PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29175486-8	2018	15k-PGE2 further demonstrated modification to Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2, at cysteine 288 (Cys288) site post-translationally.	Dinoprostone	4-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119	
28684418-8	2017	Greater reductions in HO-1 expression and increase in PGE2/IL-6 production were observed in HG+IL-1beta-stimulated chondrocytes from Nrf-2-/- mice than in chondrocytes from wild-type mice.	Dinoprostone	54-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	133-138	
27463229-8	2017	They activated Nrf2 transcription factor, abolished IL-1beta-induced NO, PGE2 , MMP-13, and HNE production as well as IL-beta-induced GSTA4-4 down-regulation.	Dinoprostone	73-77	nuclear factor, erythroid derived 2, like 2	Mus musculus	15-19	
24858719-5	2014	The mechanisms involved in the renoprotective effects of osthole on the acFSGS model were mainly a result of an activated Nrf2-mediated antioxidant pathway in the early stage (proteinuria and ischemic collapse of the glomeruli) of acFSGS, followed by a decrease in: (1) NF-kappaB activation and COX-2 expression as well as PGE2 production, (2) podocyte injury, and (3) apoptosis.	Dinoprostone	323-327	nuclear factor, erythroid derived 2, like 2	Mus musculus	122-126	
27050800-9	2016	In addition, Nrf2 activation inhibited thrombin-induced cyclooxygenase-2 protein levels and secretion of prostaglandin E2, IL-1beta, IL-6, IL-8, TNFalpha, and granulocyte-macrophage colony-stimulating factor in the media.	Dinoprostone	105-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17	
21651978-0	2011	PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2.	Dinoprostone	9-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79	
24365262-6	2014	Additionally, beta-HIVS caused the induction of heme oxygenase-1 (HO-1) via upregulation of nuclear factor-erythroid 2-related factor 2 (Nrf2), both of which are involved in the secretion of proinflammatory mediators such as NO and PGE2.	Dinoprostone	232-236	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-135	
24365262-6	2014	Additionally, beta-HIVS caused the induction of heme oxygenase-1 (HO-1) via upregulation of nuclear factor-erythroid 2-related factor 2 (Nrf2), both of which are involved in the secretion of proinflammatory mediators such as NO and PGE2.	Dinoprostone	232-236	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141	
24291391-6	2014	Our results showed that TIA suppressed NO and PGE2 production through the induction of nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent heme oxygenase-1 (HO-1).	Dinoprostone	46-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-130	
24291391-6	2014	Our results showed that TIA suppressed NO and PGE2 production through the induction of nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent heme oxygenase-1 (HO-1).	Dinoprostone	46-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	132-136	
19174151-2	2009	Pretreatment of microglial cells with tBHQ, a phenolic antioxidant activating Nrf2, attenuated the LPS-derived overproduction of pro-inflammatory neurotoxic mediators like TNF-alpha, IL-1beta, IL-6, PGE(2), and NO as well as the morphological changes associated with microglial hyperactivation.	Dinoprostone	199-205	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82	
32891712-4	2020	Nrf2-mediated reduction of PGE2 was dependent on the enhanced expression of heme oxygenase 1 (HO-1) and glutamate-cysteine ligase (GCLC), and decreased COX-2 expression in breast cancer cells.	Dinoprostone	27-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4