PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8738072-6	1996	The results obtained demonstrated significant changes in prostaglandin E2 and kallikrein activity during ACE inhibition.	Dinoprostone	57-73	angiotensin I converting enzyme	Homo sapiens	105-108	
18566439-1	2008	PGE2, an endogenous lipid mediator released in inflammatory conditions, affects both dendritic cell (DC) differentiation and maturation.	Dinoprostone	0-4	angiotensin I converting enzyme	Homo sapiens	101-103	
18566439-2	2008	Whereas the effect of PGE2 on fully differentiated DC was studied extensively, little is known about its effects on DC differentiation.	Dinoprostone	22-26	angiotensin I converting enzyme	Homo sapiens	51-53	
18566439-3	2008	In this study, we show that bone marrow-derived DC generated in the presence of PGE2 (DCp) acquire a proinflammatory profile; produce higher levels of proinflammatory cytokines/chemokines; express higher levels of MHC class II, costimulatory molecules, and TLRs; and exhibit increased activation of the NF-kappaB-signaling pathway.	Dinoprostone	80-84	angiotensin I converting enzyme	Homo sapiens	48-50	
18566439-4	2008	In addition, DCp exhibit a different IL-12/IL-23 profile than DC generated in the absence of PGE2.	Dinoprostone	93-97	angiotensin I converting enzyme	Homo sapiens	13-15	
18566439-9	2008	Our results suggest that the proinflammatory effects of PGE2 could be mediated, at least partially, through effects on differentiating DC and subsequent alterations in CD4+ T cell differentiation, resulting in the preferential development of pathogenic autoimmune Th17 cells.	Dinoprostone	56-60	angiotensin I converting enzyme	Homo sapiens	135-137	
2442780-2	1987	Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II activity, the other, is a direct effect on water flow independent of PGE2.	Dinoprostone	134-138	angiotensin I converting enzyme	Homo sapiens	170-181