PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2578327-0 1985 Effect of prostaglandin E2 on the gamma-interferon induction of antigen-presenting ability in P388D1 cells and on IL-2 production by T-cell hybridomas. Dinoprostone 10-26 interferon gamma Mus musculus 34-50 2578327-1 1985 The effect of prostaglandin E2 on the gamma-interferon (IFN-gamma)-mediated induction of Ia expression and antigen-presenting activity in macrophage cell lines was studied. Dinoprostone 14-30 interferon gamma Mus musculus 38-54 2578327-1 1985 The effect of prostaglandin E2 on the gamma-interferon (IFN-gamma)-mediated induction of Ia expression and antigen-presenting activity in macrophage cell lines was studied. Dinoprostone 14-30 interferon gamma Mus musculus 56-65 6330202-0 1984 Interferon-gamma reduces macrophage-suppressive activity by inhibiting prostaglandin E2 release and inducing interleukin 1 production. Dinoprostone 71-87 interferon gamma Mus musculus 0-16 6330202-6 1984 In contrast, M phi exposed to IFN-gamma showed only impairment of PGE2 production, whereas O2- release was not significantly affected. Dinoprostone 66-70 interferon gamma Mus musculus 30-39 6815267-7 1982 The data suggest that LPS inhibits IFN-gamma regulation of macrophage Ia antigen expression by stimulating macrophage prostaglandin E2 production, and consequently enhancing intracellular cAMP levels. Dinoprostone 118-134 interferon gamma Mus musculus 35-44 28445497-8 2017 Because the levels of IFN-beta were lower in AH23848-treated mice but the level of IL-6 was similar, over-production of pathogenic IFN-beta was modulated and the generation of IFN-gamma-producing T cell responses was enhanced by the inhibition of PGE2 signaling. Dinoprostone 247-251 interferon gamma Mus musculus 176-185 29890469-3 2018 In this study, we found that solanine A markedly suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide/interferon-gamma (LPS/IFNgamma)-stimulated RAW264.7 cells, and attenuated xylene, carrageenan and agar-induced inflammation in mice. Dinoprostone 100-116 interferon gamma Mus musculus 146-162 29890469-3 2018 In this study, we found that solanine A markedly suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide/interferon-gamma (LPS/IFNgamma)-stimulated RAW264.7 cells, and attenuated xylene, carrageenan and agar-induced inflammation in mice. Dinoprostone 100-116 interferon gamma Mus musculus 168-176 29890469-3 2018 In this study, we found that solanine A markedly suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide/interferon-gamma (LPS/IFNgamma)-stimulated RAW264.7 cells, and attenuated xylene, carrageenan and agar-induced inflammation in mice. Dinoprostone 118-122 interferon gamma Mus musculus 146-162 29890469-3 2018 In this study, we found that solanine A markedly suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide/interferon-gamma (LPS/IFNgamma)-stimulated RAW264.7 cells, and attenuated xylene, carrageenan and agar-induced inflammation in mice. Dinoprostone 118-122 interferon gamma Mus musculus 168-176 32034203-5 2020 Pro-inflammatory cytokines such as TNF-alpha and IFN-gamma increased immunosuppressive protein such as HGF, TSG-6, PGE2 and TGF-beta in EVs. Dinoprostone 115-119 interferon gamma Mus musculus 49-58 26928462-0 2016 IFNgamma-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2-Mediated Inhibition of Antitumor CTL Responses. Dinoprostone 68-84 interferon gamma Mus musculus 0-8 27133739-1 2016 The present in vitro experiments demonstrate inhibitory effects of polysubstituted 2-aminopyrimidines on high output production of nitric oxide (NO) and prostaglandin E2 (PGE2) stimulated by interferon-gamma and lipopolysaccharide (LPS) in peritoneal macrophages of mouse and rat origin. Dinoprostone 153-169 interferon gamma Mus musculus 191-207 27133739-1 2016 The present in vitro experiments demonstrate inhibitory effects of polysubstituted 2-aminopyrimidines on high output production of nitric oxide (NO) and prostaglandin E2 (PGE2) stimulated by interferon-gamma and lipopolysaccharide (LPS) in peritoneal macrophages of mouse and rat origin. Dinoprostone 171-175 interferon gamma Mus musculus 191-207 26928462-2 2016 This study shows that overproduction of prostaglandin (PG) E2 by metastatic murine renal carcinoma (Renca) cells inhibited direct priming of tumor-specific CTL responses in vivo by preventing the IFNgamma-dependent upregulation of ICAM-1 that is vital during the initial priming of naive CD8(+) T cells. Dinoprostone 40-61 interferon gamma Mus musculus 196-204 26928462-3 2016 The addition of exogenous IFNgamma during naive CD8(+) T-cell priming abrogated PGE2-mediated suppression, and overexpression of ICAM-1 by tumor cells restored IFNgamma production and proliferation among PGE2-treated tumor-specific CD8(+) T cells; preventing tumor growth in vivo These findings suggest that novel anticancer immunotherapies, which increase expression of ICAM-1 on tumor cells, could help alleviate PGE2-mediated immunosuppression of antitumor CTL responses. Dinoprostone 80-84 interferon gamma Mus musculus 26-34 26416179-7 2015 In addition, we found that induction of PGE2 expression downregulates the expression of interferon (IFN)-gamma and interleukin (IL)-2, and promotes the secretion of IL-10 in vitro through the EP4 receptor. Dinoprostone 40-44 interferon gamma Mus musculus 88-110 26869183-3 2016 Using mouse-derived astrocytes as well as APP/PS1 transgenic mice as model systems, we firstly elucidated the mechanisms of interferon gamma (IFNgamma) regulation by PGE2 and PGI2. Dinoprostone 166-170 interferon gamma Mus musculus 124-140 26869183-3 2016 Using mouse-derived astrocytes as well as APP/PS1 transgenic mice as model systems, we firstly elucidated the mechanisms of interferon gamma (IFNgamma) regulation by PGE2 and PGI2. Dinoprostone 166-170 interferon gamma Mus musculus 142-150 26528946-5 2016 Moreover, compared to BM-MSCs, MenSCs activated with IFN-gamma and IL-1beta produced lower amounts of immunosuppressive factors such as IDO, PDL-1, PGE2, and Activin A and exhibited a substantial lower expression level of IFN-gamma receptor subunits. Dinoprostone 148-152 interferon gamma Mus musculus 53-62 26869183-4 2016 Specifically, PGE2 accumulation in astrocytes activated the ERK1/2 and NF-kappaB signaling pathways by phosphorylation, which resulted in IFNgamma expression. Dinoprostone 14-18 interferon gamma Mus musculus 138-146 26869183-5 2016 In contrast, the administration of PGI2 attenuated the effects of PGE2 on stimulating the production of IFNgamma via inhibiting the translocation of NF-kappaB from the cytosol to the nucleus. Dinoprostone 66-70 interferon gamma Mus musculus 104-112 26869183-7 2016 In detail, PGE2 induced IFNgamma expression in an Abeta1-42-dependent manner, whereas PGI2-induced Abeta1-42 production did not alleviate cells from IFNgamma inhibition by PGI2 treatment. Dinoprostone 11-15 interferon gamma Mus musculus 24-32 23893854-6 2013 LPS +- IFN-gamma-induced increases in PTGES expression and in PGE2 production in mixed glial and microglial cultures were abrogated in the absence of C/EBPbeta. Dinoprostone 62-66 interferon gamma Mus musculus 7-16 25088998-6 2014 The enhanced production of IFN-gamma and IL-17A was abolished by EP2 and EP4 antagonists, demonstrating PGE2 was responsible for enhanced cytokine production. Dinoprostone 104-108 interferon gamma Mus musculus 27-36 26520095-17 2015 Interestingly, despite that LPS and IFNgamma induced an increase in phospho-cPLA2 and prostaglandin E2 (PGE2) release, LPS- and IFNgamma-induced NO and ROS production were not altered by the COX-1/2 inhibitor but were suppressed by the LOX-12 and LOX-15 inhibitors instead. Dinoprostone 86-102 interferon gamma Mus musculus 36-44 26520095-17 2015 Interestingly, despite that LPS and IFNgamma induced an increase in phospho-cPLA2 and prostaglandin E2 (PGE2) release, LPS- and IFNgamma-induced NO and ROS production were not altered by the COX-1/2 inhibitor but were suppressed by the LOX-12 and LOX-15 inhibitors instead. Dinoprostone 104-108 interferon gamma Mus musculus 36-44 26520095-17 2015 Interestingly, despite that LPS and IFNgamma induced an increase in phospho-cPLA2 and prostaglandin E2 (PGE2) release, LPS- and IFNgamma-induced NO and ROS production were not altered by the COX-1/2 inhibitor but were suppressed by the LOX-12 and LOX-15 inhibitors instead. Dinoprostone 104-108 interferon gamma Mus musculus 128-136 26538826-4 2015 To understand how TIE elicits its anti-inflammatory activity, we uncovered that it significantly inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS/IFNgamma-stimulated RAW264.7 cells. Dinoprostone 146-162 interferon gamma Mus musculus 177-185 26538826-4 2015 To understand how TIE elicits its anti-inflammatory activity, we uncovered that it significantly inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS/IFNgamma-stimulated RAW264.7 cells. Dinoprostone 164-168 interferon gamma Mus musculus 177-185 24192281-5 2014 In response to the addition of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma to the culture medium, primary osteoblasts showed increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) at early time points and decreases in cell viability. Dinoprostone 222-238 interferon gamma Mus musculus 109-125 24192281-5 2014 In response to the addition of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma to the culture medium, primary osteoblasts showed increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) at early time points and decreases in cell viability. Dinoprostone 240-244 interferon gamma Mus musculus 109-125 23837588-7 2013 They also inhibited the LPS/IFN-gamma-mediated induction of COX-2 expression and PGE2 production. Dinoprostone 81-85 interferon gamma Mus musculus 28-37 23942037-8 2013 The compounds down-regulated the inflammatory response (TNF-alpha, PGE2 and nitrite) more strongly in cells challenged with INF-gamma than LPS, and silencing HO-1 or Nrf2 with shRNA differentially affected the levels of inflammatory markers. Dinoprostone 67-71 interferon gamma Mus musculus 124-133 22333568-6 2012 Although the PGE2 secretion by MSCs was completely abrogated by addition of indomethacin under all culture conditions tested, L-NMA, a NOS inhibitor could only partially inhibit it when the cells were elicited in the concomitant presence of TNF-alpha and IFN-gamma. Dinoprostone 13-17 interferon gamma Mus musculus 255-264 23467936-5 2013 Blocking PGE2 synthesis attenuated IDENs inhibition of induction of IFN-gamma and IL-4 by alpha-galactosylceramide (alpha-GalCer)-stimulated liver NKT cells in a PGE2 E-type prostanoid 2/E-type prostanoid 4 receptor-mediated manner. Dinoprostone 9-13 interferon gamma Mus musculus 68-77 23467936-5 2013 Blocking PGE2 synthesis attenuated IDENs inhibition of induction of IFN-gamma and IL-4 by alpha-galactosylceramide (alpha-GalCer)-stimulated liver NKT cells in a PGE2 E-type prostanoid 2/E-type prostanoid 4 receptor-mediated manner. Dinoprostone 162-166 interferon gamma Mus musculus 68-77 22333568-5 2012 In contrast, when soluble recombinant pro-inflammatory cytokines were added to the MSC cultures, TNF-alpha and IFN-gamma act synergistically to induce PGE2 production, whereas only high amount of TNF-alpha but not IFN-gamma was able to do so alone. Dinoprostone 151-155 interferon gamma Mus musculus 111-120 23554642-6 2010 In the presence of IFN-gamma, NCA significantly promoted IL-6, IL-10 and PGE2 secretion from RAW 264.7 cells. Dinoprostone 73-77 interferon gamma Mus musculus 19-28 20633531-7 2010 Furthermore, in purified NK cell culture, PGE2 directly suppressed the production of IFN-gamma by activated NK cells, which was reversed by selective inhibition of EP4 activity. Dinoprostone 42-46 interferon gamma Mus musculus 85-94 21191767-4 2010 In order to evaluate the anti-inflammatory effects of these compounds, their inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-gamma- and lipopolysaccharide-stimulated RAW 264.7 cells were examined. Dinoprostone 124-142 interferon gamma Mus musculus 157-166 20633531-0 2010 Promotion of interferon-gamma production by natural killer cells via suppression of murine peritoneal macrophage prostaglandin E2 production using intravenous anesthetic propofol. Dinoprostone 113-129 interferon gamma Mus musculus 13-29 18827359-4 2008 PGE(2) production by LPS/IFN-gamma-stimulated macrophages was inhibited by APO at much lower concentrations (IC(50)=0.27 microM) than those required for the inhibition of NO production. Dinoprostone 0-6 interferon gamma Mus musculus 25-34 18391003-5 2008 Further, we show that prostaglandin E(2) secretion in the lung is responsible for the difference in the gamma interferon (IFN-gamma) response. Dinoprostone 22-40 interferon gamma Mus musculus 122-131 15968705-5 2005 PGE2 production induced by lipopolysaccharide/interferon-gamma (LPS/IFN-gamma) in RAW264.7 cells was also reduced by treatment with IHE and isohumulone in a dose-dependent manner. Dinoprostone 0-4 interferon gamma Mus musculus 46-62 16777230-3 2007 Cardamonin suppressed the production of NO and PGE2 in interferon-gamma (IFN-gamma)- and lipopolysaccharide (LPS)-induced RAW 264.7 cells. Dinoprostone 47-51 interferon gamma Mus musculus 55-71 16777230-3 2007 Cardamonin suppressed the production of NO and PGE2 in interferon-gamma (IFN-gamma)- and lipopolysaccharide (LPS)-induced RAW 264.7 cells. Dinoprostone 47-51 interferon gamma Mus musculus 73-82 16766656-10 2006 Prostaglandin E(2) (PGE(2)) production was induced by IL-15, IFN-gamma, or ET-1. Dinoprostone 0-18 interferon gamma Mus musculus 61-70 18449498-2 2008 Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E(2) production in interferon-gamma (INF-gamma) and lipopolysaccharide (LPS)-activated RAW 264.7 cells in vitro (COX-2) of the isolated compounds were evaluated. Dinoprostone 66-84 interferon gamma Mus musculus 99-115 18449498-2 2008 Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E(2) production in interferon-gamma (INF-gamma) and lipopolysaccharide (LPS)-activated RAW 264.7 cells in vitro (COX-2) of the isolated compounds were evaluated. Dinoprostone 66-84 interferon gamma Mus musculus 117-126 17141756-2 2007 We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E(2) (PGE(2)), nitric oxide (NO), tumor necrosis factor (TNF-alpha), and their capacity to scavenge NO. Dinoprostone 224-242 interferon gamma Mus musculus 93-109 16778191-9 2006 IFN-gamma-producing CD4 T cells in spleens obtained from TA3-Ha tumor-bearing mice were significantly reduced compared with TA3-St tumor-bearing mice, suggesting that mucins cause PGE2-mediated immune suppression. Dinoprostone 180-184 interferon gamma Mus musculus 0-9 16793600-1 2006 OBJECTIVE: To determine if Ganoderma polysaccharides can antagonize prostaglandin E2 (PGE2)-induced suppression of murine splenocyte interferongamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) mRNA expression. Dinoprostone 68-84 interferon gamma Mus musculus 133-159 15968705-5 2005 PGE2 production induced by lipopolysaccharide/interferon-gamma (LPS/IFN-gamma) in RAW264.7 cells was also reduced by treatment with IHE and isohumulone in a dose-dependent manner. Dinoprostone 0-4 interferon gamma Mus musculus 68-77 15657087-7 2005 In the presence of LPS and IFN-gamma, PGHS-2 expression and PGE2 release by IL-10(-/-) and Balb/c splenic MO were enhanced compared with stimulation with LPS alone or IFN-gamma alone. Dinoprostone 60-64 interferon gamma Mus musculus 27-36 12834283-2 2003 In this study, we combined several agents and examined their suppressive effects on the combined lipopolysaccharide (LPS)- and interferon(IFN)-gamma-induced formation of proinflammatory mediators, including prostaglandin (PG) E2 and tumor necrosis factor (TNF)-alpha, in RAW264.7 murine macrophages. Dinoprostone 207-228 interferon gamma Mus musculus 127-148 15728492-7 2005 Interestingly, IFN-gamma induction of the COX-2 and PGE(2) synthesis was absent in macrophages from TNF(-/-) mice, and neutralizing anti-TNF Abs inhibited COX-2 promoter induction by IFN-gamma in RAW 264.7 macrophages. Dinoprostone 52-58 interferon gamma Mus musculus 15-24 15789752-2 2005 In the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated macrophages, but reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) upon stimulation by IFN-gamma/LPS or LPS. Dinoprostone 158-174 interferon gamma Mus musculus 202-211 15789752-2 2005 In the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated macrophages, but reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) upon stimulation by IFN-gamma/LPS or LPS. Dinoprostone 176-180 interferon gamma Mus musculus 202-211 15123779-8 2004 Blocking PGE2 production in vivo results in a marked reduction in lung metastasis of 4T1 tumors, accompanied by enhanced ability of peritoneal macrophages to produce IL-12 and spleen lymphocytes to produce interferon-gamma. Dinoprostone 9-13 interferon gamma Mus musculus 206-222 11702410-1 2001 Mycobacterium microti-infected mouse peritoneal macrophages produced high amounts of prostaglandin E2 (PGE2) and nitric oxide (NO) when activated with interferon-gamma (IFN-gamma). Dinoprostone 85-101 interferon gamma Mus musculus 151-167 11982590-6 2002 Exogenous PGE2 reduced cytotoxic activity and IFN-gamma and TNF-alpha production of PEC. Dinoprostone 10-14 interferon gamma Mus musculus 46-55 11702410-4 2001 Enhanced PGE2 and NO upregulated IL-10 expression and down-regulated IL-12 and MHC class-II (Ia) expression in M. microti-infected and IFN-gamma-treated mouse peritoneal macrophages. Dinoprostone 9-13 interferon gamma Mus musculus 135-144 11379045-7 2001 In addition, both IFN gamma and carbachol increase prostaglandin E2 production in SMG, but while indomethacin potentiates IFN gamma effect on amylase secretion, it blunted amylase secretion exerted by carbachol. Dinoprostone 51-67 interferon gamma Mus musculus 18-27 11298293-4 2001 The present study concerns the effects of TGF-beta on interferon (IFN)-gamma-induced activation of murine macrophages with respect to induction of toxoplasmastatic activity, and production of tumour necrosis factor (TNF)-alpha, prostaglandin E2 (PGE2) and reactive nitrogen intermediates (RNI). Dinoprostone 228-244 interferon gamma Mus musculus 54-76 11298293-4 2001 The present study concerns the effects of TGF-beta on interferon (IFN)-gamma-induced activation of murine macrophages with respect to induction of toxoplasmastatic activity, and production of tumour necrosis factor (TNF)-alpha, prostaglandin E2 (PGE2) and reactive nitrogen intermediates (RNI). Dinoprostone 246-250 interferon gamma Mus musculus 54-76 11298293-6 2001 The IFN-gamma-induced toxoplasmastatic activity of macrophages was inhibited by TGF-beta (mean FI = 6.3), which was also found for the IFN-gamma-induced production of TNF-alpha, RNI and PGE2 by macrophages. Dinoprostone 186-190 interferon gamma Mus musculus 4-13 11298293-6 2001 The IFN-gamma-induced toxoplasmastatic activity of macrophages was inhibited by TGF-beta (mean FI = 6.3), which was also found for the IFN-gamma-induced production of TNF-alpha, RNI and PGE2 by macrophages. Dinoprostone 186-190 interferon gamma Mus musculus 135-144 11702410-1 2001 Mycobacterium microti-infected mouse peritoneal macrophages produced high amounts of prostaglandin E2 (PGE2) and nitric oxide (NO) when activated with interferon-gamma (IFN-gamma). Dinoprostone 85-101 interferon gamma Mus musculus 169-178 11702410-1 2001 Mycobacterium microti-infected mouse peritoneal macrophages produced high amounts of prostaglandin E2 (PGE2) and nitric oxide (NO) when activated with interferon-gamma (IFN-gamma). Dinoprostone 103-107 interferon gamma Mus musculus 151-167 11702410-1 2001 Mycobacterium microti-infected mouse peritoneal macrophages produced high amounts of prostaglandin E2 (PGE2) and nitric oxide (NO) when activated with interferon-gamma (IFN-gamma). Dinoprostone 103-107 interferon gamma Mus musculus 169-178 11034408-6 2000 Measurements of PGE2 levels revealed a strong correlation between PGE2 secretion and IFN-gamma-induced COX-2 mRNA and protein levels in DN PKC-alpha-overexpressing clones. Dinoprostone 16-20 interferon gamma Mus musculus 85-94 11034408-6 2000 Measurements of PGE2 levels revealed a strong correlation between PGE2 secretion and IFN-gamma-induced COX-2 mRNA and protein levels in DN PKC-alpha-overexpressing clones. Dinoprostone 66-70 interferon gamma Mus musculus 85-94 11034408-7 2000 Taken together, these results suggest a role for PKC-alpha in the modulation of LPS- and IFN-gamma-induced COX-2 expression, as well as in IFN-gamma-induced PGE2 secretion. Dinoprostone 157-161 interferon gamma Mus musculus 139-148 10859338-3 2000 In this study, we demonstrate that interferon (IFN)-gamma alone or in synergy with lipopolysaccharide (LPS) or interleukin 1alpha induces Cox-2 expression in mouse peritoneal macrophages, which is paralleled by changes in Cox-2 protein levels and prostaglandin E(2) (PGE(2)) release. Dinoprostone 247-265 interferon gamma Mus musculus 35-57 10933609-0 2000 IFN-gamma inhibits the suppressive effects of PGE2 on the production of tumor necrosis factor-alpha by mouse macrophages. Dinoprostone 46-50 interferon gamma Mus musculus 0-9 10933609-8 2000 Macrophages primed with IFN-gamma showed the reduced responsiveness to the suppressive effect of PGE2 on the production of TNF-alpha and the accumulation of TNF-alpha mRNA. Dinoprostone 97-101 interferon gamma Mus musculus 24-33 10933609-9 2000 These findings indicate that the suppressive effects induced by PGE2 on the accumulation of TNF-alpha mRNA as well as the production of TNF-alpha can be reduced by the pretreatment of macrophages with IFN-gamma. Dinoprostone 64-68 interferon gamma Mus musculus 201-210 10933609-10 2000 These studies demonstrate the role of IFN-gamma as an immunomodulating compound that may effectively regulate TNF-alpha production by modulation of macrophage responsiveness to PGE2. Dinoprostone 177-181 interferon gamma Mus musculus 38-47 10834941-5 2000 We found that the induction of PGHS-2 and generation of PGE2 in these cells by IFN-gamma and lipopolysaccharide (LPS) were greatly reduced by two selective NOS II inhibitors, L-NIL and SMT. Dinoprostone 56-60 interferon gamma Mus musculus 79-88 10357877-5 1999 Antigen-evoked secretion of IFN-gamma by influenza hemagglutinin-specific mouse lymph node Th1 cells, that also express EP3Rs and EP4Rs, was increased a maximum of 12-fold by 10(-9) to 10(-8) M PGE2, 14-fold by 10(-9) M sulprostone, and 10-fold by 10(-9) M misoprostol. Dinoprostone 194-198 interferon gamma Mus musculus 28-37 10679074-2 2000 We studied the role of PGE2 in IFN-gamma production by Staphylococcus aureus Cowan I-stimulated spleen cells from several mouse strains such as BALB/c, C3H/HeN, and C57BL/6. Dinoprostone 23-27 interferon gamma Mus musculus 31-40 10679074-5 2000 When various concentrations of PGE2 were exogeneously added to spleen cells, PGE2 showed a stronger suppressive effect on IFN-gamma production in spleen cells from BALB/c mice than from other strains of mice. Dinoprostone 31-35 interferon gamma Mus musculus 122-131 10679074-5 2000 When various concentrations of PGE2 were exogeneously added to spleen cells, PGE2 showed a stronger suppressive effect on IFN-gamma production in spleen cells from BALB/c mice than from other strains of mice. Dinoprostone 77-81 interferon gamma Mus musculus 122-131 10679074-10 2000 From these results, we propose that the modulation of PGE2 is important for Th1 activation via IFN-gamma and IL-12p70 production in vitro and in vivo and that PGE2 is one of the pivotal factors in the Th2-dominant immune response in BALB/c mice. Dinoprostone 54-58 interferon gamma Mus musculus 95-104 10374812-6 1999 Opposite to IFN-gamma, the lipid mediator prostaglandin E2 (PGE2) enhanced the LPS-induced production of IL-10 and inhibited that of TNF. Dinoprostone 60-64 interferon gamma Mus musculus 12-21 10374812-7 1999 The effects of PGE2 on cytokine gene expression and secretion were antagonized by IFN-gamma. Dinoprostone 15-19 interferon gamma Mus musculus 82-91 10357877-0 1999 Prostaglandin E2 enhancement of interferon-gamma production by antigen-stimulated type 1 helper T cells. Dinoprostone 0-16 interferon gamma Mus musculus 32-48 10357877-7 1999 The generation of IFN-gamma by antigen-stimulated Th1 cells thus is significantly enhanced by physiologically relevant concentrations of PGE2. Dinoprostone 137-141 interferon gamma Mus musculus 18-27 9671112-2 1998 Stimulation of the J774 cells with lipopolysaccharide together with interferon-gamma resulted in a dose-dependent cytotoxicity and production of PGE2 and NO, measured as nitrite. Dinoprostone 145-149 interferon gamma Mus musculus 68-84 9886421-3 1999 Taxol alone or taxol plus IFN-gamma increased PGE2 formation, PGHS-2 protein expression, and PGHS-2 mRNA expression in RAW 264.7 murine macrophages. Dinoprostone 46-50 interferon gamma Mus musculus 26-35 10376946-0 1999 Interferon-gamma reduces cyclooxygenase-2-mediated prostaglandin E2 production from primary mouse astrocytes independent of nitric oxide formation. Dinoprostone 51-67 interferon gamma Mus musculus 0-16 10376946-8 1999 Exposure of LPS-treated astrocytes to IFNgamma resulted in a concentration-dependent decrease in PGE2 accumulation which was accompanied by a striking parallel increase in NO formation. Dinoprostone 97-101 interferon gamma Mus musculus 38-46 9850155-6 1998 RNI production in response to IFN-gamma or IFN-gamma and TNF-alpha in combination was enhanced by PGE2 in both populations, however, the effect was markedly greater in Mphi from injured mice. Dinoprostone 98-102 interferon gamma Mus musculus 30-39 9850155-6 1998 RNI production in response to IFN-gamma or IFN-gamma and TNF-alpha in combination was enhanced by PGE2 in both populations, however, the effect was markedly greater in Mphi from injured mice. Dinoprostone 98-102 interferon gamma Mus musculus 43-52 8582790-0 1995 Stimulation of macrophages with IFN gamma or TNF alpha shuts off the suppressive effect played by PGE2. Dinoprostone 98-102 interferon gamma Mus musculus 32-41 8993009-5 1997 PGE2 and cholera toxin increased the production of nitrite (an indicator of nitric oxide production) in IFN-gamma-treated ANA-1 macrophages by at least twofold. Dinoprostone 0-4 interferon gamma Mus musculus 104-113 8757336-5 1996 IFN-gamma protein was detected by ELISA in supernatants of mast cells cultured with 2 U/ml recombinant mouse IL-12 for between 6 and 24 h. The production of IFN-gamma was dependent on the dose of IL-12 and was significantly inhibited by concurrent treatment with IL-10 or PGE2. Dinoprostone 272-276 interferon gamma Mus musculus 0-9 9201262-0 1997 Timing of prostaglandin exposure is critical for the inhibition of LPS- or IFN-gamma-induced macrophage NO synthesis by PGE2. Dinoprostone 120-124 interferon gamma Mus musculus 75-84 9201262-6 1997 PGE2 also suppressed NO synthesis in response to interferon-gamma (IFN-gamma) alone and a combination of LPS + IFN-gamma. Dinoprostone 0-4 interferon gamma Mus musculus 49-65 9201262-6 1997 PGE2 also suppressed NO synthesis in response to interferon-gamma (IFN-gamma) alone and a combination of LPS + IFN-gamma. Dinoprostone 0-4 interferon gamma Mus musculus 67-76 9201262-6 1997 PGE2 also suppressed NO synthesis in response to interferon-gamma (IFN-gamma) alone and a combination of LPS + IFN-gamma. Dinoprostone 0-4 interferon gamma Mus musculus 111-120 9113098-9 1997 In macrophages cultured with lipopolysaccharide and interferon-gamma to induce the generation of large amounts of both PGE2 and nitric oxide, tetrandrine reduced mediator release and their forming enzymes (cyclo-oxygenase-2 and inducible nitric oxide synthase), secondary to cytotoxicity. Dinoprostone 119-123 interferon gamma Mus musculus 52-68 8855294-2 1996 PGE2 can shape the immune response by stimulating the production of IgE antibody by B lymphocytes and the synthesis of T-helper type 2 cytokines [e.g., interleukin (IL)-4, IL-10], while inhibiting production of Th1 cytokines (e.g., interferon-gamma, IL-12). Dinoprostone 0-4 interferon gamma Mus musculus 232-248 8587796-3 1996 In the unprotected BALB/c mice the levels of PGE2 that were responsible for the depression of interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF alpha) Th1-associated cytokines and for the relative increase in the interleukin-4 (IL-4) became higher and higher as the lesion progressed. Dinoprostone 45-49 interferon gamma Mus musculus 94-110 8587796-3 1996 In the unprotected BALB/c mice the levels of PGE2 that were responsible for the depression of interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF alpha) Th1-associated cytokines and for the relative increase in the interleukin-4 (IL-4) became higher and higher as the lesion progressed. Dinoprostone 45-49 interferon gamma Mus musculus 112-121 8582790-2 1995 In this study, carried out on peritoneal macrophages obtained from healthy, tumour-bearing and Corynebacterium parvum-treated mice, we demonstrated that PGE2 is involved in the down-regulation of macrophage activation, but it cannot exert its inhibiting effect when macrophages are further stimulated with activating cytokines, such as IFN gamma and TNF alpha. Dinoprostone 153-157 interferon gamma Mus musculus 336-345 7543922-7 1995 Finally, PGE2 and cAMP enhanced expression of inducible nitric oxide synthase mRNA in response to IFN-gamma and TNF-alpha, and this effect was inhibited by the cAMP antagonist 2"-O-methyl adenosine. Dinoprostone 9-13 interferon gamma Mus musculus 98-107 7543922-0 1995 Effect of PGE2 and of agents that raise cAMP levels on macrophage activation induced by IFN-gamma and TNF-alpha. Dinoprostone 10-14 interferon gamma Mus musculus 88-97 7543922-8 1995 These findings are consistent with the hypothesis that PGE2 acts as a positive agonist in macrophage activation by IFN-gamma and TNF-alpha via its capacity to modulate intracellular cAMP levels. Dinoprostone 55-59 interferon gamma Mus musculus 115-124 7578978-1 1995 Lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) induced nitric oxide synthase (NOS) activity, tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and prostaglandin (PG)E2 release in J774 cells, a murine macrophage cell line. Dinoprostone 169-189 interferon gamma Mus musculus 29-56 8077668-3 1994 MTF activity could be inhibited by small concentrations of prostaglandin E2, but not by polymyxin B. M phi activated by IFN-gamma plus MTF produce cytostatic effects on tumor cells through a nitric oxide-dependent pathway. Dinoprostone 59-75 interferon gamma Mus musculus 120-129 7533135-8 1994 Inhibition of prostaglandin E2 (PGE2) biosynthesis in abscess and naive macrophages pretreated with amoebic proteins augmented IFN-gamma- and LPS-induced killing of L929 cells and TNF-alpha production, but failed to increase killing of P815 cells and amoebae as well as iNOS mRNA levels or NO production. Dinoprostone 14-30 interferon gamma Mus musculus 127-136 7533135-8 1994 Inhibition of prostaglandin E2 (PGE2) biosynthesis in abscess and naive macrophages pretreated with amoebic proteins augmented IFN-gamma- and LPS-induced killing of L929 cells and TNF-alpha production, but failed to increase killing of P815 cells and amoebae as well as iNOS mRNA levels or NO production. Dinoprostone 32-36 interferon gamma Mus musculus 127-136 8398988-3 1993 In this report we show evidence for differential regulation of prostaglandin E2 (PGE2), a physiological agent that elevated cAMP and IFN-gamma on slgM and Lyb2 mediated B cell activation. Dinoprostone 63-79 interferon gamma Mus musculus 133-142 8398988-3 1993 In this report we show evidence for differential regulation of prostaglandin E2 (PGE2), a physiological agent that elevated cAMP and IFN-gamma on slgM and Lyb2 mediated B cell activation. Dinoprostone 81-85 interferon gamma Mus musculus 133-142 1907426-5 1991 gamma-IFN (1000 U/ml) almost totally inhibited 45Ca release stimulated by bradykinin (1 mumol/l), but the inhibitory effect could only be partially overcome by PGE2. Dinoprostone 160-164 interferon gamma Mus musculus 0-9 8354638-12 1993 In fact, IFN-gamma addition increased PGE2 production two-fold in MLR cultures. Dinoprostone 38-42 interferon gamma Mus musculus 9-18 8354638-13 1993 However, IFN-gamma partly reduced suppression mediated by exogenous PGE2 added to M phi-depleted cultures. Dinoprostone 68-72 interferon gamma Mus musculus 9-18 8382248-8 1993 Thus, agents stimulating cAMP generation, including PGE2, counterbalance the generation of CSF-1 and JE/MCP-1 in response to IFN-gamma, TNF-alpha, and IgG complexes. Dinoprostone 52-56 interferon gamma Mus musculus 125-134 1458686-6 1992 Experiments with combinations of recombinant mouse IFN-gamma and human lymphotoxin or TNF-alpha showed that these lymphokines could substitute for the direct T lymphocyte effects causing a synergistic growth inhibition and PGE2 release from mouse MC. Dinoprostone 223-227 interferon gamma Mus musculus 51-60 1318336-2 1992 We recently reported that PGE2 potentiated the ability of IFN-gamma to augment IgG2a production in both Ag-specific and polyclonal systems via a cAMP-dependent pathway. Dinoprostone 26-30 interferon gamma Mus musculus 58-67 1318336-5 1992 Moreover, the combined treatment of B lymphocytes with IFN-gamma and PGE2 followed by anti-Ia and LPS resulted in a fourfold rise in IgG2a levels compared with IFN-gamma and LPS. Dinoprostone 69-73 interferon gamma Mus musculus 160-169 1318336-8 1992 B cell cultures incubated with either PGE2 or anti-Ia exhibited elevated levels of cAMP and treatment with IFN-gamma primed these lymphocytes to the cAMP-elevating effects of either PGE2 or anti-Ia. Dinoprostone 38-42 interferon gamma Mus musculus 107-116 1318336-8 1992 B cell cultures incubated with either PGE2 or anti-Ia exhibited elevated levels of cAMP and treatment with IFN-gamma primed these lymphocytes to the cAMP-elevating effects of either PGE2 or anti-Ia. Dinoprostone 182-186 interferon gamma Mus musculus 107-116 7687200-4 1993 Both interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), two cytokines involved in activating the cellular contact sensitivity reaction, were downregulated by prostaglandin E2 (PGE2) and to a lesser extent by 6-keto PGF2 alpha (PGI2). Dinoprostone 162-178 interferon gamma Mus musculus 30-46 7687200-4 1993 Both interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), two cytokines involved in activating the cellular contact sensitivity reaction, were downregulated by prostaglandin E2 (PGE2) and to a lesser extent by 6-keto PGF2 alpha (PGI2). Dinoprostone 162-178 interferon gamma Mus musculus 48-57 7687200-4 1993 Both interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), two cytokines involved in activating the cellular contact sensitivity reaction, were downregulated by prostaglandin E2 (PGE2) and to a lesser extent by 6-keto PGF2 alpha (PGI2). Dinoprostone 180-184 interferon gamma Mus musculus 30-46 7687200-4 1993 Both interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), two cytokines involved in activating the cellular contact sensitivity reaction, were downregulated by prostaglandin E2 (PGE2) and to a lesser extent by 6-keto PGF2 alpha (PGI2). Dinoprostone 180-184 interferon gamma Mus musculus 48-57 8436811-2 1993 PGE2 is an immunomodulator that selectively inhibits the production of lymphokines associated with Th1 cells (IL-2 and IFN-gamma) but not Th2 cells (IL-4 and IL-5). Dinoprostone 0-4 interferon gamma Mus musculus 119-128 1907426-7 1991 The stimulatory effects of PGE2 (1 mumol/l) on radioactive calcium mobilization was partially inhibited by gamma-IFN (1000 U/ml), whereas indomethacin (1 mumol/l) was without effect. Dinoprostone 27-31 interferon gamma Mus musculus 107-116 1907426-8 1991 The inhibitory effect of gamma-IFN on 45Ca release stimulated by bradykinin and PGE2 was dose-dependent with threshold for action at 3-30 U/ml. Dinoprostone 80-84 interferon gamma Mus musculus 25-34 1907426-11 1991 gamma-IFN (1000 U/ml) partially inhibited the stimulatory effect of bradykinin on PGE2 formation. Dinoprostone 82-86 interferon gamma Mus musculus 0-9 1904523-4 1991 Because IFN gamma also stimulated prostaglandin E2 (PGE2) production, the effect of indomethacin, which is an inhibitor of cyclooxygenase and which inhibits PGE2 biosynthesis, on IL-1 and TNF production by Kupffer cells was examined. Dinoprostone 34-50 interferon gamma Mus musculus 8-17 1904523-4 1991 Because IFN gamma also stimulated prostaglandin E2 (PGE2) production, the effect of indomethacin, which is an inhibitor of cyclooxygenase and which inhibits PGE2 biosynthesis, on IL-1 and TNF production by Kupffer cells was examined. Dinoprostone 52-56 interferon gamma Mus musculus 8-17 2126942-0 1990 Prostaglandin E2-mediated suppression of murine lymphokine-activated killer cell activity generated from tumor-bearing hosts by interferon-gamma. Dinoprostone 0-16 interferon gamma Mus musculus 128-144 2121324-6 1990 These findings suggest that IFN-gamma non-preferentially inhibits bone resorption induced by various bone-resorbing factors in fetal mouse forearm bones via a PGE2-independent mechanism. Dinoprostone 159-163 interferon gamma Mus musculus 28-37 33774932-0 2021 Feline adipose tissue-derived mesenchymal stem cells pretreated with IFN-gamma enhance immunomodulatory effects through the PGE2 pathway. Dinoprostone 124-128 interferon gamma Mus musculus 69-78 2116476-8 1990 TNF and PGE2 also synergized to inhibit Ia expression induced on bone marrow-derived and splenic macrophages by either IFN-gamma or IL-4. Dinoprostone 8-12 interferon gamma Mus musculus 119-128 33774932-8 2021 CONCLUSIONS: IFN-gamma pretreatment improves the immune regulatory profile of fAT-MSCs mainly via the secretion of PGE2, which induces macrophage polarization and increases regulatory T-cell numbers. Dinoprostone 115-119 interferon gamma Mus musculus 13-22 2177198-0 1990 Interferon gamma stimulates prostaglandin E2 production by mouse Kupffer cells. Dinoprostone 28-44 interferon gamma Mus musculus 0-16 2177198-2 1990 In this study, we examined the effect of in vitro Kupffer cell activation with recombinant murine IFN gamma on PGE2 and LTB4 secretion. Dinoprostone 111-115 interferon gamma Mus musculus 98-107 2177198-3 1990 IFN gamma enhanced PGE2 secretion, and this effect of IFN gamma was stronger than that of IL-1 or TNF. Dinoprostone 19-23 interferon gamma Mus musculus 0-9 2177198-3 1990 IFN gamma enhanced PGE2 secretion, and this effect of IFN gamma was stronger than that of IL-1 or TNF. Dinoprostone 19-23 interferon gamma Mus musculus 54-63 2177198-5 1990 On the other hand, dexamethasone and indomethacin inhibited and, EGTA and TMB-8, which reduce intracellular Ca++ Levels, blocked IFN gamma induced PGE2 production, which suggested that the activation of phospholipase A2 and cyclooxygenase in Kupffer cells requires the elevation of intracellular Ca++ levels. Dinoprostone 147-151 interferon gamma Mus musculus 129-138 33774932-7 2021 Further, prostaglandin E2 (PGE2) inhibitor NS-398 attenuated the immunoregulatory potential of MSCs, suggesting that the increased PGE2 levels induced by IFN-gamma stimulation is a crucial factor in the immune regulatory capacity of MSCs pretreated with IFN-gamma. Dinoprostone 9-25 interferon gamma Mus musculus 154-163 33774932-7 2021 Further, prostaglandin E2 (PGE2) inhibitor NS-398 attenuated the immunoregulatory potential of MSCs, suggesting that the increased PGE2 levels induced by IFN-gamma stimulation is a crucial factor in the immune regulatory capacity of MSCs pretreated with IFN-gamma. Dinoprostone 9-25 interferon gamma Mus musculus 254-263 33774932-7 2021 Further, prostaglandin E2 (PGE2) inhibitor NS-398 attenuated the immunoregulatory potential of MSCs, suggesting that the increased PGE2 levels induced by IFN-gamma stimulation is a crucial factor in the immune regulatory capacity of MSCs pretreated with IFN-gamma. Dinoprostone 27-31 interferon gamma Mus musculus 154-163 33774932-7 2021 Further, prostaglandin E2 (PGE2) inhibitor NS-398 attenuated the immunoregulatory potential of MSCs, suggesting that the increased PGE2 levels induced by IFN-gamma stimulation is a crucial factor in the immune regulatory capacity of MSCs pretreated with IFN-gamma. Dinoprostone 27-31 interferon gamma Mus musculus 254-263 33774932-7 2021 Further, prostaglandin E2 (PGE2) inhibitor NS-398 attenuated the immunoregulatory potential of MSCs, suggesting that the increased PGE2 levels induced by IFN-gamma stimulation is a crucial factor in the immune regulatory capacity of MSCs pretreated with IFN-gamma. Dinoprostone 131-135 interferon gamma Mus musculus 154-163 33774932-7 2021 Further, prostaglandin E2 (PGE2) inhibitor NS-398 attenuated the immunoregulatory potential of MSCs, suggesting that the increased PGE2 levels induced by IFN-gamma stimulation is a crucial factor in the immune regulatory capacity of MSCs pretreated with IFN-gamma. Dinoprostone 131-135 interferon gamma Mus musculus 254-263 34598950-1 2021 In this issue of Cancer Discovery, Pelly and colleagues show that inhibition of prostaglandin E2 synthesis or its activity on EP2 and EP4 receptors synergizes with anti-PD-1 immunotherapy and triggers a potent intratumoral IFNgamma response in mouse models and in fresh surgical human tumor explants. Dinoprostone 80-96 interferon gamma Mus musculus 223-231 34198981-3 2021 Exposure of RAW macrophages to LPS and IFN-gamma stimuli induced high levels of nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) production. Dinoprostone 129-145 interferon gamma Mus musculus 39-48 34198981-3 2021 Exposure of RAW macrophages to LPS and IFN-gamma stimuli induced high levels of nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) production. Dinoprostone 147-151 interferon gamma Mus musculus 39-48 34198981-8 2021 From these findings, we suggest that MFSC-Ex exert anti-inflammatory activities, which suppressed LPS/IFN-gamma-induced production of NO, COX-2 and PGE2 by regulation of NF-kappaB and MAPK signaling pathway in RAW 264.7 macrophages. Dinoprostone 148-152 interferon gamma Mus musculus 102-111 35086457-15 2022 Furthermore, UC-MSC-derived PGE2 enhanced PD-L1 expression in RAW264.7 cells, which in turn promoted programmed cell death protein 1 (PD-1) expression and reduced IL-2 and IFN-gamma production in Jurkat T cells. Dinoprostone 28-32 interferon gamma Mus musculus 172-181 35083262-8 2021 The antiinflammatory effects and the regulations of COX-2/PGE2 signaling pathway were revealed on the LPS-induced RAW264.7 cells, indicating that the SCE not only increased cellular proliferation but also downregulated the COX-2, PGE2, NO, and IFN-gamma cytokines in the RAW264.7 cells. Dinoprostone 58-62 interferon gamma Mus musculus 244-253 2701577-7 1989 In contrast with marrow M phi, thioglycollate-elicited peritoneal M phi, which normally release only small quantities of PGE2, showed over 5-fold increases in PGE2 production following treatment with IFN gamma, IFN alpha/beta, or TNF, but not with other cytokines or mouse serum. Dinoprostone 121-125 interferon gamma Mus musculus 200-209 2701577-7 1989 In contrast with marrow M phi, thioglycollate-elicited peritoneal M phi, which normally release only small quantities of PGE2, showed over 5-fold increases in PGE2 production following treatment with IFN gamma, IFN alpha/beta, or TNF, but not with other cytokines or mouse serum. Dinoprostone 159-163 interferon gamma Mus musculus 200-209