PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12860389-0 2003 IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. Dinoprostone 52-56 nuclear factor kappa B subunit 1 Homo sapiens 33-42 12860389-4 2003 These data conclusively demonstrate a substantial role for NF-kappaB in the co-ordinate induction of COX-2, mPGES and in the corresponding release of PGE2 by IL-1beta. Dinoprostone 150-154 nuclear factor kappa B subunit 1 Homo sapiens 59-68 12860389-1 2003 Prostaglandin (PG) E2 release is induced in pulmonary A549 cells by the NF-kappaB-activating stimuli interleukin-1beta (IL-1beta) and phorbol 12-myristate 13-acetate (PMA). Dinoprostone 0-21 nuclear factor kappa B subunit 1 Homo sapiens 72-81 10395693-5 1999 Macrophages exposed to LPS showed a rapid and sustained expression of COX-2 mRNA and protein for up to 48 h, whereas PGE2 production was notably enhanced only after 12 h. LPS increased COX-2 gene transcription and activation of the transcription factor NF-kappa B in a transient manner. Dinoprostone 117-121 nuclear factor kappa B subunit 1 Homo sapiens 253-263 12349897-11 2002 These results suggest that NFkappaB transcription factor is a key regulator of COX-2 expression in TNF-alpha-induced PGE2 production, which is mediated through a tyrosine kinase pathway in HGF. Dinoprostone 117-121 nuclear factor kappa B subunit 1 Homo sapiens 27-35 11509575-9 2001 Consistent with this evidence, prostaglandin E(2) strongly synergizes with the inflammatory cytokine tumor necrosis factor-alpha to promote NF-kappaB-dependent transcription and gene expression. Dinoprostone 31-49 nuclear factor kappa B subunit 1 Homo sapiens 140-149 12349897-0 2002 Tumor necrosis factor alpha (TNF-alpha)-induced prostaglandin E2 release is mediated by the activation of cyclooxygenase-2 (COX-2) transcription via NFkappaB in human gingival fibroblasts. Dinoprostone 48-64 nuclear factor kappa B subunit 1 Homo sapiens 149-157 12349897-5 2002 In this paper, we investigated the involvement of NFkappaB on TNF-alpha-mediated prostaglandin E2 (PGE2) release and COX-2 gene expression in human gingival fibroblasts (HGF). Dinoprostone 81-97 nuclear factor kappa B subunit 1 Homo sapiens 50-58 12349897-5 2002 In this paper, we investigated the involvement of NFkappaB on TNF-alpha-mediated prostaglandin E2 (PGE2) release and COX-2 gene expression in human gingival fibroblasts (HGF). Dinoprostone 99-103 nuclear factor kappa B subunit 1 Homo sapiens 50-58 11289656-12 2001 CONCLUSION: The present results indicate that the activation of NF-kappaB plays an important role in the proliferative response to IL-1beta in human fibroblasts, and suggest that PGE2 acts as a modulator of cell proliferation in inflamed synovial tissue. Dinoprostone 179-183 nuclear factor kappa B subunit 1 Homo sapiens 64-73 10662731-0 2000 DDM-PGE(2)-mediated cytoprotection in renal epithelial cells by a thromboxane A(2) receptor coupled to NF-kappaB. Dinoprostone 4-10 nuclear factor kappa B subunit 1 Homo sapiens 103-112 9009221-5 1997 Furthermore, we show that exogenous PGE2 mimics the NF-kappaB inhibitory effect of FCM. Dinoprostone 36-40 nuclear factor kappa B subunit 1 Homo sapiens 52-61 9353419-0 1997 Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine. Dinoprostone 61-77 nuclear factor kappa B subunit 1 Homo sapiens 14-22 9009221-0 1997 Nuclear factor-kappaB activation in human monocytes stimulated with lipopolysaccharide is inhibited by fibroblast conditioned medium and exogenous PGE2. Dinoprostone 147-151 nuclear factor kappa B subunit 1 Homo sapiens 15-21 9680006-11 1998 Inhibition of NFkappaB with TPCK reduced COX-2 but not COX-1 gene expression and decreased PGE2 production by LPS-stimulated Mphi. Dinoprostone 91-95 nuclear factor kappa B subunit 1 Homo sapiens 14-22 9680006-13 1998 Cyclooxygenase inhibitors reduced PGE2 production by inhibiting both COX-2 mRNA expression and preventing NFkappaB activation. Dinoprostone 34-38 nuclear factor kappa B subunit 1 Homo sapiens 106-114 34486757-0 2021 Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-kappaB signaling pathway. Dinoprostone 64-68 nuclear factor kappa B subunit 1 Homo sapiens 171-180 8940164-0 1996 Manipulation of distinct NFkappaB proteins alters interleukin-1beta-induced human rheumatoid synovial fibroblast prostaglandin E2 formation. Dinoprostone 113-129 nuclear factor kappa B subunit 1 Homo sapiens 25-33 8940164-6 1996 An NFkappaB classical oligonucleotide decoy produced a concentration-dependent decrease in IL-1-stimulated PGE2 production (IC50 = approximately 2 microM), indicating a role of NFkappaB. Dinoprostone 107-111 nuclear factor kappa B subunit 1 Homo sapiens 3-11 8940164-6 1996 An NFkappaB classical oligonucleotide decoy produced a concentration-dependent decrease in IL-1-stimulated PGE2 production (IC50 = approximately 2 microM), indicating a role of NFkappaB. Dinoprostone 107-111 nuclear factor kappa B subunit 1 Homo sapiens 177-185 8018594-8 1994 Interestingly, PGE2 or di-butyryl (Bt2)cAMP abolished the binding of NF-kappa B (p50/p65) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA/A23187. Dinoprostone 15-19 nuclear factor kappa B subunit 1 Homo sapiens 69-79 8018594-8 1994 Interestingly, PGE2 or di-butyryl (Bt2)cAMP abolished the binding of NF-kappa B (p50/p65) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA/A23187. Dinoprostone 15-19 nuclear factor kappa B subunit 1 Homo sapiens 81-84 8018594-11 1994 It seems therefore that PGE2, by elevating cAMP levels, interferes with the activation pathway for NF-kappa B but not for NF-AT, AP-1 or CLE0 binding protein. Dinoprostone 24-28 nuclear factor kappa B subunit 1 Homo sapiens 99-109 8660843-5 1996 In EMSAs, nuclear extracts from primary human T cells stimulated with ionomycin and phorbol esters in the presence of PGE2 demonstrated decreased binding at the AP-1 and NF-AT sites of the human IL-2 promoter; binding to the OCT-1 and NF-kappa B sites was not affected. Dinoprostone 118-122 nuclear factor kappa B subunit 1 Homo sapiens 235-245 35121582-2 2022 Here we demonstrate that COX-2-derived PGE2, an inflammatory mediator and tumor promoter, induces PD-1 expression by enhancing NF-kappaB"s binding to the PD-1 promoter via an EP4-PI3K-Akt signaling pathway in both CD8+ T cells and macrophages. Dinoprostone 39-43 nuclear factor kappa B subunit 1 Homo sapiens 127-136 34246631-6 2021 Sustained p38 MAPK activation also induces NF-kappaB-mediated increase in expression of cyclooxygenase-2 (COX-2) that is involved in the conversion of arachidonic acid to prostanoids resulting in enhanced biosynthesis and release of PGE2 from neurons. Dinoprostone 233-237 nuclear factor kappa B subunit 1 Homo sapiens 43-52 35121582-3 2022 Moreover, PGE2 suppresses CD8+ T cell proliferation and cytotoxicity against tumor cells and impairs macrophage phagocytosis of cancer cells via an EP4-PI3K-Akt-NF-kappaB-PD-1 signaling pathway. Dinoprostone 10-14 nuclear factor kappa B subunit 1 Homo sapiens 161-170 32446877-7 2020 By activating NF-kappaB signaling, IL-1beta induced the expression of cyclooxygenase-2 (Cox-2) and stimulated the release of the anorexigenic prostaglandin E2 (PGE2) from tanycytes. Dinoprostone 142-158 nuclear factor kappa B subunit 1 Homo sapiens 14-23 35497094-11 2022 These findings supported that COX-2/PGE2 expression triggered by thrombin was engaged in PAR1/Gq or Gi/o/PKCalpha/MAPK-dependent NF-kappaB activation in HTSMCs. Dinoprostone 36-40 nuclear factor kappa B subunit 1 Homo sapiens 129-138 35242277-2 2022 Our recent study has found that, in HCFs, sphingosine 1-phosphate (S1P) can upregulate the expression of cyclooxygenase-2 (COX-2) leading to prostaglandin E2 (PGE2) generation mediated by S1P receptors/PKCalpha/MAPKs cascade-dependent activation of NF-kappaB. Dinoprostone 141-157 nuclear factor kappa B subunit 1 Homo sapiens 249-258 35242277-2 2022 Our recent study has found that, in HCFs, sphingosine 1-phosphate (S1P) can upregulate the expression of cyclooxygenase-2 (COX-2) leading to prostaglandin E2 (PGE2) generation mediated by S1P receptors/PKCalpha/MAPKs cascade-dependent activation of NF-kappaB. Dinoprostone 159-163 nuclear factor kappa B subunit 1 Homo sapiens 249-258 33192511-8 2020 These results concluded that in HCFs, activation of NF-kappaB by PKCalpha-mediated MAPK cascades was essential for S1P-induced up-regulation of the COX-2/PGE2 system. Dinoprostone 154-158 nuclear factor kappa B subunit 1 Homo sapiens 52-61 32602017-8 2020 The NF-kappaB-specific small molecule inhibitor BAY 11-7082, prostaglandin E2, and LY294002 prevented hypoxia-induced EndMT. Dinoprostone 61-77 nuclear factor kappa B subunit 1 Homo sapiens 4-13 35477424-11 2022 However, NFkappaB activation mimicked the negative loading effects and enhanced PGE2 production while inhibition of catabolic NFkappaB signaling rescued the load-induced negative effects on ECM synthesis in MSC-derived neocartilage. Dinoprostone 80-84 nuclear factor kappa B subunit 1 Homo sapiens 9-17 35497094-0 2022 Thrombin Induces COX-2 and PGE2 Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells. Dinoprostone 27-31 nuclear factor kappa B subunit 1 Homo sapiens 76-85 32446877-7 2020 By activating NF-kappaB signaling, IL-1beta induced the expression of cyclooxygenase-2 (Cox-2) and stimulated the release of the anorexigenic prostaglandin E2 (PGE2) from tanycytes. Dinoprostone 160-164 nuclear factor kappa B subunit 1 Homo sapiens 14-23 32755957-3 2020 It demonstrated that aspirin inhibited NF-kappaB activation and suppressed NF-kappaB regulated COX-2 expression and prostaglandin E2 (PGE2) synthesis. Dinoprostone 116-132 nuclear factor kappa B subunit 1 Homo sapiens 75-84 32265223-6 2020 Our results indicate that inhibition of the PGE2/p50/NO axis prevents MDSC-suppressive functions and restores the efficacy of anticancer immunotherapy. Dinoprostone 44-48 nuclear factor kappa B subunit 1 Homo sapiens 49-52 30365124-12 2019 Additionally, we found that SND1 upregulated PGE2 expression through the NF-kappaB/cyclooxygenase-2 (COX-2) pathway. Dinoprostone 45-49 nuclear factor kappa B subunit 1 Homo sapiens 73-82 31822119-0 2019 Cyclooxygenase 2 promotes proliferation and invasion in ovarian cancer cells via the PGE2/NF-kappaB pathway. Dinoprostone 85-89 nuclear factor kappa B subunit 1 Homo sapiens 90-99 30481583-10 2019 TLR4/MyD88/NF-kappaB and Nrf2 signaling pathways may be involved in the activation of MG and the increased production of NO and PGE2. Dinoprostone 128-132 nuclear factor kappa B subunit 1 Homo sapiens 11-20 30733814-6 2019 More interestingly, AQP3 expression was suppressed by RFP treatment both in the rat colons and in HT-29 cells, while the NF-kappaB pathway-mediated PGE2 production was activated. Dinoprostone 148-152 nuclear factor kappa B subunit 1 Homo sapiens 121-130 30733814-8 2019 Conclusions: The purgative property of the purified resin glycoside fraction was attributed to NF-kappaB activation in the colon, which increased the COX-2-mediated secretion of PGE2. Dinoprostone 178-182 nuclear factor kappa B subunit 1 Homo sapiens 95-104 31502430-13 2019 CONCLUSION: It was concluded that FTY720-P stimulates the Na+/K+ ATPase via PGE2 by activating sequentially S1PR3, PKC, ERK, NF-kappaB. Dinoprostone 76-80 nuclear factor kappa B subunit 1 Homo sapiens 125-134 28651842-9 2017 These data show that SDX protects HREC from HG damage and suggest that it counteracts the activation of ERK/cPLA2/COX-2/PGE2 pathway by reducing AGE-related signaling and downstream NFkappaB activity. Dinoprostone 120-124 nuclear factor kappa B subunit 1 Homo sapiens 182-190 30012671-5 2018 Reduction of RIPK3 in MDSC and colorectal cancer cells elicited NFkappaB-transcribed COX-2, which catalyzed the synthesis of prostaglandin E2 (PGE2). Dinoprostone 125-141 nuclear factor kappa B subunit 1 Homo sapiens 64-72 30012671-5 2018 Reduction of RIPK3 in MDSC and colorectal cancer cells elicited NFkappaB-transcribed COX-2, which catalyzed the synthesis of prostaglandin E2 (PGE2). Dinoprostone 143-147 nuclear factor kappa B subunit 1 Homo sapiens 64-72 30012671-7 2018 Moreover, PGE2 suppressed RIPK3 expression while enhancing expression of NFkappaB and COX-2 in MDSCs and colorectal cancer cells. Dinoprostone 10-14 nuclear factor kappa B subunit 1 Homo sapiens 73-81 28288820-7 2017 BK-induced COX-2/PGE2 expression is mediated through a B2R-PKCmu-dependent MAPKs, AP-1, and NF-kappaB cascade. Dinoprostone 17-21 nuclear factor kappa B subunit 1 Homo sapiens 92-101 26261008-14 2015 Knockdown of ERK1 or PI3K p85alpha also attenuated PGE2-induced activation of NF-kappaB in LS-174T cells. Dinoprostone 51-55 nuclear factor kappa B subunit 1 Homo sapiens 78-87 28424532-5 2017 The antagonist effect of sinapic acid against stemness damage was mediated by reduceing PGE2 production through inhibition of p38 MAPK and NF-kappaB. Dinoprostone 88-92 nuclear factor kappa B subunit 1 Homo sapiens 139-148 27377703-8 2017 Deletion and site-directed mutagenesis studies demonstrated the involvement of transcription factor activator protein (AP)-1 and nuclear factor-kappa B (NF-kappaB) in PGE2 -induced uPAR expression. Dinoprostone 167-171 nuclear factor kappa B subunit 1 Homo sapiens 153-162 27377703-11 2017 To the best of our knowledge, this is the first report that PGE2 -induced uPAR expression, which stimulates invasiveness of human gastric cancer AGS cells, is mediated by the EP2 receptor-dependent Src/EGFR/JNK1/2, Erk1/2/AP-1, and Src/EGFR/JNK1/2, Erk1/2/NF-kappaB cascades. Dinoprostone 60-64 nuclear factor kappa B subunit 1 Homo sapiens 256-265 27414656-7 2016 Finally, DA greatly reduced the PGE2-induced activation of NF-kappaB p50 and p65 subunits. Dinoprostone 32-36 nuclear factor kappa B subunit 1 Homo sapiens 59-72 27501354-8 2016 When NF-kappaB was inhibited, the effect of exogenous PGE2 still appeared, but that of PMA did not manifest, suggesting that NF-kappaB is upstream of PGE2 and downstream of PKC. Dinoprostone 54-58 nuclear factor kappa B subunit 1 Homo sapiens 5-14 27501354-8 2016 When NF-kappaB was inhibited, the effect of exogenous PGE2 still appeared, but that of PMA did not manifest, suggesting that NF-kappaB is upstream of PGE2 and downstream of PKC. Dinoprostone 54-58 nuclear factor kappa B subunit 1 Homo sapiens 125-134 27501354-8 2016 When NF-kappaB was inhibited, the effect of exogenous PGE2 still appeared, but that of PMA did not manifest, suggesting that NF-kappaB is upstream of PGE2 and downstream of PKC. Dinoprostone 150-154 nuclear factor kappa B subunit 1 Homo sapiens 5-14 27501354-8 2016 When NF-kappaB was inhibited, the effect of exogenous PGE2 still appeared, but that of PMA did not manifest, suggesting that NF-kappaB is upstream of PGE2 and downstream of PKC. Dinoprostone 150-154 nuclear factor kappa B subunit 1 Homo sapiens 125-134 26586210-3 2016 We found that in primary human amniocytes, Atosiban (10 muM) signals via PTX-sensitive Galphai to activate transcription factor NF-kappaB p65, ERK1/2, and p38 which subsequently drives upregulation of the prostaglandin synthesis enzymes, COX-2 and phospho-cPLA2 and excretion of prostaglandins (PGE2) (n = 6; p < 0.05, ANOVA). Dinoprostone 295-299 nuclear factor kappa B subunit 1 Homo sapiens 128-137 26415983-7 2015 PGE2 increased the expressions of EP4, NF-kappaB and down-regulated cAMP level of DCs. Dinoprostone 0-4 nuclear factor kappa B subunit 1 Homo sapiens 39-48 26415983-11 2015 These results demonstrate that PGE2 and TNF-alpha could enhance DCs functions by mediating PGE2-EP4-cAMP pathway, TNF-alpha-TNFR1-TRADD-TRAF2-NF-kappaB pathway respectively. Dinoprostone 31-35 nuclear factor kappa B subunit 1 Homo sapiens 142-151 27826040-5 2017 Importantly, we identified that NF-kappaB/COX-2/PGE2 axis acted as downstream signaling of caspase 3, mediating proangiogenic response after irradiation. Dinoprostone 48-52 nuclear factor kappa B subunit 1 Homo sapiens 32-41 27414656-0 2016 Decursinol angelate inhibits PGE2-induced survival of the human leukemia HL-60 cell line via regulation of the EP2 receptor and NFkappaB pathway. Dinoprostone 29-33 nuclear factor kappa B subunit 1 Homo sapiens 128-136 27363023-4 2016 DHA could inhibit proliferation and invasion of breast cancer cells in vitro, and this was mainly through blocking Cox-2-PGE2-NF-kappaB-MMPs cascades. Dinoprostone 121-125 nuclear factor kappa B subunit 1 Homo sapiens 126-135 27034605-11 2016 The inhibitory effect of lactoferrin on the IL-1beta induced expression of COX-2 or production of PGE2 was mediated at least in part via suppression of NF-kappaB activation. Dinoprostone 98-102 nuclear factor kappa B subunit 1 Homo sapiens 152-161 27034605-15 2016 Abbreviations Used: OA: Osteoarthritis IL-1beta: Interleukin-1 beta NF-kappaB: Nuclear factor-kappa B COX-2: cyclooxygenase-2 PGE2: prostaglandin E2. Dinoprostone 126-130 nuclear factor kappa B subunit 1 Homo sapiens 68-77 24584670-16 2014 Treatment with 17-PT-PGE2 induced NF-kappaB activation, and the selective NF-kappaB inhibitor pyrrolidinedithiocarbamate inhibited 17-PT-PGE2-mediated beta1 integrin expression. Dinoprostone 21-25 nuclear factor kappa B subunit 1 Homo sapiens 34-43 26530254-8 2015 METHODS: A library of ASA prodrugs was synthesized and screened for inhibition of NFkappaB activity and cancer stem-like cell (CSC) properties, an important PGE2-and NFkappaB-dependent phenotype of aggressive breast cancers. Dinoprostone 157-161 nuclear factor kappa B subunit 1 Homo sapiens 82-90 25546515-2 2015 The present study investigated the possible involvement of the cystic fibrosis transmembrane conductance regulator (CFTR), which has been previously shown to negatively regulate nuclear factor-kappaB (NF-kappaB)/cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) pathway, in the pathogenesis of BPH. Dinoprostone 236-252 nuclear factor kappa B subunit 1 Homo sapiens 201-210 25546515-2 2015 The present study investigated the possible involvement of the cystic fibrosis transmembrane conductance regulator (CFTR), which has been previously shown to negatively regulate nuclear factor-kappaB (NF-kappaB)/cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) pathway, in the pathogenesis of BPH. Dinoprostone 254-258 nuclear factor kappa B subunit 1 Homo sapiens 201-210 25546515-4 2015 Furthermore, suppression of CFTR led to increased expression of COX2 and over-production of PGE2 in a normal human prostate epithelial cell line (PNT1A) with elevated NF-kappaB activity. Dinoprostone 92-96 nuclear factor kappa B subunit 1 Homo sapiens 167-176 25546515-8 2015 The present results suggest that CFTR may be involved in regulating PGE2 production through its negative regulation on NF-kappaB/COX2 pathway in prostate epithelial cells, which consequently stimulates cell growth of prostate stromal cells. Dinoprostone 68-72 nuclear factor kappa B subunit 1 Homo sapiens 119-128 25431425-13 2014 PGE2 markedly activated nuclear translocation of NF-kappaB. Dinoprostone 0-4 nuclear factor kappa B subunit 1 Homo sapiens 49-58 25431425-15 2014 These results suggest that inhibition of curcumin-induced apoptosis by PGE2 through activation of PKA, Ras, and NF-kappaB signaling pathways may provide a molecular basis for the reversal of curcumin-induced colon carcinoma cell death. Dinoprostone 71-75 nuclear factor kappa B subunit 1 Homo sapiens 112-121 25289898-0 2014 Prostaglandin E2 stimulates beta1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-kappaB pathway. Dinoprostone 0-16 nuclear factor kappa B subunit 1 Homo sapiens 111-120 25289898-8 2014 17-PT-PGE2 treatment induced PKC and NF-kappaB activation; PKC and NF-kappaB inhibitors suppressed 17-PT-PGE2-mediated beta1-integrin expression. Dinoprostone 6-10 nuclear factor kappa B subunit 1 Homo sapiens 37-46 25289898-8 2014 17-PT-PGE2 treatment induced PKC and NF-kappaB activation; PKC and NF-kappaB inhibitors suppressed 17-PT-PGE2-mediated beta1-integrin expression. Dinoprostone 105-109 nuclear factor kappa B subunit 1 Homo sapiens 67-76 25289898-10 2014 NF-kappaB inhibitor suppressed 17-PT-PGE2-mediated FoxC2 upregulation. Dinoprostone 37-41 nuclear factor kappa B subunit 1 Homo sapiens 0-9 25289898-12 2014 This study suggested that PGE2 upregulates beta1-integrin expression and cell migration in HCC cells by activating the PKC/NF-kappaB signaling pathway. Dinoprostone 26-30 nuclear factor kappa B subunit 1 Homo sapiens 123-132 25289898-13 2014 Targeting PGE2/EP1/PKC/NF-kappaB/FoxC2/beta1-integrin pathway may represent a new therapeutic strategy for the prevention and treatment of this cancer. Dinoprostone 10-14 nuclear factor kappa B subunit 1 Homo sapiens 23-32 24902855-12 2014 CONCLUSIONS AND IMPLICATIONS: These findings demonstrate that MAPKs-mediated activation of AP-1/NF-kappaB pathways is, at least in part, required for COX-2/PGE2 /EP2 -triggered cell proliferation in human cardiomyocytes. Dinoprostone 156-160 nuclear factor kappa B subunit 1 Homo sapiens 96-105 25229003-0 2014 Prostaglandin E2 Induces IL-6 and IL-8 Production by the EP Receptors/Akt/NF-kappaB Pathways in Nasal Polyp-Derived Fibroblasts. Dinoprostone 0-16 nuclear factor kappa B subunit 1 Homo sapiens 74-83 25229003-5 2014 To determine the signaling pathway for the expression of PGE2-induced IL-6 and IL-8, PGE2 was treated with Akt and NF-kappaB inhibitors in NPDFs. Dinoprostone 57-61 nuclear factor kappa B subunit 1 Homo sapiens 115-124 25229003-5 2014 To determine the signaling pathway for the expression of PGE2-induced IL-6 and IL-8, PGE2 was treated with Akt and NF-kappaB inhibitors in NPDFs. Dinoprostone 85-89 nuclear factor kappa B subunit 1 Homo sapiens 115-124 25229003-12 2014 The Akt and NF-kappaB inhibitors significantly blocked PGE2-induced expression of IL-6 and IL-8. Dinoprostone 55-59 nuclear factor kappa B subunit 1 Homo sapiens 12-21 24760275-4 2014 PGE2/Akt/NF-kappaB pathway was investigated in Huh-7 and Hep3B cells after treatment with PGE2, EP4 receptor (EP4R) agonist, Akt inhibitor, and NF-kappaB inhibitor, respectively, by real-time reverse transcription (RT)-PCR, Western blotting, and immunofluorescence (IF) staining. Dinoprostone 0-4 nuclear factor kappa B subunit 1 Homo sapiens 144-153 24760275-4 2014 PGE2/Akt/NF-kappaB pathway was investigated in Huh-7 and Hep3B cells after treatment with PGE2, EP4 receptor (EP4R) agonist, Akt inhibitor, and NF-kappaB inhibitor, respectively, by real-time reverse transcription (RT)-PCR, Western blotting, and immunofluorescence (IF) staining. Dinoprostone 90-94 nuclear factor kappa B subunit 1 Homo sapiens 9-18 25898207-0 2015 Advanced glycation end-products induce apoptosis in pancreatic islet endothelial cells via NF-kappaB-activated cyclooxygenase-2/prostaglandin E2 up-regulation. Dinoprostone 128-144 nuclear factor kappa B subunit 1 Homo sapiens 91-100 25898207-13 2015 These results implicate the involvement of NF-kappaB-activated COX-2/PGE2 up-regulation in AGEs/RAGE-induced islet endothelial cell apoptosis and cytotoxicity. Dinoprostone 69-73 nuclear factor kappa B subunit 1 Homo sapiens 43-52 24760275-21 2014 In conclusion, PGE2 activates Akt/NF-kappaB signaling and then upregulates Snail via the EP4R/EGFR to promote migration and invasion in hepatoma cells. Dinoprostone 15-19 nuclear factor kappa B subunit 1 Homo sapiens 34-43 24584670-16 2014 Treatment with 17-PT-PGE2 induced NF-kappaB activation, and the selective NF-kappaB inhibitor pyrrolidinedithiocarbamate inhibited 17-PT-PGE2-mediated beta1 integrin expression. Dinoprostone 137-141 nuclear factor kappa B subunit 1 Homo sapiens 74-83 24520096-11 2014 Reduced levels and activity of STAT3, NF-kappaB, and their crosstalk led to transcriptional suppression of COX-2 and subsequent decreased levels of prostaglandin E2 (PGE2) and PGF2. Dinoprostone 148-164 nuclear factor kappa B subunit 1 Homo sapiens 38-47 24520096-11 2014 Reduced levels and activity of STAT3, NF-kappaB, and their crosstalk led to transcriptional suppression of COX-2 and subsequent decreased levels of prostaglandin E2 (PGE2) and PGF2. Dinoprostone 166-170 nuclear factor kappa B subunit 1 Homo sapiens 38-47 23808420-7 2013 Through targeting NKRF, miR-301a affected the activity of NF-kappaB and the expression of pro-inflammatory genes downstream of NF-kappaB such as COX-2, prostaglandin E2 and interleukin-6. Dinoprostone 152-168 nuclear factor kappa B subunit 1 Homo sapiens 58-67 24808633-0 2014 An Asp49 phospholipase A2 from snake venom induces cyclooxygenase-2 expression and prostaglandin E2 production via activation of NF-kappaB, p38MAPK, and PKC in macrophages. Dinoprostone 83-99 nuclear factor kappa B subunit 1 Homo sapiens 129-138 24808633-5 2014 By using NF-kappaB selective inhibitors, the involvement of this factor in MT-III-induced COX-2 expression and PGE2 production was demonstrated. Dinoprostone 111-115 nuclear factor kappa B subunit 1 Homo sapiens 9-18 24516373-9 2014 The model also predicted that PGE2 production could be significantly reduced when COX2 expression was blocked via either NFkappaB inactivation or treatment of cells with exogenous COX2 inhibitors, which led to a decrease in the rate of conversion from arachidonic acid to prostaglandin H2 in the PR pathway. Dinoprostone 30-34 nuclear factor kappa B subunit 1 Homo sapiens 121-129 24808633-9 2014 Altogether, these results show for the first time that the induction of COX-2 protein expression and PGE2 release, which occur via NF-kappaB activation induced by the sPLA2-MT-III in macrophages, are modulated by p38MAPK and PKC, but not by PI3K signaling proteins. Dinoprostone 101-105 nuclear factor kappa B subunit 1 Homo sapiens 131-140 23808420-7 2013 Through targeting NKRF, miR-301a affected the activity of NF-kappaB and the expression of pro-inflammatory genes downstream of NF-kappaB such as COX-2, prostaglandin E2 and interleukin-6. Dinoprostone 152-168 nuclear factor kappa B subunit 1 Homo sapiens 127-136 22185664-4 2011 As with exercise, it is well known that moderate exercise is good for health, whereas excessive exercise is not.Severe oxidative stress activates nuclear transcriptional factor kappa B (NFkappaB), resulting in an inflammatory response and tissue injury via the production of COX2, PGE2, and cytokines. Dinoprostone 281-285 nuclear factor kappa B subunit 1 Homo sapiens 146-184 22747921-9 2012 Furthermore, the up-regulation of PGE2 and IL-6 was related to the activation of p38 and NF-kappaB. Dinoprostone 34-38 nuclear factor kappa B subunit 1 Homo sapiens 89-98 22771391-0 2012 Modulation of NF-kappaB activation by resveratrol in LPS treated human intestinal cells results in downregulation of PGE2 production and COX-2 expression. Dinoprostone 117-121 nuclear factor kappa B subunit 1 Homo sapiens 14-23 21913191-8 2012 In conclusion, CFTR is a negative regulator of PGE(2)-mediated inflammatory response, defect of which may result in excessive activation of NF-kappaB, leading to over production of PGE(2) as seen in inflammatory CF tissues. Dinoprostone 47-53 nuclear factor kappa B subunit 1 Homo sapiens 140-149 22808181-8 2012 Using a variety of TLR2 ligands, we established that PGE(2) release by GM-CSF-primed BMDMs was dependent on TLR2 co-receptors (TLR1, TLR6), CD14, MyD88 and the nuclear translocation of NFkappaB but was not dependent on peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation. Dinoprostone 53-59 nuclear factor kappa B subunit 1 Homo sapiens 185-193 23439561-10 2013 Knockdown of NF-kappaB1 p50 by p50 siRNA significantly decreased acid-induced increase in mPGES1 expression, thymidine incorporation, and PGE2 production. Dinoprostone 138-142 nuclear factor kappa B subunit 1 Homo sapiens 24-27 23439561-10 2013 Knockdown of NF-kappaB1 p50 by p50 siRNA significantly decreased acid-induced increase in mPGES1 expression, thymidine incorporation, and PGE2 production. Dinoprostone 138-142 nuclear factor kappa B subunit 1 Homo sapiens 31-34 22865689-10 2012 Moreover, production of PGE2 by hMSC spheroids was dependent on the activity of caspases and NFkappaB activation in the hMSCs. Dinoprostone 24-28 nuclear factor kappa B subunit 1 Homo sapiens 93-101 22185664-4 2011 As with exercise, it is well known that moderate exercise is good for health, whereas excessive exercise is not.Severe oxidative stress activates nuclear transcriptional factor kappa B (NFkappaB), resulting in an inflammatory response and tissue injury via the production of COX2, PGE2, and cytokines. Dinoprostone 281-285 nuclear factor kappa B subunit 1 Homo sapiens 186-194 20338073-11 2010 The mechanism of action implicated seems to be via the inhibition of activation of NF-kappaB and MAPK, down-regulation of COX-2 and mPGES-1 expressions, and consequently,via the reduction of PGE2 production. Dinoprostone 191-195 nuclear factor kappa B subunit 1 Homo sapiens 83-92 21546578-10 2011 In aggregate, these results strongly suggest that, in colonic myofibroblasts, NF-kappaB and NFAT serve as important positive and negative transcriptional regulators of TNF-alpha-induced COX-2-dependent PGE(2) production, respectively, at the downstream of TRPC1-associated Ca(2+) influx. Dinoprostone 202-208 nuclear factor kappa B subunit 1 Homo sapiens 78-87 21848814-5 2011 In this study we found that EspT induces expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2) an enzyme involved in production of prostaglandin E(2) (PGE2), interleukin (Il)-8 and Il-1beta in U937 human macrophages by activating the nuclear factor kappa-B (NF-kappaB), the extracellular signal-regulated kinases 1 and 2 (Erk1/2) and c-Jun N-terminal kinase (JNK) pathways. Dinoprostone 147-165 nuclear factor kappa B subunit 1 Homo sapiens 250-272 21848814-5 2011 In this study we found that EspT induces expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2) an enzyme involved in production of prostaglandin E(2) (PGE2), interleukin (Il)-8 and Il-1beta in U937 human macrophages by activating the nuclear factor kappa-B (NF-kappaB), the extracellular signal-regulated kinases 1 and 2 (Erk1/2) and c-Jun N-terminal kinase (JNK) pathways. Dinoprostone 147-165 nuclear factor kappa B subunit 1 Homo sapiens 274-283 21143185-4 2011 There is recent evidence that the NF-kappaB-dependent gene expression of interleukin 8, interleukin 6, cyclooxygenase-2, tumor necrosis factor and interleukin 33 in directly irradiated cells produced the cytokines and prostaglandin E2 with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone 218-234 nuclear factor kappa B subunit 1 Homo sapiens 34-43 21143185-4 2011 There is recent evidence that the NF-kappaB-dependent gene expression of interleukin 8, interleukin 6, cyclooxygenase-2, tumor necrosis factor and interleukin 33 in directly irradiated cells produced the cytokines and prostaglandin E2 with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone 218-234 nuclear factor kappa B subunit 1 Homo sapiens 326-335 21356375-12 2011 Progesterone withdrawal, hypoxia, and PGE(2) regulate endometrial IL-8 by acting via HIF-1 and NF-kappaB. Dinoprostone 38-44 nuclear factor kappa B subunit 1 Homo sapiens 95-104 20398340-13 2010 The involvement of the signal pathways JNK and NF-kappaB in the regulation of PGE2 induced by TNFalpha may suggest these two pathways as possible attractive targets in the chronic inflammatory disease periodontitis. Dinoprostone 78-82 nuclear factor kappa B subunit 1 Homo sapiens 47-56 20206688-2 2010 The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone 151-167 nuclear factor kappa B subunit 1 Homo sapiens 4-13 20206688-2 2010 The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone 151-167 nuclear factor kappa B subunit 1 Homo sapiens 266-275 20206688-2 2010 The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone 169-173 nuclear factor kappa B subunit 1 Homo sapiens 4-13 20206688-2 2010 The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone 169-173 nuclear factor kappa B subunit 1 Homo sapiens 266-275 20337886-10 2010 A cAMP-dependent protein kinase inhibitor, H89, and a nuclear factor kappaB (NF kappaB) inhibitor, pyrrolidine dithiocarbamate, inhibited RANKL expression, prostaglandin E(2) production and NF kappaB translocation. Dinoprostone 156-174 nuclear factor kappa B subunit 1 Homo sapiens 77-86 19680656-0 2010 Epidermal growth factor increases prostaglandin E2 production via ERK1/2 MAPK and NF-kappaB pathway in fibroblast like synoviocytes from patients with rheumatoid arthritis. Dinoprostone 34-50 nuclear factor kappa B subunit 1 Homo sapiens 82-91 20398340-10 2010 Inhibitors of JNK and NF-kappaB also decreased the TNFalpha-stimulated up-regulation of mPGES-1 and COX-2 as well as PGE2 production. Dinoprostone 117-121 nuclear factor kappa B subunit 1 Homo sapiens 22-31 20838026-5 2010 Collectively, curcumin inhibits the PAR2-triggered PGE(2) production by suppressing COX-2 upregulation and Akt/NF-kappaB signals in A549 cells. Dinoprostone 51-57 nuclear factor kappa B subunit 1 Homo sapiens 111-120 20847443-10 2010 The importance of NF-kappaB in COX-2 induction and PGE2 synthesis by Abeta1-42 was corroborated by using the pharmacological inhibitor of the NF-kappaB pathway, PDTC. Dinoprostone 51-55 nuclear factor kappa B subunit 1 Homo sapiens 142-151 20847443-12 2010 Summing up, our results indicate that Abeta1-42 was able to induce COX-2 and PGE2 synthesis in astrocytic cells through a NF-kappaB dependent mechanism. Dinoprostone 77-81 nuclear factor kappa B subunit 1 Homo sapiens 122-131 19147120-4 2009 The nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA and protein were inhibited by an NFkappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), by approximately 50%. Dinoprostone 35-53 nuclear factor kappa B subunit 1 Homo sapiens 116-124 19717552-10 2009 These results demonstrated that in HTSMCs, CSE-induced COX-2-dependent PGE2 generation was mediated through PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt leading to the recruitment of p300 with NF-kappaB complex. Dinoprostone 71-75 nuclear factor kappa B subunit 1 Homo sapiens 184-193 19881225-0 2009 Proteinase-activated receptor-2-triggered prostaglandin E(2) release, but not cyclooxygenase-2 upregulation, requires activation of the phosphatidylinositol 3-kinase/Akt / nuclear factor-kappaB pathway in human alveolar epithelial cells. Dinoprostone 42-60 nuclear factor kappa B subunit 1 Homo sapiens 172-193 19881225-3 2009 Here, we investigated the roles of nuclear factor-kappaB (NF-kappaB)-related signals in the PAR2-triggered PGE(2) release / COX-2 upregulation in A549 cells. Dinoprostone 107-113 nuclear factor kappa B subunit 1 Homo sapiens 35-56 19881225-3 2009 Here, we investigated the roles of nuclear factor-kappaB (NF-kappaB)-related signals in the PAR2-triggered PGE(2) release / COX-2 upregulation in A549 cells. Dinoprostone 107-113 nuclear factor kappa B subunit 1 Homo sapiens 58-67 19881225-4 2009 The PAR2-triggered PGE(2) release was clearly blocked by an inhibitor of the NF-kappaB pathway. Dinoprostone 19-25 nuclear factor kappa B subunit 1 Homo sapiens 77-86 19734210-0 2009 P2Y2 receptor transcription is increased by NF-kappa B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells. Dinoprostone 102-106 nuclear factor kappa B subunit 1 Homo sapiens 44-54 19776509-1 2009 Interleukin-1beta (IL-1beta) stimulates expression of the highly inducible enzyme cyclooxygenase-2 (COX-2) via activation of nuclear factor kappaB (NFkappaB), and consequently provokes prostaglandin E(2) (PGE(2)) synthesis, which induces inflammatory responses. Dinoprostone 185-203 nuclear factor kappa B subunit 1 Homo sapiens 125-146 19776509-1 2009 Interleukin-1beta (IL-1beta) stimulates expression of the highly inducible enzyme cyclooxygenase-2 (COX-2) via activation of nuclear factor kappaB (NFkappaB), and consequently provokes prostaglandin E(2) (PGE(2)) synthesis, which induces inflammatory responses. Dinoprostone 185-203 nuclear factor kappa B subunit 1 Homo sapiens 148-156 17928629-13 2008 By coordinately regulating PTGS2 and PTGES, NFkappaB may contribute to an inducible PGE(2) biosynthesis pathway during human parturition. Dinoprostone 84-90 nuclear factor kappa B subunit 1 Homo sapiens 44-52 18261039-7 2008 By contrast, PGE2-supplemented DC could be characterized by negligible responses to LPS and IFN-gamma and a remarkable NF-kappaB response to CD40L. Dinoprostone 13-17 nuclear factor kappa B subunit 1 Homo sapiens 119-128 18237405-11 2008 Moreover, the expressions of COX-2 and PGE2 were significantly inhibited by specific inhibitors of p38 MAPK and NF-kappa B. Dinoprostone 39-43 nuclear factor kappa B subunit 1 Homo sapiens 112-122 18237405-13 2008 CONCLUSION: NTHi induces COX-2 and PGE2 expression in a p38 MAPK and NF-kappa B-dependent manner through TLR2 in lung epithelial cells in vitro and lung tissues in vivo. Dinoprostone 35-39 nuclear factor kappa B subunit 1 Homo sapiens 69-79 18480072-0 2008 17-Beta estradiol and hydroxyestradiols interact via the NF-kappa B pathway to elevate cyclooxygenase 2 expression and prostaglandin E2 secretion in human bronchial epithelial cells. Dinoprostone 119-135 nuclear factor kappa B subunit 1 Homo sapiens 57-67 16414978-13 2006 In summary, p38 MAPK- and NF-kappaB-controlled COX-2 expression and subsequent PGE(2) release by lung epithelial cells may contribute significantly to the host response in pneumococcal pneumonia. Dinoprostone 79-85 nuclear factor kappa B subunit 1 Homo sapiens 26-35 18237405-0 2008 Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B. Dinoprostone 53-57 nuclear factor kappa B subunit 1 Homo sapiens 125-135 18237405-2 2008 Herein, we tested that the hypothesis that NTHi induces the expression of cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) via activation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappa B in pulmonary alveolar epithelial cells. Dinoprostone 119-123 nuclear factor kappa B subunit 1 Homo sapiens 191-218 17403674-5 2007 Knockdown of NOX5-S or NF-kappaB1 p50 by their small interfering RNA significantly inhibited acid-induced COX2 expression and PGE2 production in SEG1 cells. Dinoprostone 126-130 nuclear factor kappa B subunit 1 Homo sapiens 34-37 16600383-10 2006 Inhibitors of NF-kappaB, MEK1/2 and p38 blocked MALP-2-inducible PGE(2) production. Dinoprostone 65-71 nuclear factor kappa B subunit 1 Homo sapiens 14-23 16427328-0 2006 Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. Dinoprostone 88-104 nuclear factor kappa B subunit 1 Homo sapiens 55-64 16272352-0 2005 Resolution of inflammation: prostaglandin E2 dissociates nuclear trafficking of individual NF-kappaB subunits (p65, p50) in stimulated rheumatoid synovial fibroblasts. Dinoprostone 28-44 nuclear factor kappa B subunit 1 Homo sapiens 116-119 16272352-2 2005 We tested whether PGE2 regulated nuclear localization of individual NF-kappaB subunits, p65 and p50, in synovial fibroblasts harvested from patients with rheumatoid arthritis (RA). Dinoprostone 18-22 nuclear factor kappa B subunit 1 Homo sapiens 96-99 16272352-4 2005 PGE2 (10 nM, 6 h) enhanced p50, but inhibited p65 translocation and NF-kappaB activation. Dinoprostone 0-4 nuclear factor kappa B subunit 1 Homo sapiens 27-30 16272352-5 2005 In contrast, depletion of endogenous PGE2 by ibuprofen (100 microM) and celecoxib (5 microM) enhanced p65, but inhibited p50 nuclear translocation as well as binding to NF-kappaB DNA binding sites. Dinoprostone 37-41 nuclear factor kappa B subunit 1 Homo sapiens 121-124 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. Dinoprostone 105-109 nuclear factor kappa B subunit 1 Homo sapiens 141-144 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. Dinoprostone 105-109 nuclear factor kappa B subunit 1 Homo sapiens 215-218 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. Dinoprostone 105-109 nuclear factor kappa B subunit 1 Homo sapiens 141-144 16272352-6 2005 PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. Dinoprostone 105-109 nuclear factor kappa B subunit 1 Homo sapiens 215-218 15760676-4 2005 However, the regulation of IL-8 production seems to be mediated via a cAMP-independent PKA pathway, since drugs known to enhance cAMP concentrations [PGE2, cholera toxin and dibutyryl cAMP] decrease IL-8 production in irradiated cells by down-regulating NF-kappa B activation in response to UVB radiation. Dinoprostone 150-154 nuclear factor kappa B subunit 1 Homo sapiens 254-264