PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26435723-4	2015	By treatment with PGE2, the chondrocytes apoptosis was significantly increased, the proapoptotic CHOP and JNK were upregulated, the prosurvival GRP78 and XBP1 were downregulated, and GSK-3beta was also upregulated.	Dinoprostone	18-22	DNA damage inducible transcript 3	Homo sapiens	97-101	
18772138-2	2008	We have previously shown that in human T lymphocytes the CHOP phosphorylation induced by prostaglandin E(2) (PGE(2))-increased interleukin-8 (IL-8) gene expression.	Dinoprostone	89-107	DNA damage inducible transcript 3	Homo sapiens	57-61	
21471847-6	2011	PGE2-treated astroglioma cells showed a marked upregulation of IL-8, C/EBP-beta, and CHOP, as well as increased proliferation and decreased apoptosis compared with untreated cells.	Dinoprostone	0-4	DNA damage inducible transcript 3	Homo sapiens	85-89	
21471847-10	2011	(2) C/EBP-beta and CHOP may be involved in mediating PGE2-induced IL-8 activation in these tumors.	Dinoprostone	53-57	DNA damage inducible transcript 3	Homo sapiens	19-23	
20501519-5	2011	We found that ATO induced the expression of the proapoptotic GADD153 protein, a key player involved in ER stress-induced apoptosis, activated nuclear nuclear factor kappaB (NF-kappaB) DNA binding activities, and increased prostaglandine E2 (PGE2) production.	Dinoprostone	241-245	DNA damage inducible transcript 3	Homo sapiens	61-68	
18772138-9	2008	Finally, chromatin immunoprecipitation data confirmed in vivo that PGE(2) induces CHOP binding to the IL-8 promoter.	Dinoprostone	67-73	DNA damage inducible transcript 3	Homo sapiens	82-86	
17709599-9	2008	We conclude that PGE-2 stimulates IL-8 production through the CHOP transcription factor in CF cells.	Dinoprostone	17-22	DNA damage inducible transcript 3	Homo sapiens	62-66	
15659384-0	2005	Prostaglandin E2 induces interleukin-8 gene transcription by activating C/EBP homologous protein in human T lymphocytes.	Dinoprostone	0-16	DNA damage inducible transcript 3	Homo sapiens	72-96	
15659384-3	2005	Several kinases, including protein kinase C, Src family tyrosine kinases, phosphatidylinositol 3-kinase, and p38 MAPK, were involved in PGE(2)-induced CHOP activation and IL-8 production.	Dinoprostone	136-142	DNA damage inducible transcript 3	Homo sapiens	151-155