PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20501519-5 2011 We found that ATO induced the expression of the proapoptotic GADD153 protein, a key player involved in ER stress-induced apoptosis, activated nuclear nuclear factor kappaB (NF-kappaB) DNA binding activities, and increased prostaglandine E2 (PGE2) production. Dinoprostone 241-245 DNA damage inducible transcript 3 Homo sapiens 61-68 26435723-4 2015 By treatment with PGE2, the chondrocytes apoptosis was significantly increased, the proapoptotic CHOP and JNK were upregulated, the prosurvival GRP78 and XBP1 were downregulated, and GSK-3beta was also upregulated. Dinoprostone 18-22 DNA damage inducible transcript 3 Homo sapiens 97-101 21471847-6 2011 PGE2-treated astroglioma cells showed a marked upregulation of IL-8, C/EBP-beta, and CHOP, as well as increased proliferation and decreased apoptosis compared with untreated cells. Dinoprostone 0-4 DNA damage inducible transcript 3 Homo sapiens 85-89 21471847-10 2011 (2) C/EBP-beta and CHOP may be involved in mediating PGE2-induced IL-8 activation in these tumors. Dinoprostone 53-57 DNA damage inducible transcript 3 Homo sapiens 19-23 18772138-2 2008 We have previously shown that in human T lymphocytes the CHOP phosphorylation induced by prostaglandin E(2) (PGE(2))-increased interleukin-8 (IL-8) gene expression. Dinoprostone 89-107 DNA damage inducible transcript 3 Homo sapiens 57-61 18772138-9 2008 Finally, chromatin immunoprecipitation data confirmed in vivo that PGE(2) induces CHOP binding to the IL-8 promoter. Dinoprostone 67-73 DNA damage inducible transcript 3 Homo sapiens 82-86 17709599-9 2008 We conclude that PGE-2 stimulates IL-8 production through the CHOP transcription factor in CF cells. Dinoprostone 17-22 DNA damage inducible transcript 3 Homo sapiens 62-66 15659384-0 2005 Prostaglandin E2 induces interleukin-8 gene transcription by activating C/EBP homologous protein in human T lymphocytes. Dinoprostone 0-16 DNA damage inducible transcript 3 Homo sapiens 72-96 15659384-3 2005 Several kinases, including protein kinase C, Src family tyrosine kinases, phosphatidylinositol 3-kinase, and p38 MAPK, were involved in PGE(2)-induced CHOP activation and IL-8 production. Dinoprostone 136-142 DNA damage inducible transcript 3 Homo sapiens 151-155