PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33552081-5	2020	Hyaluronic acid binding to TLR4 in pericryptal macrophages results in cyclooxygenase2- dependent PGE2 production, which transactivates EGFR in LGR5+ crypt epithelial stem cells leading to increased proliferation.	Dinoprostone	97-101	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	143-147	
33552081-12	2020	PGE2 released by these mesenchymal stem cells transactivates EGFR in LGR5+ epithelial stem cells leading to increased proliferation.	Dinoprostone	0-4	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	69-73	
33552081-15	2020	PGE2 produced by these mesenchymal stem cells, blocks radiation-induced apoptosis in LGR5+ epithelial stem cells by an EGFR mediated pathway.	Dinoprostone	0-4	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	85-89	
24336194-3	2014	Because transformation of adult stem cells is an extremely important route toward initiating intestinal cancer, we utilized the leucine-rich-repeat-containing G-protein-coupled receptor 5 (Lgr5)-enhanced green fluorescent protein-internal ribosome entry site (IRES)-creER(T2) knock-in mouse model to isolate and culture colonic organoids, in order to document ex vivo responses to exogenous PGE2 and PGE3.	Dinoprostone	391-395	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	189-193	
32538139-0	2020	Hyaluronic acid promotes Lgr5+ stem cell proliferation and crypt fission through TLR4 and PGE2 transactivation of EGFR.	Dinoprostone	90-94	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	25-29	
32538139-8	2020	Administration of dimethyl PGE2, a stable PGE2 analog, increased crypt fission and Lgr5+ stem cell proliferation.	Dinoprostone	27-31	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	83-87	
32538139-11	2020	PGE2 transactivates EGFR in Lgr5+ epithelial stem cells, resulting in Lgr5+ stem cell proliferation and crypt fission.NEW & NOTEWORTHY This study, in newborn mice, describes a novel molecular pathway regulating Lgr5+ epithelial stem cell proliferation and normal intestinal elongation, as assessed by crypt fission.	Dinoprostone	0-4	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	28-32	
32538139-11	2020	PGE2 transactivates EGFR in Lgr5+ epithelial stem cells, resulting in Lgr5+ stem cell proliferation and crypt fission.NEW & NOTEWORTHY This study, in newborn mice, describes a novel molecular pathway regulating Lgr5+ epithelial stem cell proliferation and normal intestinal elongation, as assessed by crypt fission.	Dinoprostone	0-4	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	70-74	
32538139-11	2020	PGE2 transactivates EGFR in Lgr5+ epithelial stem cells, resulting in Lgr5+ stem cell proliferation and crypt fission.NEW & NOTEWORTHY This study, in newborn mice, describes a novel molecular pathway regulating Lgr5+ epithelial stem cell proliferation and normal intestinal elongation, as assessed by crypt fission.	Dinoprostone	0-4	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	70-74	
32538139-12	2020	In this pathway, endogenous extracellular hyaluronic acid binds to Toll-like receptor 4 on pericryptal macrophages releasing PGE2 which binds to epidermal growth factor receptor on Lgr5+ stem cells resulting in proliferation.	Dinoprostone	125-129	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	181-185	
24336194-8	2014	In contrast, the Lgr5-green fluorescent protein-positive stem cell number was uniquely elevated by >2-fold in PGE2-treated cultures compared with PGE3 and control.	Dinoprostone	113-117	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	17-21