PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33130269-5 2021 Furthermore, ELISA and Western blotting results demonstrated that the NF-kappaB signaling pathway positively regulated autophagic activity to inhibit the productions of PGE2 and NO during this inflammatory response. Dinoprostone 169-173 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 70-79 32813003-7 2020 To explore the underlying mechanism responsible for these observations, we compared the classical bone resorption OPG/RANKL/NF-kappaB pathway mediated by PGE2/EP4. Dinoprostone 154-158 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 124-133 32512418-6 2020 Concurrently, the nuclear factor-kappa B (NF-kappaB) signalling pathway was also activated in the Cu-treatment, as demonstrated by higher expressions of NF-kappaB and cyclooxygenase-2 (COX-2), activities of inducible nitric oxide synthase (iNOS), contents of nitric oxide (NO) and prostaglandin E2 (PGE2), and reducing levels of expression of inhibitory kappa B (IkappaB). Dinoprostone 281-297 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 18-40 32512418-6 2020 Concurrently, the nuclear factor-kappa B (NF-kappaB) signalling pathway was also activated in the Cu-treatment, as demonstrated by higher expressions of NF-kappaB and cyclooxygenase-2 (COX-2), activities of inducible nitric oxide synthase (iNOS), contents of nitric oxide (NO) and prostaglandin E2 (PGE2), and reducing levels of expression of inhibitory kappa B (IkappaB). Dinoprostone 281-297 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 42-51 32512418-6 2020 Concurrently, the nuclear factor-kappa B (NF-kappaB) signalling pathway was also activated in the Cu-treatment, as demonstrated by higher expressions of NF-kappaB and cyclooxygenase-2 (COX-2), activities of inducible nitric oxide synthase (iNOS), contents of nitric oxide (NO) and prostaglandin E2 (PGE2), and reducing levels of expression of inhibitory kappa B (IkappaB). Dinoprostone 299-303 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 18-40 32512418-6 2020 Concurrently, the nuclear factor-kappa B (NF-kappaB) signalling pathway was also activated in the Cu-treatment, as demonstrated by higher expressions of NF-kappaB and cyclooxygenase-2 (COX-2), activities of inducible nitric oxide synthase (iNOS), contents of nitric oxide (NO) and prostaglandin E2 (PGE2), and reducing levels of expression of inhibitory kappa B (IkappaB). Dinoprostone 299-303 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 42-51 32813003-8 2020 The ratio of n-6/n-3 PUFAs in the bone affected the production of PGE2, a factor regulating the OPG/RANKL pathway, thereby regulating osteoclastogenesis by stimulating the NF-kappaB pathway. Dinoprostone 66-70 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 172-181 32813003-12 2020 Thus, AKO could significantly improve osteoporosis via the OPG/RANKL/NF-kappaB pathway mediated by PGE2/EP4 to inhibit osteoclastogenesis, whereas AAO aggravated osteoporosis via the same pathway. Dinoprostone 99-103 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 69-78 32525310-4 2020 Our in vitro results demonstrated that 0.1 mM MBP down-regulated the expression of matrix metalloproteinase-2 (MMP-2) by inhibiting the activation of nuclear factor-kappaB (NF-kappaB)/cyclooxygenase-2 (COX-2)/ prostaglandin E2 (PGE2) cascades via attenuated binding of NF-kappaB to both MMP-2 promoter and COX-2 promoter. Dinoprostone 210-226 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 150-171 32525310-4 2020 Our in vitro results demonstrated that 0.1 mM MBP down-regulated the expression of matrix metalloproteinase-2 (MMP-2) by inhibiting the activation of nuclear factor-kappaB (NF-kappaB)/cyclooxygenase-2 (COX-2)/ prostaglandin E2 (PGE2) cascades via attenuated binding of NF-kappaB to both MMP-2 promoter and COX-2 promoter. Dinoprostone 228-232 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 150-171 32186111-7 2019 CONCLUSION: The present study demonstrated an inhibitory effect of YYP on the NF-kappaB-regulated inflammatory mediators NO, PGE2 and TNF-alpha in LPS-stimulated RAW 264.7 macrophages, providing a pharmacological basis for the use of YYP in treating inflammatory disorders. Dinoprostone 125-129 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 78-87 27588407-3 2016 Our results show that the NF-kappaB/COX-2/PGE2 pathway is activated whereas the beta-catenin pathway is suppressed in CF mouse intestine and CFTR-knockdown cells. Dinoprostone 42-46 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 26-35 30886580-4 2019 Macrophages sense TsV via innate immune receptors, including TLR2, TLR4, and CD14 that promote inflammation and mortality via PGE2/cAMP/PKA/NF-kappaB/IL-1beta axis. Dinoprostone 126-130 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 140-149 28174280-0 2017 Prostaglandin E2-EP2-NF-kappaB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Dinoprostone 0-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 21-30 27588407-4 2016 Activation of beta-catenin pathway by GSK3 inhibitors suppresses CFTR mutation/knockdown-induced NF-kappaB/COX-2/PGE2 pathway in DeltaF508 mouse intestine and CFTR-knockdown cells. Dinoprostone 113-117 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 97-106 26189370-0 2016 Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-kappaB pathways. Dinoprostone 0-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 138-147 26869183-0 2016 Prostaglandin I2 Attenuates Prostaglandin E2-Stimulated Expression of Interferon gamma in a beta-Amyloid Protein- and NF-kappaB-Dependent Mechanism. Dinoprostone 28-44 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 118-127 26869183-4 2016 Specifically, PGE2 accumulation in astrocytes activated the ERK1/2 and NF-kappaB signaling pathways by phosphorylation, which resulted in IFNgamma expression. Dinoprostone 14-18 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 71-80 26869183-5 2016 In contrast, the administration of PGI2 attenuated the effects of PGE2 on stimulating the production of IFNgamma via inhibiting the translocation of NF-kappaB from the cytosol to the nucleus. Dinoprostone 66-70 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 149-158 26261008-16 2015 Knockdown experiments showed that NF-kappaB was required for PGE2 induction of CSCs and metastasis in mice. Dinoprostone 61-65 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 34-43 26261008-17 2015 CONCLUSIONS: PGE2 induces CSC expansion by activating NF-kappaB, via EP4-PI3K and EP4-mitogen-activated protein kinase signaling, and promotes the formation of liver metastases in mice. Dinoprostone 13-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 54-63 23416211-4 2013 Inhibition of nuclear factor kappaB (NF-kappaB) significantly reduced MT-II-induced PGE2, but not PGD2 production and COX-2 expression. Dinoprostone 84-88 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 37-46 23362215-6 2014 These results indicated that the blockade of PGE2 and NO production by wogonin in LPS/INFgamma-stimulated BV2 cells is attributed mainly to interference in the Src-MEK1/2-ERK1/2-NFkappaB-signaling pathway. Dinoprostone 45-49 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 178-186 24677730-4 2015 Exposure to NP stimulated activation of NF-kappaB, whereas the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, attenuated NP-enhanced COX-2 expression and IL-6 and PGE2 release in TM4 cells in a dose-dependent manner. Dinoprostone 166-170 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 63-72 23900806-8 2014 These data therefore suggest that renal medullary interstitial cell NFkappaB plays an important role in mediating renal medullary COX2 expression and promoting renal PGE2 synthesis in response to increased dietary sodium. Dinoprostone 166-170 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 68-76 23317035-9 2013 A PI3K specific inhibitor (LY294002), Akt inhibitor VIII (Akti) and NF-kappaB inhibitors (Bay-11-7082 and MG-132) attenuated the induction of ICAM-1 by PGE2. Dinoprostone 152-156 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 68-77 23317035-10 2013 PGE2, dbcAMP and 8-Cpt-cAMP induced the phosphorylation of Akt, IkappaB kinase and IkappaBalpha and the translocation of p65 to the nucleus and increased NF-kappaB dependent reporter gene activity, which was diminished by Akti. Dinoprostone 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 154-163 23317035-11 2013 CONCLUSION AND IMPLICATIONS: Our findings suggest that PGE2 induces ICAM-1 expression via EP4 receptor and Epac/Akt/NF-kappaB signalling pathway in bEnd.3 brain endothelial cells, supporting its pathophysiological role in brain inflammation. Dinoprostone 55-59 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 116-125 23041393-9 2012 Netrin-1-induced suppression of PGE2 production was mediated through suppression of NFkappaB-mediated cyclooxygenase-2 (COX-2) in renal tubular epithelial cells. Dinoprostone 32-36 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 84-92 23482668-10 2013 CONCLUSION: LPS inhibit the pacemaker currents in ICCs via prostaglandin E2- and NO-dependent mechanism through toll-like receptor 4 and suggest that MAPK and NF-kappaB are implicated in these actions. Dinoprostone 59-75 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 159-168 23343326-0 2013 Up-regulation of COX-2/PGE2 by endothelin-1 via MAPK-dependent NF-kappaB pathway in mouse brain microvascular endothelial cells. Dinoprostone 23-27 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 63-72 23343326-9 2013 CONCLUSIONS: These results suggested that in mouse bEnd.3 cells, activation of NF-kappaB by ETB-dependent MAPK cascades is essential for ET-1-induced up-regulation of COX-2/PGE2 system. Dinoprostone 173-177 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 79-88 24716155-10 2013 These results support a role of the GBEE in suppressing activation of NF-kappaB to inhibit NO and PGE2 production in the LPS-induced inflammatory response by RAW 264.7 cells. Dinoprostone 98-102 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 70-79 24191131-6 2013 PGE2 enhanced extracellular signal-related kinase (ERK) signaling and suppressed nuclear factor- kappa B (NF- kappa B) signaling. Dinoprostone 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 106-117 22406106-6 2012 This compound also inhibited the production of prostaglandin (PG)E(2) at the transcriptional level by suppression of Syk/NF-kappaB, IKKe/IRF-3, and p38/AP-1 pathways in lipopolysaccharide (LPS)-activated RAW264.7 cells and peritoneal macrophages. Dinoprostone 47-69 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 121-130 22777528-0 2012 Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-kappaB/COX-2/PGE2. Dinoprostone 137-141 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 121-130 21856412-9 2011 LPS-induced activation of redox-sensitive signaling intermediates such as MAPKs, transcription factor NF-kappaB, and EGR-1, a transcriptional regulator of mPGES-1, which in collaboration with COX-2 leads to the production of PGE2, was also significantly prevented by AR inhibition. Dinoprostone 225-229 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 102-111 18270204-4 2008 Here we demonstrate that PGE(2) pretreatment selectively inhibits lipopolysaccharide (LPS)-induced nuclear factor kappaB1 (NF-kappaB1) p105 phosphorylation and degradation in mouse bone marrow-derived macrophages through EP4-dependent mechanisms. Dinoprostone 25-31 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 123-133 20546888-12 2010 Our findings point out to Egr-1 and NF-kappaB cooperation as determinant for PGE2 synthesis by macrophages in inflammatory processes through the coordinated regulation of COX-2 and mPGES-1. Dinoprostone 77-81 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 36-45 20188213-9 2010 Additionally, by altering nuclear factor (NF)-kappaB transcription activity in FLSs, curcumin inhibited PGE(2) production, COX-2 expression, and MMP secretion. Dinoprostone 104-110 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 26-52 20127032-2 2010 We have previously shown that tumor-derived factors such as transforming growth factor beta (TGFbeta) and prostaglandin E2 (PGE2) modulate NFkappaB and C/EBP expression in macrophages. Dinoprostone 106-122 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 139-147 20127032-2 2010 We have previously shown that tumor-derived factors such as transforming growth factor beta (TGFbeta) and prostaglandin E2 (PGE2) modulate NFkappaB and C/EBP expression in macrophages. Dinoprostone 124-128 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 139-147 20503171-9 2010 Immunohistochemical or immunofluorescent examinations in the liver tissue generally support these findings, suggesting that PGE2 inhibited APAP-induced activation of nuclear factor kappa B (NF-kappaB). Dinoprostone 124-128 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 166-188 20503171-9 2010 Immunohistochemical or immunofluorescent examinations in the liver tissue generally support these findings, suggesting that PGE2 inhibited APAP-induced activation of nuclear factor kappa B (NF-kappaB). Dinoprostone 124-128 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 190-199 19384903-2 2009 As already widely studied, Cyclooxygenase-2 (COX-2) is a key enzyme for prostaglandin E2 (PGE(2)) production, which induces the nuclear factor kappa B (NFkappaB) activation and is beneficial to fracture healing. Dinoprostone 72-88 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 128-150 19384903-2 2009 As already widely studied, Cyclooxygenase-2 (COX-2) is a key enzyme for prostaglandin E2 (PGE(2)) production, which induces the nuclear factor kappa B (NFkappaB) activation and is beneficial to fracture healing. Dinoprostone 72-88 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 152-160 19384903-2 2009 As already widely studied, Cyclooxygenase-2 (COX-2) is a key enzyme for prostaglandin E2 (PGE(2)) production, which induces the nuclear factor kappa B (NFkappaB) activation and is beneficial to fracture healing. Dinoprostone 90-96 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 128-150 19384903-2 2009 As already widely studied, Cyclooxygenase-2 (COX-2) is a key enzyme for prostaglandin E2 (PGE(2)) production, which induces the nuclear factor kappa B (NFkappaB) activation and is beneficial to fracture healing. Dinoprostone 90-96 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 152-160 19136385-10 2009 Inhibition of phosphoinositide-3 (PI3)-kinase, p38 MAPK, or NF-kappaB pathways reduced LPS-induced PGE2, IL-6, and KC secretion. Dinoprostone 99-103 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 60-69 18270204-4 2008 Here we demonstrate that PGE(2) pretreatment selectively inhibits lipopolysaccharide (LPS)-induced nuclear factor kappaB1 (NF-kappaB1) p105 phosphorylation and degradation in mouse bone marrow-derived macrophages through EP4-dependent mechanisms. Dinoprostone 25-31 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 135-139 18270204-10 2008 Thus, PGE(2)-EP4 signaling augments NF-kappaB1 p105 protein stability through EPRAP after proinflammatory stimulation, limiting macrophage activation. Dinoprostone 6-12 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 36-48 18297109-8 2008 In RAW264.7 cells, PGE2-G and PGE2 produced similar, dose-related changes in NFkappaB activity. Dinoprostone 19-23 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 77-85 18297109-8 2008 In RAW264.7 cells, PGE2-G and PGE2 produced similar, dose-related changes in NFkappaB activity. Dinoprostone 30-34 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 77-85 18297109-10 2008 While the effects of PGE2 on thermal hyperalgesia and NFkappaB activity were completely blocked by a cocktail of antagonists for prostanoid receptors, the same cocktail of antagonists only partially antagonized the actions of PGE2-G. Dinoprostone 21-25 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 54-62 18058233-4 2008 Using several cell systems, it was shown that the SK inhibitors block the ability of TNFalpha to activate nuclear factor kappa B (NFkappaB), induce expression of adhesion proteins, and promote production of prostaglandin E(2) (PGE(2)). Dinoprostone 207-225 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 106-128 16061956-9 2005 These data suggested that the inhibition of NF-kappaB was one of the mechanisms for the reduced COX-2 expression and PGE(2) release by 10t,12c-CLA. Dinoprostone 117-123 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 44-53 16041399-0 2005 Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. Dinoprostone 107-111 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 26-35 15890324-0 2004 Enhanced expression of cyclooxygenase-2 and prostaglandin E2 in response to endotoxin after trauma is dependent on MAPK and NF-kappaB mechanisms. Dinoprostone 44-60 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 124-133 15890324-2 2004 We hypothesized that macrophage PGE2 production after trauma is regulated by mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappaB). Dinoprostone 32-36 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 121-143 15890324-2 2004 We hypothesized that macrophage PGE2 production after trauma is regulated by mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappaB). Dinoprostone 32-36 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 145-154 15890324-9 2004 This suggests that trauma-induced PGE2 production is mediated through MAPK and NF-kappaB activation and offers potential for modifying the macrophages" responses following injury. Dinoprostone 34-38 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 79-88 9862429-4 1998 PGE2 and iloprost also blocked disappearance of I kappaB-alpha from cytosolic fraction and nuclear translocation of NF-kappaB subunits p50 and p65. Dinoprostone 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 116-125 12529332-7 2003 Furthermore, NF-kappa B inhibition resulted in significantly greater reduction in PGE(2) production and COX activity in old compared with young M phi. Dinoprostone 82-88 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 13-23 12529332-9 2003 Bay 11-7082 or NF-kappa B decoy prevented this ceramide-induced increase in NF-kappa B binding activity and PGE(2) production. Dinoprostone 108-114 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 15-25 10713711-5 2000 Positive correlations were found between PGE2 production and activation of nuclear factor (NF)-kappa B as well as expression of both COX-2 mRNA and protein in LPS-stimulated CE-1 cells. Dinoprostone 41-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 75-102 12964033-13 2003 Lastly, the present study also provides evidence that shows there is a positive association between the expression of cAMP, PKC, or NF-kappaB and the levels of NO, PGE2 and TNF in the liver of Kupffer-cell-blocked mice, and suggests that Kupffer cells may play a part in mediating liver function and hepatocellular activity. Dinoprostone 164-168 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 132-141 12957128-10 2003 CONCLUSION: Our data show that MAPK cascades regulate COX-2 gene expression and PGE2 production in LPS-stimulated Mphi through NFkappaB independent pathways. Dinoprostone 80-84 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 127-135 10864883-4 2000 UTP-induced increased PGE(2) release was demonstrated by a concomitant increase in COX-2 protein expression, and was decreased by inhibitors specific for phosphatidylinositide-phospholipase C (PI-PLC), CaMK, protein kinase C (PKC), nuclear factor-kappa B (NF-kappaB) or COX-2. Dinoprostone 22-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 232-254 10864883-4 2000 UTP-induced increased PGE(2) release was demonstrated by a concomitant increase in COX-2 protein expression, and was decreased by inhibitors specific for phosphatidylinositide-phospholipase C (PI-PLC), CaMK, protein kinase C (PKC), nuclear factor-kappa B (NF-kappaB) or COX-2. Dinoprostone 22-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 256-265 10815618-7 1999 Inhibition of NF-kappaB inhibits the LPS- but not the MTP-PE-induced release of TNF-alpha, nitric oxide and PGE2. Dinoprostone 108-112 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 14-23 9862429-4 1998 PGE2 and iloprost also blocked disappearance of I kappaB-alpha from cytosolic fraction and nuclear translocation of NF-kappaB subunits p50 and p65. Dinoprostone 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 135-138 9862429-5 1998 These results show for the first time that PGE2 and iloprost down-regulate iNOS protein expression by inhibiting NF-kappaB activation and suggest a negative feed-back mechanism that may be important for limiting excessive or prolonged NO production in pathological events. Dinoprostone 43-47 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 113-122 2160978-14 1990 Although Bt2cAMP or PGE2 when used alone had no effect, they did consistently modify the level of NF-kappa B activity induced by IL-1 alpha. Dinoprostone 20-24 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 98-108 8394097-5 1993 The pre-treatment of J774 cells with dibutyric cAMP, forskolin, prostaglandin E2 or cholera toxin resulted in NF-kappa B activation. Dinoprostone 64-80 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 110-120 9990673-8 1998 A cell permeable peptide and a direct inhibitor of NF-kappa B translocation, SN50, attenuated the accumulation of PGE2 in cell supernatant in a concentration-dependent manner. Dinoprostone 114-118 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 51-61 34316376-0 2021 lncRNA-PACER upregulates COX-2 and PGE2 through the NF-kappaB pathway to promote the proliferation and invasion of colorectal-cancer cells. Dinoprostone 35-39 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 52-61 35460827-4 2022 Meanwhile, jujube peel polyphenols attenuated the generation of TNF-alpha, IL-1beta, IL-6, NO and PGE2 by inhibiting MAPK and NF-kappaB signaling pathways. Dinoprostone 98-102 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 126-135