PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24336194-3 2014 Because transformation of adult stem cells is an extremely important route toward initiating intestinal cancer, we utilized the leucine-rich-repeat-containing G-protein-coupled receptor 5 (Lgr5)-enhanced green fluorescent protein-internal ribosome entry site (IRES)-creER(T2) knock-in mouse model to isolate and culture colonic organoids, in order to document ex vivo responses to exogenous PGE2 and PGE3. Dinoprostone 391-395 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 189-193 33552081-5 2020 Hyaluronic acid binding to TLR4 in pericryptal macrophages results in cyclooxygenase2- dependent PGE2 production, which transactivates EGFR in LGR5+ crypt epithelial stem cells leading to increased proliferation. Dinoprostone 97-101 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 143-147 33552081-12 2020 PGE2 released by these mesenchymal stem cells transactivates EGFR in LGR5+ epithelial stem cells leading to increased proliferation. Dinoprostone 0-4 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 69-73 33552081-15 2020 PGE2 produced by these mesenchymal stem cells, blocks radiation-induced apoptosis in LGR5+ epithelial stem cells by an EGFR mediated pathway. Dinoprostone 0-4 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 85-89 32538139-0 2020 Hyaluronic acid promotes Lgr5+ stem cell proliferation and crypt fission through TLR4 and PGE2 transactivation of EGFR. Dinoprostone 90-94 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 25-29 32538139-8 2020 Administration of dimethyl PGE2, a stable PGE2 analog, increased crypt fission and Lgr5+ stem cell proliferation. Dinoprostone 27-31 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 83-87 32538139-11 2020 PGE2 transactivates EGFR in Lgr5+ epithelial stem cells, resulting in Lgr5+ stem cell proliferation and crypt fission.NEW & NOTEWORTHY This study, in newborn mice, describes a novel molecular pathway regulating Lgr5+ epithelial stem cell proliferation and normal intestinal elongation, as assessed by crypt fission. Dinoprostone 0-4 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 28-32 32538139-11 2020 PGE2 transactivates EGFR in Lgr5+ epithelial stem cells, resulting in Lgr5+ stem cell proliferation and crypt fission.NEW & NOTEWORTHY This study, in newborn mice, describes a novel molecular pathway regulating Lgr5+ epithelial stem cell proliferation and normal intestinal elongation, as assessed by crypt fission. Dinoprostone 0-4 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 70-74 32538139-11 2020 PGE2 transactivates EGFR in Lgr5+ epithelial stem cells, resulting in Lgr5+ stem cell proliferation and crypt fission.NEW & NOTEWORTHY This study, in newborn mice, describes a novel molecular pathway regulating Lgr5+ epithelial stem cell proliferation and normal intestinal elongation, as assessed by crypt fission. Dinoprostone 0-4 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 70-74 32538139-12 2020 In this pathway, endogenous extracellular hyaluronic acid binds to Toll-like receptor 4 on pericryptal macrophages releasing PGE2 which binds to epidermal growth factor receptor on Lgr5+ stem cells resulting in proliferation. Dinoprostone 125-129 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 181-185 24336194-8 2014 In contrast, the Lgr5-green fluorescent protein-positive stem cell number was uniquely elevated by >2-fold in PGE2-treated cultures compared with PGE3 and control. Dinoprostone 113-117 leucine rich repeat containing G protein coupled receptor 5 Mus musculus 17-21