PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31978868-5 2020 The expression of IL-6, TNF-alpha, and IL-8 mRNA and proteins were noticeably lower in the treatment group in comparison to those of the PDT control group, while PDT plus borneol activated the p38-COX-2-PGE2 signaling pathway, increasing expression in the treatment group. Dinoprostone 201-207 mitogen activated protein kinase 14 Rattus norvegicus 193-196 35614946-12 2022 The mechanism through regulating the signal pathway of p38 mitogen-activated protein kinase (p38/MAPK), which reduces the release of TNF-alpha, IL-6, and PGE2 in the serum. Dinoprostone 154-158 mitogen activated protein kinase 14 Rattus norvegicus 55-91 35614946-12 2022 The mechanism through regulating the signal pathway of p38 mitogen-activated protein kinase (p38/MAPK), which reduces the release of TNF-alpha, IL-6, and PGE2 in the serum. Dinoprostone 154-158 mitogen activated protein kinase 14 Rattus norvegicus 93-101 34764879-9 2021 The benefits of exercise were related with the downregulation of p38-mitogen-activated protein kinase (MAPK), and the subsequent inhibition of the pathways of the cyclooxygenase 2 (COX-2) product, prostaglandin E2 (PGE2). Dinoprostone 197-213 mitogen activated protein kinase 14 Rattus norvegicus 65-101 34764879-9 2021 The benefits of exercise were related with the downregulation of p38-mitogen-activated protein kinase (MAPK), and the subsequent inhibition of the pathways of the cyclooxygenase 2 (COX-2) product, prostaglandin E2 (PGE2). Dinoprostone 197-213 mitogen activated protein kinase 14 Rattus norvegicus 103-107 34764879-9 2021 The benefits of exercise were related with the downregulation of p38-mitogen-activated protein kinase (MAPK), and the subsequent inhibition of the pathways of the cyclooxygenase 2 (COX-2) product, prostaglandin E2 (PGE2). Dinoprostone 215-219 mitogen activated protein kinase 14 Rattus norvegicus 65-101 34764879-9 2021 The benefits of exercise were related with the downregulation of p38-mitogen-activated protein kinase (MAPK), and the subsequent inhibition of the pathways of the cyclooxygenase 2 (COX-2) product, prostaglandin E2 (PGE2). Dinoprostone 215-219 mitogen activated protein kinase 14 Rattus norvegicus 103-107 31978868-6 2020 Borneol has significant analgesic and anti-inflammatory effects on PDT of acne, and enhances the healing of acne by activating p38-COX-2-PGE2 signaling pathway. Dinoprostone 135-141 mitogen activated protein kinase 14 Rattus norvegicus 127-130 26071411-14 2015 CONCLUSIONS: HHcy aggravated DSS-induced colitis by stimulating IL-17 expression via the p38/cPLA2/COX2/PGE2 signalling pathway. Dinoprostone 104-108 mitogen activated protein kinase 14 Rattus norvegicus 89-92 30977668-0 2019 Electroacupuncture for pain relief in labour inhibits spinal p38 MAPK-mediated prostaglandin E2 release and uterine prostaglandin E2 receptor expression in rats. Dinoprostone 79-95 mitogen activated protein kinase 14 Rattus norvegicus 61-64 30977668-1 2019 BACKGROUND: p38 mitogen-activated protein kinase (p38 MAPK) activation involves the release of prostaglandin E2 (PGE2) and hyperalgesia. Dinoprostone 95-111 mitogen activated protein kinase 14 Rattus norvegicus 12-48 30977668-1 2019 BACKGROUND: p38 mitogen-activated protein kinase (p38 MAPK) activation involves the release of prostaglandin E2 (PGE2) and hyperalgesia. Dinoprostone 95-111 mitogen activated protein kinase 14 Rattus norvegicus 50-58 30977668-1 2019 BACKGROUND: p38 mitogen-activated protein kinase (p38 MAPK) activation involves the release of prostaglandin E2 (PGE2) and hyperalgesia. Dinoprostone 113-117 mitogen activated protein kinase 14 Rattus norvegicus 12-48 30977668-1 2019 BACKGROUND: p38 mitogen-activated protein kinase (p38 MAPK) activation involves the release of prostaglandin E2 (PGE2) and hyperalgesia. Dinoprostone 113-117 mitogen activated protein kinase 14 Rattus norvegicus 50-58 30977668-12 2019 CONCLUSIONS: This study indicates that EA relieves labour pain through, at least in part, inhibition of spinal p38 MAPK-mediated PGE2 release and uterine PGER2 expression in rats. Dinoprostone 129-133 mitogen activated protein kinase 14 Rattus norvegicus 111-114 25736434-6 2015 In vitro co-culture experiments provided evidence that MSCs down-regulated COX-2/PGE2 in macrophages through inhibition of the activation-associated phosphorylation of p38 MAPK and ERK. Dinoprostone 81-85 mitogen activated protein kinase 14 Rattus norvegicus 168-171 21551240-0 2011 Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-kappaB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway. Dinoprostone 124-140 mitogen activated protein kinase 14 Rattus norvegicus 86-89 24986006-8 2015 Moreover, treatment with PGE2 increased the phosphorylation of p38 MAPK and CREB, as well as Bcl-2 expression, and this effect was inhibited by a PKA inhibitor (Rp-cAMP). Dinoprostone 25-29 mitogen activated protein kinase 14 Rattus norvegicus 63-66 23396374-15 2013 Treatment of the cultured FLS with the specific inhibitors of p38, ERK, AKT, and AP-1 significantly decreased the secretion of RANKL, IL-6, PGE2, and MMP-13 proteins. Dinoprostone 140-144 mitogen activated protein kinase 14 Rattus norvegicus 62-65 20610553-0 2010 Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase. Dinoprostone 11-29 mitogen activated protein kinase 14 Rattus norvegicus 99-102 18496512-4 2008 Treatment with PGE(2) stimulated phosphorylation of both p38 and ERK in primary cultures of medullary thick ascending limb cells. Dinoprostone 15-21 mitogen activated protein kinase 14 Rattus norvegicus 57-60 19631696-3 2009 Previously, we have shown that TGF-beta and bombesin (BBS) synergistically induce cyclooxygenase-2 (COX-2) expression and subsequent prostaglandin E(2) (PGE2) production through p38(MAPK) in rat intestinal epithelial cell line stably transfected with GRP receptor (RIE/GRPR), suggesting the interaction between TGF-beta signaling pathway and GRPR. Dinoprostone 133-151 mitogen activated protein kinase 14 Rattus norvegicus 178-181 19631696-3 2009 Previously, we have shown that TGF-beta and bombesin (BBS) synergistically induce cyclooxygenase-2 (COX-2) expression and subsequent prostaglandin E(2) (PGE2) production through p38(MAPK) in rat intestinal epithelial cell line stably transfected with GRP receptor (RIE/GRPR), suggesting the interaction between TGF-beta signaling pathway and GRPR. Dinoprostone 153-157 mitogen activated protein kinase 14 Rattus norvegicus 178-181 18567640-7 2008 Incubation of ventricular cardiomyocytes with PGE(2) led to a time-dependent decrease in the DOX-induced caspase3 activation, reaching a maximal inhibition of 70 +/- 5% after 4 h. Similarly, PGE(2) inhibited DOX-induced DNA fragmentation by 58 +/- 5% after 24 h. This antiapoptotic action of PGE(2) was strongly reduced by the ERK1/2 inhibitor, U0126, whereas the p38 MAP kinase inhibitor, SB203580, had no effect. Dinoprostone 46-52 mitogen activated protein kinase 14 Rattus norvegicus 364-367 18567640-7 2008 Incubation of ventricular cardiomyocytes with PGE(2) led to a time-dependent decrease in the DOX-induced caspase3 activation, reaching a maximal inhibition of 70 +/- 5% after 4 h. Similarly, PGE(2) inhibited DOX-induced DNA fragmentation by 58 +/- 5% after 24 h. This antiapoptotic action of PGE(2) was strongly reduced by the ERK1/2 inhibitor, U0126, whereas the p38 MAP kinase inhibitor, SB203580, had no effect. Dinoprostone 191-197 mitogen activated protein kinase 14 Rattus norvegicus 364-367 20027123-10 2010 CONCLUSION: These findings suggest that central inflammation in pathophysiological conditions activates the sympathetic nervous system via NAD(P)H oxidase and p38 mitogen-activated protein kinase-dependent synthesis of prostaglandin E2. Dinoprostone 219-235 mitogen activated protein kinase 14 Rattus norvegicus 159-162 19233864-8 2009 CONCLUSION: Our results suggest that in VSMCs, activation of p42/p44 MAPK, p38 MAPK, and NF-kappaB is essential for ATPgammaS-induced COX-2 expression and PGE2 synthesis. Dinoprostone 155-159 mitogen activated protein kinase 14 Rattus norvegicus 75-78 18030065-5 2007 Phosphorylation of the p42/44 and p38 mitogen-activated protein kinases (MAPK) was also induced by PGE2, and U0126 [a mitogen-activated extracellular signal regulated kinase kinase (MEK) 1/2 inhibitor] significantly inhibited the PGE2-induced protein synthesis. Dinoprostone 99-103 mitogen activated protein kinase 14 Rattus norvegicus 34-37 18030065-5 2007 Phosphorylation of the p42/44 and p38 mitogen-activated protein kinases (MAPK) was also induced by PGE2, and U0126 [a mitogen-activated extracellular signal regulated kinase kinase (MEK) 1/2 inhibitor] significantly inhibited the PGE2-induced protein synthesis. Dinoprostone 230-234 mitogen activated protein kinase 14 Rattus norvegicus 34-37 17686952-6 2007 Application of PGE(2) significantly stimulated the phosphorylation of P38 and ERK within 5 min. Dinoprostone 15-21 mitogen activated protein kinase 14 Rattus norvegicus 70-73 12649265-4 2003 Interleukin-1beta induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and stimulated RNA polymerase II binding to the COX-2 promoter, COX-2 transcription, COX-2 protein synthesis, and prostaglandin E2 (PGE2) release. Dinoprostone 208-224 mitogen activated protein kinase 14 Rattus norvegicus 49-57 17091492-8 2007 By analyzing the expression of astrocytic glial fibrillary acidic protein (GFAP), we found that PGE(2) alone only triggered the EP2-induced cAMP/PKA/p38MAPK signaling pathway in astrocytes. Dinoprostone 96-102 mitogen activated protein kinase 14 Rattus norvegicus 149-156 16176831-0 2005 Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Dinoprostone 0-16 mitogen activated protein kinase 14 Rattus norvegicus 80-83 15800925-4 2005 We further show that exogenously added ceramide analogue (C2-ceramide) also induce PGE2 synthesis through a p38 MAPK-dependent pathway. Dinoprostone 83-87 mitogen activated protein kinase 14 Rattus norvegicus 108-111 12649265-4 2003 Interleukin-1beta induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and stimulated RNA polymerase II binding to the COX-2 promoter, COX-2 transcription, COX-2 protein synthesis, and prostaglandin E2 (PGE2) release. Dinoprostone 226-230 mitogen activated protein kinase 14 Rattus norvegicus 49-57 12649265-5 2003 Infecting cardiomyocytes with adenoviruses that encode mutant, phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited interleukin-1beta-induced p38 MAPK activation, COX-2 gene expression, and PGE2 release. Dinoprostone 195-199 mitogen activated protein kinase 14 Rattus norvegicus 97-100 12649265-9 2003 These results provide direct evidence that MKK6 mediated p38 MAPK activation is necessary for interleukin-1beta-induced cardiac myocyte COX-2 gene expression and PGE2 biosynthesis in vitro and is sufficient for COX-2 gene expression by cardiac myocytes in vitro and in vivo. Dinoprostone 162-166 mitogen activated protein kinase 14 Rattus norvegicus 57-60 12428674-4 2002 PGE2 levels increased rapidly following treatment with fsAbeta, an effect that was prevented by SB202190, a selective inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), and by NS-398, which preferentially inhibits cyclooxygenase-2 (COX-2) compared to COX-1. Dinoprostone 0-4 mitogen activated protein kinase 14 Rattus norvegicus 131-167 12428674-4 2002 PGE2 levels increased rapidly following treatment with fsAbeta, an effect that was prevented by SB202190, a selective inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), and by NS-398, which preferentially inhibits cyclooxygenase-2 (COX-2) compared to COX-1. Dinoprostone 0-4 mitogen activated protein kinase 14 Rattus norvegicus 169-177 9786861-4 1998 Similarly, overexpression of the kinase-dead form of p38 MAPK also inhibits IL-1beta-induced Cox-2 expression and PGE2 production. Dinoprostone 114-118 mitogen activated protein kinase 14 Rattus norvegicus 53-56 9786861-9 1998 This study suggests that the activation of both JNK/SAPK and p38 MAPK signaling cascades is required for IL-1beta-induced Cox-2 expression and PGE2 synthesis. Dinoprostone 143-147 mitogen activated protein kinase 14 Rattus norvegicus 61-64