PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33916321-9 2021 Both basal and IL-1beta-mediated PGE2 secretion was greater in MALAT1 depleted osteoblasts. Dinoprostone 33-37 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 63-69 34324865-9 2021 Knockdown of LncRNA-Malat1 improved neurological deficit scores, reduced cerebral infarction volume in vivo, and significantly promoted cell viability, reduced apoptosis and proinflammatory factors PGE2 and IL-10 in vitro. Dinoprostone 198-202 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 20-26 34638541-7 2021 Accordingly, a mechanistic investigation of MALAT1 overexpression in EOC cells showed that expressions of the cytokines interleukin (IL)-1beta and p-P38/p-NFkappaB/Cox2/prostaglandin E2 (PGE2) signaling were significantly increased, which stimulated inflammatory responses, whereas cell apoptosis was inhibited due to increased Bcl-2 levels and reduced Caspase3 levels. Dinoprostone 169-185 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 44-50 34638541-7 2021 Accordingly, a mechanistic investigation of MALAT1 overexpression in EOC cells showed that expressions of the cytokines interleukin (IL)-1beta and p-P38/p-NFkappaB/Cox2/prostaglandin E2 (PGE2) signaling were significantly increased, which stimulated inflammatory responses, whereas cell apoptosis was inhibited due to increased Bcl-2 levels and reduced Caspase3 levels. Dinoprostone 187-191 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 44-50 33916321-10 2021 The induction of MALAT1 in human OA osteoblasts upon inflammatory challenge and its modulation of PGE2 production suggests that MALAT1 may play a role in regulating inflammation in OA subchondral bone. Dinoprostone 98-102 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 17-23 33916321-10 2021 The induction of MALAT1 in human OA osteoblasts upon inflammatory challenge and its modulation of PGE2 production suggests that MALAT1 may play a role in regulating inflammation in OA subchondral bone. Dinoprostone 98-102 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 128-134