the culture medium. Dinoprostone 130-146 interleukin 1 beta Homo sapiens 16-20 1451738-2 1992 The addition of IL-1 from 1.2 x 10(-8) to 10(-10) M increased insulin secretion in the 0-4-h period after IL-1 administration and prostaglandin E2 (PGE2) production was suppressed by IL-1 from 1.2 x 10(-8) to 10(-12) M. At all doses used, IL-1 inhibited insulin secretion in the 4-24-h period after IL-1 administration and PGE2 levels were increased in the culture medium. Dinoprostone 148-152 interleukin 1 beta Homo sapiens 16-20 1451738-2 1992 The addition of IL-1 from 1.2 x 10(-8) to 10(-10) M increased insulin secretion in the 0-4-h period after IL-1 administration and prostaglandin E2 (PGE2) production was suppressed by IL-1 from 1.2 x 10(-8) to 10(-12) M. At all doses used, IL-1 inhibited insulin secretion in the 4-24-h period after IL-1 administration and PGE2 levels were increased in the culture medium. Dinoprostone 323-327 interleukin 1 beta Homo sapiens 16-20 1451738-5 1992 It also prevented the effects of IL-1 on PGE2 production. Dinoprostone 41-45 interleukin 1 beta Homo sapiens 33-37 1400321-2 1992 We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (Ballou, L. R., Barker, S. C., Postlethwaite, A. E., and Kang, A. H. (1990) J. Immunol. Dinoprostone 86-102 interleukin 1 beta Homo sapiens 51-69 1400321-2 1992 We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (Ballou, L. R., Barker, S. C., Postlethwaite, A. E., and Kang, A. H. (1990) J. Immunol. Dinoprostone 86-102 interleukin 1 beta Homo sapiens 71-75 1400321-2 1992 We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (Ballou, L. R., Barker, S. C., Postlethwaite, A. E., and Kang, A. H. (1990) J. Immunol. Dinoprostone 104-108 interleukin 1 beta Homo sapiens 51-69 1400321-2 1992 We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (Ballou, L. R., Barker, S. C., Postlethwaite, A. E., and Kang, A. H. (1990) J. Immunol. Dinoprostone 104-108 interleukin 1 beta Homo sapiens 71-75 1400321-8 1992 We also found that IL-1-mediated PGE2 production was dramatically enhanced in cells treated simultaneously with sphingomyelinase which led us to directly test the effect of IL-1 on sphingomyelin turnover. Dinoprostone 33-37 interleukin 1 beta Homo sapiens 19-23 1400321-10 1992 Taken together, our results suggest that enhanced Cox expression may account for the observed enhancement of IL-1-mediated PGE2 production by sphingosine and C2-cer. Dinoprostone 123-127 interleukin 1 beta Homo sapiens 109-113 1410528-4 1992 EGF, IL-1 beta and TNF-alpha alone caused a dose-dependent increase in PGE2 production, while IL-6, IL-8 and GM-CSF were ineffective over the dose range tested. Dinoprostone 71-75 interleukin 1 beta Homo sapiens 5-14 1410528-5 1992 When cells were preincubated with IL-1 beta or TNF-alpha, there was a dose-dependent potentiation of EGF-induced PGE2 production that was greater than the sum of EGF alone and IL-1 beta or TNF-alpha alone. Dinoprostone 113-117 interleukin 1 beta Homo sapiens 34-43 1410528-6 1992 In each case, the minimum dose of IL-1 beta or TNF-alpha which amplified EGF-induced PGE2 production was 0.1 ng/ml (p less than 0.05, Student"s t-test). Dinoprostone 85-89 interleukin 1 beta Homo sapiens 34-43 1410528-7 1992 These data show that low concentrations of IL-1 beta or TNF-alpha may serve to amplify EGF-mediated PGE2 biosynthesis in amnion-derived cells and suggest that cytokines may modulate EGF function in responsive cells. Dinoprostone 100-104 interleukin 1 beta Homo sapiens 43-52 1330055-1 1992 Recombinant human interleukin-1 beta (IL-1 beta) and bradykinin (BK) synergistically stimulate prostaglandin E2 (PGE2) formation in human gingival fibroblasts cultured for 24 h. Neither BK or IL-1 beta per se, nor their combinations, caused any acute stimulation of cellular cyclic AMP accumulation. Dinoprostone 95-111 interleukin 1 beta Homo sapiens 18-36 1330055-1 1992 Recombinant human interleukin-1 beta (IL-1 beta) and bradykinin (BK) synergistically stimulate prostaglandin E2 (PGE2) formation in human gingival fibroblasts cultured for 24 h. Neither BK or IL-1 beta per se, nor their combinations, caused any acute stimulation of cellular cyclic AMP accumulation. Dinoprostone 95-111 interleukin 1 beta Homo sapiens 38-47 1330055-1 1992 Recombinant human interleukin-1 beta (IL-1 beta) and bradykinin (BK) synergistically stimulate prostaglandin E2 (PGE2) formation in human gingival fibroblasts cultured for 24 h. Neither BK or IL-1 beta per se, nor their combinations, caused any acute stimulation of cellular cyclic AMP accumulation. Dinoprostone 113-117 interleukin 1 beta Homo sapiens 18-36 1330055-1 1992 Recombinant human interleukin-1 beta (IL-1 beta) and bradykinin (BK) synergistically stimulate prostaglandin E2 (PGE2) formation in human gingival fibroblasts cultured for 24 h. Neither BK or IL-1 beta per se, nor their combinations, caused any acute stimulation of cellular cyclic AMP accumulation. Dinoprostone 113-117 interleukin 1 beta Homo sapiens 38-47 1504741-4 1992 IL-1 alpha (1.5-6.0 ng ml-1) and IL-1 beta (30-300 pg ml-1), dose-dependently, stimulated PGE2 formation, in 24 h cultures, with IL-beta being the most potent agonist. Dinoprostone 90-94 interleukin 1 beta Homo sapiens 33-42 1504741-6 1992 PHT (2.5-20 micrograms ml-1) did not induce PGE2 formation itself but potentiated IL-1 alpha- and IL-1 beta-induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentrations of both IL-1 and PHT. Dinoprostone 116-120 interleukin 1 beta Homo sapiens 98-107 1504741-6 1992 PHT (2.5-20 micrograms ml-1) did not induce PGE2 formation itself but potentiated IL-1 alpha- and IL-1 beta-induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentrations of both IL-1 and PHT. Dinoprostone 116-120 interleukin 1 beta Homo sapiens 82-86 1501156-3 1992 In fibroblasts, derived after 9 months of PHT therapy, IL-1 alpha, IL-1 beta and TNF alpha induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy. Dinoprostone 135-139 interleukin 1 beta Homo sapiens 67-76 1443157-7 1992 Furthermore, we showed the dose- and time-dependent suppression of IL-1 beta-stimulated PF-derived MCP-1 by dexamethasone and prostaglandin E2. Dinoprostone 126-142 interleukin 1 beta Homo sapiens 67-76 1420999-0 1992 Regulation of synovial cell growth: basic fibroblast growth factor synergizes with interleukin 1 beta stimulating phospholipase A2 enzyme activity, phospholipase A2 activating protein production and release of prostaglandin E2 by rheumatoid arthritis synovial cells in culture. Dinoprostone 210-226 interleukin 1 beta Homo sapiens 83-101 1330055-4 1992 Ionomycin and A23187, two calcium ionophores, synergistically potentiated the stimulatory effect of IL-1 beta on PGE2 formation. Dinoprostone 113-117 interleukin 1 beta Homo sapiens 100-109 1330055-5 1992 Three different phorbol esters known to activate protein kinase C also synergistically potentiated the action of IL-1 beta on PGE2 formation. Dinoprostone 126-130 interleukin 1 beta Homo sapiens 113-122 1330055-7 1992 In IL-1 beta treated cells, the enhancement of PGE2 formation seen after addition of arachidonic acid, was synergistically upregulated by IL-1 beta. Dinoprostone 47-51 interleukin 1 beta Homo sapiens 3-12 1330055-7 1992 In IL-1 beta treated cells, the enhancement of PGE2 formation seen after addition of arachidonic acid, was synergistically upregulated by IL-1 beta. Dinoprostone 47-51 interleukin 1 beta Homo sapiens 138-147 1322806-4 1992 IL-1 alpha and IL-1 beta stimulated a time (0-72 hr) and concentration-dependent (0.01-10 ng/ml) production of collagenase, gelatinase, caseinase, and prostaglandin E2 (PGE2) in BNC monolayer cultures. Dinoprostone 151-167 interleukin 1 beta Homo sapiens 15-24 1322806-4 1992 IL-1 alpha and IL-1 beta stimulated a time (0-72 hr) and concentration-dependent (0.01-10 ng/ml) production of collagenase, gelatinase, caseinase, and prostaglandin E2 (PGE2) in BNC monolayer cultures. Dinoprostone 169-173 interleukin 1 beta Homo sapiens 15-24 1315688-2 1992 After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation. Dinoprostone 217-233 interleukin 1 beta Homo sapiens 48-52 1315688-2 1992 After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation. Dinoprostone 235-239 interleukin 1 beta Homo sapiens 62-71 1315688-2 1992 After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation. Dinoprostone 235-239 interleukin 1 beta Homo sapiens 48-52 1315688-5 1992 Indomethacin blocked IL-1 stimulation of IL-1R mRNA expression, PGE2 production and cAMP. Dinoprostone 64-68 interleukin 1 beta Homo sapiens 21-25 1315688-9 1992 These results indicate that IL-1 does not directly stimulate expression of IL-1R mRNA or cell surface IL-1R, but only indirectly by stimulation of endogenous PGE2. Dinoprostone 158-162 interleukin 1 beta Homo sapiens 28-32 1575744-2 1992 RSF incubated in the presence of IL-1 beta (120 pg/ml) for 18 h secreted 35 fold more PGE2 than did those incubated without IL-1 beta. Dinoprostone 86-90 interleukin 1 beta Homo sapiens 33-42 1575744-6 1992 These findings demonstrate that an elevation in a cytosolic PLA2, rather than a sPLA2, is associated with increased PGE2 production in IL-1 beta stimulated RSF. Dinoprostone 116-120 interleukin 1 beta Homo sapiens 135-144 1508964-5 1992 Although IL-1 reduced plasma prostaglandin (PG) E2 levels in standard diet-fed rats, IL-1 did not affect plasma PGE2 levels in the animals fed the probucol-containing diet. Dinoprostone 29-50 interleukin 1 beta Homo sapiens 9-13 1529798-6 1992 The synovial and skin lines both exhibited a significant stimulation of PGE2 and all three metalloproteinases in response to interleukin-1 beta (IL-1 beta). Dinoprostone 72-76 interleukin 1 beta Homo sapiens 125-143 1529798-6 1992 The synovial and skin lines both exhibited a significant stimulation of PGE2 and all three metalloproteinases in response to interleukin-1 beta (IL-1 beta). Dinoprostone 72-76 interleukin 1 beta Homo sapiens 145-154 1539653-0 1992 Effect of intravenous injection of IL-1 beta on PGE2 levels in several brain areas as determined by microdialysis. Dinoprostone 48-52 interleukin 1 beta Homo sapiens 35-44 1539653-1 1992 Using perfusion microdialysis, the effect of intravenous injection of recombinant human interleukin-1 beta (IL-1 beta) on prostaglandin E2 (PGE2) release into the interstitial fluid of the organum vasculosum laminae terminalis (OVLT), medial preoptic area (MPOA), paraventricular nucleus (PVN), dorsal hippocampus (HPC), and cerebrospinal fluid (CSF) of the lateral ventricle (LV) was examined. Dinoprostone 122-138 interleukin 1 beta Homo sapiens 88-106 1539653-1 1992 Using perfusion microdialysis, the effect of intravenous injection of recombinant human interleukin-1 beta (IL-1 beta) on prostaglandin E2 (PGE2) release into the interstitial fluid of the organum vasculosum laminae terminalis (OVLT), medial preoptic area (MPOA), paraventricular nucleus (PVN), dorsal hippocampus (HPC), and cerebrospinal fluid (CSF) of the lateral ventricle (LV) was examined. Dinoprostone 122-138 interleukin 1 beta Homo sapiens 108-117 1539653-1 1992 Using perfusion microdialysis, the effect of intravenous injection of recombinant human interleukin-1 beta (IL-1 beta) on prostaglandin E2 (PGE2) release into the interstitial fluid of the organum vasculosum laminae terminalis (OVLT), medial preoptic area (MPOA), paraventricular nucleus (PVN), dorsal hippocampus (HPC), and cerebrospinal fluid (CSF) of the lateral ventricle (LV) was examined. Dinoprostone 140-144 interleukin 1 beta Homo sapiens 88-106 1539653-1 1992 Using perfusion microdialysis, the effect of intravenous injection of recombinant human interleukin-1 beta (IL-1 beta) on prostaglandin E2 (PGE2) release into the interstitial fluid of the organum vasculosum laminae terminalis (OVLT), medial preoptic area (MPOA), paraventricular nucleus (PVN), dorsal hippocampus (HPC), and cerebrospinal fluid (CSF) of the lateral ventricle (LV) was examined. Dinoprostone 140-144 interleukin 1 beta Homo sapiens 108-117 1539653-3 1992 The results showed that 1) IL-1 beta induced a significant increase in PGE2 levels in the OVLT and the medial part of the MPOA in the first 20 min, which is more rapid and to a greater extent than that in PVN, HPC, and LV; 2) inclusion of indomethacin in the perfusate abolished the IL-1 beta-induced PGE2 response in the OVLT, but a suppressive effect in the PVN was insignificant. Dinoprostone 71-75 interleukin 1 beta Homo sapiens 27-36 1539653-3 1992 The results showed that 1) IL-1 beta induced a significant increase in PGE2 levels in the OVLT and the medial part of the MPOA in the first 20 min, which is more rapid and to a greater extent than that in PVN, HPC, and LV; 2) inclusion of indomethacin in the perfusate abolished the IL-1 beta-induced PGE2 response in the OVLT, but a suppressive effect in the PVN was insignificant. Dinoprostone 71-75 interleukin 1 beta Homo sapiens 283-292 1539653-3 1992 The results showed that 1) IL-1 beta induced a significant increase in PGE2 levels in the OVLT and the medial part of the MPOA in the first 20 min, which is more rapid and to a greater extent than that in PVN, HPC, and LV; 2) inclusion of indomethacin in the perfusate abolished the IL-1 beta-induced PGE2 response in the OVLT, but a suppressive effect in the PVN was insignificant. Dinoprostone 301-305 interleukin 1 beta Homo sapiens 27-36 1309558-7 1992 The toxin, or its B oligomer, inhibited PGE2 synthesis in human gingival fibroblasts stimulated by IL-1, but not by PMA. Dinoprostone 40-44 interleukin 1 beta Homo sapiens 99-103 1546442-2 1992 Human interleukin-1 beta was about three to ten times as active on equine synovial cells as human interleukin-1 alpha in terms of prostaglandin E2 production. Dinoprostone 130-146 interleukin 1 beta Homo sapiens 6-24 1930911-4 1991 IL-1, IL-6 and TNF-alpha have several functions which suggest that they participate in the chronic disease process of rheumatoid arthritis, such as increasing production of eicosanoid, collagenase and prostaglandin E2. Dinoprostone 201-217 interleukin 1 beta Homo sapiens 0-4 1455368-6 1992 The RA patients demonstrated direct correlations between the level of IL-1 beta, TNF-alpha and PGE2 in supernatants of PBM, whereas the donors showed up a negative correlation between IL-1 beta activity and PGE2. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 70-79 1455368-6 1992 The RA patients demonstrated direct correlations between the level of IL-1 beta, TNF-alpha and PGE2 in supernatants of PBM, whereas the donors showed up a negative correlation between IL-1 beta activity and PGE2. Dinoprostone 207-211 interleukin 1 beta Homo sapiens 184-193 1661292-3 1991 Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone. Dinoprostone 66-70 interleukin 1 beta Homo sapiens 189-198 1666517-0 1991 Cholera toxin synergizes LPS- and IL-1 beta-induced PGE2 release: potential amplification systems in cholera. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 34-43 1666517-1 1991 Incubation of LPS/IL-1 beta and cholera toxin combinations resulted in a synergistic rise of immunoreactive and [3H]PGE2 released from HGFs. Dinoprostone 116-120 interleukin 1 beta Homo sapiens 18-27 1815239-7 1991 The combinations of IL-1 alpha or IL-1 beta with either TNF-alpha or TNF-beta caused a synergistic stimulation of amnion cell PGE2 production as well, whereas the combinations of IL-1 alpha with IL-1 beta or of TNF-alpha with TNF-beta were not synergistic. Dinoprostone 126-130 interleukin 1 beta Homo sapiens 34-43 1748714-5 1991 When cultures were treated with both IL-1 beta and the cyclooxygenase inhibitor, indomethacin, the expression of alpha 2-, alpha 5-, and alpha v-subunit mRNA levels were dramatically increased relative to untreated controls; co-treatment with 0.5 mM prostaglandin E2 (PGE2) partially reversed this effect. Dinoprostone 250-266 interleukin 1 beta Homo sapiens 37-46 1748714-5 1991 When cultures were treated with both IL-1 beta and the cyclooxygenase inhibitor, indomethacin, the expression of alpha 2-, alpha 5-, and alpha v-subunit mRNA levels were dramatically increased relative to untreated controls; co-treatment with 0.5 mM prostaglandin E2 (PGE2) partially reversed this effect. Dinoprostone 268-272 interleukin 1 beta Homo sapiens 37-46 1748714-9 1991 These findings indicate that (a) IL-1 beta differentially regulates the expression of integrins and (b) that PGE2, which is induced by IL-1 beta, may provide a negative feedback loop which counteracts the stimulatory effect of IL-1 beta on integrin gene expression. Dinoprostone 109-113 interleukin 1 beta Homo sapiens 33-42 1748714-9 1991 These findings indicate that (a) IL-1 beta differentially regulates the expression of integrins and (b) that PGE2, which is induced by IL-1 beta, may provide a negative feedback loop which counteracts the stimulatory effect of IL-1 beta on integrin gene expression. Dinoprostone 109-113 interleukin 1 beta Homo sapiens 135-144 1748714-9 1991 These findings indicate that (a) IL-1 beta differentially regulates the expression of integrins and (b) that PGE2, which is induced by IL-1 beta, may provide a negative feedback loop which counteracts the stimulatory effect of IL-1 beta on integrin gene expression. Dinoprostone 109-113 interleukin 1 beta Homo sapiens 135-144 1954699-3 1991 IL-1 beta was found to depress 35S-proteoglycan synthesis rates and to enhance prostaglandin E2 (PGE2) production in these monolayer cultured chondrocytes. Dinoprostone 79-95 interleukin 1 beta Homo sapiens 0-9 1954699-3 1991 IL-1 beta was found to depress 35S-proteoglycan synthesis rates and to enhance prostaglandin E2 (PGE2) production in these monolayer cultured chondrocytes. Dinoprostone 97-101 interleukin 1 beta Homo sapiens 0-9 1661707-2 1991 IL-1 alpha and IL-1 beta stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts with IL-1 beta being the most potent agonist. Dinoprostone 36-52 interleukin 1 beta Homo sapiens 15-24 1661707-2 1991 IL-1 alpha and IL-1 beta stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts with IL-1 beta being the most potent agonist. Dinoprostone 54-58 interleukin 1 beta Homo sapiens 15-24 1661707-3 1991 The effects of both IL-1 alpha and IL-1 beta on PGE2 biosynthesis was synergistically potentiated by BK, in a dose-related manner. Dinoprostone 48-52 interleukin 1 beta Homo sapiens 35-44 1661707-4 1991 The synergistic interaction between IL-1 beta and BK on PGE2 production was seen both with B1 (des-Arg9-BK) and B2 (BK, Lys-BK) BK receptor agonists. Dinoprostone 56-60 interleukin 1 beta Homo sapiens 36-45 1717193-5 1991 ATRA inhibited both IL-1 beta- and TNF alpha-induced secretion of prostaglandin-E2 (PGE2), a potent feedback inhibitor of cytokine-stimulated HSN proliferation. Dinoprostone 66-82 interleukin 1 beta Homo sapiens 20-29 1717193-5 1991 ATRA inhibited both IL-1 beta- and TNF alpha-induced secretion of prostaglandin-E2 (PGE2), a potent feedback inhibitor of cytokine-stimulated HSN proliferation. Dinoprostone 84-88 interleukin 1 beta Homo sapiens 20-29 1661739-7 1991 Furthermore, IL-1 beta production was elevated to a lesser extent by the addition of increasing concentrations of the protein kinase C activator phorbol myristate acetate or by low concentration (0.001 microgram/ml) of PGE2. Dinoprostone 219-223 interleukin 1 beta Homo sapiens 13-22 1648785-3 1991 In this study we show that in LPS-activated human monocytes, elevated cAMP concentrations (induced by either prostaglandin E2, forskolin or dibutyrylcyclic AMP) affected specifically secretion of IL-1 beta; the amount of secreted IL-1 beta was clearly reduced whereas the cell-associated level remained unchanged. Dinoprostone 109-125 interleukin 1 beta Homo sapiens 196-205 1648785-3 1991 In this study we show that in LPS-activated human monocytes, elevated cAMP concentrations (induced by either prostaglandin E2, forskolin or dibutyrylcyclic AMP) affected specifically secretion of IL-1 beta; the amount of secreted IL-1 beta was clearly reduced whereas the cell-associated level remained unchanged. Dinoprostone 109-125 interleukin 1 beta Homo sapiens 230-239 1893073-2 1991 Recombinant interleukin-1-beta (IL-1-beta) and tumor necrosis factor-alpha (TNF-alpha) stimulated moderately the DNA synthesis and markedly the production of PGE2. Dinoprostone 158-162 interleukin 1 beta Homo sapiens 12-30 1893073-2 1991 Recombinant interleukin-1-beta (IL-1-beta) and tumor necrosis factor-alpha (TNF-alpha) stimulated moderately the DNA synthesis and markedly the production of PGE2. Dinoprostone 158-162 interleukin 1 beta Homo sapiens 32-41 1893073-5 1991 Incubation with a crude T cell supernatant or a mixture of cytokines including IL-1-beta, TNF-alpha and IFN-gamma enhanced synovial cell growth and PGE2 production as compared to the effect elicited by each single cytokine. Dinoprostone 148-152 interleukin 1 beta Homo sapiens 79-88 1651782-2 1991 Since IL-1 alpha, IL-1 beta and TNF alpha have been previously demonstrated to play an important role in connective tissue destruction by stimulating the production of prostaglandin E2 (PGE2) and collagenase, these functions were investigated in the presence or absence of natural human IL-6 (nhIL-6) or recombinant human IL-6 (rhIL-6). Dinoprostone 168-184 interleukin 1 beta Homo sapiens 18-27 1649133-2 1991 IL-1 beta markedly enhanced PGE2 production in chondrocytes and, to the lesser extent, in synovial cells. Dinoprostone 28-32 interleukin 1 beta Homo sapiens 0-9 2051729-6 1991 IL-1 beta concentrations correlated directly with those of IL-2; IL-1 beta presence was associated with higher stimulation indices, higher mean concentrations of TNF alpha, IL-2, stromelysin, and PGE2, and with positive endotoxin assays, suggesting activation of the cytokine cascade in vivo. Dinoprostone 196-200 interleukin 1 beta Homo sapiens 65-74 1651782-2 1991 Since IL-1 alpha, IL-1 beta and TNF alpha have been previously demonstrated to play an important role in connective tissue destruction by stimulating the production of prostaglandin E2 (PGE2) and collagenase, these functions were investigated in the presence or absence of natural human IL-6 (nhIL-6) or recombinant human IL-6 (rhIL-6). Dinoprostone 186-190 interleukin 1 beta Homo sapiens 18-27 1888884-2 1991 In addition, IL-1 beta dose-dependently stimulated the formation of prostaglandin E2 (PGE2) and 6-keto-PGF1 alpha in the calvarial bones. Dinoprostone 68-84 interleukin 1 beta Homo sapiens 13-22 1888884-2 1991 In addition, IL-1 beta dose-dependently stimulated the formation of prostaglandin E2 (PGE2) and 6-keto-PGF1 alpha in the calvarial bones. Dinoprostone 86-90 interleukin 1 beta Homo sapiens 13-22 1888884-3 1991 However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 9-18 1888884-3 1991 However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta. Dinoprostone 143-147 interleukin 1 beta Homo sapiens 173-182 1888884-3 1991 However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta. Dinoprostone 143-147 interleukin 1 beta Homo sapiens 173-182 1997611-9 1991 Moreover, the IL-1 alpha and IL-1 beta concentrations correlated with those of Prostaglandin E2 and F2 alpha in AF, measured by RIA. Dinoprostone 79-95 interleukin 1 beta Homo sapiens 29-38 1873492-6 1991 However, in contrast to mouse or human MC the potency of IL-1 beta to induce PGE2 in Sprague Dawley rat MC was 26-fold higher compared to IL-1 alpha. Dinoprostone 77-81 interleukin 1 beta Homo sapiens 57-66 2175219-4 1990 A structural analog of cyclic adenosine monophosphate (dbcAMP) or agents elevating the endogenous cAMP levels (prostaglandin E2, forskolin) were not alone able to induce IL-1 beta expression, but they strongly enhanced the PMA-induced IL-1 beta production and IL-1 beta mRNA accumulation. Dinoprostone 111-127 interleukin 1 beta Homo sapiens 170-179 2124235-4 1990 Human IL-1 beta (180 pM) and human rTNF-alpha (3 nM) significantly stimulated both CAT activity and PGE2 release. Dinoprostone 100-104 interleukin 1 beta Homo sapiens 6-15 2125363-6 1990 Both IL-1 alpha and IL-1 beta induced production of IL-6 mRNA and of PGE2 in these cell types. Dinoprostone 69-73 interleukin 1 beta Homo sapiens 20-29 2169012-11 1990 In addition, TN-55 may also work as an IL-1 antagonist to block PGE2 production induced by IL-1 through receptor competition. Dinoprostone 64-68 interleukin 1 beta Homo sapiens 39-43 2169012-11 1990 In addition, TN-55 may also work as an IL-1 antagonist to block PGE2 production induced by IL-1 through receptor competition. Dinoprostone 64-68 interleukin 1 beta Homo sapiens 91-95 2169012-0 1990 A human IL-1 alpha derivative which lacks prostaglandin E2 inducing activity and inhibits the activity of IL-1 through receptor competition. Dinoprostone 42-58 interleukin 1 beta Homo sapiens 8-12 2166111-0 1990 IL-1 binds to high affinity receptors on human osteosarcoma cells and potentiates prostaglandin E2 stimulation of cAMP production. Dinoprostone 82-98 interleukin 1 beta Homo sapiens 0-4 2166111-9 1990 Although IL-1 had no effect on PGE2 synthesis, both IL-1 alpha and IL-1 beta enhanced PGE2 stimulation of adenylate cyclase two- to four-fold in a dose-dependent manner. Dinoprostone 86-90 interleukin 1 beta Homo sapiens 67-76 2166111-12 1990 IL-1 enhancement of PGE2-stimulated adenylate cyclase was detected between 1 to 2 h, was maximal at 4 to 5 h, was not prevented by cycloheximide treatment, and was seen in membranes from IL-1 pretreated cells. Dinoprostone 20-24 interleukin 1 beta Homo sapiens 0-4 2166111-12 1990 IL-1 enhancement of PGE2-stimulated adenylate cyclase was detected between 1 to 2 h, was maximal at 4 to 5 h, was not prevented by cycloheximide treatment, and was seen in membranes from IL-1 pretreated cells. Dinoprostone 20-24 interleukin 1 beta Homo sapiens 187-191 2107353-7 1990 However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2. Dinoprostone 218-222 interleukin 1 beta Homo sapiens 47-56 2116086-6 1990 Concentrations of PGE2 correlated significantly with PGI2, IL-1 beta, TNF, and lactate and inversely correlated with glucose concentrations in the first CSF specimens. Dinoprostone 18-22 interleukin 1 beta Homo sapiens 59-68 2104229-2 1990 PGE2 release by IL 1 beta-stimulated RA synovial cells grown for 14 days in serum-free RPMI was significantly less than that released by the same cells grown in medium plus 10% FBS (p less than 0.03; two-tailed). Dinoprostone 0-4 interleukin 1 beta Homo sapiens 16-25 2104229-4 1990 Both EGF and bFGF significantly enhanced IL 1 beta-induced release of PGE2 (p less than 0.05; paired t test, one-tailed), while PDGF was synergistic with IL 1 beta, significantly increasing release of PGE2 by these cultured cells (p less than 0.02; two-tailed). Dinoprostone 70-74 interleukin 1 beta Homo sapiens 41-50 2104229-4 1990 Both EGF and bFGF significantly enhanced IL 1 beta-induced release of PGE2 (p less than 0.05; paired t test, one-tailed), while PDGF was synergistic with IL 1 beta, significantly increasing release of PGE2 by these cultured cells (p less than 0.02; two-tailed). Dinoprostone 201-205 interleukin 1 beta Homo sapiens 41-50 2104229-4 1990 Both EGF and bFGF significantly enhanced IL 1 beta-induced release of PGE2 (p less than 0.05; paired t test, one-tailed), while PDGF was synergistic with IL 1 beta, significantly increasing release of PGE2 by these cultured cells (p less than 0.02; two-tailed). Dinoprostone 201-205 interleukin 1 beta Homo sapiens 154-163 1716487-2 1990 In this study, we report the effects of prostaglandin E2 (PGE2), and two other cAMP-elevating agents, dibutyryl cAMP and 3-isobutyl-1-methyl-xanthine, on the in vitro LPS-induced production of IL 6, IL 1 alpha, IL 1 beta and TNF alpha by human monocytes. Dinoprostone 40-56 interleukin 1 beta Homo sapiens 211-220 1716487-8 1990 These results demonstrate that IL 6, TNF alpha, IL 1 alpha and IL 1 beta production can be differently modulated by an agent, PGE2, which is produced simultaneously by LPS-stimulated monocytes. Dinoprostone 126-130 interleukin 1 beta Homo sapiens 63-72 2139669-6 1990 The recombinant IL-1ra also blocks IL-1 alpha and IL-1 beta stimulation of PGE2 production in human synovial cells and rabbit articular chondrocytes, and of collagenase production by the synovial cells. Dinoprostone 75-79 interleukin 1 beta Homo sapiens 50-59 2107353-8 1990 In the case of IL-1 beta + PDGF-BB the induction of PGE2 release was at least partly due to the synergistic induction of cyclooxygenase activity. Dinoprostone 52-56 interleukin 1 beta Homo sapiens 15-24 2138997-5 1990 Moreover, both IL-1 beta and IL-1 alpha stimulated prostaglandin E2 production of cultured porcine thyroid cells, although the potency of IL-1 alpha was slightly greater than that of IL-1 beta. Dinoprostone 51-67 interleukin 1 beta Homo sapiens 15-24 34072123-5 2021 In the current study, we determined that treating interleukin-1 beta (IL-1beta-stimulated chondrocyte cells) with cardamonin significantly reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) and significantly inhibited the expression of pro-inflammatory proteins, including inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2). Dinoprostone 184-200 interleukin 1 beta Homo sapiens 50-68 2193579-6 1990 Therefore, one mechanism by which IL-1 induces anorexia appears to require cyclooxygenase metabolites, such as PGE2. Dinoprostone 111-115 interleukin 1 beta Homo sapiens 34-38 34374483-10 2021 Co-treatment of macrophages with HGF and PGE2 reduced pro-IL-1beta expression level and active IL-1beta secretion. Dinoprostone 41-45 interleukin 1 beta Homo sapiens 54-66 34072123-5 2021 In the current study, we determined that treating interleukin-1 beta (IL-1beta-stimulated chondrocyte cells) with cardamonin significantly reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) and significantly inhibited the expression of pro-inflammatory proteins, including inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2). Dinoprostone 202-206 interleukin 1 beta Homo sapiens 50-68 2528582-8 1989 In addition, the inhibitor blocked IL-1-stimulated collagenase production from rabbit articular chondrocytes and IL-1-induced PGE2 production from human fibroblasts and synovial cells. Dinoprostone 126-130 interleukin 1 beta Homo sapiens 35-39 34069060-10 2021 Luteinizing hormone, through interleukin-1beta, stimulates the nerve growth factor-tropomyosin receptor kinase A axis in the ovarian cells and promotes tropomyosin receptor kinase A and nerve growth factor gene expression and prostaglandin E2 release. Dinoprostone 226-242 interleukin 1 beta Homo sapiens 29-46 2506272-0 1989 Prostaglandin E2 production is synergistically increased in cultured human glomerular mesangial cells by combinations of IL-1 and tumor necrosis factor-alpha 1. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 121-159 2506272-1 1989 Both IL-1 alpha and IL-1 beta and TNF-alpha induced a time- and dose-dependent release of authentic PGE2 from cultured human glomerular mesangial cells (HMC). Dinoprostone 100-104 interleukin 1 beta Homo sapiens 20-29 2506272-3 1989 Combinations of IL-1 and TNF-alpha when added simultaneously to HMC resulted in a dose-dependent synergistic increase in PGE2 production. Dinoprostone 121-125 interleukin 1 beta Homo sapiens 16-20 2528582-8 1989 In addition, the inhibitor blocked IL-1-stimulated collagenase production from rabbit articular chondrocytes and IL-1-induced PGE2 production from human fibroblasts and synovial cells. Dinoprostone 126-130 interleukin 1 beta Homo sapiens 113-117 2528582-9 1989 The IL-1 inhibitor was not transforming growth factor beta (TGF beta) as determined by: the failure of anti-TGF beta antibodies to reduce IL-1 inhibitory activity, the separation of TGF beta from the IL-1 inhibitor by ion exchange chromatography, and the failure of TGF beta to inhibit IL-1-induced PGE2 production from synovial cells. Dinoprostone 299-303 interleukin 1 beta Homo sapiens 4-8 2785913-1 1989 Recombinant human interleukin-1 beta (IL-1 beta) significantly increased prostaglandin E2 (PGE2) in a dose-dependent manner in rat astrocyte culture. Dinoprostone 73-89 interleukin 1 beta Homo sapiens 18-36 2787354-5 1989 Purified human rIL-1 alpha and IL-1 beta increased the levels of both products in the supernatants of the synovial cells; TNF-alpha raised the PGE2 levels but raised the plasminogen activator activity only weakly and inconsistently. Dinoprostone 143-147 interleukin 1 beta Homo sapiens 31-40 2507329-3 1989 When the cells were pretreated with IL-1 alpha or IL-1 beta for 24 h, their ability to release PGE2 in response to a short incubation (1 h) with bradykinin, TNF alpha or a second dose of IL-1 was potentiated. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 50-59 2507329-3 1989 When the cells were pretreated with IL-1 alpha or IL-1 beta for 24 h, their ability to release PGE2 in response to a short incubation (1 h) with bradykinin, TNF alpha or a second dose of IL-1 was potentiated. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 36-40 2507329-7 1989 It seems likely, therefore, that activation of phospholipase A2 which occurs during a short incubation with IL-1, TNF alpha or bradykinin releases substrate, AA, which is more rapidly converted to PGE2 by cells in which CO has been induced. Dinoprostone 197-201 interleukin 1 beta Homo sapiens 108-112 2472445-0 1989 Preincubation of human synovial cells with IL-1 modulates prostaglandin E2 release in response to bradykinin. Dinoprostone 58-74 interleukin 1 beta Homo sapiens 43-47 2472445-4 1989 However, after a period of preincubation with the cytokine, IL-1, which is itself a stimulus for PGE2 production, synovial cells exhibited a further striking time- and dose-dependent response to bradykinin. Dinoprostone 97-101 interleukin 1 beta Homo sapiens 60-64 2472445-5 1989 Maximal release of PGE2 was observed in response to 10(-7) to 10(-6) M bradykinin after first pretreating the cells for 24 h with 5 to 10 U/ml of IL-1. Dinoprostone 19-23 interleukin 1 beta Homo sapiens 146-150 2472445-7 1989 The bradykinin analog, lysylbradykinin, was equipotent in inducing PGE2 release from IL-1 pretreated synovial cells, whereas des(Arg9) bradykinin, substance P, and neurokinins A and B were ineffective in this regard in both IL-1-pretreated and in resting cells. Dinoprostone 67-71 interleukin 1 beta Homo sapiens 85-89 2472445-9 1989 The synergistic response in PGE2 production induced by IL-1 and bradykinin was significantly inhibited by pretreatment with 1 microM indomethacin or dexamethasone (96 and 94% inhibition, respectively). Dinoprostone 28-32 interleukin 1 beta Homo sapiens 55-59 2785913-1 1989 Recombinant human interleukin-1 beta (IL-1 beta) significantly increased prostaglandin E2 (PGE2) in a dose-dependent manner in rat astrocyte culture. Dinoprostone 73-89 interleukin 1 beta Homo sapiens 38-47 2785913-1 1989 Recombinant human interleukin-1 beta (IL-1 beta) significantly increased prostaglandin E2 (PGE2) in a dose-dependent manner in rat astrocyte culture. Dinoprostone 91-95 interleukin 1 beta Homo sapiens 18-36 2785913-1 1989 Recombinant human interleukin-1 beta (IL-1 beta) significantly increased prostaglandin E2 (PGE2) in a dose-dependent manner in rat astrocyte culture. Dinoprostone 91-95 interleukin 1 beta Homo sapiens 38-47 3264290-5 1988 This stimulatory effect of IL-1 was observed only when IL-1-stimulated PGE2 synthesis was blocked by the cyclooxygenase inhibitor indomethacin. Dinoprostone 71-75 interleukin 1 beta Homo sapiens 27-31 2785834-2 1989 Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2). Dinoprostone 184-200 interleukin 1 beta Homo sapiens 126-144 2785834-2 1989 Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2). Dinoprostone 202-206 interleukin 1 beta Homo sapiens 126-144 2784033-6 1989 In addition, after 24 h in culture, LPS-stimulated HS macrophages released significantly less prostaglandin E2 (PGE2) (which can suppress IL-1 production) than did NS macrophages; in the presence of indomethacin, which abolished macrophage PGE2 release, no augmentation of LPS-stimulated IL-1 release was observed. Dinoprostone 94-110 interleukin 1 beta Homo sapiens 138-142 2784033-6 1989 In addition, after 24 h in culture, LPS-stimulated HS macrophages released significantly less prostaglandin E2 (PGE2) (which can suppress IL-1 production) than did NS macrophages; in the presence of indomethacin, which abolished macrophage PGE2 release, no augmentation of LPS-stimulated IL-1 release was observed. Dinoprostone 112-116 interleukin 1 beta Homo sapiens 138-142 3265268-6 1988 The PGE2 levels were measured in the perfusate and were found to be enhanced more than 10-fold after the infusion of IL-1 alpha or IL-1 beta. Dinoprostone 4-8 interleukin 1 beta Homo sapiens 131-140 2784676-2 1989 IL-1 beta stimulated cellular proliferation and the synthesis of prostaglandin E2 and plasminogen activator activity by the cultured human osteoblast-like cells. Dinoprostone 65-81 interleukin 1 beta Homo sapiens 0-9 2784408-4 1989 In addition, IL-1 beta and TNF alpha were potent inducers of PGE2 production while exogenous PGE2 was growth inhibiting. Dinoprostone 61-65 interleukin 1 beta Homo sapiens 13-22 2784408-6 1989 Further examination of IL-1 beta- and TNF alpha-induced PGE2 secretion revealed IL-1 beta to be a more potent stimulator; however, this observation may be due, in part, to differences in the kinetics of induction. Dinoprostone 56-60 interleukin 1 beta Homo sapiens 23-32 2784408-6 1989 Further examination of IL-1 beta- and TNF alpha-induced PGE2 secretion revealed IL-1 beta to be a more potent stimulator; however, this observation may be due, in part, to differences in the kinetics of induction. Dinoprostone 56-60 interleukin 1 beta Homo sapiens 80-89 2784408-7 1989 Rabbit anti-IL-1 beta and anti-TNF alpha specifically neutralized both proliferation and PGE2 production induced by these monokines, but anti-IL-1 beta (or anti-IL-1 alpha) did not block TNF alpha activity. Dinoprostone 89-93 interleukin 1 beta Homo sapiens 12-21 2786697-5 1989 Glucocorticoids strongly inhibit and PGE2 slightly inhibits IL-1-induced IL-6 mRNA expression in synoviocytes. Dinoprostone 37-41 interleukin 1 beta Homo sapiens 60-64 3264290-5 1988 This stimulatory effect of IL-1 was observed only when IL-1-stimulated PGE2 synthesis was blocked by the cyclooxygenase inhibitor indomethacin. Dinoprostone 71-75 interleukin 1 beta Homo sapiens 55-59 2901097-1 1988 Human recombinant interleukin 1 alpha (IL-1 alpha) and IL-1 beta stimulated prostaglandin E2 synthesis in 3T3 fibroblasts in a time- and concentration-dependent manner. Dinoprostone 76-92 interleukin 1 beta Homo sapiens 55-64 3263855-4 1988 These data suggest that IL-1 and prostaglandin (mainly PGE2) may act synergistically to stimulate IL-1 gene expression in dermal fibroblasts, contributing as a local amplifier system to the alterations of connective tissue in inflammatory processes. Dinoprostone 55-59 interleukin 1 beta Homo sapiens 24-28 3263855-4 1988 These data suggest that IL-1 and prostaglandin (mainly PGE2) may act synergistically to stimulate IL-1 gene expression in dermal fibroblasts, contributing as a local amplifier system to the alterations of connective tissue in inflammatory processes. Dinoprostone 55-59 interleukin 1 beta Homo sapiens 98-102 3262792-7 1988 IL-1 alpha and IL-1 beta both induced a dose-related increase in prostaglandin E2, but only in the human fibroblasts. Dinoprostone 65-81 interleukin 1 beta Homo sapiens 15-24 2901097-2 1988 Enhanced prostaglandin E2 synthesis after IL-1 treatment was apparent by 1 hr and continued to increase for at least 2 days. Dinoprostone 9-25 interleukin 1 beta Homo sapiens 42-46 2901097-5 1988 In cells that had been pretreated with IL-1 for 24 hr, prostaglandin E2 synthesis in response to bradykinin was amplified more than 10-fold. Dinoprostone 55-71 interleukin 1 beta Homo sapiens 39-43 2901097-6 1988 IL-1 also amplified the receptor-mediated formation of prostaglandin E2 by bombesin and thrombin. Dinoprostone 55-71 interleukin 1 beta Homo sapiens 0-4 2901097-10 1988 Thus, IL-1 enhanced receptor-mediated release of prostaglandin E2 in response to bradykinin, bombesin, and thrombin by increasing the cellular levels of phospholipase A2, cyclooxygenase, and GTP-binding regulatory protein(s). Dinoprostone 49-65 interleukin 1 beta Homo sapiens 6-10 3497983-10 1987 EC stimulated with rIL-1 produced prostaglandin E2, which inhibits IL-1 production by other cell types and also decreases the responsiveness of thymocytes to IL-1. Dinoprostone 34-50 interleukin 1 beta Homo sapiens 20-24 3259598-4 1988 Antibodies recognizing the regions 133-148 and 251-269 of human IL-1 beta could inhibit the activity of IL-1 beta, but not of IL-1 alpha, in two different biologic assays, the murine thymocyte proliferation and PGE2 release from human fibroblasts. Dinoprostone 211-215 interleukin 1 beta Homo sapiens 64-73 3259598-4 1988 Antibodies recognizing the regions 133-148 and 251-269 of human IL-1 beta could inhibit the activity of IL-1 beta, but not of IL-1 alpha, in two different biologic assays, the murine thymocyte proliferation and PGE2 release from human fibroblasts. Dinoprostone 211-215 interleukin 1 beta Homo sapiens 104-113 3500170-8 1987 These cells were more responsive to the hIL-1 beta preparation than to the mIL-1 alpha (half-maximal stimulation of PGE2 production was observed at approximately 2.5-5 pM hIL-1 beta and at approximately 2.5 nM mIL-1 alpha). Dinoprostone 116-120 interleukin 1 beta Homo sapiens 40-50 3500170-8 1987 These cells were more responsive to the hIL-1 beta preparation than to the mIL-1 alpha (half-maximal stimulation of PGE2 production was observed at approximately 2.5-5 pM hIL-1 beta and at approximately 2.5 nM mIL-1 alpha). Dinoprostone 116-120 interleukin 1 beta Homo sapiens 171-181 2900159-4 1988 Moreover, administration of SP and IL-1 beta to human PDL fibroblasts in vitro for 1 to 60 minutes resulted in significant increases in the levels of the intracellular "second messenger" cAMP, as well as of PGE2, a plasma membrane-associated fatty acid believed to serve as a local regulator of bone cell activity. Dinoprostone 207-211 interleukin 1 beta Homo sapiens 35-44 3306235-1 1987 Il-1, a multifunctional monokine, can stimulate both synoviocytes and articular chondrocytes to release neutral proteases and prostaglandin E2. Dinoprostone 126-142 interleukin 1 beta Homo sapiens 0-4 3497983-10 1987 EC stimulated with rIL-1 produced prostaglandin E2, which inhibits IL-1 production by other cell types and also decreases the responsiveness of thymocytes to IL-1. Dinoprostone 34-50 interleukin 1 beta Homo sapiens 67-71 3497983-11 1987 When EC were exposed to rIL-1 in the presence of indomethacin (1 microgram/ml), which blocked prostaglandin E2 production, greater amounts of rIL-1-induced IL-1 release were detected, although the inhibitor did not affect IL-1-beta mRNA levels. Dinoprostone 94-110 interleukin 1 beta Homo sapiens 25-29 3516896-3 1986 We recently have presented data demonstrating that lipoxygenase derived leukotriene B4 and C4 can induce the release of IL-1 by macrophages, while PGE2 and PGI2 can suppress the production of IL-1. Dinoprostone 147-151 interleukin 1 beta Homo sapiens 192-196 3494764-0 1987 Augmentation of IL 1-induced fibroblast PGE2 production by a urine-derived IL 1 inhibitor. Dinoprostone 40-44 interleukin 1 beta Homo sapiens 16-20 2947968-1 1987 Native human IL-1 beta and IL-1 alpha stimulated prostaglandin E2 secretion by human embryonic lung fibroblasts at half-maximal concentrations of 3 +/- 1.2 pM (+/- SEM) and 10 +/- 2.3 pM, respectively. Dinoprostone 49-65 interleukin 1 beta Homo sapiens 13-22 2947968-6 1987 Comparison of the biological response curves and binding curves obtained for IL-1 alpha and IL-1 beta showed that they were parallel and that 10-15% occupancy of the estimated 3,000 sites by either species of IL-1 was sufficient to give half-maximal stimulation of prostaglandin E2 secretion. Dinoprostone 265-281 interleukin 1 beta Homo sapiens 92-101 2947968-6 1987 Comparison of the biological response curves and binding curves obtained for IL-1 alpha and IL-1 beta showed that they were parallel and that 10-15% occupancy of the estimated 3,000 sites by either species of IL-1 was sufficient to give half-maximal stimulation of prostaglandin E2 secretion. Dinoprostone 265-281 interleukin 1 beta Homo sapiens 77-81 3109443-0 1987 Interleukin-1 beta and interleukin-1 alpha stimulate the plasminogen activator activity and prostaglandin E2 levels of human synovial cells. Dinoprostone 92-108 interleukin 1 beta Homo sapiens 0-18 3109443-3 1987 We report here that samples of purified human interleukin-1 beta (IL-1 beta) and recombinant IL-1 alpha stimulate both the plasminogen activator activity and prostaglandin E2 levels of human synovial fibroblast-like cells. Dinoprostone 158-174 interleukin 1 beta Homo sapiens 46-64 3109443-3 1987 We report here that samples of purified human interleukin-1 beta (IL-1 beta) and recombinant IL-1 alpha stimulate both the plasminogen activator activity and prostaglandin E2 levels of human synovial fibroblast-like cells. Dinoprostone 158-174 interleukin 1 beta Homo sapiens 66-75 34055194-3 2021 The aim of this study was to elucidate the role of PPARgamma in interleukin-1beta- (IL-1beta-) induced cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) expression through ROS generation in OA chondrocytes. Dinoprostone 132-148 interleukin 1 beta Homo sapiens 64-81 34055194-3 2021 The aim of this study was to elucidate the role of PPARgamma in interleukin-1beta- (IL-1beta-) induced cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) expression through ROS generation in OA chondrocytes. Dinoprostone 150-154 interleukin 1 beta Homo sapiens 64-81 33441600-3 2021 We next demonstrated that KH176m selectively inhibited lipopolysaccharide (LPS) or interleukin-1beta (IL-1beta)-induced PGE2 production in control skin fibroblasts. Dinoprostone 120-124 interleukin 1 beta Homo sapiens 83-100 31678609-8 2020 Interleukin-1beta (IL-1beta; 1 ng/ml) enhanced COX-2 protein and PGE2 content in un-stretched tissues. Dinoprostone 65-69 interleukin 1 beta Homo sapiens 0-17 31953420-3 2020 Previously, we demonstrated that HST decreased interleukin 1beta-induced prostaglandin E2 production in human oral keratinocytes (HOKs) and OUM-induced mechanical or spontaneous pain in rats. Dinoprostone 73-89 interleukin 1 beta Homo sapiens 47-64 33117381-1 2020 The pro-inflammatory cytokine interleukin 1beta (IL-1beta) induces the synthesis of prostaglandin E2 by upregulating cyclooxygenase-2 (COX-2) in the synovial tissue of individuals with autoimmune diseases, such as rheumatoid arthritis (RA). Dinoprostone 84-100 interleukin 1 beta Homo sapiens 30-47 31678609-8 2020 Interleukin-1beta (IL-1beta; 1 ng/ml) enhanced COX-2 protein and PGE2 content in un-stretched tissues. Dinoprostone 65-69 interleukin 1 beta Homo sapiens 19-27 31810887-4 2020 Here we show that exposure of human gingival fibroblasts to IL-1beta increases expression of maintenance methyltransferase DNMT1 but decreases expression of de novo methyltransferase DNMT3a and the demethylating enzyme TET1, while exposure to PGE2 decreases expression of all three enzymes. Dinoprostone 243-247 interleukin 1 beta Homo sapiens 60-68 32420752-8 2020 A variety of pain-related substances released by glial cells such as the proinflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, interleukin-6, and prostaglandins such as prostaglandins E2 can also be reduced. Dinoprostone 189-206 interleukin 1 beta Homo sapiens 128-145 31765890-10 2020 Specifically, in GPx1 kd cells IL-1beta stimulation led to a dramatic shift of the PGE2/PGD2 ratio towards pro-inflammatory PGE2. Dinoprostone 83-87 interleukin 1 beta Homo sapiens 31-39 31785208-0 2020 Apigenin Reverses Interleukin-1beta-induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes. Dinoprostone 87-91 interleukin 1 beta Homo sapiens 18-35 31785208-5 2020 Intriguingly, Apg profoundly induced cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) gene expression in response to IL-1beta treatment. Dinoprostone 65-81 interleukin 1 beta Homo sapiens 120-128 31785208-5 2020 Intriguingly, Apg profoundly induced cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) gene expression in response to IL-1beta treatment. Dinoprostone 83-87 interleukin 1 beta Homo sapiens 120-128 31765890-10 2020 Specifically, in GPx1 kd cells IL-1beta stimulation led to a dramatic shift of the PGE2/PGD2 ratio towards pro-inflammatory PGE2. Dinoprostone 124-128 interleukin 1 beta Homo sapiens 31-39 31468982-7 2019 The results showed that juglanin dose-dependently suppressed PGE2, NO, MMP-1, MMP3, MMP13, TNF-alpha and IL-6 production induced by IL-1beta. Dinoprostone 61-65 interleukin 1 beta Homo sapiens 132-140 31293216-5 2019 Results: In vitro, astragaloside induced a dose-dependent inhibition of IL-1beta-induced the production of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), prostaglandin E2 (PGE2), expression of MMP 13 and ADAMTS-5, and the activation of NF-kappaB signaling. Dinoprostone 221-237 interleukin 1 beta Homo sapiens 72-80 31735077-9 2021 Meanwhile, silencing LINC01534 also significantly inhibited the productions of proinflammatory factors NO, PGE2, TNF-alpha, IL-6, and IL-8 in the IL-1beta-induced chondrocytes. Dinoprostone 107-111 interleukin 1 beta Homo sapiens 146-154 31497826-5 2019 In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes. Dinoprostone 103-119 interleukin 1 beta Homo sapiens 27-45 31497826-5 2019 In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes. Dinoprostone 103-119 interleukin 1 beta Homo sapiens 47-55 31293088-0 2019 Preconditioning with interleukin-1 beta and interferon-gamma enhances the efficacy of human umbilical cord blood-derived mesenchymal stem cells-based therapy via enhancing prostaglandin E2 secretion and indoleamine 2,3-dioxygenase activity in dextran sulfate sodium-induced colitis. Dinoprostone 172-188 interleukin 1 beta Homo sapiens 21-39 31497826-5 2019 In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes. Dinoprostone 121-125 interleukin 1 beta Homo sapiens 27-45 31497826-5 2019 In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes. Dinoprostone 121-125 interleukin 1 beta Homo sapiens 47-55 31293216-5 2019 Results: In vitro, astragaloside induced a dose-dependent inhibition of IL-1beta-induced the production of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), prostaglandin E2 (PGE2), expression of MMP 13 and ADAMTS-5, and the activation of NF-kappaB signaling. Dinoprostone 239-243 interleukin 1 beta Homo sapiens 72-80 30891836-5 2019 The results proved that isofraxidin attenuated the IL-1beta-induced significant increases in inflammatory mediators and cytokines including nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and IL-6. Dinoprostone 215-231 interleukin 1 beta Homo sapiens 51-59 30843219-7 2019 HQ prevented the interleukin (IL)-1beta-induced 8-isoprostane, and PGE2 production, but not IL-8 production of pulp cells. Dinoprostone 67-71 interleukin 1 beta Homo sapiens 17-39 30891836-5 2019 The results proved that isofraxidin attenuated the IL-1beta-induced significant increases in inflammatory mediators and cytokines including nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and IL-6. Dinoprostone 233-237 interleukin 1 beta Homo sapiens 51-59 31055848-9 2019 Vitexin suppressed IL-1beta-induced production of NO and prostaglandin E2 (PGE2 ) in chondrocytes culture. Dinoprostone 57-73 interleukin 1 beta Homo sapiens 19-27 31055848-9 2019 Vitexin suppressed IL-1beta-induced production of NO and prostaglandin E2 (PGE2 ) in chondrocytes culture. Dinoprostone 75-79 interleukin 1 beta Homo sapiens 19-27 31130634-4 2019 To deepen the modulatory effects of these molecules we studied: i) their influence on the synthesis of proinflammatory molecules (PGE2, IL-8, IL-6, MCP-1, and ICAM-1) in IL-1beta-treated myofibroblasts of the colon CCD-18Co cell line, and ii) the inhibitory potential of the formation of advanced glycation end products (AGEs). Dinoprostone 130-134 interleukin 1 beta Homo sapiens 170-178 31213577-5 2019 The IL-1beta-dependent up-regulation of inflammatory molecules including inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and IL-6 was attenuated by higenamine in NPCs. Dinoprostone 132-148 interleukin 1 beta Homo sapiens 4-12 31213577-5 2019 The IL-1beta-dependent up-regulation of inflammatory molecules including inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and IL-6 was attenuated by higenamine in NPCs. Dinoprostone 150-154 interleukin 1 beta Homo sapiens 4-12 30674535-0 2019 An ARC-Regulated IL1beta/Cox-2/PGE2/beta-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML. Dinoprostone 31-35 interleukin 1 beta Homo sapiens 17-24 30776647-4 2019 IL-1beta-induced NO and PGE2 production, as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression were also attenuated by oridonin. Dinoprostone 24-28 interleukin 1 beta Homo sapiens 0-8 31008484-5 2019 The results showed that, PGE2 increased interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) output, decreased chemokine (c-x-c motif) ligand 8 (CXCL8) output in a dose-dependent manner, but had no effect on IL-1beta and chemokine (c-c motif) ligand 2 (CCL-2) secretion of HUSMCs. Dinoprostone 25-29 interleukin 1 beta Homo sapiens 219-227 30674535-3 2019 Malignant cells have been reported to release IL1beta, which induces PGE2 synthesis in mesenchymal stromal cells (MSC), in turn activating beta-catenin signaling and inducing the cancer stem cell phenotype. Dinoprostone 69-73 interleukin 1 beta Homo sapiens 46-53 30674535-5 2019 Here, we report that AML-MSC cocultures greatly increase Cox-2 expression in MSC and PGE2 production in an ARC/IL1beta-dependent manner. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 111-118 31106534-8 2019 CONCLUSION: IL-1beta pretreatment enhanced the secretion of PGE2 and VEGF, and induced macrophage M2 polarization, which depended on COX-2-PGE2 signal pathway. Dinoprostone 60-64 interleukin 1 beta Homo sapiens 12-20 31106534-5 2019 RESULTS: IL-1beta pretreating ADMSCs increased the expression level of COX-2, enhanced PGE2 and VEGF secretions (P<0.05). Dinoprostone 87-91 interleukin 1 beta Homo sapiens 9-17 31106534-8 2019 CONCLUSION: IL-1beta pretreatment enhanced the secretion of PGE2 and VEGF, and induced macrophage M2 polarization, which depended on COX-2-PGE2 signal pathway. Dinoprostone 139-143 interleukin 1 beta Homo sapiens 12-20 30172103-5 2018 The results showed that treatment of abietic acid significantly inhibited IL-1beta-induced TNF-alpha, NO, PGE2 production, and COX-2 expression. Dinoprostone 106-110 interleukin 1 beta Homo sapiens 74-82 30661603-7 2019 Adding Statil or NS-398 to IL-1beta blunted PGF2alpha and PGE2 release, but did not alter IL-1beta effects on adipose tissue function markers. Dinoprostone 58-62 interleukin 1 beta Homo sapiens 27-35 30665457-4 2019 Effects on inhibiting IL-1beta-induced release of arachidonic acid (AA) and prostaglandin E2 (PGE2) were measured using SW982 synoviocyte cells. Dinoprostone 76-92 interleukin 1 beta Homo sapiens 22-30 30665457-4 2019 Effects on inhibiting IL-1beta-induced release of arachidonic acid (AA) and prostaglandin E2 (PGE2) were measured using SW982 synoviocyte cells. Dinoprostone 94-98 interleukin 1 beta Homo sapiens 22-30 30391743-5 2019 Casticin significantly inhibited IL-1beta-induced NO and PGE2 production, and iNOS and COX-2 expression in human OA chondrocytes. Dinoprostone 57-61 interleukin 1 beta Homo sapiens 33-41 30205322-5 2018 The results showed that IF blocked IL-1beta-stimulated production of NO and PGE2. Dinoprostone 76-80 interleukin 1 beta Homo sapiens 35-43 29356988-7 2018 Prostaglandin E2 (PGE2) was increased by IL-1beta on the third day, and angiopoietin-1 (Ang-1) was inhibited appreciably by TNF-alpha on the seventh day. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 41-49 30119184-6 2018 IL-1beta also efficiently induced the production of nitric oxide (NO), prostaglandin E2 (PGE2), MMP-3, MMP-13, ADAMTS-4 and ADAMTS-5 in chondrocytes. Dinoprostone 71-87 interleukin 1 beta Homo sapiens 0-8 30119184-6 2018 IL-1beta also efficiently induced the production of nitric oxide (NO), prostaglandin E2 (PGE2), MMP-3, MMP-13, ADAMTS-4 and ADAMTS-5 in chondrocytes. Dinoprostone 89-93 interleukin 1 beta Homo sapiens 0-8 30171593-11 2018 Prostaglandin E2 induces IL-17A independent of IL-23 via IL-1beta and IL-6. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 57-65 30126849-8 2018 Simultaneously, PVT1 inhibition also antagonized the production of inflammatory cytokines upon IL-1beta stimulation, including prostaglandin E2 (PGE2), NO, IL-6, IL-8 and TNF-alpha. Dinoprostone 127-143 interleukin 1 beta Homo sapiens 95-103 29356988-7 2018 Prostaglandin E2 (PGE2) was increased by IL-1beta on the third day, and angiopoietin-1 (Ang-1) was inhibited appreciably by TNF-alpha on the seventh day. Dinoprostone 18-22 interleukin 1 beta Homo sapiens 41-49 29894720-0 2018 LTB4 and PGE2 modulate the release of MIP-1alpha and IL-1beta by cells stimulated with Bothrops snake venoms. Dinoprostone 9-13 interleukin 1 beta Homo sapiens 53-61 29894720-4 2018 Recently, our group demonstrated that leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) regulate macrophage production of interleukin-1beta (IL-1beta) induced by scorpion venom. Dinoprostone 64-80 interleukin 1 beta Homo sapiens 122-139 29894720-4 2018 Recently, our group demonstrated that leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) regulate macrophage production of interleukin-1beta (IL-1beta) induced by scorpion venom. Dinoprostone 64-80 interleukin 1 beta Homo sapiens 141-149 29894720-4 2018 Recently, our group demonstrated that leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) regulate macrophage production of interleukin-1beta (IL-1beta) induced by scorpion venom. Dinoprostone 82-86 interleukin 1 beta Homo sapiens 122-139 29894720-4 2018 Recently, our group demonstrated that leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) regulate macrophage production of interleukin-1beta (IL-1beta) induced by scorpion venom. Dinoprostone 82-86 interleukin 1 beta Homo sapiens 141-149 28589946-0 2018 Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1beta-related lung injury. Dinoprostone 9-25 interleukin 1 beta Homo sapiens 63-80 29257341-6 2018 In conclusion, the present results demonstrated that carvacrol was able to inhibit IL-1beta-induced NO and PGE2 production, as well as iNOS, COX-2 and MMPs expression in human chondrocytes by suppressing the activation of NF-kappaB signaling pathway. Dinoprostone 107-111 interleukin 1 beta Homo sapiens 83-91 28942223-12 2017 We found that baicalin significantly inhibited the IL-1beta-induced production of NO and PGE2, expression of COX-2, iNOS, MMP-3, MMP-13 and ADAMTS-5 and degradation of aggrecan and collagen-II. Dinoprostone 89-93 interleukin 1 beta Homo sapiens 51-59 29168867-8 2018 In this study, we found that phloretin significantly inhibited the IL-1beta-induced production of NO, PGE2, TNF-alpha, and IL-6, the expression of COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5, and the degradation of aggrecan and collagen-II in human OA chondrocytes. Dinoprostone 102-106 interleukin 1 beta Homo sapiens 67-75 28856805-3 2017 Here, we investigated downstream effects of pro-inflammatory IL-1beta to induce cyclooxygenase-2 (COX2) and prostaglandin E2 (PGE2) production in white matter. Dinoprostone 108-124 interleukin 1 beta Homo sapiens 61-69 28756519-3 2017 Results demonstrated that Lico A treatment significantly inhibited PGE2 and NO production induced by IL-1beta. Dinoprostone 67-71 interleukin 1 beta Homo sapiens 101-109 28619001-11 2018 RESULTS: IL-1beta induced pronounced expression of COX-2 and iNOS, and stimulated production of prostaglandin E2 and nitric oxide. Dinoprostone 96-112 interleukin 1 beta Homo sapiens 9-17 29257281-5 2018 The results of the present study determined that PF inhibited the production of nitric oxide and prostaglandin E2 induced by IL-1beta, and the expression of inducible nitric oxide synthase and cyclooxygenase-2 in chondrocytes. Dinoprostone 97-113 interleukin 1 beta Homo sapiens 125-133 30504721-5 2018 RESULTS: The results revealed that IL-1beta significantly increased the production of NO, PGE2, MMP1, MMP3, and MMP13. Dinoprostone 90-94 interleukin 1 beta Homo sapiens 35-43 29763932-8 2018 RESULTS: In OA chondrocytes stimulated with IL-1beta, microvesicles and exosomes reduced the production of inflammatory mediators tumor necrosis factor-alpha, IL-6, PGE2 and NO. Dinoprostone 165-169 interleukin 1 beta Homo sapiens 44-52 27086951-7 2017 Moreover, IL-1beta also induced increased cyclooxygenase-2 expression in slanDCs, which in turn enabled the cells to secrete prostaglandin (PG)-E2. Dinoprostone 125-146 interleukin 1 beta Homo sapiens 10-18 28856805-3 2017 Here, we investigated downstream effects of pro-inflammatory IL-1beta to induce cyclooxygenase-2 (COX2) and prostaglandin E2 (PGE2) production in white matter. Dinoprostone 126-130 interleukin 1 beta Homo sapiens 61-69 28666239-9 2017 We found that CTS significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5. Dinoprostone 84-88 interleukin 1 beta Homo sapiens 46-54 28701056-6 2017 IL-1beta stimulation induced an inflammatory response with a significant increase in the secretion of PGE2, IL-6, IL-8 and MMP-1. Dinoprostone 102-106 interleukin 1 beta Homo sapiens 0-8 28701056-7 2017 Treatment of IL-1beta stimulated fibroblasts in combination with PHMG-P or CHX at concentrations of 0.000045 or 0.0.00009% resulted in significantly decreased PGE2, IL-6, IL-8 and MMP-1 levels. Dinoprostone 159-163 interleukin 1 beta Homo sapiens 13-21 28952621-8 2017 We found that OL significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-13, and ADAMTS-5; and degradation of aggrecan and collagen-II. Dinoprostone 83-87 interleukin 1 beta Homo sapiens 45-53 28536017-8 2017 On horse and human chondrocytes, they reduced the IL-1beta-induced liberation of NO and PGE2, and on RAW 264.7 immortalized macrophage-like cell line, C4S, C6S, Ch and Sk-CS decreased the LPS-induced liberation of TNF-alpha, but did not affect IL-6. Dinoprostone 88-92 interleukin 1 beta Homo sapiens 50-58 28731170-5 2017 Pretreatment with ISH inhibited the IL-1beta-stimulated synthesis of NO and prostaglandin E2 induced by IL-1beta, in addition to the expression of inducible nitric oxide synthase and prostaglandin G/H synthase 2 in chondrocytes. Dinoprostone 76-92 interleukin 1 beta Homo sapiens 36-44 28731170-5 2017 Pretreatment with ISH inhibited the IL-1beta-stimulated synthesis of NO and prostaglandin E2 induced by IL-1beta, in addition to the expression of inducible nitric oxide synthase and prostaglandin G/H synthase 2 in chondrocytes. Dinoprostone 76-92 interleukin 1 beta Homo sapiens 104-112 29179489-7 2017 The results showed that SSa inhibited IL-1beta-induced PGE2 and NO production in a concentration-dependent manner. Dinoprostone 55-59 interleukin 1 beta Homo sapiens 38-46 28887458-4 2017 Incubation of IL-1beta stimulated healthy tendon cells with 15-epi-LXA4 or MaR1 down-regulated PGE2 and PGD2 production. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 14-22 28586061-7 2017 The results indicated that CGA reversed IL-1beta-induced increases in iNOS/NO, IL-6, MMP-13 and COX-2/PGE2 production, and reversed the IL-1beta-mediated downregulation of collagen II. Dinoprostone 102-106 interleukin 1 beta Homo sapiens 40-48 28422402-4 2017 Our results showed that GP dose-dependently inhibited IL-1beta-induced NO and PGE2 production in human OA chondrocytes. Dinoprostone 78-82 interleukin 1 beta Homo sapiens 54-62 28364187-9 2017 We found that chrysin significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5; and degradation of aggrecan and collagen-II. Dinoprostone 88-92 interleukin 1 beta Homo sapiens 50-58 28684418-7 2017 The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and IL-6 release in HG+IL-1beta-treated cells than in NG+IL-1beta-treated cells. Dinoprostone 70-74 interleukin 1 beta Homo sapiens 98-106 28588495-1 2017 The history of what, in 1979, was called interleukin-1 (IL-1), orchestrator of leukocyte inter-communication, began many years before then, initially by the observation of fever induction via the endogenous pyrogen (EP) (1974) and then in rheumatology on the role in tissue destruction in rheumatoid diseases via the induction of collagenase and PGE2 in human synovial cells by a mononuclear cell factor (MCF) (1977). Dinoprostone 346-350 interleukin 1 beta Homo sapiens 56-60 28915567-10 2017 NFAT5 depletion mimicked the suppressive effects of melatonin on IL-1beta-elevated production of inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), IL-1beta, prostaglandin E2 (PGE2), and nitric oxide (NO) in chondrocytes. Dinoprostone 200-204 interleukin 1 beta Homo sapiens 65-73 28168658-10 2017 We found that plumbagin significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-3, and MMP-13; and degradation of aggrecan and collagen-II. Dinoprostone 90-94 interleukin 1 beta Homo sapiens 52-60 27515563-5 2016 Here, we showed that EGCG inhibits COX-2 mRNA/protein expression or prostaglandin E2 (PGE2 ) production via up-regulating microRNA hsa-miR-199a-3p expression in interleukin (IL)-1beta-stimulated human OA chondrocytes. Dinoprostone 68-84 interleukin 1 beta Homo sapiens 161-183 28298525-0 2017 The Induction of Pro-IL-1beta by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production. Dinoprostone 72-88 interleukin 1 beta Homo sapiens 17-29 28298525-1 2017 PGE2 has been shown to increase the transcription of pro-IL-1beta. Dinoprostone 0-4 interleukin 1 beta Homo sapiens 53-65 28298525-2 2017 However, recently it has been demonstrated that PGE2 can block the maturation of IL-1beta by inhibiting the NLRP3 inflammasome in macrophages. Dinoprostone 48-52 interleukin 1 beta Homo sapiens 81-89 28298525-3 2017 These apparently conflicting results have led us to reexamine the effect of PGE2 on IL-1beta production. Dinoprostone 76-80 interleukin 1 beta Homo sapiens 84-92 28298525-4 2017 We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha. Dinoprostone 62-66 interleukin 1 beta Homo sapiens 199-207 28298525-6 2017 We also examined the effect of endogenously produced PGE2 on IL-1beta production. Dinoprostone 53-57 interleukin 1 beta Homo sapiens 61-69 28298525-7 2017 By blocking PGE2 production with indomethacin, we made a striking finding that endogenous PGE2 is essential for LPS-induced pro-IL-1beta production, suggesting a positive feedback loop. Dinoprostone 12-16 interleukin 1 beta Homo sapiens 124-136 28298525-7 2017 By blocking PGE2 production with indomethacin, we made a striking finding that endogenous PGE2 is essential for LPS-induced pro-IL-1beta production, suggesting a positive feedback loop. Dinoprostone 90-94 interleukin 1 beta Homo sapiens 124-136 28298525-9 2017 In primary human monocytes, where LPS alone is sufficient to induce mature IL-1beta, PGE2 boosted LPS-induced IL-1beta production. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 75-83 28298525-9 2017 In primary human monocytes, where LPS alone is sufficient to induce mature IL-1beta, PGE2 boosted LPS-induced IL-1beta production. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 110-118 28298525-11 2017 Because PGE2 mediates the pyrogenic effect of IL-1beta, these effects might be especially relevant for the role of monocytes in the induction of fever. Dinoprostone 8-12 interleukin 1 beta Homo sapiens 46-54 28298525-12 2017 A positive feedback loop from IL-1beta and back to PGE2, which itself is induced by IL-1beta, is likely to be operating. Dinoprostone 51-55 interleukin 1 beta Homo sapiens 30-38 28298525-12 2017 A positive feedback loop from IL-1beta and back to PGE2, which itself is induced by IL-1beta, is likely to be operating. Dinoprostone 51-55 interleukin 1 beta Homo sapiens 84-92 28386088-4 2017 Further study in human amnion fibroblasts showed that SAA1 production was augmented by interleukin-1beta (IL-1beta) and cortisol alone and synergistically, and SAA1 in turn induced the expression of IL-1beta, interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and PGE2 production. Dinoprostone 260-264 interleukin 1 beta Homo sapiens 87-104 28386088-4 2017 Further study in human amnion fibroblasts showed that SAA1 production was augmented by interleukin-1beta (IL-1beta) and cortisol alone and synergistically, and SAA1 in turn induced the expression of IL-1beta, interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and PGE2 production. Dinoprostone 260-264 interleukin 1 beta Homo sapiens 199-207 28054591-1 2017 The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. Dinoprostone 66-82 interleukin 1 beta Homo sapiens 29-46 28054591-1 2017 The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. Dinoprostone 66-82 interleukin 1 beta Homo sapiens 48-56 28054591-1 2017 The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. Dinoprostone 84-88 interleukin 1 beta Homo sapiens 29-46 28054591-1 2017 The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. Dinoprostone 84-88 interleukin 1 beta Homo sapiens 48-56 28054591-4 2017 In the presence of MAPK inhibitors, IL-1beta-induced COX-2 expression and PGE2 release were both attenuated. Dinoprostone 74-78 interleukin 1 beta Homo sapiens 36-44 28054591-11 2017 These observations suggest that JNK1 phosphorylation is necessary for the activation of the MEK/ERK1/2 pathway and the subsequent COX-2 expression for PGE2 release, and p38 independently contributes to the IL-1beta effect in synovial fibroblasts. Dinoprostone 151-155 interleukin 1 beta Homo sapiens 206-214 28296552-5 2017 We found that siRNA-mediated SOCS3 knock-down in human osteoarthritic chondrocytes increased production of IL-1beta-induced prostaglandin E2, cell growth, transcript level and nuclear translocation of cyclin D1. Dinoprostone 124-140 interleukin 1 beta Homo sapiens 107-115 27863411-3 2016 Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1beta. Dinoprostone 68-72 interleukin 1 beta Homo sapiens 102-110 27734234-6 2017 MFN inhibited IL-1beta-induced inflammatory mediators PGE2 and NO production. Dinoprostone 54-58 interleukin 1 beta Homo sapiens 14-22 27863298-10 2017 We found that butein significantly inhibited the IL-1beta-induced production of NO and PGE2, expression of COX-2, iNOS, TNF-alpha, IL-6 and MMP-13, degradation of COL-2 and SOX-9 at mRNA and protein levels as well as MMP-1, MMP-3, ADAMTS-4 and ADAMTS-5 gene expression. Dinoprostone 87-91 interleukin 1 beta Homo sapiens 49-57 27515563-9 2016 EGCG treatment consistently up-regulated the IL-1beta-decreased hsa-miR-199a-3p expression (P < 0.05) and significantly inhibited the IL-1beta-induced COX-2 expression/PGE2 production (P < 0.05) in OA chondrocytes transfected with anti-hsa-miR-199a-3p. Dinoprostone 171-175 interleukin 1 beta Homo sapiens 45-53 27515563-9 2016 EGCG treatment consistently up-regulated the IL-1beta-decreased hsa-miR-199a-3p expression (P < 0.05) and significantly inhibited the IL-1beta-induced COX-2 expression/PGE2 production (P < 0.05) in OA chondrocytes transfected with anti-hsa-miR-199a-3p. Dinoprostone 171-175 interleukin 1 beta Homo sapiens 137-145 26997368-8 2016 Our results showed that SchA inhibited IL-1beta-induced NO, PGE2, and TNF-alpha production in a dose-dependent manner. Dinoprostone 60-64 interleukin 1 beta Homo sapiens 39-47 27743553-6 2016 The results showed that PYD significantly inhibited IL-1beta-induced MMP1, MMP13, IL-8, RANTES, PGE2, and NO production. Dinoprostone 96-100 interleukin 1 beta Homo sapiens 52-60 27512095-6 2016 Results demonstrated that either IL-1beta or HMGB1 promoted the release of the inflammatory cytokines such as prostaglandin E2 (PGE2), TNF-alpha, IL-6 and IL-8 in human IVD cells. Dinoprostone 110-126 interleukin 1 beta Homo sapiens 33-41 27512095-6 2016 Results demonstrated that either IL-1beta or HMGB1 promoted the release of the inflammatory cytokines such as prostaglandin E2 (PGE2), TNF-alpha, IL-6 and IL-8 in human IVD cells. Dinoprostone 128-132 interleukin 1 beta Homo sapiens 33-41 27484716-8 2016 The levels of prostaglandin E2 in orbital fibroblasts induced by IL-1beta were also suppressed by celastrol. Dinoprostone 14-30 interleukin 1 beta Homo sapiens 65-73 27771306-3 2016 We found that the overexpression of HMGB1 A-box significantly decreased the IL-1beta-stimulated the production of MMP-1, MMP-3 and MMP-9, and also reduced the elevated levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) associated with the inhibition of prostaglandin E2 (PGE2) and nitric oxide (NO) production in IL-1beta-stimulated chondrocytes. Dinoprostone 280-296 interleukin 1 beta Homo sapiens 76-84 27771306-3 2016 We found that the overexpression of HMGB1 A-box significantly decreased the IL-1beta-stimulated the production of MMP-1, MMP-3 and MMP-9, and also reduced the elevated levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) associated with the inhibition of prostaglandin E2 (PGE2) and nitric oxide (NO) production in IL-1beta-stimulated chondrocytes. Dinoprostone 298-302 interleukin 1 beta Homo sapiens 76-84 29732384-7 2016 Our results indicated that pre-activation of MSCs with IL-1beta resulted in upregulated PGE2 secretion post exposure. Dinoprostone 88-92 interleukin 1 beta Homo sapiens 55-63 27181326-13 2016 This sensitization is likely initiated by cyclo-oxygenase-2 dependent synthesis of prostaglandin E2, which is stimulated by elevated levels of IL-1beta or IL-6. Dinoprostone 83-99 interleukin 1 beta Homo sapiens 143-151 27313839-6 2016 RESULTS: ESE-1 and COX-2 were induced by IL-1beta in RASFs that corresponded with an increase in PGE2. Dinoprostone 97-101 interleukin 1 beta Homo sapiens 41-49 27102898-6 2016 It also inhibited the IL-1beta-induced expression of inducible nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the production of NO and prostaglandin E2 (PGE2) in human OA chondrocytes. Dinoprostone 163-179 interleukin 1 beta Homo sapiens 22-30 26155780-2 2016 In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1beta-stimulated SK-N-SH cells. Dinoprostone 83-87 interleukin 1 beta Homo sapiens 102-110 26155780-3 2016 METHODS: An enzyme immunoassay (EIA) was used to measure prostaglandin E2 (PGE2) production from supernatants of IL-1beta-stimulated SK-N-SH cells. Dinoprostone 57-73 interleukin 1 beta Homo sapiens 113-121 26155780-3 2016 METHODS: An enzyme immunoassay (EIA) was used to measure prostaglandin E2 (PGE2) production from supernatants of IL-1beta-stimulated SK-N-SH cells. Dinoprostone 75-79 interleukin 1 beta Homo sapiens 113-121 26155780-6 2016 RESULTS: PWE (25-200 mug/ml) dose dependently reduced COX-2-dependent PGE2 production in SK-N-SH cells stimulated with IL-1beta. Dinoprostone 70-74 interleukin 1 beta Homo sapiens 119-127 27102898-6 2016 It also inhibited the IL-1beta-induced expression of inducible nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the production of NO and prostaglandin E2 (PGE2) in human OA chondrocytes. Dinoprostone 181-185 interleukin 1 beta Homo sapiens 22-30 27107084-9 2016 Hangeshashinto potently inhibited PGE2 production by interleukin (IL)-1beta-stimulated HPLFs and HGFs. Dinoprostone 34-38 interleukin 1 beta Homo sapiens 53-75 26846886-8 2016 The results showed that treatment of TEN significantly inhibited IL-1beta-induced NO and PGE2 production. Dinoprostone 89-93 interleukin 1 beta Homo sapiens 65-73 27034605-10 2016 Moreover, Bay 11-7082 also inhibited IL-1beta-induced expression of COX-2 and production of PGE2. Dinoprostone 92-96 interleukin 1 beta Homo sapiens 37-45 26499345-7 2016 The results showed that EA suppressed IL-1beta-induced collagenase-3 (MMP-13), NO, and PGE2 production in a dose-dependent manner. Dinoprostone 87-91 interleukin 1 beta Homo sapiens 38-46 27034605-11 2016 The inhibitory effect of lactoferrin on the IL-1beta induced expression of COX-2 or production of PGE2 was mediated at least in part via suppression of NF-kappaB activation. Dinoprostone 98-102 interleukin 1 beta Homo sapiens 44-52 26565141-4 2016 IL-1beta-treated disc organ cultures showed a statistically significant upregulation of proinflammatory markers (IL-6, IL-8, prostaglandin E2 [PGE2]) and metalloproteases (MMP1, MMP3) expression, while extracellular matrix (ECM) proteins (collagen II, aggrecan) were significantly downregulated. Dinoprostone 125-141 interleukin 1 beta Homo sapiens 0-8 26707272-8 2016 MF also attenuated the IL-1beta-induced production of NO and PGE2, and reduced iNOS and COX-2 expression. Dinoprostone 61-65 interleukin 1 beta Homo sapiens 23-31 27073697-3 2016 IL-1beta activates key degradative enzymes, including MMPs and aggrecanases, and other proinflammatory mediators such as PGE2 which contribute to ECM breakdown. Dinoprostone 121-125 interleukin 1 beta Homo sapiens 0-8 27807462-5 2016 Baseline and IL-1beta-induced secretion of PGE2 was inhibited by treatment with essential oil from O. gratissimum. Dinoprostone 43-47 interleukin 1 beta Homo sapiens 13-21 27807462-6 2016 Essential oils from B. pilosa and C. nardus had synergistic effects with IL-1beta on PGE2 seceretion. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 73-81 26565141-4 2016 IL-1beta-treated disc organ cultures showed a statistically significant upregulation of proinflammatory markers (IL-6, IL-8, prostaglandin E2 [PGE2]) and metalloproteases (MMP1, MMP3) expression, while extracellular matrix (ECM) proteins (collagen II, aggrecan) were significantly downregulated. Dinoprostone 143-147 interleukin 1 beta Homo sapiens 0-8 26391061-6 2015 The results showed that BA dose-dependently inhibited IL-1beta-induced MMP-1, MMP-3, MMP-13, PGE2 and NO productions. Dinoprostone 93-97 interleukin 1 beta Homo sapiens 54-62 26403276-0 2015 The stellate vascular smooth muscle cell phenotype is induced by IL-1beta via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 65-73 26403276-6 2015 Experiments in the presence of IL-1beta or medium conditioned by IL-1beta-treated VSMCs and pharmacological tools demonstrated that the long-term increase in intracellular cAMP concentration was induced by the secretion of an autocrine/paracrine mediator, prostaglandin E2(PGE2), acting through the EP4 receptor. Dinoprostone 256-272 interleukin 1 beta Homo sapiens 65-73 26403276-6 2015 Experiments in the presence of IL-1beta or medium conditioned by IL-1beta-treated VSMCs and pharmacological tools demonstrated that the long-term increase in intracellular cAMP concentration was induced by the secretion of an autocrine/paracrine mediator, prostaglandin E2(PGE2), acting through the EP4 receptor. Dinoprostone 273-277 interleukin 1 beta Homo sapiens 65-73 26443270-6 2015 SF attenuated IL-1beta-induced expression and activity of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and also reduced the elevated levels of cyclooxygenase-2 and inducible nitric oxide synthase associated with the inhibition of prostaglandin E2 and nitric oxide production in IL-1beta-stimulated SW1353 chondrocytes. Dinoprostone 237-253 interleukin 1 beta Homo sapiens 14-22 26156811-5 2015 The results demonstrated that thymoquinone concentration-dependently inhibited IL-1beta-induced COX-2, iNOS, NO, and PGE2 production. Dinoprostone 117-121 interleukin 1 beta Homo sapiens 79-87 26162701-5 2015 The results showed that farrerol remarkably inhibited IL-1beta-induced NO and PGE2 production, as well as COX-2 and iNOS expression. Dinoprostone 78-82 interleukin 1 beta Homo sapiens 54-62 26175191-4 2015 Incubation of DCs with IL-1beta decreased PR expression and significantly increased PGE2 and PGF2alpha production and COX-2 expression. Dinoprostone 84-88 interleukin 1 beta Homo sapiens 23-31 26216515-7 2015 This occurs via IL-1beta-primed secretion of PGE2 and activates T-cell intrinsic regulatory mechanisms (SOCS2, GADD45A). Dinoprostone 45-49 interleukin 1 beta Homo sapiens 16-24 25987541-8 2015 RESULTS: With IL-1beta stimulation, IL-6 and PGE2 release was greater in human DM than non-DM OA cartilage (2.7- and 3-fold, respectively) (P < 0.05). Dinoprostone 45-49 interleukin 1 beta Homo sapiens 14-22 26292179-5 2015 The presence of IL-1beta determined a significant increase (P<0.001) in PGE2 levels measured by an ELISA assay, and in COX-2 and MMP-3, -9, and -13 gene expression analyzed by RT-PCR. Dinoprostone 75-79 interleukin 1 beta Homo sapiens 16-24 25865800-4 2015 Activation of human MoDC resulted in the release of TNFalpha and IL-1beta that in turn stimulated MMP-1 (human collagenase) and PGE2 secretion by human dermal fibroblasts. Dinoprostone 128-132 interleukin 1 beta Homo sapiens 65-73 25992485-3 2015 IL-1beta, COX-2-dependent PGE2 activated the PI3-K/AKT and p38 signaling pathways, which were in turn responsible for MMP-1 synthesis via NF-kappaB- and c-Jun-transactivating pathways. Dinoprostone 26-30 interleukin 1 beta Homo sapiens 0-8 26156631-8 2015 RESULTS: This study demonstrates that IL-1beta mimics some aspects of tendinopathies with PGE2 induction, MMP expression (mostly MMP1 and MMP3), and increases of type III/I collagen ratio. Dinoprostone 90-94 interleukin 1 beta Homo sapiens 38-46 25913073-4 2015 TiO2 NPs significantly enhanced the IL-1beta-induced prostaglandin E2 production and COX-1 and COX-2 protein expression. Dinoprostone 53-69 interleukin 1 beta Homo sapiens 36-44 25872797-9 2015 Our results revealed that H2S markedly reversed the effects of IL-1beta on the gene expression of COX-2, MMP-13 and iNOS and on the production of MMP-13, PGE2 and NO. Dinoprostone 154-158 interleukin 1 beta Homo sapiens 63-71 25917098-11 2015 Additionally, constitutive IL-1beta secretion from LPS-primed PBMCs of cryopyrin-associated periodic fever syndromes patients was substantially reduced by high doses of PGE2. Dinoprostone 169-173 interleukin 1 beta Homo sapiens 27-35 25958832-7 2015 The screen revealed that LPS and IL-1beta potently activated monolayer MSCs to enhance PGE2 production and attenuate macrophage TNF-alpha. Dinoprostone 87-91 interleukin 1 beta Homo sapiens 33-41 25958832-8 2015 Activation by LPS and IL-1beta together synergistically increased MSC PGE2, but did not synergistically reduce macrophage TNF-alpha. Dinoprostone 70-74 interleukin 1 beta Homo sapiens 22-30 25797286-8 2015 Our results demonstrated that taraxasterol dose-dependently suppressed MMP-1, MMP3, MMP13, PGE2 and NO production induced by IL-1beta. Dinoprostone 91-95 interleukin 1 beta Homo sapiens 125-133 26191174-5 2015 We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta). Dinoprostone 74-90 interleukin 1 beta Homo sapiens 109-127 26191174-5 2015 We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta). Dinoprostone 74-90 interleukin 1 beta Homo sapiens 129-137 26191174-5 2015 We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta). Dinoprostone 92-96 interleukin 1 beta Homo sapiens 109-127 26191174-5 2015 We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta). Dinoprostone 92-96 interleukin 1 beta Homo sapiens 129-137 25319133-4 2014 The exposure of HEI-OC1 cells to IL-1beta increased COX-2 protein and mRNA expression, COX-2 promoter-driven luciferase activity and COX-2 enzymatic activity [as indicated by the increased production of prostaglandin E2 (PGE2), a major COX-2 metabolite]. Dinoprostone 203-219 interleukin 1 beta Homo sapiens 33-41 25687411-7 2015 KLF5 silencing in myometrial cells significantly decreased IL1beta-induced cytokine expression (IL6 and IL8 mRNA expression and release), COX2 mRNA expression, and subsequent release of prostaglandins PGE2 and PGF2 alpha. Dinoprostone 201-205 interleukin 1 beta Homo sapiens 59-66 25976054-4 2015 RESULTS: A dose of 2.5 microg/L IL-1beta induced the protein expressions of cPLA2 and COX-2 and a subsequent release of PGE2 in a time-dependent manner. Dinoprostone 120-124 interleukin 1 beta Homo sapiens 32-40 25976054-7 2015 Both SB203580 and PD98059 inhibitors reduced IL-1beta-induced PGE2 production while SB203580 alone reduced the expressions of both cPLA2 and COX-2. Dinoprostone 62-66 interleukin 1 beta Homo sapiens 45-53 25976054-8 2015 CONCLUSION: IL-1beta induces the expressions of cPLA2 and COX-2 and affects COX-2 at the post-translational level by modulating PGE2 production through the signal transduction pathways of p38 and p42/44 MAPKs. Dinoprostone 128-132 interleukin 1 beta Homo sapiens 12-20 25637445-6 2015 We found that astragalin dose-dependently inhibited IL-1beta-induced NO and PGE2 production, as well as iNOS and COX-2 expression. Dinoprostone 76-80 interleukin 1 beta Homo sapiens 52-60 25637445-9 2015 The inhibition of astragalin on IL-1beta-induced NO and PGE2 production can be reversed by PPAR-gamma antagonist GW9662. Dinoprostone 56-60 interleukin 1 beta Homo sapiens 32-40 25041143-7 2015 Among many other potential actions, IL-1beta increases cyclooxygenase-2 expression leading to local increases in inflammatory mediators such as prostaglandin E2 (PGE2). Dinoprostone 144-160 interleukin 1 beta Homo sapiens 36-44 25041143-7 2015 Among many other potential actions, IL-1beta increases cyclooxygenase-2 expression leading to local increases in inflammatory mediators such as prostaglandin E2 (PGE2). Dinoprostone 162-166 interleukin 1 beta Homo sapiens 36-44 25446010-7 2015 BRE inhibited TNF-alpha/IL-1beta-induced NFkappaB p65 nuclear translocation, PGE2 production, up-regulation of COX-2, ICAM-1 and VCAM-1 gene and protein expression and leukocyte binding in HEMEC but not in HIMEC. Dinoprostone 77-81 interleukin 1 beta Homo sapiens 24-32 25319133-4 2014 The exposure of HEI-OC1 cells to IL-1beta increased COX-2 protein and mRNA expression, COX-2 promoter-driven luciferase activity and COX-2 enzymatic activity [as indicated by the increased production of prostaglandin E2 (PGE2), a major COX-2 metabolite]. Dinoprostone 221-225 interleukin 1 beta Homo sapiens 33-41 25319133-5 2014 However, PDN markedly inhibited the IL-1beta-induced COX-2 protein and mRNA expression, COX-2 promoter activity and PGE2 production in the HEI-OC1 cells without affecting COX-2 protein and mRNA stability. Dinoprostone 116-120 interleukin 1 beta Homo sapiens 36-44 25266361-9 2014 Maximal PGE2 release involved IL-1beta priming of MSCs after close contact between the NK cells and UC-MSCs. Dinoprostone 8-12 interleukin 1 beta Homo sapiens 30-38 24671668-0 2014 Sulforaphane inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of MMPs, COX-2, and PGE2. Dinoprostone 137-141 interleukin 1 beta Homo sapiens 22-30 24671668-1 2014 This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs. Dinoprostone 270-286 interleukin 1 beta Homo sapiens 66-83 24671668-1 2014 This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs. Dinoprostone 270-286 interleukin 1 beta Homo sapiens 85-93 24671668-1 2014 This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs. Dinoprostone 288-292 interleukin 1 beta Homo sapiens 66-83 24671668-1 2014 This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs. Dinoprostone 288-292 interleukin 1 beta Homo sapiens 85-93 24671668-4 2014 Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta. Dinoprostone 148-152 interleukin 1 beta Homo sapiens 39-47 24671668-4 2014 Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta. Dinoprostone 148-152 interleukin 1 beta Homo sapiens 175-183 25122505-4 2014 In addition, its effect on IL-1beta-induced prostaglandin E2 (PGE2) production by fibroblasts was determined. Dinoprostone 44-60 interleukin 1 beta Homo sapiens 27-35 24975660-6 2014 RESULTS: We found a significant reduction of IL-1beta induced PGE2, 8-iso-PGF2beta and IL-6 chondrocytes by 5-HT(3)RA especially by dolasetron. Dinoprostone 62-66 interleukin 1 beta Homo sapiens 45-53 25122505-4 2014 In addition, its effect on IL-1beta-induced prostaglandin E2 (PGE2) production by fibroblasts was determined. Dinoprostone 62-66 interleukin 1 beta Homo sapiens 27-35 25122505-8 2014 It also inhibited IL-1beta-induced PGE2 production, but not COX-2 expression of fibroblasts. Dinoprostone 35-39 interleukin 1 beta Homo sapiens 18-26 24346509-9 2014 RESULTS: Pretreatment with cordycepin significantly inhibited the production of PGE2 and NO induced by IL-1beta. Dinoprostone 80-84 interleukin 1 beta Homo sapiens 103-111 23953749-7 2014 FOXM1 silencing in primary amnion cells increased interleukin (IL)-1beta-induced pro-inflammatory cytokines (IL-6 and IL-8 mRNA expression and secretion), cyclooxygenase (COX)-2 expression and subsequent prostaglandin (PG)E2 and PGF2alpha release as well as gene expression and secretion of the matrix-degrading enzyme matrix metalloproteinase 9 (MMP-9). Dinoprostone 204-224 interleukin 1 beta Homo sapiens 50-72 24982221-9 2014 Interleukin-1beta (3 ng/ml) stimulated HGF, but not HPC cells to produce PGE2 in the culture medium. Dinoprostone 73-77 interleukin 1 beta Homo sapiens 0-17 24982223-3 2014 Rikkosan alone did not induce prostaglandin E2 (PGE2) production, but inhibited interleukin-1beta (IL-1beta) (5 ng/ml)-stimulated PGE2 production in human gingival fibroblasts and human periodontal ligament fibroblasts, with a selectivity index higher than 4.0 and 4.3, respectively. Dinoprostone 130-134 interleukin 1 beta Homo sapiens 80-97 24982223-3 2014 Rikkosan alone did not induce prostaglandin E2 (PGE2) production, but inhibited interleukin-1beta (IL-1beta) (5 ng/ml)-stimulated PGE2 production in human gingival fibroblasts and human periodontal ligament fibroblasts, with a selectivity index higher than 4.0 and 4.3, respectively. Dinoprostone 130-134 interleukin 1 beta Homo sapiens 99-107 24982223-8 2014 These results demonstrated that Rikkosan inhibited both IL-1beta production by LPS-activated macrophages and PGE2 production by IL-1beta-stimulated human gingival fibroblasts and human periodontal ligament fibroblasts, suggesting that anti-inflammatory effects of Rikkosan may partially be generated by the inhibition of these pro-inflammatory substances via the IL-1beta network through macrophages to oral tissue cells. Dinoprostone 109-113 interleukin 1 beta Homo sapiens 128-136 24982223-8 2014 These results demonstrated that Rikkosan inhibited both IL-1beta production by LPS-activated macrophages and PGE2 production by IL-1beta-stimulated human gingival fibroblasts and human periodontal ligament fibroblasts, suggesting that anti-inflammatory effects of Rikkosan may partially be generated by the inhibition of these pro-inflammatory substances via the IL-1beta network through macrophages to oral tissue cells. Dinoprostone 109-113 interleukin 1 beta Homo sapiens 128-136 24858301-5 2014 Moreover, HA/sorbitol stifled IL-1beta-induced metalloproteinase-13, nitric oxide (NO) and prostaglandin E2 release as well as inducible NO synthase expression. Dinoprostone 91-107 interleukin 1 beta Homo sapiens 30-38 24674991-12 2014 Knockout cells also maintained their ability to increase PGE2 production in response to IL-1beta. Dinoprostone 57-61 interleukin 1 beta Homo sapiens 88-96 24792209-9 2014 Gel-200 inhibited IL-1beta-induced production of MMP-1, 3 and 13 in human chondrocytes and production of prostaglandin E2 in human synoviocytes in a concentration-dependent manner, respectively. Dinoprostone 105-121 interleukin 1 beta Homo sapiens 18-26 23931157-4 2014 The co-incubation of the cells with Ind, at a nutritionally relevant concentration (5-25 muM), and IL-1beta prevented the release of the pro-inflammatory cytokines IL-6 and IL-8, PGE2 and NO, the formation of ROS and the loss of thiols in a dose-dependent manner. Dinoprostone 179-183 interleukin 1 beta Homo sapiens 99-107 24286238-9 2014 In amnion cells, SLIT3 siRNA knockdown decreased IL-1beta-induced COX-2 expression and prostaglandin PGE2 release. Dinoprostone 87-105 interleukin 1 beta Homo sapiens 49-57 24491645-0 2014 Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL-1beta-stimulated SK-N-SH neuronal cells. Dinoprostone 32-36 interleukin 1 beta Homo sapiens 100-108 24491645-2 2014 In this study we have investigated the effects of an extract obtained from the seeds of Picralima nitida (PNE) on PGE2 production in IL-1beta-stimulated cells. Dinoprostone 114-118 interleukin 1 beta Homo sapiens 133-141 24491645-3 2014 MATERIALS AND METHODS: Prostaglandin E2 (PGE2) was measured in supernatants of IL-1beta-stimulated SK-N-SH cells using enzyme immunoassay (EIA) for PGE2. Dinoprostone 23-39 interleukin 1 beta Homo sapiens 79-87 24491645-3 2014 MATERIALS AND METHODS: Prostaglandin E2 (PGE2) was measured in supernatants of IL-1beta-stimulated SK-N-SH cells using enzyme immunoassay (EIA) for PGE2. Dinoprostone 41-45 interleukin 1 beta Homo sapiens 79-87 24491645-12 2014 CONCLUSIONS: Taken together, these results clearly demonstrate that Picralima nitida suppresses PGE2 production by targeting multiple pathways involving NF-kappaB and MAPK signalling in IL-1beta-stimulated SK-N-SH neuronal cells. Dinoprostone 96-100 interleukin 1 beta Homo sapiens 186-194 24870145-3 2014 TLR agonists induced PGE2 in macrophages exclusively via IL-1beta-independent mechanisms. Dinoprostone 21-25 interleukin 1 beta Homo sapiens 57-65 24870145-5 2014 Recombinant human IL-1beta augmented COX-2 and mPGES-1 mRNA and PGE2 production in LPS-pretreated monocytes but not in un-primed or Pam3CSK4-primed monocytes. Dinoprostone 64-68 interleukin 1 beta Homo sapiens 18-26 24870145-8 2014 Blocking of TLR4 endocytosis during LPS priming prevented the increase in PGE2 production by exogenous IL-1beta. Dinoprostone 74-78 interleukin 1 beta Homo sapiens 103-111 24870145-10 2014 In the case of TLR4, IL-1beta augments PGE2 production in LPS-primed monocytes (but not in macrophages) through a mechanism that requires TLR4 internalization and activation of the TRIF/IRF3 pathway. Dinoprostone 39-43 interleukin 1 beta Homo sapiens 21-29 24375705-8 2014 Our data showed that IL-1beta markedly stimulated the expressions of iNOS and COX-2 and the productions of NO, PGE2 , and IL-6, which could be significantly reversed by honokiol. Dinoprostone 111-115 interleukin 1 beta Homo sapiens 21-29 24632976-8 2014 Interleukin-1beta (IL-1beta) (3 ng/ml) stimulated the secretion of PGE2 into the culture medium by HGF cells. Dinoprostone 67-71 interleukin 1 beta Homo sapiens 0-17 24632976-8 2014 Interleukin-1beta (IL-1beta) (3 ng/ml) stimulated the secretion of PGE2 into the culture medium by HGF cells. Dinoprostone 67-71 interleukin 1 beta Homo sapiens 19-27 24438745-12 2014 Interestingly, PGE2, which is produced by chondrocytes in response to IL-1beta and visfatin/NAMPT, did not stimulate NGF production. Dinoprostone 15-19 interleukin 1 beta Homo sapiens 70-78 23835558-9 2013 Both 10 or 100 mug/ml Rb1 inhibited the effect of IL-1beta on chondrocytes by decreasing levels of PGE2, NO(2)-, MMP-13, COX-2, iNOS, caspase-3 and PARP and increasing aggrecan and Col2A1 gene expression levels, to block IL-1beta-induced cell inflammation and apoptosis. Dinoprostone 99-103 interleukin 1 beta Homo sapiens 50-58 23941558-7 2014 Vitamin D, 25(OH)D, and 1,25(OH)2D significantly inhibited IL-1beta-induced microsomal PGE synthase (mPGES)-1 expression; in contrast, all three forms of vitamin D stimulated 15-hydroxy PG dehydrogenase, an enzyme that degrades PGE2. Dinoprostone 228-232 interleukin 1 beta Homo sapiens 59-67 24286132-8 2013 RESULTS: Both FN-fs and IL-1beta increased NO, PGE2 and MMP production (all P< 0.001). Dinoprostone 47-51 interleukin 1 beta Homo sapiens 24-32 23934131-0 2013 Kaempferol inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs. Dinoprostone 125-129 interleukin 1 beta Homo sapiens 20-28 23838114-10 2013 We found that piperine inhibited the production of PGE2 and NO induced by IL-1beta. Dinoprostone 51-55 interleukin 1 beta Homo sapiens 74-82 23934131-6 2013 Kaempferol inhibited the proliferation of both unstimulated and IL-1beta-stimulated RASFs, as well as the mRNA and protein expression of MMP-1, MMP-3, COX-2 and PGE2 induced by IL-1beta. Dinoprostone 161-165 interleukin 1 beta Homo sapiens 177-185 23927563-9 2013 We propose that the effect of IL1beta on the invasiveness of the MDA-MB-231 cells involves elevation of matrix metalloproteinase-9 (MMP-9) production, induction of COX-2 expression and PGE2 biosynthesis. Dinoprostone 185-189 interleukin 1 beta Homo sapiens 30-37 23864609-9 2013 IL-1beta and TNF-alpha enhanced the production of PGE2. Dinoprostone 50-54 interleukin 1 beta Homo sapiens 0-8 23778262-8 2013 Specifically, FOXO1 knockdown significantly decreased IL-1beta-induced IL-6 and IL-8 expression; production and COX-2 expression and subsequent prostaglandin (PGE2 and PGF2alpha) release; and MMP-9 mRNA expression and activity. Dinoprostone 159-163 interleukin 1 beta Homo sapiens 54-62 23927563-5 2013 The ability of IL1beta to stimulate the expression of cyclooxygenase-2 (COX-2) and biosynthesis of the prostaglandin E2 (PGE2) in MDA-MB-231 cells were also determined. Dinoprostone 121-125 interleukin 1 beta Homo sapiens 15-22 23971009-2 2013 Upon stimulation by various proinflammatory stimuli such as lipopolysaccharide (LPS), interleukin (IL)-1beta, and tumor necrosis factor (TNF)-alpha, PGE2 synthesis is upregulated by the expression of cyclooxygenases. Dinoprostone 149-153 interleukin 1 beta Homo sapiens 86-108 23441755-6 2013 RESULTS: IL-1beta increased PGE2 production and COX-1 protein expression in control-NM fibroblasts, but no changes were found in AIA-NM. Dinoprostone 28-32 interleukin 1 beta Homo sapiens 9-17 23664858-0 2013 Pirfenidone attenuates IL-1beta-induced COX-2 and PGE2 production in orbital fibroblasts through suppression of NF-kappaB activity. Dinoprostone 50-54 interleukin 1 beta Homo sapiens 23-31 23664858-3 2013 The level of PGE2 in orbital fibroblasts treated with IL-1beta in the presence or absence of pirfenidone was measured using an enzyme-linked immunosorbent assay. Dinoprostone 13-17 interleukin 1 beta Homo sapiens 54-62 23664858-7 2013 Pirfenidone significantly attenuated IL-1beta-induced PGE2 release in both TAO and non-TAO cells. Dinoprostone 54-58 interleukin 1 beta Homo sapiens 37-45 23883591-8 2013 There was strong parallelism in the actions of CNP on cGMP induction resulting in enhanced GAG synthesis and reduction of NO and PGE2 release induced by IL-1beta. Dinoprostone 129-133 interleukin 1 beta Homo sapiens 153-161 23681674-10 2013 SeMet also inhibited the production of PGE2 and NO induced by IL-1beta. Dinoprostone 39-43 interleukin 1 beta Homo sapiens 62-70 23488692-0 2013 IL-1beta/HMGB1 complexes promote The PGE2 biosynthesis pathway in synovial fibroblasts. Dinoprostone 37-41 interleukin 1 beta Homo sapiens 0-8 23488692-6 2013 We aimed to investigate the effects of IL-1beta/HMGB1 complexes on mPGES-1 and other enzymes of the PGE2 pathway in synovial fibroblasts (SFs) from patients with arthritis. Dinoprostone 100-104 interleukin 1 beta Homo sapiens 39-47 23488692-8 2013 Stimulation of SFs with HMGB1 in complex with suboptimal amounts of IL-1beta significantly increased mPGES-1 and COX-2 expressions as well as PGE2 production, as compared to treatment with HMGB1 or IL-1beta alone. Dinoprostone 142-146 interleukin 1 beta Homo sapiens 68-76 23488692-11 2013 IL-1beta/HMGB1 complexes promote the induction of mPGES-1, COX-2 and PGE2 in SF. Dinoprostone 69-73 interleukin 1 beta Homo sapiens 0-8 23664858-11 2013 Our results suggest that pirfenidone attenuates the IL-1beta-induced PGE2/COX-2 production in TAO orbital fibroblasts, which is related with suppression of the NF-kappaB activation. Dinoprostone 69-73 interleukin 1 beta Homo sapiens 52-60 23788611-6 2013 Conversely, IL-1beta strongly stimulated PGE2 protein levels in gingival fibroblasts, and chitosan inhibited this response at 50 microg/mL. Dinoprostone 41-45 interleukin 1 beta Homo sapiens 12-20 23788611-7 2013 IL-1beta-stimulated PGE2 production was dependent on the JNK pathway, and chitosan strongly inhibited this response. Dinoprostone 20-24 interleukin 1 beta Homo sapiens 0-8 23788611-8 2013 IL-1beta stimulated NF-kappaB activation, another signaling pathway involved in PGE2 production. Dinoprostone 80-84 interleukin 1 beta Homo sapiens 0-8 23475986-7 2013 In myometrial cells, all treatments attenuated IL-1beta-induced COX-2 expression, release of PGE2 and PGF2alpha and expression and activity of MMP-9. Dinoprostone 93-97 interleukin 1 beta Homo sapiens 47-55 23755232-11 2013 A549 cells incubated with TGF-beta1 for 72 h showed down-regulated COX-2 expression and low basal PGE2 secretion in response to IL-1beta. Dinoprostone 98-102 interleukin 1 beta Homo sapiens 128-136 23564509-10 2013 RelB overexpression reduced IL-1beta-induced cyclooxygenase (Cox)-2, PGE2, and cytokine production, and RelB downregulation increased Cox-2 expression and PGE2 production. Dinoprostone 69-73 interleukin 1 beta Homo sapiens 28-36 23564509-10 2013 RelB overexpression reduced IL-1beta-induced cyclooxygenase (Cox)-2, PGE2, and cytokine production, and RelB downregulation increased Cox-2 expression and PGE2 production. Dinoprostone 155-159 interleukin 1 beta Homo sapiens 28-36 23564509-12 2013 miR-146a overexpression ablated the effects of RelB downregulation on IL-1beta-induced Cox-2, PGE2, and IL-6 production, suggesting that RelB mediates IL-1beta-induced inflammatory mediator production in lung fibroblasts through miRNA-146a. Dinoprostone 94-98 interleukin 1 beta Homo sapiens 70-78 23392593-7 2013 RESULTS: Delphinidin inhibited IL-1beta-induced expression of COX-2 and production of PGE2 in human chondrocytes. Dinoprostone 86-90 interleukin 1 beta Homo sapiens 31-39 23392593-10 2013 CONCLUSION: These data identify delphinidin as a novel inhibitor of IL-1beta-induced production of cartilage-degrading molecule PGE2 via inhibition of COX-2 expression and provide new insight into the mechanism of its action. Dinoprostone 128-132 interleukin 1 beta Homo sapiens 68-76 23392593-12 2013 Given the important role played by IL-1beta-induced NF-kappaB activation, COX-2 expression and PGE2 production in OA, our results may have important implications for the development of novel therapeutic strategies for the prevention/treatment of OA. Dinoprostone 95-99 interleukin 1 beta Homo sapiens 35-43 23507189-9 2013 Studies on CAS showed significant and dose-dependent inhibition of TNFalpha, IL-6 and PGE2 production in IL-1beta-stimulated cells without affecting viability. Dinoprostone 86-90 interleukin 1 beta Homo sapiens 105-113 22992945-9 2012 S1P dose-dependently inhibited IL-1beta-induced NF-kappaB p65, cyclooxygenase (COX)-2, MMP-1, MMP-3, MMP-13 and MMP-14 mRNA expression in human chondrocytes and IL-1beta-induced PGE2 synthesis and GAG degradation in human cartilage explants. Dinoprostone 178-182 interleukin 1 beta Homo sapiens 31-39 22982753-5 2013 We show here that PGE2 blocks the production of IL-23 by LPS-stimulated monocytes in an IL-10 and IL-1beta independent manner. Dinoprostone 18-22 interleukin 1 beta Homo sapiens 98-106 21468727-0 2012 Increased expression of IL-1 receptors in response to IL-1beta may produce more IL-6, IL-8, VEGF, and PGE2 in senescent synovial cells induced in vitro than in presenescent cells. Dinoprostone 102-106 interleukin 1 beta Homo sapiens 24-28 22592909-0 2012 Quercetin inhibits IL-1beta-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 19-27 22592909-1 2012 This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs. Dinoprostone 238-254 interleukin 1 beta Homo sapiens 66-83 22592909-1 2012 This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs. Dinoprostone 238-254 interleukin 1 beta Homo sapiens 85-93 22592909-1 2012 This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs. Dinoprostone 256-260 interleukin 1 beta Homo sapiens 66-83 22592909-1 2012 This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs. Dinoprostone 256-260 interleukin 1 beta Homo sapiens 85-93 22592909-4 2012 Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta. Dinoprostone 147-151 interleukin 1 beta Homo sapiens 36-44 22592909-4 2012 Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta. Dinoprostone 147-151 interleukin 1 beta Homo sapiens 176-184 22549135-4 2012 Adiponectin functioned synergistically with IL-1beta to activate IL-6, IL-8, and PGE2 expression in RA fibroblast-like synoviocytes; Levels of VEGF, MMP-1, and MMP-13 were not synergistically stimulated. Dinoprostone 81-85 interleukin 1 beta Homo sapiens 44-52 22517618-0 2012 Prostaglandin E2 represses interleukin 1 beta-induced inflammatory mediator output from pregnant human myometrial cells through the EP2 and EP4 receptors. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 27-45 22822059-0 2012 Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1beta-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets. Dinoprostone 108-124 interleukin 1 beta Homo sapiens 82-99 22638761-0 2012 Fasitibant prevents the bradykinin and interleukin 1beta synergism on prostaglandin E2 release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes. Dinoprostone 70-86 interleukin 1 beta Homo sapiens 39-56 21468727-6 2012 Production of IL-6, IL-8, vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE(2)) in response to IL-1beta was significantly increased in cells at passage 7 compared with passage 3. Dinoprostone 73-89 interleukin 1 beta Homo sapiens 114-122 21468727-0 2012 Increased expression of IL-1 receptors in response to IL-1beta may produce more IL-6, IL-8, VEGF, and PGE2 in senescent synovial cells induced in vitro than in presenescent cells. Dinoprostone 102-106 interleukin 1 beta Homo sapiens 54-62 22332123-9 2012 RESULTS: SFN inhibited the production of PGE2 and NO induced by IL-1beta and TNF-alpha. Dinoprostone 41-45 interleukin 1 beta Homo sapiens 64-72 22294637-12 2012 Modulation of miR-199a* expression also caused significant inhibition of IL-1beta-induced upregulation of mPGES1 and prostaglandin E(2) production in OA chondrocytes. Dinoprostone 117-135 interleukin 1 beta Homo sapiens 73-81 21940790-8 2012 Stimulation of endogenous PGE2 secretion by IL-1beta was associated with amelioration of their myofibroblast differentiation in vitro, whereas its inhibition by indomethacin augmented alpha-SMA expression. Dinoprostone 26-30 interleukin 1 beta Homo sapiens 44-52 21954917-4 2012 Treatment with the HO-1 inducer CoPP (cobalt protoporphyrin IX) counteracted the stimulatory effects of IL-1beta on IL-6, nitrite, PGE2 (prostaglandin E2), TGF (transforming growth factor) beta2, TGFbeta3 and osteocalcin. Dinoprostone 131-135 interleukin 1 beta Homo sapiens 104-112 22244821-0 2012 Morin inhibits interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes. Dinoprostone 58-74 interleukin 1 beta Homo sapiens 15-32 22149896-6 2012 IL-1beta (5 ng/ml)-induced COX-2/PGE(2) levels are downregulated by stretch in RA FLSs only. Dinoprostone 33-39 interleukin 1 beta Homo sapiens 0-8 21828177-0 2011 IL-1beta stimulates activin betaA mRNA expression in human skin fibroblasts through the MAPK pathways, the nuclear factor-kappaB pathway, and prostaglandin E2. Dinoprostone 142-158 interleukin 1 beta Homo sapiens 0-8 21945458-0 2011 Sodium dl-alpha-tocopheryl-6-O-phosphate inhibits PGE2 production in keratinocytes induced by UVB, IL-1beta and peroxidants. Dinoprostone 50-54 interleukin 1 beta Homo sapiens 99-107 21702012-0 2011 Cytosolic phospholipase A2 induction and prostaglandin E2 release by interleukin-1beta via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-kappaB activity in human rheumatoid arthritis synovial fibroblasts. Dinoprostone 41-57 interleukin 1 beta Homo sapiens 69-86 21702012-8 2011 RESULTS: IL-1beta-induced cPLA2 expression and PGE2 release were mediated through a myeloid differentiation factor 88 (MyD88)/c-Src-dependent matrix metalloproteinase (MMP)/heparin-binding epidermal growth factor (HB-EGF) cascade linking to transactivation of the EGF receptor (EGFR)/phosphatidylinositol 3-kinase (PI 3-kinase)/Akt, p300, and NF-kappaB p65 pathways. Dinoprostone 47-51 interleukin 1 beta Homo sapiens 9-17 21848814-5 2011 In this study we found that EspT induces expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2) an enzyme involved in production of prostaglandin E(2) (PGE2), interleukin (Il)-8 and Il-1beta in U937 human macrophages by activating the nuclear factor kappa-B (NF-kappaB), the extracellular signal-regulated kinases 1 and 2 (Erk1/2) and c-Jun N-terminal kinase (JNK) pathways. Dinoprostone 147-165 interleukin 1 beta Homo sapiens 197-205 21702012-12 2011 Up-regulation of cPLA2 by IL-1beta increased PGE(2) biosynthesis in RASFs. Dinoprostone 45-51 interleukin 1 beta Homo sapiens 26-34 21828177-4 2011 A prostaglandin-endoperoxide synthase inhibitor indomethacin, a potent inhibitor of prostaglandin E(2) (PGE(2)) synthesis, also significantly suppressed the IL-1beta-stimulated INHBA but not FST mRNA expression. Dinoprostone 84-102 interleukin 1 beta Homo sapiens 157-165 21762793-3 2011 Data now indicate that the proinflammatory cytokine interleukin (IL)-1beta impairs respiration during infection via prostaglandin E2 (PGE(2)) and that infection, with associated eicosanoid release, is one of the main causes of respiratory disorders in preterm infants. Dinoprostone 116-132 interleukin 1 beta Homo sapiens 52-74 20697789-0 2011 Adrenomedullin inhibits IL-1beta-induced rheumatoid synovial fibroblast proliferation and MMPs, COX-2 and PGE2 production. Dinoprostone 106-110 interleukin 1 beta Homo sapiens 24-32 21506092-0 2011 Estrogen receptor-related receptor alpha regulation by interleukin-1beta in prostaglandin E(2)- and cAMP-dependent pathways in osteoarthritic chondrocytes. Dinoprostone 76-94 interleukin 1 beta Homo sapiens 55-72 21884514-6 2011 Conversely, IL-23 plus IL-1beta partially opposed the PGE2-mediated repression of early interferon gamma (IFN-gamma) secretion from CD161(+) cells, as well as the PGE2-mediated depletion of IFN-gamma(+) CD161(+) cells. Dinoprostone 54-58 interleukin 1 beta Homo sapiens 23-31 21884514-6 2011 Conversely, IL-23 plus IL-1beta partially opposed the PGE2-mediated repression of early interferon gamma (IFN-gamma) secretion from CD161(+) cells, as well as the PGE2-mediated depletion of IFN-gamma(+) CD161(+) cells. Dinoprostone 163-167 interleukin 1 beta Homo sapiens 23-31 21397936-7 2011 RESULTS: Compared with NM from control subjects, PGE(2) concentrations were significantly lower in IL-1beta-stimulated fibroblasts from patients with NPs who were tolerant to aspirin and even lower in polyps from patients with AIA. Dinoprostone 49-55 interleukin 1 beta Homo sapiens 99-107 21296955-3 2011 In human vascular smooth muscle cells (VSMC), hypoxia and interleukin (IL)-1beta synergistically increased prostaglandin (PG)I2 but not PGE2 release, thereby increasing the PGI2/PGE2 ratio. Dinoprostone 136-140 interleukin 1 beta Homo sapiens 58-80 20887233-0 2011 Cyclic mechanical stretch downregulates IL-1beta-induced COX-2 expression and PGE(2) production in rheumatoid arthritis fibroblast-like synoviocytes. Dinoprostone 78-84 interleukin 1 beta Homo sapiens 40-48 21557245-13 2011 In our organ culture model, IL-1beta stimulated PGE2 secretion in a dose-dependent manner. Dinoprostone 48-52 interleukin 1 beta Homo sapiens 28-36 21296955-3 2011 In human vascular smooth muscle cells (VSMC), hypoxia and interleukin (IL)-1beta synergistically increased prostaglandin (PG)I2 but not PGE2 release, thereby increasing the PGI2/PGE2 ratio. Dinoprostone 178-182 interleukin 1 beta Homo sapiens 58-80 21035557-8 2011 RESULTS: SeMet inhibited chondrocyte gene expression of IL-1beta induced iNOS (31-54%, P=0.031) and COX2 (50-65%, P=0.031) with corresponding reductions in both NO (19-47%, P=0.031) and PGE2 (24-32%, P=0.031) production. Dinoprostone 186-190 interleukin 1 beta Homo sapiens 56-64 20840837-11 2010 The results suggest that CO induced COX-2 expression and PGE2 production through activating the Akt, PKG, and MAPK pathways, and CO-induced PGE2 may modulate inflammation during macrophage activation by suppressing IL-1beta expression and inducing IL-10 production. Dinoprostone 140-144 interleukin 1 beta Homo sapiens 215-223 21417548-9 2011 IL-1beta and TNF strongly increased PGE2 production, with IL-1beta as the most prominent inducer. Dinoprostone 36-40 interleukin 1 beta Homo sapiens 0-8 19998410-4 2010 The objective of this study was to investigate direct effects of PGE2 on IL-1beta-induced MMP-1 and MMP-13 expression and the intracellular signaling in articular chondrocytes. Dinoprostone 65-69 interleukin 1 beta Homo sapiens 73-81 20883667-1 2010 The MAPK/ERK pathway is involved in IL-1beta-induced cyclooxygenase (COX-2) expression and prostaglandin E2 (PGE2) production; two factors that play important roles in OA pathogenesis. Dinoprostone 91-107 interleukin 1 beta Homo sapiens 36-44 20883667-2 2010 In the present study, we find that IL-1beta induced COX-2 expression and PGE2 production in human chondrocytes via a process that required the activation of the MAPK/ERK pathway. Dinoprostone 73-77 interleukin 1 beta Homo sapiens 35-43 20522791-3 2010 OBJECTIVES: The present study determined if fibroblasts from subjects with COPD overproduce PGE2 after stimulation with the inflammatory cytokines IL-1beta and tumor necrosis factor-alpha, and further defined the mechanism for overproduction. Dinoprostone 92-96 interleukin 1 beta Homo sapiens 147-187 19697035-0 2010 Differential effect of IL-1beta and TNFalpha on the production of IL-6, IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages. Dinoprostone 81-85 interleukin 1 beta Homo sapiens 23-31 19825412-5 2010 Human IL-1beta overexpression activated glia, elevated murine IL-1beta protein and PGE(2) levels, and increased pro-inflammatory cytokine and chemokine mRNAs specifically within the hippocampus, while having no detectable effect on inflammatory mRNAs in the liver. Dinoprostone 83-89 interleukin 1 beta Homo sapiens 6-14 19998410-5 2010 PGE2 showed inhibitory effects on IL-1beta-induced MMP-1 and MMP-13 expression demonstrated by immunoblotting both in OA and normal chondrocytes, which was further confirmed by enzyme-linked immunosorbent assay and immunohistochemistry of explant cultures of articular cartilages. Dinoprostone 0-4 interleukin 1 beta Homo sapiens 34-42 19998410-9 2010 These results demonstrate that PGE2 inhibits IL-1beta-induced MMP-1 and MMP-13 productions via EP4 by suppressing MKK4-JNK MAP kinase-c-JUN pathway. Dinoprostone 31-35 interleukin 1 beta Homo sapiens 45-53 19776509-1 2009 Interleukin-1beta (IL-1beta) stimulates expression of the highly inducible enzyme cyclooxygenase-2 (COX-2) via activation of nuclear factor kappaB (NFkappaB), and consequently provokes prostaglandin E(2) (PGE(2)) synthesis, which induces inflammatory responses. Dinoprostone 185-203 interleukin 1 beta Homo sapiens 0-17 20460758-5 2010 The IL-1beta -stimulated proliferation was inhibited by the MAPK kinase (MEK) inhibitor PD98059 but not by the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 or the cyclooxygenase-2 specific inhibitor NS-398, suggesting that IL-1beta stimulated proliferation via MEK, without affecting prostaglandin E(2) synthesis. Dinoprostone 302-320 interleukin 1 beta Homo sapiens 4-12 19776509-1 2009 Interleukin-1beta (IL-1beta) stimulates expression of the highly inducible enzyme cyclooxygenase-2 (COX-2) via activation of nuclear factor kappaB (NFkappaB), and consequently provokes prostaglandin E(2) (PGE(2)) synthesis, which induces inflammatory responses. Dinoprostone 185-203 interleukin 1 beta Homo sapiens 19-27 19776509-2 2009 In this study, the contribution of protein kinase C (PKC) to IL-1beta-induced PGE(2) synthesis in human gingival fibroblasts was investigated. Dinoprostone 78-84 interleukin 1 beta Homo sapiens 61-69 19776509-3 2009 The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta. Dinoprostone 67-73 interleukin 1 beta Homo sapiens 162-170 19660121-10 2009 IL-1beta and the NO donor diethylenetriamine/nitric oxide (DETA/NO) elevated PGE2 release by satellite cells. Dinoprostone 77-81 interleukin 1 beta Homo sapiens 0-8 19426689-4 2009 Garcinol suppressed 5-lipoxygenase product formation also in intact human neutrophils and reduced PGE2 formation in interleukin-1beta-stimulated A549 human lung carcinoma cells as well as in human whole blood stimulated by lipopolysaccharide. Dinoprostone 98-102 interleukin 1 beta Homo sapiens 116-133 19444894-13 2009 Ex vivo analysis indicates IL-1beta is responsible for the activation of the COX-2 / PGE2 pathway. Dinoprostone 85-89 interleukin 1 beta Homo sapiens 27-35 19428335-3 2009 We have investigated whether HO-1 induction may modify chondrocyte viability and the production of relevant mediators such as oxidative stress and prostaglandin E(2) (PGE(2)) elicited by IL-1beta in OA chondrocytes. Dinoprostone 147-165 interleukin 1 beta Homo sapiens 187-195 19074288-3 2008 Here we find that vitamin E forms differentially inhibit COX-2-catalyzed prostaglandin E(2) in IL-1beta-stimulated A549 cells without affecting COX-2 expression, showing the relative potency of gamma-tocotrienol approximately delta-tocopherol > gamma-tocopherol >> alpha- or beta-tocopherol. Dinoprostone 73-91 interleukin 1 beta Homo sapiens 95-103 19273625-5 2009 Furthermore, PGE2 synergizes with IL-1beta and IL-23 to drive retinoic acid receptor-related orphan receptor (ROR)-gammat, IL-17, IL-17F, CCL20, and CCR6 expression, which is consistent with the reported Th17 phenotype. Dinoprostone 13-17 interleukin 1 beta Homo sapiens 34-42 19452719-0 2009 [Effect of hypoxia and IL-1beta on COX-2 expression and PGE2 release in human nasal epithelia]. Dinoprostone 56-60 interleukin 1 beta Homo sapiens 23-31 19452719-6 2009 COX-2 expression and PGE2 release increased in HNE induced by hypoxia and/or IL-1beta in time-dependent manner. Dinoprostone 21-25 interleukin 1 beta Homo sapiens 77-85 19452719-7 2009 Stronger expressions of COX-2 and PGE2 induced by hypoxia and/or IL-1beta than control were detected on different time (P < 0.05). Dinoprostone 34-38 interleukin 1 beta Homo sapiens 65-73 19452719-9 2009 The expressions of COX-2 and PGE2 in hypoxia+IL-1beta group were more than the sum of hypoxia group and IL-1beta group on same time. Dinoprostone 29-33 interleukin 1 beta Homo sapiens 45-53 19452719-9 2009 The expressions of COX-2 and PGE2 in hypoxia+IL-1beta group were more than the sum of hypoxia group and IL-1beta group on same time. Dinoprostone 29-33 interleukin 1 beta Homo sapiens 104-112 19452719-10 2009 CONCLUSION: Hypoxia and/or IL-1beta effectively induce COX-2 expression and PGE2 release in HNE. Dinoprostone 76-80 interleukin 1 beta Homo sapiens 27-35 19452719-11 2009 Synergistic effect between hypoxia and IL-1beta has been found in induction of COX-2 and PGE2 in HNE. Dinoprostone 89-93 interleukin 1 beta Homo sapiens 39-47 19452719-12 2009 Results indicate that the increased expressions of COX-2 and PGE2 are involved in inflammation of HNE induced by hypoxia and/or IL-1beta in vitro. Dinoprostone 61-65 interleukin 1 beta Homo sapiens 128-136 19444759-0 2009 IL-1beta stimulates the expression of prostaglandin receptor EP4 in human chondrocytes by increasing production of prostaglandin E2. Dinoprostone 115-131 interleukin 1 beta Homo sapiens 0-8 19670527-13 2009 The former predicts, that Il-1 influences the tissue, stimulating them to the synthesis, via the cyclooxygenases (COX) activation, and release molecules such as prostaglandines (especially PGE2), which have the ability to penetrate the brain barrier. Dinoprostone 189-193 interleukin 1 beta Homo sapiens 26-30 18562219-10 2009 Transfection of OA chondrocytes with MK2 siRNA antisense significantly reduced both basal and IL-1beta induced PGE2 release. Dinoprostone 111-115 interleukin 1 beta Homo sapiens 94-102 18448096-5 2008 Aurothiomalate inhibited IL-1beta-induced COX-2 protein expression and PGE(2) production in chondrocytes in a dose-dependent manner. Dinoprostone 71-77 interleukin 1 beta Homo sapiens 25-33 18790761-6 2008 FuEP2/Ex2 neutralized PGE2-induced cyclic AMP production, cyclic AMP-responsive element binding protein phosphorylation, and subsequent induction of cyclooxygenase-2, interleukin (IL)-1beta, and IL-6 mRNAs. Dinoprostone 22-26 interleukin 1 beta Homo sapiens 167-189 18571585-11 2008 U937-conditioned medium and interleukin-1beta stimulated expression of cyclooxygenase-2 and prostaglandin E(2) production in pancreatic cancer cells, which was mediated by activation of the ERK1/2 pathway. Dinoprostone 92-110 interleukin 1 beta Homo sapiens 28-45 18547825-8 2008 In cultured chondrocytes, both NSAID decreased COX-2 and mPGES-1 synthesis and prostaglandin E2 (PGE2) release induced by IL-1beta, while no effect was observed on nitric oxide or iNOS synthesis. Dinoprostone 79-95 interleukin 1 beta Homo sapiens 122-130 18547825-8 2008 In cultured chondrocytes, both NSAID decreased COX-2 and mPGES-1 synthesis and prostaglandin E2 (PGE2) release induced by IL-1beta, while no effect was observed on nitric oxide or iNOS synthesis. Dinoprostone 97-101 interleukin 1 beta Homo sapiens 122-130 18417374-0 2008 Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes. Dinoprostone 83-99 interleukin 1 beta Homo sapiens 40-57 18417374-13 2008 CONCLUSIONS: These data indicate that HDAC inhibitors suppressed IL-1-induced NO and PGE(2) synthesis, iNOS and COX-2 expression, as well as proteoglycan degradation. Dinoprostone 85-91 interleukin 1 beta Homo sapiens 65-69 18313744-9 2008 Experiments employing neutralising antibodies indicate that exposure of co-cultured macrophages to both Ti-based particles induces the release of M-CSF, GM-CSF, IL-6 and PGE2 through up-regulation of IL-1beta and TNF-alpha. Dinoprostone 170-174 interleukin 1 beta Homo sapiens 200-208 18598258-0 2008 Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta. Dinoprostone 78-94 interleukin 1 beta Homo sapiens 121-129 18598258-6 2008 In this study we report that IL-1beta did not modulate NTS synaptic transmission per se, whereas prostaglandin E(2) (PGE(2)), which is produced downstream of IL-1beta, produced opposite effects on spontaneous and evoked release. Dinoprostone 97-115 interleukin 1 beta Homo sapiens 158-166 18438860-8 2008 Visfatin, like IL-1beta, triggered excessive release of PGE2, due to increased mPGES-1 synthesis and decreased 15-PGDH synthesis. Dinoprostone 56-60 interleukin 1 beta Homo sapiens 15-23 18438860-9 2008 Visfatin knockout with siRNA reduced IL-1beta-induced PGE2 overrelease. Dinoprostone 54-58 interleukin 1 beta Homo sapiens 37-45 17982107-5 2007 Surprisingly, interrupting Jak2 function also blocked the expected increase in PGE(2) synthesis usually provoked by IL-1beta. Dinoprostone 79-85 interleukin 1 beta Homo sapiens 116-124 18353001-8 2008 The most consistent result was a peak of cytokine levels at 24 h. Associations existed between prostaglandin E(2) (PGE(2)) and interleukin-1beta (IL-1beta) and pain, velocity of tooth movement, and treatment mechanics. Dinoprostone 95-113 interleukin 1 beta Homo sapiens 127-144 18353001-8 2008 The most consistent result was a peak of cytokine levels at 24 h. Associations existed between prostaglandin E(2) (PGE(2)) and interleukin-1beta (IL-1beta) and pain, velocity of tooth movement, and treatment mechanics. Dinoprostone 95-113 interleukin 1 beta Homo sapiens 146-154 17485421-9 2008 When prostaglandin-E2 was added, in addition to IL-1beta+TNFalpha, proteoglycan release increased further, but proteoglycan synthesis was not influenced further. Dinoprostone 5-21 interleukin 1 beta Homo sapiens 48-56 17485421-10 2008 Addition of a selective COX-2 inhibitor to the IL-1beta+TNFalpha treated cartilage inhibited the enhanced prostaglandin-E2 production and almost completely normalised proteoglycan release, whereas synthesis remained unaffected. Dinoprostone 106-122 interleukin 1 beta Homo sapiens 47-55 17485421-14 2008 IL-1beta+TNFalpha induced NO seems to be involved in inhibition of proteoglycan synthesis, independent of prostaglandin-E2, and thus seems insensitive to regulation by (selective) COX-2 inhibitors. Dinoprostone 106-122 interleukin 1 beta Homo sapiens 0-8 18348730-14 2008 IL-1beta induced a transient increase in COX-2 expression and stimulated the cumulative production of PGE2 release. Dinoprostone 102-106 interleukin 1 beta Homo sapiens 0-8 18295521-5 2008 Activation of the monocyte ETB subtype by ET (1 ng/ml) concentration-dependently stimulated TNF-alpha (744%) >PGE2 (570%) > IL-1 beta (112%) and had no effect on 5-lipoxygenase metabolism. Dinoprostone 113-117 interleukin 1 beta Homo sapiens 130-139 18295521-6 2008 Compared with ET a different profile of IL-1 beta >TNF-alpha >PGE2 was induced by LPS. Dinoprostone 68-72 interleukin 1 beta Homo sapiens 40-49 18382052-0 2008 [Effect of IGF-1 on NO and PGE2 in rabbit articular chondrocytes induced by IL-1]. Dinoprostone 27-31 interleukin 1 beta Homo sapiens 76-80 18382052-1 2008 OBJECTIVE: To explore the effect of insulin-like growth factor (IGF-1) on the concentration of NO and PGE(2) in the supernatant of rabbit articular chondrocytes induced by IL-1, and to explore the mechanism of IGF-1 in the development of osteoarthritis (OA). Dinoprostone 102-108 interleukin 1 beta Homo sapiens 172-176 18097066-0 2008 Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. Dinoprostone 0-16 interleukin 1 beta Homo sapiens 26-34 18097066-3 2008 In this study, we examine the role of IL-1beta-mediated induction of cyclooxygenase-2 and PGE2, and evaluate the significance of individual E prostanoid (EP) receptors in mediating the fibroproliferative effects of IL-1beta in ALI. Dinoprostone 90-94 interleukin 1 beta Homo sapiens 38-46 18097066-4 2008 Blocking studies on human lung fibroblasts indicate that IL-1beta is the major cyclooxygenase-2 mRNA and PGE2-inducing factor in pulmonary edema fluid and accounts for the differential PGE2 induction noted in samples from ALI patients. Dinoprostone 105-109 interleukin 1 beta Homo sapiens 57-65 18097066-4 2008 Blocking studies on human lung fibroblasts indicate that IL-1beta is the major cyclooxygenase-2 mRNA and PGE2-inducing factor in pulmonary edema fluid and accounts for the differential PGE2 induction noted in samples from ALI patients. Dinoprostone 185-189 interleukin 1 beta Homo sapiens 57-65 18097066-5 2008 Surprisingly, we found that PGE2 produced by IL-1beta-stimulated fibroblasts enhances fibroblast proliferation. Dinoprostone 28-32 interleukin 1 beta Homo sapiens 45-53 17707523-4 2007 The cytokines TNFalpha and IL-1beta increased protein expression and activity of mPGES-1, accompanied by increased COX-2 expression and PGE2 production. Dinoprostone 136-140 interleukin 1 beta Homo sapiens 27-35 17592175-0 2007 Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation. Dinoprostone 127-143 interleukin 1 beta Homo sapiens 101-118 17592175-4 2007 Interleukin-1beta-stimulated prostaglandin E(2) formation is dose-dependently suppressed by SPC, which is paralleled by reduced secretory phospholipase A(2) (sPLA(2)) protein expression and activity. Dinoprostone 29-47 interleukin 1 beta Homo sapiens 0-17 17525067-5 2007 METHODS AND RESULTS: Co-stimulation with LIF and IL-1beta induced higher amounts of PGE2 production and further migration of HTR-8/SVneo cells compared with that by stimulation with LIF or IL-1beta alone. Dinoprostone 84-88 interleukin 1 beta Homo sapiens 49-57 17559635-1 2007 BACKGROUND AND OBJECTIVE: Interleukin-1beta-stimulated receptor activator of nuclear factor-kappaB ligand (RANKL) expression in human periodontal ligament cells is partially mediated by endogenous prostaglandin E2, whereas mitogen-activated protein kinases (MAPKs) are implicated in regulating various interleukin-1-responsive genes. Dinoprostone 197-213 interleukin 1 beta Homo sapiens 26-43 17559635-9 2007 CONCLUSION: In human periodontal ligament cells, three types of MAPK inhibitor may abrogate RANKL expression and activity induced by interleukin-1beta, directly or indirectly through partial suppression of prostaglandin E2 synthesis. Dinoprostone 206-222 interleukin 1 beta Homo sapiens 133-150 17335379-1 2007 BACKGROUND: In previous work, the cyclooxygenase-2 inhibitor NS-398 inhibited interleukin (IL)-1beta-stimulated prostaglandin E(2) (PGE(2)) production almost completely while partially inhibiting IL-6 production in aggressive periodontitis (AgP) human gingival fibroblasts. Dinoprostone 112-130 interleukin 1 beta Homo sapiens 78-100 17283078-6 2007 We demonstrate that PGE(2) represses interleukin-1beta-induced matrix metalloproteinase (MMP)-1 and that transient overexpression of NURR1 is sufficient to antagonize expression of this gene. Dinoprostone 20-26 interleukin 1 beta Homo sapiens 37-54 17328065-5 2007 RESULTS: PGE(2) formation and cyclooxygenase 2 (COX-2) protein expression were induced by IL-1beta and potentiated by kinins with affinity for the B1 or B2 receptors, resulting in PGE(2)-dependent enhancement of RANKL. Dinoprostone 9-15 interleukin 1 beta Homo sapiens 90-98 17570156-6 2007 Using human myometrial cells in culture, we demonstrated that PDE4B2 can be induced by its own substrate, under the control of one of the major utero-contractile agonists, PGE2, itself upregulated by the proinflammatory cytokine IL-1beta. Dinoprostone 172-176 interleukin 1 beta Homo sapiens 229-237 17085450-12 2007 AuTM blocks the release of PGE2 and prevents the activation of NFkappaB, therefore blocking IL-1beta-induced hyaluronan accumulation and likely a series of other pro-inflammatory NFkappaB-dependent genes. Dinoprostone 27-31 interleukin 1 beta Homo sapiens 92-100 17208929-4 2007 The output of prostaglandin E(2) from non-activated fetal membranes in response to IL-1beta was decreased by approximately 80% at 16 and 24 h of culture, whereas the inhibition of IL-6 production was time-dependent, reaching 90% after 16 h and 50% after 24 h. Tissues obtained after labour (or after the activation of inflammatory processes leading to labour) were not inhibited by the low levels of oxygen, indicating that only before the onset of labour does oxygen regulate fetal membrane biology. Dinoprostone 14-32 interleukin 1 beta Homo sapiens 83-91 16794572-7 2007 IL-1 also increased blood concentration of corticosterone and PGE2, and increased the activities of cytosolic and secretory [corrected] PLA2. Dinoprostone 62-66 interleukin 1 beta Homo sapiens 0-4 16794572-10 2007 Quinacrine, [corrected] a PLA2 antagonist significantly blocked IL-1-induced [corrected] increase in PGE2 and corticosterone concentrations. Dinoprostone 101-105 interleukin 1 beta Homo sapiens 64-68 16794572-11 2007 These results demonstrated the hypotheses that IL-1 effects may be via PLA2-PGE2-corticosterone pathway and EPA attenuated IL-1 effects may be through the suppression of PLA2 expression, which then reduced PGE2 synthesis and corticosterone secretion. Dinoprostone 76-80 interleukin 1 beta Homo sapiens 47-51 16948668-11 2006 CONCLUSIONS: Interleukin-1beta and TNF-alpha may stimulate PGE(2) production in dental pulp cells. Dinoprostone 59-65 interleukin 1 beta Homo sapiens 13-30 17683641-11 2007 Real-time PCR analysis of articular cartilage from five patients with OA revealed that PGE2 at 10 pg/ml suppressed the expression of matrix metalloproteinase (MMP)-13 and to a smaller extent MMP-1, as well as the proinflammatory cytokines IL-1beta and TNF-alpha and type X collagen (COL10A1), the last of these being a marker of chondrocyte hypertrophy. Dinoprostone 87-91 interleukin 1 beta Homo sapiens 239-247 17035941-5 2006 IL-1beta induced a time-dependent formation of VEGF (analyzed by enzyme-linked immunosorbent assay) and PGE2 (analyzed by enzyme immunoassay). Dinoprostone 104-108 interleukin 1 beta Homo sapiens 0-8 17244328-4 2007 This study focused on: (1) the effects of PGE2 on keloid fibroblast migration, contraction, and collagen synthesis and (2) endogenous PGE2 synthesis in response interleukin-1beta. Dinoprostone 134-138 interleukin 1 beta Homo sapiens 161-178 17014957-0 2006 Alpha-MSH and gamma-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1beta differently. Dinoprostone 63-67 interleukin 1 beta Homo sapiens 86-94 17014957-1 2006 Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO). Dinoprostone 151-155 interleukin 1 beta Homo sapiens 0-17 17014957-1 2006 Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO). Dinoprostone 151-155 interleukin 1 beta Homo sapiens 19-27 17014957-3 2006 Our study investigated whether alpha-melanocyte stimulating hormone (alpha-MSH) and gamma-MSH could inhibit IL-1beta-induced PGE2 and NO release in hypothalamus in the rapid activation of the HPA axis. Dinoprostone 125-129 interleukin 1 beta Homo sapiens 108-116 17014957-5 2006 injection of 12.5 ng/microl of IL-1beta significantly increased the release of PGE2 and NOS activity in the hypothalamus. Dinoprostone 79-83 interleukin 1 beta Homo sapiens 31-39 17014957-6 2006 Treatment with alpha-MSH (0.1 microg/microl) inhibited the effect of IL-1beta on PGE2 release. Dinoprostone 81-85 interleukin 1 beta Homo sapiens 69-77 16959838-9 2006 Treatment of hGL cells with IL-1beta increased the concentrations of both PGE2 and PGF2alpha, accompanied by a 70+/-25% increase in net cortisol oxidation. Dinoprostone 74-78 interleukin 1 beta Homo sapiens 28-36 17229988-0 2006 Production of prostacyclin and prostaglandin E2 in resting and IL-1beta-stimulated A549, HUVEC and hybrid EA.HY 926 cells. Dinoprostone 31-47 interleukin 1 beta Homo sapiens 63-71 17229988-3 2006 The aim of this study was to examine the production of prostacyclin and PGE2 in resting and IL-1beta-stimulated EA.ha 926 cells, in comparison with its progenitor cells. Dinoprostone 72-76 interleukin 1 beta Homo sapiens 92-100 16326073-3 2006 Treatment of these cells with IL-1beta increased the levels of COX-2 mRNA and protein and hence the production of PGE2. Dinoprostone 114-118 interleukin 1 beta Homo sapiens 30-38 16955275-6 2006 Exposure to hyperthermia reduces IL-1beta-induced prostaglandin E2 release, suppresses activation of the adhesion molecules VCAM-1, ICAM-1, the cytokines TNFalpha, IL-1alpha, IL-1beta, IL-8 as well as COX-2 protein synthesis. Dinoprostone 50-66 interleukin 1 beta Homo sapiens 33-41 16741924-0 2006 PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8. Dinoprostone 0-4 interleukin 1 beta Homo sapiens 30-38 16741924-6 2006 As indicated by pharmacological studies, the full PGE2-dependent potentiation of IL-1beta induced PLA2 secretion is associated with a change of regulation exerted by the subtypes 3 G(i)-coupled PGE2 receptors toward adenylyl cyclase(s) activated by the subtype 4 G(s)-linked PGE2 receptor. Dinoprostone 50-54 interleukin 1 beta Homo sapiens 81-89 16807371-0 2006 Activation of sPLA2-IIA and PGE2 production by high mobility group protein B1 in vascular smooth muscle cells sensitized by IL-1beta. Dinoprostone 28-32 interleukin 1 beta Homo sapiens 124-132 16698013-4 2006 The production of IL-6, IL-8, and prostaglandin (PG)E2 was significantly increased by IL-1beta plus A beta (1-42) in a time-dependent manner (P < 0.05). Dinoprostone 34-54 interleukin 1 beta Homo sapiens 86-94 16698013-5 2006 JST significantly inhibited the IL-1beta plus A beta (1-42)-induced IL-6, IL-8, and PGE2 production at 24 h (P < 0.05). Dinoprostone 84-88 interleukin 1 beta Homo sapiens 32-40 16492401-15 2006 Inhibition of PGE2 synthesis by indomethacin increased the cell death induced by IL-1beta/Act-D (59%). Dinoprostone 14-18 interleukin 1 beta Homo sapiens 81-89 16544161-1 2006 Mechanical loading and interleukin-1 beta (IL-1 beta) influence the release of nitric oxide (*NO) and prostaglandin E2 (PGE2) from articular chondrocytes via distinct signalling mechanisms. Dinoprostone 102-118 interleukin 1 beta Homo sapiens 23-41 16544161-1 2006 Mechanical loading and interleukin-1 beta (IL-1 beta) influence the release of nitric oxide (*NO) and prostaglandin E2 (PGE2) from articular chondrocytes via distinct signalling mechanisms. Dinoprostone 102-118 interleukin 1 beta Homo sapiens 43-52 16544161-1 2006 Mechanical loading and interleukin-1 beta (IL-1 beta) influence the release of nitric oxide (*NO) and prostaglandin E2 (PGE2) from articular chondrocytes via distinct signalling mechanisms. Dinoprostone 120-124 interleukin 1 beta Homo sapiens 23-41 16544161-1 2006 Mechanical loading and interleukin-1 beta (IL-1 beta) influence the release of nitric oxide (*NO) and prostaglandin E2 (PGE2) from articular chondrocytes via distinct signalling mechanisms. Dinoprostone 120-124 interleukin 1 beta Homo sapiens 43-52