PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24323317-4 2014 Atherosclerotic plaques produce significant amounts of prostaglandin E2 (PGE2), which activates its receptor EP3 on platelets and aggravates atherothrombosis. Dinoprostone 55-71 prostaglandin E receptor 3 (subtype EP3) Mus musculus 109-112 26463849-4 2015 Since the pathway PGE2/EP3 is not involved in murine hemostasis, we propose a "platelet EP3 paradigm" to describe this apparently paradoxical association between the facilitating impact on atherothrombosis and the unaltered hemostasis. Dinoprostone 18-22 prostaglandin E receptor 3 (subtype EP3) Mus musculus 88-91 26463849-10 2015 Thus, the murine "platelet EP3 paradigm" would apply to humans if the aggravating role of PGE2 on atherothrombosis is shown in patients. Dinoprostone 90-94 prostaglandin E receptor 3 (subtype EP3) Mus musculus 27-30 25997851-9 2015 Treatment of OPCs with an EP1/EP3 agonist 17 phenyl-trinor PGE2 reversed protection from a COX-2 inhibitor while inhibition of EP3 receptor protected OPCs from excitotoxicity. Dinoprostone 59-63 prostaglandin E receptor 3 (subtype EP3) Mus musculus 30-33 25205726-7 2015 All inhibitors of EP1, EP2, EP3 and EP4 receptors suppressed the PAR1-triggered PGE2 release. Dinoprostone 80-84 prostaglandin E receptor 3 (subtype EP3) Mus musculus 28-31 26632188-9 2015 These results suggest that the PGE2-to-EP3 signaling pathway is mediated mainly by the EP3gamma isoform in the motor neurons of mice, and that modulation of the EP3gamma isoform in motor neurons may be a promising new therapeutic approach for ALS. Dinoprostone 31-35 prostaglandin E receptor 3 (subtype EP3) Mus musculus 39-42 25847406-4 2015 EP receptor subtype 3 (EP3) is the most abundant EP receptor in the brain and we have previously shown that signaling through the PGE2 -EP3 axis exacerbates excitotoxicity and ischemic stroke outcomes. Dinoprostone 130-134 prostaglandin E receptor 3 (subtype EP3) Mus musculus 0-21 25847406-4 2015 EP receptor subtype 3 (EP3) is the most abundant EP receptor in the brain and we have previously shown that signaling through the PGE2 -EP3 axis exacerbates excitotoxicity and ischemic stroke outcomes. Dinoprostone 130-134 prostaglandin E receptor 3 (subtype EP3) Mus musculus 23-26 25847406-4 2015 EP receptor subtype 3 (EP3) is the most abundant EP receptor in the brain and we have previously shown that signaling through the PGE2 -EP3 axis exacerbates excitotoxicity and ischemic stroke outcomes. Dinoprostone 130-134 prostaglandin E receptor 3 (subtype EP3) Mus musculus 136-139 25847406-7 2015 To start investigating the mechanisms involved in neuroprotection with impaired PGE2 -EP3 signaling, histological staining was performed to evaluate blood and ferric iron accumulation, neuroinflammation, blood-brain barrier dysfunction, and peripheral neutrophil infiltration. Dinoprostone 80-84 prostaglandin E receptor 3 (subtype EP3) Mus musculus 86-89 25847406-10 2015 Collectively, these results suggest an injurious role for the PGE2 -EP3 signaling axis in modulating brain injury, inflammation, and neurological functional recovery after ICH. Dinoprostone 62-66 prostaglandin E receptor 3 (subtype EP3) Mus musculus 68-71 25847406-11 2015 Modulation of the PGE2 -EP3 signaling axis may represent a putative therapeutic avenue for the treatment of ICH. Dinoprostone 18-22 prostaglandin E receptor 3 (subtype EP3) Mus musculus 24-27 25054560-0 2014 PGE2 promotes apoptosis induced by cytokine deprivation through EP3 receptor and induces Bim in mouse mast cells. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 64-67 25054560-4 2014 We report here that PGE2 through the EP3 receptor promotes cell death of mast cells initiated by cytokine withdrawal. Dinoprostone 20-24 prostaglandin E receptor 3 (subtype EP3) Mus musculus 37-40 25054560-5 2014 Furthermore, the ability of PGE2 to limit reconstitution of tissues with cultured mast cells is lost in cell lacking the EP3 receptor. Dinoprostone 28-32 prostaglandin E receptor 3 (subtype EP3) Mus musculus 121-124 24323317-4 2014 Atherosclerotic plaques produce significant amounts of prostaglandin E2 (PGE2), which activates its receptor EP3 on platelets and aggravates atherothrombosis. Dinoprostone 73-77 prostaglandin E receptor 3 (subtype EP3) Mus musculus 109-112 24323317-6 2014 METHODS AND RESULTS: Inhibiting in vivo the receptor EP3 for PGE2 with the blocking agent DG-041 reduced murine thrombosis triggered by local delivery of arachidonic acid or ferric chloride on healthy arteries. Dinoprostone 61-65 prostaglandin E receptor 3 (subtype EP3) Mus musculus 53-56 24342806-0 2014 Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation. Dinoprostone 0-16 prostaglandin E receptor 3 (subtype EP3) Mus musculus 17-20 24342806-3 2014 Arachidonate- or PGE2-induced vascular permeability was significantly reduced in EP3-deficient mice. Dinoprostone 17-21 prostaglandin E receptor 3 (subtype EP3) Mus musculus 81-84 24342806-6 2014 Although the number of mast cells, protease activity, and histamine contents in ear tissues in EP3-deficient mice were comparable to those in wild-type mice, the histamine contents in ear tissues were attenuated upon PGE2 treatment in wild-type but not in EP3-deficient mice. Dinoprostone 217-221 prostaglandin E receptor 3 (subtype EP3) Mus musculus 95-98 24342806-6 2014 Although the number of mast cells, protease activity, and histamine contents in ear tissues in EP3-deficient mice were comparable to those in wild-type mice, the histamine contents in ear tissues were attenuated upon PGE2 treatment in wild-type but not in EP3-deficient mice. Dinoprostone 217-221 prostaglandin E receptor 3 (subtype EP3) Mus musculus 256-259 24342806-7 2014 Consistently, PGE2-EP3 signaling elicited histamine release in mouse peritoneal and bone marrow-derived mast cells, and it exerted degranulation and IL-6 production in a manner sensitive to pertussis toxin and a PI3K inhibitor and dependent on extracellular Ca(2+) ions. Dinoprostone 14-18 prostaglandin E receptor 3 (subtype EP3) Mus musculus 19-22 24342806-8 2014 These results demonstrate that PGE2 triggers mast cell activation via an EP3-Gi/o-Ca(2+) influx/PI3K pathway, and this mechanism underlies PGE2-induced vascular permeability and consequent edema formation. Dinoprostone 31-35 prostaglandin E receptor 3 (subtype EP3) Mus musculus 73-76 24342806-8 2014 These results demonstrate that PGE2 triggers mast cell activation via an EP3-Gi/o-Ca(2+) influx/PI3K pathway, and this mechanism underlies PGE2-induced vascular permeability and consequent edema formation. Dinoprostone 139-143 prostaglandin E receptor 3 (subtype EP3) Mus musculus 73-76 24154697-7 2013 Moreover, PGE2 and agonists/antagonists of EP3 and EP4 receptors significantly affected bladder dysfunction in EAE mice. Dinoprostone 10-14 prostaglandin E receptor 3 (subtype EP3) Mus musculus 43-46 24622825-7 2014 The effects of PGE2 on various gastric functions are mediated by different EP receptor subtypes; inhibition of acid secretion (EP3) and motility (EP1), stimulation of mucus secretion (EP4) and HCO3- secretion (EP1), and an increase in mucosal blood flow (EP2/EP4). Dinoprostone 15-19 prostaglandin E receptor 3 (subtype EP3) Mus musculus 127-130 23349487-3 2013 The EP3 receptor is stimulated by prostaglandin E2 (PGE2) and couples to G-proteins of the Gi subfamily to decrease intracellular cAMP, blunting glucose-stimulated insulin secretion (GSIS). Dinoprostone 34-50 prostaglandin E receptor 3 (subtype EP3) Mus musculus 4-7 23922752-9 2013 Taken together, PGE2-EP3 signaling is essential for fine-tuning excessive skin inflammation by restricting DC functions. Dinoprostone 16-20 prostaglandin E receptor 3 (subtype EP3) Mus musculus 21-24 23595951-13 2013 CONCLUSIONS: COX-2-derived PGE2 facilitated the neointimal hyperplasia response to injury through EP3alpha/beta-mediated cAMP/protein kinase A and phosphatidylinositol 3-kinase pathways, indicating EP3 inhibition may be a promising therapeutic strategy for percutaneous transluminal coronary angioplasty. Dinoprostone 27-31 prostaglandin E receptor 3 (subtype EP3) Mus musculus 98-101 23349487-3 2013 The EP3 receptor is stimulated by prostaglandin E2 (PGE2) and couples to G-proteins of the Gi subfamily to decrease intracellular cAMP, blunting glucose-stimulated insulin secretion (GSIS). Dinoprostone 52-56 prostaglandin E receptor 3 (subtype EP3) Mus musculus 4-7 23349487-6 2013 We confirmed that the PGE2-to-EP3 signaling pathway was active in islets from confirmed diabetic BTBR mice and human cadaveric donors, with increased EP3 expression, PGE2 production, and function of EP3 agonists and antagonists to modulate cAMP production and GSIS. Dinoprostone 22-26 prostaglandin E receptor 3 (subtype EP3) Mus musculus 30-33 23349487-6 2013 We confirmed that the PGE2-to-EP3 signaling pathway was active in islets from confirmed diabetic BTBR mice and human cadaveric donors, with increased EP3 expression, PGE2 production, and function of EP3 agonists and antagonists to modulate cAMP production and GSIS. Dinoprostone 166-170 prostaglandin E receptor 3 (subtype EP3) Mus musculus 30-33 20935544-1 2010 We first investigated whether the prostaglandin (PG) E2-PGE receptor subtype EP3 axis regulates the development of murine experimental allergic conjunctivitis because it has been reported that this pathway negatively regulates allergic reactions in a murine allergic asthma model. Dinoprostone 34-55 prostaglandin E receptor 3 (subtype EP3) Mus musculus 77-80 22915243-11 2012 INTERPRETATION: Our findings identify the PGE(2) EP3 receptor as a novel proinflammatory, proamyloidogenic, and synaptotoxic signaling pathway, and suggest a role for COX-PGE(2) -EP3 signaling in the development of AD. Dinoprostone 42-48 prostaglandin E receptor 3 (subtype EP3) Mus musculus 49-52 22915243-11 2012 INTERPRETATION: Our findings identify the PGE(2) EP3 receptor as a novel proinflammatory, proamyloidogenic, and synaptotoxic signaling pathway, and suggest a role for COX-PGE(2) -EP3 signaling in the development of AD. Dinoprostone 171-177 prostaglandin E receptor 3 (subtype EP3) Mus musculus 49-52 21311040-0 2011 Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation. Dinoprostone 9-25 prostaglandin E receptor 3 (subtype EP3) Mus musculus 26-29 21311040-8 2011 Lymphangiogenesis was suppressed in the granulation tissues of mice lacking either EP3 or EP4, suggesting that these molecules are receptors in response to endogenous PGE2. Dinoprostone 167-171 prostaglandin E receptor 3 (subtype EP3) Mus musculus 83-86 21116297-2 2011 Prostaglandin E(2) (PGE(2)), acting through its four receptor subtypes (EP1, EP2, EP3 and EP4), is involved in these stress responses. Dinoprostone 0-18 prostaglandin E receptor 3 (subtype EP3) Mus musculus 82-85 20935544-7 2010 These data suggest that PGE2 acts on EP3 in the conjunctival epithelium and downregulates the progression of experimental allergic conjunctivitis. Dinoprostone 24-28 prostaglandin E receptor 3 (subtype EP3) Mus musculus 37-40 18815228-0 2008 Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix. Dinoprostone 33-49 prostaglandin E receptor 3 (subtype EP3) Mus musculus 18-21 20110411-11 2010 The present results address the novel activities of COX-2/PGE2-EP3/EP4 signaling that modulate tumor biology and show that CXCL12/CXCR4 axis may play a crucial role in tumor stromal formation and angiogenesis under the control of prostaglandins. Dinoprostone 58-62 prostaglandin E receptor 3 (subtype EP3) Mus musculus 63-66 20857620-8 2010 The protective effect of PGE2 on indomethacin-induced small intestinal damage is mimicked by both EP3 and EP4 agonists. Dinoprostone 25-29 prostaglandin E receptor 3 (subtype EP3) Mus musculus 98-101 20857620-10 2010 The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown. Dinoprostone 46-50 prostaglandin E receptor 3 (subtype EP3) Mus musculus 193-196 20857620-10 2010 The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown. Dinoprostone 46-50 prostaglandin E receptor 3 (subtype EP3) Mus musculus 326-329 20166995-8 2010 These results suggest that the HCO(3)(-) stimulatory effect of PGE(2) in the duodenum is mediated by both EP3 and EP4 receptors, being coupled intracellularly with Ca(2+) and cAMP, while that in the stomach is mediated by EP1 receptors, coupled with Ca(2+). Dinoprostone 63-69 prostaglandin E receptor 3 (subtype EP3) Mus musculus 106-109 19157987-3 2009 Prostaglandin (PG) E(2) is a metabolite from arachidonic acid, and exerts its functions through G-protein-coupled receptors called EP1, EP2, EP3, and EP4. Dinoprostone 0-23 prostaglandin E receptor 3 (subtype EP3) Mus musculus 141-144 18996575-1 2009 BACKGROUND: We previously demonstrated that the prostaglandin E(2) (PGE(2))-EP3 pathway negatively regulates allergic reactions in a murine allergic asthma model. Dinoprostone 48-66 prostaglandin E receptor 3 (subtype EP3) Mus musculus 76-79 18996575-1 2009 BACKGROUND: We previously demonstrated that the prostaglandin E(2) (PGE(2))-EP3 pathway negatively regulates allergic reactions in a murine allergic asthma model. Dinoprostone 68-74 prostaglandin E receptor 3 (subtype EP3) Mus musculus 76-79 18815228-5 2008 In contrast to the elevated cAMP-dependent adhesion of P-815 cells, EP3-mediated Ca(2+) mobilization plays a pivotal role in PGE(2)-induced adhesion of BMMCs. Dinoprostone 125-131 prostaglandin E receptor 3 (subtype EP3) Mus musculus 68-71 18815228-11 2008 These results suggested that the EP3 subtype plays a pivotal role in PGE(2)-induced adhesion of murine mast cells to the RGD-enriched matrix through Ca(2+) mobilization. Dinoprostone 69-75 prostaglandin E receptor 3 (subtype EP3) Mus musculus 33-36 18815228-3 2008 We previously demonstrated that prostaglandin (PG) E(2) stimulates adhesion of a mouse mastocytoma cell line, P-815, to the Arg-Gly-Asp (RGD)-enriched matrix through cooperation between two PGE(2) receptor subtypes: EP3 and EP4 (Hatae N, Kita A, Tanaka S, Sugimoto Y, Ichikawa A. J Biol Chem 278: 17977-17981, 2003). Dinoprostone 32-55 prostaglandin E receptor 3 (subtype EP3) Mus musculus 216-219 17606905-10 2007 Chemotaxis induced by PGE2 was mimicked by EP3 agonists, blocked by an EP3 receptor antagonist, and partially inhibited by a MAPKK inhibitor. Dinoprostone 22-26 prostaglandin E receptor 3 (subtype EP3) Mus musculus 43-46 18508878-0 2008 Enhanced bladder capacity and reduced prostaglandin E2-mediated bladder hyperactivity in EP3 receptor knockout mice. Dinoprostone 38-54 prostaglandin E receptor 3 (subtype EP3) Mus musculus 89-92 18508878-6 2008 In addition, infusion of PGE2 into WT mice induced bladder overactivity, an effect that was significantly blunted in the EP3 KO mice. Dinoprostone 25-29 prostaglandin E receptor 3 (subtype EP3) Mus musculus 121-124 18292084-3 2008 As a first step toward this issue, we examined PGE(2)-induced gene expression changes at single-cell resolution in preoptic neurons expressing EP3. Dinoprostone 47-53 prostaglandin E receptor 3 (subtype EP3) Mus musculus 143-146 17606905-10 2007 Chemotaxis induced by PGE2 was mimicked by EP3 agonists, blocked by an EP3 receptor antagonist, and partially inhibited by a MAPKK inhibitor. Dinoprostone 22-26 prostaglandin E receptor 3 (subtype EP3) Mus musculus 71-74 16644903-11 2006 injection of PGE2 (3 nmol/paw) induced a significant activation of MAPKs, namely, JNK and p38, an effect that was largely prevented by the selective EP3 receptor antagonist L826266 (10 nmol/paw). Dinoprostone 13-17 prostaglandin E receptor 3 (subtype EP3) Mus musculus 149-152 17535900-8 2007 We conclude that IL-1beta adversely affects breathing and its control by mPGES-1 activation and PGE(2) binding to brainstem EP3 receptors, resulting in increased apnea frequency and hypoxia-induced mortality. Dinoprostone 96-102 prostaglandin E receptor 3 (subtype EP3) Mus musculus 124-127 17242161-0 2007 Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors. Dinoprostone 23-39 prostaglandin E receptor 3 (subtype EP3) Mus musculus 110-113 17242161-8 2007 We demonstrate that this plaque-produced PGE2 is not altered and is still able to activate EP3. Dinoprostone 41-45 prostaglandin E receptor 3 (subtype EP3) Mus musculus 91-94 17242161-9 2007 In addition, we present evidence that PGE2 can leave the plaque and activate EP3 on blood platelets. Dinoprostone 38-42 prostaglandin E receptor 3 (subtype EP3) Mus musculus 77-80 16644903-12 2006 Collectively, these findings indicate that edematogenic responses elicited by PGE2 are mediated by EP3 receptor activation, also involving the stimulation of PLC, PKC, and MAPKs pathways and the participation of TRPV1 and NK1 receptors. Dinoprostone 78-82 prostaglandin E receptor 3 (subtype EP3) Mus musculus 99-102 15619666-20 2005 CONCLUSIONS: We conclude that PGE2 has an initial inhibitory effect on OC formation in spleen cell cultures, possibly mediated by both EP2 and EP3 receptors, and a later stimulatory effect, mediated by the EP2 receptor, possibly acting on T-cells. Dinoprostone 30-34 prostaglandin E receptor 3 (subtype EP3) Mus musculus 143-146 16189372-3 2005 PGE2 acts through four different receptor subtypes (EP1, EP2, EP3, and EP4) that may explain some of PGE2"s diverse effects. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 62-65 16189372-3 2005 PGE2 acts through four different receptor subtypes (EP1, EP2, EP3, and EP4) that may explain some of PGE2"s diverse effects. Dinoprostone 101-105 prostaglandin E receptor 3 (subtype EP3) Mus musculus 62-65 16000196-7 2005 These results suggest that prostaglandin D2 and prostaglandin E2 accelerate the recovery process of cutaneous barrier disruption caused by mechanical scratching, via specific prostanoid DP1, EP3 and EP4 receptors. Dinoprostone 48-64 prostaglandin E receptor 3 (subtype EP3) Mus musculus 191-194 15976003-13 2005 In summary, these findings demonstrate that the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the HPS/aBS model. Dinoprostone 163-167 prostaglandin E receptor 3 (subtype EP3) Mus musculus 113-116 11502472-4 2001 The PGE2 influence on bone is mediated through four well-characterized receptors (EP1, EP2, EP3, and EP4). Dinoprostone 4-8 prostaglandin E receptor 3 (subtype EP3) Mus musculus 92-95 15127302-9 2004 Using RT-PCR, we confirmed the expression of the PGE2 (EP) receptor subtypes EP1, EP3 and EP4 but not of EP2 in cultured M-1 CCD cells. Dinoprostone 49-53 prostaglandin E receptor 3 (subtype EP3) Mus musculus 82-85 14577329-10 2003 These findings indicate that two subtypes of PGE2 receptors, EP3 and EP4, cooperatively activate the cAMP-mediated adhesion event through induction of fibronectin ligand elicited by PGE2 in P-815 cells. Dinoprostone 45-49 prostaglandin E receptor 3 (subtype EP3) Mus musculus 61-64 12538661-0 2003 Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. Dinoprostone 5-23 prostaglandin E receptor 3 (subtype EP3) Mus musculus 24-27 11991626-9 2002 These results suggest that the intestinal cytoprotective action of PGE2 against indomethacin is mediated by EP3/EP4 receptors and that this effect is functionally associated with an increase of mucus secretion and enteropooling as well as inhibition of intestinal hypermotility, the former two processes mediated by both EP3 and EP4 receptors, and the latter by EP4 receptors. Dinoprostone 67-71 prostaglandin E receptor 3 (subtype EP3) Mus musculus 108-111 11991626-9 2002 These results suggest that the intestinal cytoprotective action of PGE2 against indomethacin is mediated by EP3/EP4 receptors and that this effect is functionally associated with an increase of mucus secretion and enteropooling as well as inhibition of intestinal hypermotility, the former two processes mediated by both EP3 and EP4 receptors, and the latter by EP4 receptors. Dinoprostone 67-71 prostaglandin E receptor 3 (subtype EP3) Mus musculus 321-324 14569157-5 2003 The results demonstrated that 1) PGI2 plays an important role in attenuating the ischemic injury and the pressure overload-induced hypertrophy of the hearts, and also contributes to the development of renovascular hypertension; 2) PGE2 plays a cardioprotective role against the ischemic injury via both the EP3 and EP4, and also participates in acute thromboembolism via the EP3; and 3) both PGF2alpha and TXA2, which have been produced during systemic inflammation, are responsible for tachycardia. Dinoprostone 231-235 prostaglandin E receptor 3 (subtype EP3) Mus musculus 307-310 14569157-5 2003 The results demonstrated that 1) PGI2 plays an important role in attenuating the ischemic injury and the pressure overload-induced hypertrophy of the hearts, and also contributes to the development of renovascular hypertension; 2) PGE2 plays a cardioprotective role against the ischemic injury via both the EP3 and EP4, and also participates in acute thromboembolism via the EP3; and 3) both PGF2alpha and TXA2, which have been produced during systemic inflammation, are responsible for tachycardia. Dinoprostone 231-235 prostaglandin E receptor 3 (subtype EP3) Mus musculus 375-378 9843913-0 1998 Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2. Dinoprostone 65-81 prostaglandin E receptor 3 (subtype EP3) Mus musculus 47-50 11375261-0 2001 Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice. Dinoprostone 57-73 prostaglandin E receptor 3 (subtype EP3) Mus musculus 115-118 11375261-3 2001 PGE2 could induce mechanical allodynia in EP1(+/+), EP3(+/+) and EP3(-/-) mice, but not in EP1(-/-) mice. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 52-55 11375261-3 2001 PGE2 could induce mechanical allodynia in EP1(+/+), EP3(+/+) and EP3(-/-) mice, but not in EP1(-/-) mice. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 65-68 11375261-7 2001 Although PGE2 produced thermal hyperalgesia over a wide range of dosages from 50 pg to 0.5 microg kg(-1) in EP3(+/+) mice, it showed a monophasic hyperalgesic action at 5 ng kg(-1) or higher doses in EP3(-/-) mice. Dinoprostone 9-13 prostaglandin E receptor 3 (subtype EP3) Mus musculus 108-111 11375261-7 2001 Although PGE2 produced thermal hyperalgesia over a wide range of dosages from 50 pg to 0.5 microg kg(-1) in EP3(+/+) mice, it showed a monophasic hyperalgesic action at 5 ng kg(-1) or higher doses in EP3(-/-) mice. Dinoprostone 9-13 prostaglandin E receptor 3 (subtype EP3) Mus musculus 200-203 11375261-12 2001 These results demonstrate that spinal EP1 receptors are involved in the PGE2-induced allodynia and that spinal EP3 receptors are involved in the hyperalgesia induced by low doses of PGE2. Dinoprostone 182-186 prostaglandin E receptor 3 (subtype EP3) Mus musculus 111-114 11338379-3 2001 In calvarial culture from EP1-, EP2-, and EP3- knockout mice, PGE2 stimulated bone resorption to a similar extent to that found in calvaria from the wild-type mice. Dinoprostone 62-66 prostaglandin E receptor 3 (subtype EP3) Mus musculus 42-45 10749873-5 2000 In calvarial culture from EP1-, EP2-, and EP3-knockout mice, PGE(2) stimulated bone resorption to an extent similar to that found in calvaria from the wild-type mice. Dinoprostone 61-67 prostaglandin E receptor 3 (subtype EP3) Mus musculus 42-45 10703923-1 2000 Prostaglandin E2 (PGE2) exerts its effects through the PGE receptor that consists of four subtypes (EP1, EP2, EP3, and EP4). Dinoprostone 18-22 prostaglandin E receptor 3 (subtype EP3) Mus musculus 110-113 10480485-5 1999 In mature adipocytes, however, the equipment of mRNAs encoding the EP3 receptor isoforms is in agreement with the well known effect of PGE2 on adenylate cyclase and lipolysis in mature adipocytes. Dinoprostone 135-139 prostaglandin E receptor 3 (subtype EP3) Mus musculus 67-70 11238561-0 2001 Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. Dinoprostone 42-46 prostaglandin E receptor 3 (subtype EP3) Mus musculus 25-28 11238561-6 2001 This study shows that among the four PGE2 receptors (EP1-EP4), activation of EP3 is sufficient to mediate the proaggregatory actions of low PGE2 concentration. Dinoprostone 37-41 prostaglandin E receptor 3 (subtype EP3) Mus musculus 77-80 11086097-0 2000 Prostaglandin E2 selectively enhances the IgE-mediated production of IL-6 and granulocyte-macrophage colony-stimulating factor by mast cells through an EP1/EP3-dependent mechanism. Dinoprostone 0-16 prostaglandin E receptor 3 (subtype EP3) Mus musculus 156-159 11001172-4 2000 Several important actions of PGE2 are exerted via each of the four PGE2 receptor subtypes: EP1, EP2, EP3 and EP4. Dinoprostone 29-33 prostaglandin E receptor 3 (subtype EP3) Mus musculus 101-104 11001172-7 2000 PGE2 worked as a mediator of febrile responses to both endogenous and exogenous pyrogens and as a regulator of bicarbonate secretion induced by acid-stimulation in the duodenum via the EP3. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 185-188 10807413-9 2000 PGE2 caused an inhibition of gastric motility as well as an increase of mucosal blood flow and mucus secretion, the effects being mimicked by prostanoids activating EP1 receptors, EP2/EP3/EP4 receptors and EP4 receptors, respectively. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 184-219 10703923-1 2000 Prostaglandin E2 (PGE2) exerts its effects through the PGE receptor that consists of four subtypes (EP1, EP2, EP3, and EP4). Dinoprostone 0-16 prostaglandin E receptor 3 (subtype EP3) Mus musculus 110-113 10484412-7 1999 Finally, in male mice, the EP3 receptor actively opposes the vasodepressor actions of PGE2. Dinoprostone 86-90 prostaglandin E receptor 3 (subtype EP3) Mus musculus 27-30 9843913-9 1998 This suggests that PGE2 acts through the EP3 receptor to modulate urinary concentrating mechanisms in the kidney, but these effects are not essential for normal regulation of urinary osmolality. Dinoprostone 19-23 prostaglandin E receptor 3 (subtype EP3) Mus musculus 41-44 9348184-2 1997 Four major PGE2 receptor subtypes, EP1, EP2, EP3, and EP4, mediate various PGE2 effects via their coupling to distinct signaling pathways. Dinoprostone 11-15 prostaglandin E receptor 3 (subtype EP3) Mus musculus 45-48 9751056-6 1998 PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 75-78 9751056-8 1998 Only mice lacking the EP3 receptor fail to show a febrile response to PGE2 and to either IL-1beta or LPS. Dinoprostone 70-74 prostaglandin E receptor 3 (subtype EP3) Mus musculus 22-25 9751056-9 1998 Our results establish that PGE2 mediates fever generation in response to both exogenous and endogenous pyrogens by acting at the EP3 receptor. Dinoprostone 27-31 prostaglandin E receptor 3 (subtype EP3) Mus musculus 129-132 9849653-8 1998 However, its specificity was partially changed as the EP3-specific agonist became less effective in displacing the [3H]-PGE2 binding to the mutant receptor. Dinoprostone 120-124 prostaglandin E receptor 3 (subtype EP3) Mus musculus 54-57 9348184-3 1997 Previously, we have shown that the EP1, EP3, and EP4 genes are expressed in the periimplantation mouse uterus in a spatio-temporal manner, suggesting compartmentalized actions of PGE2 during this period. Dinoprostone 179-183 prostaglandin E receptor 3 (subtype EP3) Mus musculus 40-43 9116135-11 1997 In contrast, expression of EP3 in a subpopulation of cells in the stromal bed at the mesometrial side, and of EP4 in the epithelium and stroma on these days, suggests that PGE2 effects on uterine preparation for implantation (such as epithelial cell differentiation, stromal cell proliferation, uterine edema, luminal closure, and increased localized endometrial vascular permeability at the sites of blastocyst attachment) are mediated by these receptor subtypes. Dinoprostone 172-176 prostaglandin E receptor 3 (subtype EP3) Mus musculus 27-30 9178880-6 1997 and by prostaglandin E2 or the EP3 receptor agonist sulprostone, acting via EP3 receptors. Dinoprostone 7-23 prostaglandin E receptor 3 (subtype EP3) Mus musculus 76-79 9178880-8 1997 When prostaglandin E2 or sulprostone was given first (at concentrations causing the maximum effect at EP3 receptors), the effect of histamine or imetit on the evoked overflow was attenuated by almost 50%. Dinoprostone 5-21 prostaglandin E receptor 3 (subtype EP3) Mus musculus 102-105 7647986-3 1995 administration of prostaglandin E2 (PGE2) to conscious mice was reported to induce allodynia, a state of discomfort and pain evoked by innocuous tactile stimuli through prostaglandin E receptor subtype EP1 and hyperalgesia through prostaglandin E receptor subtypes EP2 and/or EP3. Dinoprostone 18-34 prostaglandin E receptor 3 (subtype EP3) Mus musculus 276-279 7647986-3 1995 administration of prostaglandin E2 (PGE2) to conscious mice was reported to induce allodynia, a state of discomfort and pain evoked by innocuous tactile stimuli through prostaglandin E receptor subtype EP1 and hyperalgesia through prostaglandin E receptor subtypes EP2 and/or EP3. Dinoprostone 36-40 prostaglandin E receptor 3 (subtype EP3) Mus musculus 276-279 7606458-2 1995 injection of prostaglandin E2 (PGE2) to conscious mice produced a hyperalgesic action over a wide range of dosages with two apparent peaks at 100 pg and 10 ng per mouse, which may be mediated through EP3 and EP2 subtypes of the PGE receptor. Dinoprostone 13-29 prostaglandin E receptor 3 (subtype EP3) Mus musculus 200-203 7606458-2 1995 injection of prostaglandin E2 (PGE2) to conscious mice produced a hyperalgesic action over a wide range of dosages with two apparent peaks at 100 pg and 10 ng per mouse, which may be mediated through EP3 and EP2 subtypes of the PGE receptor. Dinoprostone 31-35 prostaglandin E receptor 3 (subtype EP3) Mus musculus 200-203 7606458-9 1995 These results first demonstrate that the NMDA receptor is involved in the PGE2-induced hyperalgesia and suggest that the hyperalgesic action by lower and higher doses of PGE2 may be mediated through EP3 and EP2 subtypes, respectively. Dinoprostone 74-78 prostaglandin E receptor 3 (subtype EP3) Mus musculus 199-202 7855308-3 1994 TEI-3356 selectively displaced the [3H]PGE2 binding to EP3-expressing cell membranes, but showed very low affinity for both EP1 and EP2. Dinoprostone 39-43 prostaglandin E receptor 3 (subtype EP3) Mus musculus 55-58 7606458-9 1995 These results first demonstrate that the NMDA receptor is involved in the PGE2-induced hyperalgesia and suggest that the hyperalgesic action by lower and higher doses of PGE2 may be mediated through EP3 and EP2 subtypes, respectively. Dinoprostone 170-174 prostaglandin E receptor 3 (subtype EP3) Mus musculus 199-202 7715741-0 1995 Prostanoid receptors of the EP3 subtype mediate the inhibitory effect of prostaglandin E2 on noradrenaline release in the mouse brain cortex. Dinoprostone 73-89 prostaglandin E receptor 3 (subtype EP3) Mus musculus 28-31 7855308-5 1994 On the other hand, sulprostone strongly displaced the [3H]PGE2 binding to EP1 and EP3, but not to EP2. Dinoprostone 58-62 prostaglandin E receptor 3 (subtype EP3) Mus musculus 82-85 7733888-1 1995 A cDNA encoding for mouse prostaglandin E2 (PGE2) receptor EP3 subtype was cloned from a mouse kidney cDNA library by PCR using terminal primers derived from the known sequence of mouse lung EP3 receptor cDNA. Dinoprostone 26-42 prostaglandin E receptor 3 (subtype EP3) Mus musculus 59-62 7733888-1 1995 A cDNA encoding for mouse prostaglandin E2 (PGE2) receptor EP3 subtype was cloned from a mouse kidney cDNA library by PCR using terminal primers derived from the known sequence of mouse lung EP3 receptor cDNA. Dinoprostone 26-42 prostaglandin E receptor 3 (subtype EP3) Mus musculus 191-194 7870313-7 1994 Based on these distributions, we suggest that EP3 not only mediates prostaglandin E2 signals evoked by blood-borne cytokines in the areas poor in the blood-brain barrier, but also responds to those formed intrinsically within the brain to modulate various neuronal activities. Dinoprostone 68-84 prostaglandin E receptor 3 (subtype EP3) Mus musculus 46-49 7945376-2 1994 In Chinese hamster ovary cells expressing each EP3 isoform, PGE2 induced an immediate increase in the intracellular Ca2+ concentration ([Ca2+]i) due to both Ca2+ mobilization from internal stores and influx from the extracellular medium. Dinoprostone 60-64 prostaglandin E receptor 3 (subtype EP3) Mus musculus 47-50 7870313-8 1994 Possible EP3 actions are discussed in relation to the reported neuronal activities of prostaglandin E2 in the brain. Dinoprostone 86-102 prostaglandin E receptor 3 (subtype EP3) Mus musculus 9-12 34420370-6 2021 Antagonists of prostaglandin E2-EP1/EP3 receptors and thromboxane A2-TP receptors decreased the effect of 6beta-hydroxytestosterone in restoring the angiotensin II-induced increase in systolic blood pressure, cardiac and renal collagen deposition, and reactive oxygen species production in cPLA2alpha+/+/Cyp1b1-/- mice. Dinoprostone 15-31 prostaglandin E receptor 3 (subtype EP3) Mus musculus 32-39 8382086-2 1993 PGE2 inhibited forskolin-stimulated adenylate cyclase activity in CHO cells expressing EP3 receptor and this inhibition was abolished by pertussis toxin (PT) treatment. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 87-90 8382086-6 1993 [3H]PGE2-bound EP3 receptor solubilized from the ADP-ribosylated membranes in the presence or absence of GTP gamma S was eluted at the position of M(r) = approx. Dinoprostone 4-8 prostaglandin E receptor 3 (subtype EP3) Mus musculus 15-18 1372606-6 1992 The EP3-selective agonists, M&B 28,767 or GR 63799X, potently competed for the [3H]PGE2 binding, but no competition was found with EP1- or EP2-selective ligands. Dinoprostone 87-91 prostaglandin E receptor 3 (subtype EP3) Mus musculus 4-7 34845842-9 2022 Sulprostone, a PGE2 -EP3 agonist, increased the pacemaking potential frequency, maximum rate of rise of resting membrane in pacemaker potentials and basal cellular adenylate cyclase activity in colonic ICC. Dinoprostone 15-19 prostaglandin E receptor 3 (subtype EP3) Mus musculus 21-24 34449098-3 2021 Our recent studies from genetically altered mice further suggest that vasomotor reactions to PGI2 are collectively modulated by IP, the vasoconstrictor Tx-prostanoid receptor (TP; the prototype receptor of TxA2 ) and E prostanoid receptor-3 (EP3; a vasoconstrictor receptor of PGE2 ) although with differences in potency and efficacy; a contraction to PGI2 reflects activities of TP and/or EP3 outweighing that of the concurrently activated IP. Dinoprostone 277-281 prostaglandin E receptor 3 (subtype EP3) Mus musculus 217-240 34449098-3 2021 Our recent studies from genetically altered mice further suggest that vasomotor reactions to PGI2 are collectively modulated by IP, the vasoconstrictor Tx-prostanoid receptor (TP; the prototype receptor of TxA2 ) and E prostanoid receptor-3 (EP3; a vasoconstrictor receptor of PGE2 ) although with differences in potency and efficacy; a contraction to PGI2 reflects activities of TP and/or EP3 outweighing that of the concurrently activated IP. Dinoprostone 277-281 prostaglandin E receptor 3 (subtype EP3) Mus musculus 242-245 7921597-11 1994 17-Phenyl-omega-trinor PGE2 (EP1 > EP3) and 16,16-dimethyl PGE2 (EP1 = EP2 = EP3) were as potent as PGE2 in inducing allodynia, and more potent than sulprostone. Dinoprostone 23-27 prostaglandin E receptor 3 (subtype EP3) Mus musculus 38-41 7921597-19 1994 These results demonstrate that PGE2 may exert allodynia through the EP1-receptor and hyperalgesia through EP2- and EP3-receptors in the mouse spinal cord. Dinoprostone 31-35 prostaglandin E receptor 3 (subtype EP3) Mus musculus 115-118 8198593-2 1994 Preincubation of Chinese hamster ovary cells expressing each isoform with PGE2 concentration-dependently enhanced both the basal and forskolin-stimulated cAMP formation, but two orders higher concentrations of PGE2 were required for EP3 beta than EP3 alpha for 50% enhancement of both formations. Dinoprostone 74-78 prostaglandin E receptor 3 (subtype EP3) Mus musculus 233-236 8198593-2 1994 Preincubation of Chinese hamster ovary cells expressing each isoform with PGE2 concentration-dependently enhanced both the basal and forskolin-stimulated cAMP formation, but two orders higher concentrations of PGE2 were required for EP3 beta than EP3 alpha for 50% enhancement of both formations. Dinoprostone 74-78 prostaglandin E receptor 3 (subtype EP3) Mus musculus 247-250 8198593-2 1994 Preincubation of Chinese hamster ovary cells expressing each isoform with PGE2 concentration-dependently enhanced both the basal and forskolin-stimulated cAMP formation, but two orders higher concentrations of PGE2 were required for EP3 beta than EP3 alpha for 50% enhancement of both formations. Dinoprostone 210-214 prostaglandin E receptor 3 (subtype EP3) Mus musculus 233-236 7515568-7 1994 The results support the notion that PGE2 modulates water and solute transport through the EP3 receptor in specific structures of the kidney. Dinoprostone 36-40 prostaglandin E receptor 3 (subtype EP3) Mus musculus 90-93 8381413-5 1993 Without a change in the Bmax value, GTP gamma S increased Kd for prostaglandin E2 of EP3 beta and decreased that of EP3 alpha. Dinoprostone 65-81 prostaglandin E receptor 3 (subtype EP3) Mus musculus 85-88 34626853-0 2021 Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of Type 2 diabetes enhances beta-cell proliferation and identity, and relieves oxidative damage. Dinoprostone 36-52 prostaglandin E receptor 3 (subtype EP3) Mus musculus 32-35 33467110-3 2021 The primary endogenous EP3 ligand is the arachidonic acid metabolite prostaglandin E2 (PGE2). Dinoprostone 69-85 prostaglandin E receptor 3 (subtype EP3) Mus musculus 23-26 35105690-3 2022 Restricting PGE2 signaling via knockout of microsomal prostaglandin E synthase-1 (mPGES-1) in PyMT mice or of the prostanoid E receptor 3 (EP3) in CAFs stunted mammary carcinoma growth associated with strong CAF proliferation. Dinoprostone 12-16 prostaglandin E receptor 3 (subtype EP3) Mus musculus 139-142 35228744-5 2022 Mechanistically, the protective role of mPGES-2 deletion is induced by antagonizing beta-cell senescence via interference of the PGE2-EP3-NR4A1 signalling axis. Dinoprostone 129-133 prostaglandin E receptor 3 (subtype EP3) Mus musculus 134-137 35228744-7 2022 We conclude that mPGES-2 contributes to ageing-associated beta-cell senescence and dysfunction via the PGE2-EP3-NR4A1 signalling axis. Dinoprostone 103-107 prostaglandin E receptor 3 (subtype EP3) Mus musculus 108-111 34405216-2 2021 PGE2 regulates blood pressure through its 4 G protein coupled receptors, i.e., EP1, EP2, EP3, and EP4. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 89-92 33641369-10 2021 In conclusion, interference with PPARgamma in vascular smooth muscle causes activation of the PGE2/EP3 signaling pathway in systemic and renal vasculature resulting in salt-induced impairment of vasodilation and salt-sensitive hypertension. Dinoprostone 94-98 prostaglandin E receptor 3 (subtype EP3) Mus musculus 99-102 33641369-11 2021 PGE2/EP3 axis maybe a druggable target to prevent salt-sensitive hypertension in chronic conditions associated with decreased PPARgamma activity. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 5-8 33467110-3 2021 The primary endogenous EP3 ligand is the arachidonic acid metabolite prostaglandin E2 (PGE2). Dinoprostone 87-91 prostaglandin E receptor 3 (subtype EP3) Mus musculus 23-26 31617678-0 2020 Role of the PGE2 receptor subtypes EP1, EP2, and EP3 in repetitive traumatic brain injury. Dinoprostone 12-16 prostaglandin E receptor 3 (subtype EP3) Mus musculus 49-52 32618816-4 2020 The aim of the present study is to investigate the desensitization of TRPV1 receptor by nonpungent agonists and to determine how bradykinin and prostaglandin E2 receptors (EP3 and EP4) modulate the resensitization of TRPV1 receptor after being desensitized by nonpungent agonists. Dinoprostone 144-160 prostaglandin E receptor 3 (subtype EP3) Mus musculus 172-175 29488342-0 2018 PGE2-EP3 signaling exacerbates hippocampus-dependent cognitive impairment after laparotomy by reducing expression levels of hippocampal synaptic plasticity-related proteins in aged mice. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 5-8 33654831-2 2019 PGE2 mediates fever generation via PGE receptor 3 (i.e., EP3) on neurons in the preoptic area. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 57-60 31908041-0 2020 Prostaglandin E2 sequentially activates E-prostanoid receptor-3 and thromboxane prostanoid receptor to evoke contraction and increase in resistance of the mouse renal vasculature. Dinoprostone 0-16 prostaglandin E receptor 3 (subtype EP3) Mus musculus 40-63 31908041-1 2020 Although recognized to have an in vivo vasodepressor effect blunted by the vasoconstrictor effect of E-prostanoid receptor-3 (EP3), prostaglandin E2 (PGE2 ) evokes contractions of many vascular beds that are sensitive to antagonizing the thromboxane prostanoid receptor (TP). Dinoprostone 132-148 prostaglandin E receptor 3 (subtype EP3) Mus musculus 101-124 31908041-1 2020 Although recognized to have an in vivo vasodepressor effect blunted by the vasoconstrictor effect of E-prostanoid receptor-3 (EP3), prostaglandin E2 (PGE2 ) evokes contractions of many vascular beds that are sensitive to antagonizing the thromboxane prostanoid receptor (TP). Dinoprostone 150-154 prostaglandin E receptor 3 (subtype EP3) Mus musculus 101-124 31908041-5 2020 EP3-/- diminished the response to 0.001-0.3 muM PGE2 , while TP-/- reduced that to the prostanoid of higher concentrations. Dinoprostone 48-52 prostaglandin E receptor 3 (subtype EP3) Mus musculus 0-3 31908041-6 2020 In TP-/- /EP3-/- vessels and perfused kidneys, PGE2 did not evoke contraction but instead resulted in vasodilator responses. Dinoprostone 47-51 prostaglandin E receptor 3 (subtype EP3) Mus musculus 10-13 31908041-8 2020 Also, our results suggest that EP3 dominates the vasoconstrictor effect of PGE2 of low concentrations (<=0.001-0.3 muM), but its effect is further added by that of TP, which has a higher efficacy, although activated by higher concentrations (from 0.01 muM) of the same prostanoid PGE2 . Dinoprostone 75-79 prostaglandin E receptor 3 (subtype EP3) Mus musculus 31-34 31908041-8 2020 Also, our results suggest that EP3 dominates the vasoconstrictor effect of PGE2 of low concentrations (<=0.001-0.3 muM), but its effect is further added by that of TP, which has a higher efficacy, although activated by higher concentrations (from 0.01 muM) of the same prostanoid PGE2 . Dinoprostone 280-284 prostaglandin E receptor 3 (subtype EP3) Mus musculus 31-34 32411331-5 2020 Dichlorofluorescein (DCF) fluorescence analysis of PGE2-treated cells showed that intracellular ROS levels increased markedly with time, and that this effect was antagonized by a selective EP2 antagonist (PF-04418948) but not a selective EP3 antagonist (L-798,106). Dinoprostone 51-55 prostaglandin E receptor 3 (subtype EP3) Mus musculus 238-241 31627451-5 2019 Prostaglandin E2 (PGE2) induced synergistic degranulation when bone marrow-derived MCs (BMMCs) were co-stimulated with ATP, while pharmacological analyses revealed that the effects of PGE2 and ATP were mediated by EP3 and P2X4R, respectively. Dinoprostone 0-16 prostaglandin E receptor 3 (subtype EP3) Mus musculus 214-217 31627451-5 2019 Prostaglandin E2 (PGE2) induced synergistic degranulation when bone marrow-derived MCs (BMMCs) were co-stimulated with ATP, while pharmacological analyses revealed that the effects of PGE2 and ATP were mediated by EP3 and P2X4R, respectively. Dinoprostone 18-22 prostaglandin E receptor 3 (subtype EP3) Mus musculus 214-217 30027346-2 2018 We hypothesized that an increase of renal EP2 or EP4 receptors and/or a downregulation of renal EP1 and EP3 receptors enhances PGE2-induced renal vasodilatation. Dinoprostone 127-131 prostaglandin E receptor 3 (subtype EP3) Mus musculus 104-107 29488342-11 2018 CONCLUSION: This study showed that PGE2-EP3 signaling pathway was involved in the progression of POCD and identified EP3 receptor as a promising treatment target. Dinoprostone 35-39 prostaglandin E receptor 3 (subtype EP3) Mus musculus 117-120 29488342-11 2018 CONCLUSION: This study showed that PGE2-EP3 signaling pathway was involved in the progression of POCD and identified EP3 receptor as a promising treatment target. Dinoprostone 35-39 prostaglandin E receptor 3 (subtype EP3) Mus musculus 40-43 29735520-9 2018 These findings indicate that COX-1 and the EP1 and EP3 receptors mediate the downstream pathological effects of PGE2 during polymicrobial IAI and may serve as effective therapeutic targets. Dinoprostone 112-116 prostaglandin E receptor 3 (subtype EP3) Mus musculus 51-54 30038227-2 2018 PGE2 and PGF2alpha were topically applied to induce transient OH in Wild-type (WT) and FP-, EP1-, EP2-, and EP3-deficient (knockout [KO]) mice. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 108-111 28039934-0 2017 Prostaglandin E2 promotes hepatic bile acid synthesis by an E prostanoid receptor 3-mediated hepatocyte nuclear receptor 4alpha/cholesterol 7alpha-hydroxylase pathway in mice. Dinoprostone 0-16 prostaglandin E receptor 3 (subtype EP3) Mus musculus 60-83 29522761-2 2018 We recently reported that PGE2 via its EP3 receptor could reduce cardiac contractility of isolated myocytes and the working heart preparation. Dinoprostone 26-30 prostaglandin E receptor 3 (subtype EP3) Mus musculus 39-42 28256515-7 2017 Thus, the PGE2/Ep3 axis promotes cardiac healing after MI by activating reparative Ly6Clow Mos/Mps, indicating that Ep3 receptor activation may be a promising therapeutic target for acute MI. Dinoprostone 10-14 prostaglandin E receptor 3 (subtype EP3) Mus musculus 116-119 28131828-1 2017 EP3 is a receptor for prostaglandin E2 (PGE2), and although its effect on bladder excitability has attracted considerable attention, the underlying mechanism remains unclear. Dinoprostone 22-38 prostaglandin E receptor 3 (subtype EP3) Mus musculus 0-3 28131828-1 2017 EP3 is a receptor for prostaglandin E2 (PGE2), and although its effect on bladder excitability has attracted considerable attention, the underlying mechanism remains unclear. Dinoprostone 40-44 prostaglandin E receptor 3 (subtype EP3) Mus musculus 0-3 28039934-8 2017 CONCLUSION: Our results demonstrated an unexpected role of proinflammatory mediator PGE2 in improving hepatic cholesterol metabolism through activation of the EP3-mediated PKA/HNF4alpha/CYP7A1 pathway, indicating that inhibition of this pathway may be a novel therapeutic strategy for dyslipidemia and atherosclerosis. Dinoprostone 84-88 prostaglandin E receptor 3 (subtype EP3) Mus musculus 159-162 27502370-3 2016 Thus, we hypothesized that PGE2 increases contractility via EP4 but decreases contractility via EP3. Dinoprostone 27-31 prostaglandin E receptor 3 (subtype EP3) Mus musculus 96-99 27093953-1 2017 BACKGROUND:: Prostaglandin E2 receptor subtype 3 (EP3), a Gi protein-coupled receptor activated by prostaglandin E2, plays a particular role in cardioprotection. Dinoprostone 99-115 prostaglandin E receptor 3 (subtype EP3) Mus musculus 50-53 27093953-11 2017 Overall, PGE2-EP3 is necessary to maintain the normal growth and development of the heart. Dinoprostone 9-13 prostaglandin E receptor 3 (subtype EP3) Mus musculus 14-17 27664754-8 2016 In contrast, the aggregation enhancing effect of 17-pt-PGE2 in human platelets was mediated via EP3 receptors. Dinoprostone 55-59 prostaglandin E receptor 3 (subtype EP3) Mus musculus 96-99 27837675-0 2017 PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer"s disease. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 5-8 27837675-6 2017 We provide evidence that although PGE2 had no effect both on either basal transmission or short-term plasticity, it strongly impaired presynaptic Mf-CA3 long-term potentiation (LTP) by acting on PGE2 receptor 3 (EP3) receptors. Dinoprostone 34-38 prostaglandin E receptor 3 (subtype EP3) Mus musculus 212-215 27837675-7 2017 During aging, hippocampal levels of PGE2 markedly increased in the APP/PS1 mouse model of AD and impaired specifically presynaptic LTP via a PGE2-EP3 signaling pathway. Dinoprostone 36-40 prostaglandin E receptor 3 (subtype EP3) Mus musculus 146-149 27837675-7 2017 During aging, hippocampal levels of PGE2 markedly increased in the APP/PS1 mouse model of AD and impaired specifically presynaptic LTP via a PGE2-EP3 signaling pathway. Dinoprostone 141-145 prostaglandin E receptor 3 (subtype EP3) Mus musculus 146-149 27837675-8 2017 In summary, the building up of PGE2 during the progression of AD leads to specific impairment of hippocampal presynaptic plasticity and highlights EP3 receptors as a potential target to alleviate cognitive deficits in AD. Dinoprostone 31-35 prostaglandin E receptor 3 (subtype EP3) Mus musculus 147-150 27484807-0 2016 Therapeutic effects of human gingiva-derived mesenchymal stromal cells on murine contact hypersensitivity via prostaglandin E2-EP3 signaling. Dinoprostone 110-126 prostaglandin E receptor 3 (subtype EP3) Mus musculus 127-130 27502370-0 2016 Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor. Dinoprostone 0-16 prostaglandin E receptor 3 (subtype EP3) Mus musculus 51-54 27502370-1 2016 BACKGROUND: Prostaglandin E2 (PGE2) EP receptors EP3 and EP4 signal via decreased and increased cAMP production, respectively. Dinoprostone 12-28 prostaglandin E receptor 3 (subtype EP3) Mus musculus 49-52 27502370-1 2016 BACKGROUND: Prostaglandin E2 (PGE2) EP receptors EP3 and EP4 signal via decreased and increased cAMP production, respectively. Dinoprostone 30-34 prostaglandin E receptor 3 (subtype EP3) Mus musculus 49-52 27502370-6 2016 Both PGE2 and sulprostone decreased +dp/dt (P<0.01) and left ventricular developed pressure (P<0.001) with reversal by an EP3 antagonist. Dinoprostone 5-9 prostaglandin E receptor 3 (subtype EP3) Mus musculus 128-131 27084388-0 2016 PGE2-EP3 signaling exacerbates intracerebral hemorrhage outcomes in 24-mo-old mice. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 5-8 27084388-4 2016 EP3 is the most abundant EP receptor in the brain and we have previously shown that signaling through the PGE2-EP3 axis exacerbates ICH outcomes in young mice. Dinoprostone 106-110 prostaglandin E receptor 3 (subtype EP3) Mus musculus 0-3 27084388-4 2016 EP3 is the most abundant EP receptor in the brain and we have previously shown that signaling through the PGE2-EP3 axis exacerbates ICH outcomes in young mice. Dinoprostone 106-110 prostaglandin E receptor 3 (subtype EP3) Mus musculus 111-114 27084388-8 2016 Using this aged cohort of mice, we have confirmed and extended our previous results in young mice demonstrating the deleterious role of the PGE2-EP3 signaling axis in modulating brain injury and functional recovery after ICH, further supporting the notion of the EP3 receptor as a putative therapeutic avenue for the treatment of ICH. Dinoprostone 140-144 prostaglandin E receptor 3 (subtype EP3) Mus musculus 145-148 27015117-0 2016 PGE2-EP3 signaling pathway contributes to protective effects of misoprostol on cerebral injury in APP/PS1 mice. Dinoprostone 0-4 prostaglandin E receptor 3 (subtype EP3) Mus musculus 5-8 26995650-2 2016 The prostaglandin E2 (PGE2) receptor EP3 antagonises arginine vasopressin (AVP)-mediated water reabsorption and its expression is increased in the diabetic kidney. Dinoprostone 4-20 prostaglandin E receptor 3 (subtype EP3) Mus musculus 37-40 26995650-9 2016 In WT non-injected and WT-STZ mice, EP3 activation with sulprostone (PGE2 analogue) abrogated AVP-mediated water reabsorption; this effect was absent in mice lacking EP3. Dinoprostone 69-73 prostaglandin E receptor 3 (subtype EP3) Mus musculus 36-39 26485614-1 2016 Mice carrying a targeted disruption of the prostaglandin E2 (PGE2) E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted PGE2-EP3 signaling on diabetes in a setting of diet-induced obesity. Dinoprostone 43-59 prostaglandin E receptor 3 (subtype EP3) Mus musculus 92-95 26585956-9 2016 In vitro, PGE2 activates platelets after binding to its receptor, EP3. Dinoprostone 10-14 prostaglandin E receptor 3 (subtype EP3) Mus musculus 66-69 26485614-1 2016 Mice carrying a targeted disruption of the prostaglandin E2 (PGE2) E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted PGE2-EP3 signaling on diabetes in a setting of diet-induced obesity. Dinoprostone 43-59 prostaglandin E receptor 3 (subtype EP3) Mus musculus 103-109 26485614-1 2016 Mice carrying a targeted disruption of the prostaglandin E2 (PGE2) E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted PGE2-EP3 signaling on diabetes in a setting of diet-induced obesity. Dinoprostone 61-65 prostaglandin E receptor 3 (subtype EP3) Mus musculus 92-95 26485614-1 2016 Mice carrying a targeted disruption of the prostaglandin E2 (PGE2) E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted PGE2-EP3 signaling on diabetes in a setting of diet-induced obesity. Dinoprostone 61-65 prostaglandin E receptor 3 (subtype EP3) Mus musculus 103-109 26485614-6 2016 Adipocytes isolated from EP3(-/-) mice lacked PGE2-evoked inhibition of isoproterenol stimulated lipolysis compared with EP3(+/+). Dinoprostone 46-50 prostaglandin E receptor 3 (subtype EP3) Mus musculus 25-28 26255103-6 2016 Furthermore, LTD4 plus PGE2, through cysteinyl leukotriene receptor 1 (CysLT1R) and E-prostanoid receptor (EP) 3, enhanced extracellular signal-regulated kinase (Erk) and c-fos phosphorylation, inflammatory gene expression, macrophage inflammatory protein 1beta secretion, COX-2 upregulation, and PGD2 generation in mast cells. Dinoprostone 23-27 prostaglandin E receptor 3 (subtype EP3) Mus musculus 84-112 26255103-8 2016 LTD4 plus PGE2-potentiated effects are partially sensitive to CysLT1R or EP3 antagonists but completely abolished by simultaneous treatment both in vitro and in vivo. Dinoprostone 10-14 prostaglandin E receptor 3 (subtype EP3) Mus musculus 73-76 26255103-9 2016 CONCLUSIONS: Our results unravel a unique LTD4-PGE2 interaction affecting mast cells through CysLT1R and EP3 involving Gi, protein kinase G, and Erk and contributing to vascular inflammation in vivo. Dinoprostone 47-51 prostaglandin E receptor 3 (subtype EP3) Mus musculus 105-108 27190998-2 2016 The various biological functions governed by PGE2 are mediated through its four distinct prostaglandin E receptors (EPs), designated as EP1, EP2, EP3, and EP4, among which the EP4 receptor is the one most widely distributed in the heart. Dinoprostone 45-49 prostaglandin E receptor 3 (subtype EP3) Mus musculus 146-149 27298516-1 2016 Prostaglandin E2 (PGE2), a major metabolite of arachidonic acid produced by cyclooxygenase pathways, exerts its bioactive responses by activating four E-prostanoid receptor subtypes, EP1, EP2, EP3, and EP4. Dinoprostone 0-16 prostaglandin E receptor 3 (subtype EP3) Mus musculus 193-196 27298516-1 2016 Prostaglandin E2 (PGE2), a major metabolite of arachidonic acid produced by cyclooxygenase pathways, exerts its bioactive responses by activating four E-prostanoid receptor subtypes, EP1, EP2, EP3, and EP4. Dinoprostone 18-22 prostaglandin E receptor 3 (subtype EP3) Mus musculus 193-196