PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26876621-10	2016	This study suggests the feedback roles of PGE2 in the negative regulation of NGF and MMP-1 and MMP-13 and the positive regulation of ADAMTS-4 and ADAMTS-5.	Dinoprostone	42-46	matrix metallopeptidase 13	Homo sapiens	95-101	
19998410-4	2010	The objective of this study was to investigate direct effects of PGE2 on IL-1beta-induced MMP-1 and MMP-13 expression and the intracellular signaling in articular chondrocytes.	Dinoprostone	65-69	matrix metallopeptidase 13	Homo sapiens	100-106	
19998410-5	2010	PGE2 showed inhibitory effects on IL-1beta-induced MMP-1 and MMP-13 expression demonstrated by immunoblotting both in OA and normal chondrocytes, which was further confirmed by enzyme-linked immunosorbent assay and immunohistochemistry of explant cultures of articular cartilages.	Dinoprostone	0-4	matrix metallopeptidase 13	Homo sapiens	61-67	
19998410-8	2010	PGE2 further inhibited the phosphorylation of MKK4 without suppression of MKK7 phosphorylation, and of c-JUN to decrease expression levels of MMP-1 and MMP-13.	Dinoprostone	0-4	matrix metallopeptidase 13	Homo sapiens	152-158	
19998410-9	2010	These results demonstrate that PGE2 inhibits IL-1beta-induced MMP-1 and MMP-13 productions via EP4 by suppressing MKK4-JNK MAP kinase-c-JUN pathway.	Dinoprostone	31-35	matrix metallopeptidase 13	Homo sapiens	72-78	
17683641-11	2007	Real-time PCR analysis of articular cartilage from five patients with OA revealed that PGE2 at 10 pg/ml suppressed the expression of matrix metalloproteinase (MMP)-13 and to a smaller extent MMP-1, as well as the proinflammatory cytokines IL-1beta and TNF-alpha and type X collagen (COL10A1), the last of these being a marker of chondrocyte hypertrophy.	Dinoprostone	87-91	matrix metallopeptidase 13	Homo sapiens	133-166	
18223264-0	2008	Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E2.	Dinoprostone	149-165	matrix metallopeptidase 13	Homo sapiens	56-83	
18223264-5	2008	Addition of exogenous PGE2 downregulated BCP crystal-stimulated MMP-13 expression.	Dinoprostone	22-26	matrix metallopeptidase 13	Homo sapiens	64-70	
18223264-9	2008	PGE2 had contrasting effects on BCP crystal-stimulated MMP-3 and MMP-13 mRNA expression, mediated in an EP2/EP4/cAMP-dependent manner, suggesting that PGE2 may have beneficial as well as deleterious effects in BCP crystal-associated osteoarthritis.	Dinoprostone	0-4	matrix metallopeptidase 13	Homo sapiens	65-71	
18802112-6	2008	PGE(2) inhibited spontaneous MMP-1, but augmented MMP-13 secretion by OA cartilage explant cultures.	Dinoprostone	0-6	matrix metallopeptidase 13	Homo sapiens	50-56	
15612948-0	2005	Down-regulation of interleukin-1alpha-induced matrix metalloproteinase-13 expression via EP1 receptors by prostaglandin E2 in human periodontal ligament cells.	Dinoprostone	106-122	matrix metallopeptidase 13	Homo sapiens	46-73	
15612948-1	2005	In the present study, we investigated the effect of prostaglandin (PG) E2 on matrix metalloproteinase (MMP)-13 production in human periodontal ligament cells stimulated with interleukin (IL)-1alpha.	Dinoprostone	52-73	matrix metallopeptidase 13	Homo sapiens	77-110	
12113550-6	2002	Pretreatment with the selective COX-2 inhibitor, NS-398, increased MMP-13 mRNA levels, while prostaglandin E2 and dibutyryl cyclic AMP decreased MMP-13 mRNA levels.	Dinoprostone	93-109	matrix metallopeptidase 13	Homo sapiens	145-151	
12113550-8	2002	These findings indicate that prostaglandin E2 has a lowering effect on TNFalpha-enhanced MMP-13 mRNA levels, and that this effect is dependent on cAMP.	Dinoprostone	29-45	matrix metallopeptidase 13	Homo sapiens	89-95	
12113550-9	2002	Our results suggest that TNFalpha participates in periodontal ligament destruction by stimulating the production of MMPs (MMP-1, MMP-3 and MMP-13), while endogenous prostaglandin E2 has a negative feedback role in TNFalpha-enhanced MMP-13 production.	Dinoprostone	165-181	matrix metallopeptidase 13	Homo sapiens	232-238	
15612948-3	2005	Indomethacin, a nonselective cyclooxygenase inhibitor, and NS-398, a specific cyclooxygenase-2 (COX-2) inhibitor, significantly enhanced IL-1alpha-induced MMP-13 production in periodontal ligament cells, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	Dinoprostone	268-272	matrix metallopeptidase 13	Homo sapiens	155-161	
15612948-4	2005	Exogenous PGE2 reduced IL-1alpha-induced MMP-13 mRNA and protein production in a dose-dependent manner.	Dinoprostone	10-14	matrix metallopeptidase 13	Homo sapiens	41-47	
15612948-5	2005	17-phenyl-omega-trinor PGE2, a selective EP1 receptor agonist, mimicked the inhibitory effect of PGE2 on IL-1alpha-induced MMP-13 mRNA and protein production.	Dinoprostone	23-27	matrix metallopeptidase 13	Homo sapiens	123-129	
15612948-6	2005	On the basis of these data, we suggest that COX-2-dependent PGE2 down-regulates IL-1alpha-elicited MMP-13 production via EP1 receptors in human periodontal ligament cells.	Dinoprostone	60-64	matrix metallopeptidase 13	Homo sapiens	99-105