PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21848814-5 2011 In this study we found that EspT induces expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2) an enzyme involved in production of prostaglandin E(2) (PGE2), interleukin (Il)-8 and Il-1beta in U937 human macrophages by activating the nuclear factor kappa-B (NF-kappaB), the extracellular signal-regulated kinases 1 and 2 (Erk1/2) and c-Jun N-terminal kinase (JNK) pathways. Dinoprostone 147-165 mitogen-activated protein kinase 3 Homo sapiens 338-344 20883667-1 2010 The MAPK/ERK pathway is involved in IL-1beta-induced cyclooxygenase (COX-2) expression and prostaglandin E2 (PGE2) production; two factors that play important roles in OA pathogenesis. Dinoprostone 91-107 mitogen-activated protein kinase 3 Homo sapiens 4-8 22096605-6 2011 Using a synthesis of sophisticated molecular biology techniques, we determined that PGE(2) stimulates Toll-like receptor 4 (TLR4) synthesis, which is in turn responsible for the activation of the ERK1/2, PI3K/Akt and PKA/CREB pathways that phosphorylate the NF-kappaB p65 subunit leading to NF-kappaB activation. Dinoprostone 84-90 mitogen-activated protein kinase 3 Homo sapiens 196-202 22096605-8 2011 PGD(2) or 15d-PGJ(2) concurrently downregulates TLR4 and upregulates caveolin-1, which in turn inhibit the PGE(2)-dependent ERK1/2, PI3-K and PKA activation, and ultimately with NF-kappaB-dependent IL-6 synthesis in chondrocytes. Dinoprostone 107-113 mitogen-activated protein kinase 3 Homo sapiens 124-130 21663732-2 2011 We have previously reported that BK increased the synthesis of interleukin-6 and prostaglandin E(2) via phosphorylation of ERK1/2 in human osteoblasts, SaM-1. Dinoprostone 81-99 mitogen-activated protein kinase 3 Homo sapiens 123-129 20883667-1 2010 The MAPK/ERK pathway is involved in IL-1beta-induced cyclooxygenase (COX-2) expression and prostaglandin E2 (PGE2) production; two factors that play important roles in OA pathogenesis. Dinoprostone 109-113 mitogen-activated protein kinase 3 Homo sapiens 4-8 20883667-2 2010 In the present study, we find that IL-1beta induced COX-2 expression and PGE2 production in human chondrocytes via a process that required the activation of the MAPK/ERK pathway. Dinoprostone 73-77 mitogen-activated protein kinase 3 Homo sapiens 161-165 20883667-4 2010 COX-2 expression and PGE2 production were significantly suppressed to a similar degree by the silencing of ERK1 or ERK2 alone. Dinoprostone 21-25 mitogen-activated protein kinase 3 Homo sapiens 107-111 19680656-0 2010 Epidermal growth factor increases prostaglandin E2 production via ERK1/2 MAPK and NF-kappaB pathway in fibroblast like synoviocytes from patients with rheumatoid arthritis. Dinoprostone 34-50 mitogen-activated protein kinase 3 Homo sapiens 66-72 20944107-8 2010 In Caco-2 cells, Erk1/2 was activated by substance P and prostaglandin E2. Dinoprostone 57-73 mitogen-activated protein kinase 3 Homo sapiens 17-23 20446020-0 2010 17beta-estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells. Dinoprostone 26-42 mitogen-activated protein kinase 3 Homo sapiens 111-117 20446020-5 2010 We further observed that 17beta-estradiol treatment inhibits PGE2-induced COX-2 expression and cellular motility via suppressing activation of Akt and ERK1/2 in human LoVo cancer cells. Dinoprostone 61-65 mitogen-activated protein kinase 3 Homo sapiens 151-157 20348947-4 2010 Repression of Bim expression was dependent upon PGE(2)-mediated activation of the Raf-MEK-ERK1/2 pathway, which promoted Bim phosphorylation and proteasomal degradation. Dinoprostone 48-54 mitogen-activated protein kinase 3 Homo sapiens 90-96 18571585-11 2008 U937-conditioned medium and interleukin-1beta stimulated expression of cyclooxygenase-2 and prostaglandin E(2) production in pancreatic cancer cells, which was mediated by activation of the ERK1/2 pathway. Dinoprostone 92-110 mitogen-activated protein kinase 3 Homo sapiens 190-196 19575453-10 2009 Inhibition of ERK1/2 activation by PD98059 abolished the PGE(2)-dependent but not the IL-6-dependent attenuation of insulin signaling. Dinoprostone 57-63 mitogen-activated protein kinase 3 Homo sapiens 14-20 18359889-6 2008 Extended studies using gene silencing and pharmacological approaches to inhibit specific intracellular signaling molecules demonstrated that the mechanism underlying PGE(2)-induced transcriptional upregulation of PDE4D5 involves PKA-dependent activation of G(i) protein signaling via the betagamma-subunits, the latter eliciting downstream activation of ERK1/2 and its consequent induction of PDE4D5 transcription. Dinoprostone 166-172 mitogen-activated protein kinase 3 Homo sapiens 354-360 18056380-3 2007 We now report that FcgammaR-induced PI3K/Akt and ERK-1/2 activation are inhibited by PGE2 in AMs. Dinoprostone 85-89 mitogen-activated protein kinase 3 Homo sapiens 49-56 18079197-7 2008 Furthermore, U0126, an inhibitor of MAPK kinases MEK1 and MEK2, abrogated PGE(2)-induced migration of trophoblasts, and PGE(2) or the other two EP agonists stimulated ERK1/2 activation in trophoblasts, which was not abrogated by pretreatment with C3 transferase, indicating that ERK signaling pathway is an efficient alternate pathway for RhoA in PGE(2)-mediated migration of trophoblasts. Dinoprostone 74-80 mitogen-activated protein kinase 3 Homo sapiens 167-173 18079197-7 2008 Furthermore, U0126, an inhibitor of MAPK kinases MEK1 and MEK2, abrogated PGE(2)-induced migration of trophoblasts, and PGE(2) or the other two EP agonists stimulated ERK1/2 activation in trophoblasts, which was not abrogated by pretreatment with C3 transferase, indicating that ERK signaling pathway is an efficient alternate pathway for RhoA in PGE(2)-mediated migration of trophoblasts. Dinoprostone 74-80 mitogen-activated protein kinase 3 Homo sapiens 167-170 18079197-7 2008 Furthermore, U0126, an inhibitor of MAPK kinases MEK1 and MEK2, abrogated PGE(2)-induced migration of trophoblasts, and PGE(2) or the other two EP agonists stimulated ERK1/2 activation in trophoblasts, which was not abrogated by pretreatment with C3 transferase, indicating that ERK signaling pathway is an efficient alternate pathway for RhoA in PGE(2)-mediated migration of trophoblasts. Dinoprostone 120-126 mitogen-activated protein kinase 3 Homo sapiens 167-173 18079197-7 2008 Furthermore, U0126, an inhibitor of MAPK kinases MEK1 and MEK2, abrogated PGE(2)-induced migration of trophoblasts, and PGE(2) or the other two EP agonists stimulated ERK1/2 activation in trophoblasts, which was not abrogated by pretreatment with C3 transferase, indicating that ERK signaling pathway is an efficient alternate pathway for RhoA in PGE(2)-mediated migration of trophoblasts. Dinoprostone 120-126 mitogen-activated protein kinase 3 Homo sapiens 167-170 18079197-8 2008 These results suggest that ROCK and ERK1/2 play more important roles than RhoA in PGE(2)-mediated migration stimulation of first-trimester trophoblasts. Dinoprostone 82-88 mitogen-activated protein kinase 3 Homo sapiens 36-42 18056380-4 2007 By specifically inhibiting the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in AMs, we attenuated the inhibitory effects of both PGE2 and a specific Epac-1 agonist (8-pCPT-2"-O-Me-cAMP) on FcgammaR-mediated phagocytosis and Akt/ERK-1/2 activation; PTEN inhibition also decreased PGE2-induced suppression of bacterial killing by AMs. Dinoprostone 147-151 mitogen-activated protein kinase 3 Homo sapiens 246-253 17329433-12 2007 On the basis of these observations, we propose a PGE2-dependent, ERK1/2-regulated microglia-neuron signaling pathway that mediates the microglial component of pain maintenance after injury to the spinal cord. Dinoprostone 49-53 mitogen-activated protein kinase 3 Homo sapiens 65-71 17631291-6 2007 In order to identify downstream target genes of ERK1/2 signaling, we found that PGE(2) induces expression of early growth response gene-1 (EGR-1) downstream of ERK1/2 and regulates its expression at the level of transcription. Dinoprostone 80-86 mitogen-activated protein kinase 3 Homo sapiens 48-54 17631291-6 2007 In order to identify downstream target genes of ERK1/2 signaling, we found that PGE(2) induces expression of early growth response gene-1 (EGR-1) downstream of ERK1/2 and regulates its expression at the level of transcription. Dinoprostone 80-86 mitogen-activated protein kinase 3 Homo sapiens 160-166 17384145-4 2007 Consistently, iNOS-GC pathway inhibitors blocked mitogen-activated protein kinase-ERK1/2 phosphorylation, which was required to mediate PGE2 functions. Dinoprostone 136-140 mitogen-activated protein kinase 3 Homo sapiens 82-88 17329433-7 2007 Enzyme immunoassay analysis showed that PGE2 release was dependent on microglial activation and ERK1/2 phosphorylation. Dinoprostone 40-44 mitogen-activated protein kinase 3 Homo sapiens 96-102 15567061-8 2005 Taken together, these results indicate that PMA might activate PKC to elicit activation of the Ras/Raf-1/ERK1/2 pathway, which in turn initiates NF-kappaB activation, and finally induces COX-2 expression and PGE2 release in A549 cells. Dinoprostone 208-212 mitogen-activated protein kinase 3 Homo sapiens 105-111 16574793-8 2006 Therefore, we have demonstrated that seminal plasma and PGE(2) can promote the expression of tumorigenic and angiogenic factors, in cervical adenocarcinoma cells via the EP4 receptor, EGFR, and ERK1/2 signaling pathways. Dinoprostone 56-62 mitogen-activated protein kinase 3 Homo sapiens 194-200 15358633-0 2004 n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. Dinoprostone 82-86 mitogen-activated protein kinase 3 Homo sapiens 95-107 15515144-10 2005 Inhibition of the ERK and p38 MAPK pathways inhibited COX-2 expression and PGE(2) production. Dinoprostone 75-81 mitogen-activated protein kinase 3 Homo sapiens 18-21 15024003-6 2004 Here we demonstrate that macrophage engagement of SMC-ECM triggers PKC-dependent activation of MAPK(erk1/2) leading to increased expression of cyclooxygenase (COX)-2 and prostaglandin (PG) E(2) synthesis. Dinoprostone 170-193 mitogen-activated protein kinase 3 Homo sapiens 95-99 15358633-7 2004 Moreover, they inhibited ERK-1 and -2 phosphorylation and HIF-1alpha protein over-expression, critical steps in the PGE(2)-induced signaling pathway leading to the augmented expression of VEGF in colon cancer cells. Dinoprostone 116-122 mitogen-activated protein kinase 3 Homo sapiens 25-37 15044590-8 2004 Therefore, we have demonstrated that elevated EP2 receptor expression may facilitate the PGE(2)-induced release of proangiogenic factors in reproductive tumor cells via intracellular cAMP-mediated transactivation of the EGFR and ERK1/2 pathways. Dinoprostone 89-95 mitogen-activated protein kinase 3 Homo sapiens 229-235 15024003-6 2004 Here we demonstrate that macrophage engagement of SMC-ECM triggers PKC-dependent activation of MAPK(erk1/2) leading to increased expression of cyclooxygenase (COX)-2 and prostaglandin (PG) E(2) synthesis. Dinoprostone 170-193 mitogen-activated protein kinase 3 Homo sapiens 100-106 12970327-1 2003 In this study, we investigated the effect of prostaglandin E(2) (PGE(2)) on MAPK ERK1/2 protein phosphorylation and on proliferation of epithelial cells of the human endometrium. Dinoprostone 45-63 mitogen-activated protein kinase 3 Homo sapiens 81-87 12970327-1 2003 In this study, we investigated the effect of prostaglandin E(2) (PGE(2)) on MAPK ERK1/2 protein phosphorylation and on proliferation of epithelial cells of the human endometrium. Dinoprostone 65-71 mitogen-activated protein kinase 3 Homo sapiens 81-87 12493746-8 2003 Dedifferentiation-induced COX-2 expression and PGE(2) production were mediated by ERK1/2 and p38 kinase signaling. Dinoprostone 47-53 mitogen-activated protein kinase 3 Homo sapiens 82-88 12794156-11 2003 Moreover, p38 regulates MMP-1 mainly through a PGE(2)-dependent pathway, whereas ERK1/2-mediated MMP-1 and MMP-9 production involves the activation of additional MMP promoter sites through a PGE(2)-independent mechanism. Dinoprostone 191-197 mitogen-activated protein kinase 3 Homo sapiens 81-87 34878156-6 2022 Exosomal prostaglandin E2 (PGE2)-mediated ERK1/2 and GSK-3beta phosphorylation were revealed to increase Bcl-2 and decrease Bax expression with mitochondrial permeability transition pore-inhibition which may be considered a prime mechanism of exosome-mediated hepatoprotection. Dinoprostone 9-25 mitogen-activated protein kinase 3 Homo sapiens 42-48 12533408-9 2003 In conclusion, immediate signal transduction pathways induced by CG in endometrial epithelial cells are cAMP independent and stimulate phosphorylation of ERK 1/2 via a MEK 1/2 pathway, leading to an increase in PGE(2) release as the possible result of cyclooxygenase-2 activation. Dinoprostone 211-217 mitogen-activated protein kinase 3 Homo sapiens 154-161 11861509-6 2002 The known luteotropin, PGE(2), promoted MEK- and cAMP-dependent activation of ERK1/2, and inhibitors of either MEK or PKA decreased PGE(2)-induced progesterone synthesis. Dinoprostone 23-29 mitogen-activated protein kinase 3 Homo sapiens 78-84 34878156-6 2022 Exosomal prostaglandin E2 (PGE2)-mediated ERK1/2 and GSK-3beta phosphorylation were revealed to increase Bcl-2 and decrease Bax expression with mitochondrial permeability transition pore-inhibition which may be considered a prime mechanism of exosome-mediated hepatoprotection. Dinoprostone 27-31 mitogen-activated protein kinase 3 Homo sapiens 42-48 33995374-4 2021 Here, we showed that HP-PRRSV infection increased PGE2 production in microglia via COX-2 up-regulation depending on the activation of MEK1-ERK1/2-C/EBPbeta signaling pathways. Dinoprostone 50-54 mitogen-activated protein kinase 3 Homo sapiens 139-145 35497094-11 2022 These findings supported that COX-2/PGE2 expression triggered by thrombin was engaged in PAR1/Gq or Gi/o/PKCalpha/MAPK-dependent NF-kappaB activation in HTSMCs. Dinoprostone 36-40 mitogen-activated protein kinase 3 Homo sapiens 114-118 34609050-4 2021 This study has confirmed the link between low NO bioavailability and COX-2 overexpression by COX-2-dependent PGE2-EP2-ERK1/2-NOX1/NOX4 signalling pathway in LSECs in vivo and in vitro. Dinoprostone 109-113 mitogen-activated protein kinase 3 Homo sapiens 118-124 34208772-0 2021 Isookanin Inhibits PGE2-Mediated Angiogenesis by Inducing Cell Arrest through Inhibiting the Phosphorylation of ERK1/2 and CREB in HMEC-1 Cells. Dinoprostone 19-23 mitogen-activated protein kinase 3 Homo sapiens 112-118 34208772-10 2021 The mechanism of inhibiting angiogenesis by isookanin is related to the inhibition of PGE2-mediated ERK1/2 and CREB phosphorylation. Dinoprostone 86-90 mitogen-activated protein kinase 3 Homo sapiens 100-106 35497094-0 2022 Thrombin Induces COX-2 and PGE2 Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells. Dinoprostone 27-31 mitogen-activated protein kinase 3 Homo sapiens 61-65 32820432-0 2021 Leptin reduces in vitro cementoblast mineralization and survival as well as induces PGE2 release by ERK1/2 commitment. Dinoprostone 84-88 mitogen-activated protein kinase 3 Homo sapiens 100-106 32820432-11 2021 Blockade of ERK1/2 impairs leptin-induced PGE2 secretion and reduced caspase 3 and caspase 9 expression. Dinoprostone 42-46 mitogen-activated protein kinase 3 Homo sapiens 12-18 31703303-7 2019 Extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation after PGE2 treatment significantly increased by ~2.5 times. Dinoprostone 73-77 mitogen-activated protein kinase 3 Homo sapiens 43-49 31811862-8 2020 In turn, sPLA2-induced PGE2 release and COX-2 expression, but not NF-kappaB activation, was attenuated by pre-treating macrophages with PD98059 an inhibitor of ERK1/2. Dinoprostone 23-27 mitogen-activated protein kinase 3 Homo sapiens 160-166 31811862-9 2020 These results suggest that, in macrophages, group IIA sPLA2-induced PGE2 release and COX-2 protein expression are distinctly mediated through 12-HETE followed by ERK1/2 pathway activation, independently of NF-kappaB activation. Dinoprostone 68-72 mitogen-activated protein kinase 3 Homo sapiens 162-168 32114020-6 2020 The release of PGE2 by bradykinin could be blocked inhibiting COX-2 and p65/NF-kB, ERK1/2 or p38 activation. Dinoprostone 15-19 mitogen-activated protein kinase 3 Homo sapiens 83-89 32114020-8 2020 Thus, bradykinin, acting via B2 receptors, induced PGE2 release through ERK1/2 and p38-dependent pathways and consequent p65/NF-kB translocation to nucleus. Dinoprostone 51-55 mitogen-activated protein kinase 3 Homo sapiens 72-78 31703303-9 2019 These results indicated that PGE2 is directly associated with EP1 pathway-regulated ERK1/2 and inositol trisphosphate (IP3) signaling in NHDFs. Dinoprostone 29-33 mitogen-activated protein kinase 3 Homo sapiens 84-90 29891646-5 2018 In vascular smooth muscle cells or aortic segments, PGE2 increased NADPH oxidase expression and activity and reduced mitochondrial membrane potential, effects that were abolished by antagonists of the PGE2 receptors (EP), EP1 and EP3, and by JNK (c-Jun N-terminal kinase) and ERK1/2 (extracellular-signal-regulated kinases 1/2) inhibition. Dinoprostone 52-56 mitogen-activated protein kinase 3 Homo sapiens 276-282 31440159-5 2019 The prostaglandin E2 (PGE2) derived from PTGS2 catalyzation further strengthened PTGS2 expression via the PGE2-EPs-ERK1/2 positive feedback loop, which induced multidrug resistance of NSCLC cells through up-regulation of BCL2 expression and the subsequent attenuation of cell apoptosis. Dinoprostone 106-110 mitogen-activated protein kinase 3 Homo sapiens 115-121 31440159-5 2019 The prostaglandin E2 (PGE2) derived from PTGS2 catalyzation further strengthened PTGS2 expression via the PGE2-EPs-ERK1/2 positive feedback loop, which induced multidrug resistance of NSCLC cells through up-regulation of BCL2 expression and the subsequent attenuation of cell apoptosis. Dinoprostone 4-20 mitogen-activated protein kinase 3 Homo sapiens 115-121 31440159-5 2019 The prostaglandin E2 (PGE2) derived from PTGS2 catalyzation further strengthened PTGS2 expression via the PGE2-EPs-ERK1/2 positive feedback loop, which induced multidrug resistance of NSCLC cells through up-regulation of BCL2 expression and the subsequent attenuation of cell apoptosis. Dinoprostone 22-26 mitogen-activated protein kinase 3 Homo sapiens 115-121 30367494-6 2019 PGE2 -induced increase in COX-2 expression and, thereby, in transcriptional increase in HIF-1alpha expression was due to EGFR activation, leading to the activation of Phosphoinositide 3-kinase/Akt, Extracellular signal -regulated kinases 1/2, p38 and Mitogen- and stress-activated protein kinase-1 (PI3K/Akt, Erk1/2, p38 and MSK-1). Dinoprostone 0-4 mitogen-activated protein kinase 3 Homo sapiens 309-315 26851630-7 2016 Collectively, MAD could inhibit the HGF-activated proliferation and invasiveness of HCC cells via regulating the activation of cMET-PKC-ERK1/2-COX-2-PGE2 cascade, which indicated that MAD might help control HGF-linked HCC. Dinoprostone 149-153 mitogen-activated protein kinase 3 Homo sapiens 136-142 29700097-7 2018 In addition, PGE2/sulprostone was able to stimulate the expression of Gi1, phosphorylated-extracellular signal-regulated kinases 1/2 (p-ERK1/2) and p53. Dinoprostone 13-17 mitogen-activated protein kinase 3 Homo sapiens 136-142 28222855-11 2017 In the Panc-1 cells, PGE2 activated PKA/CREB and decreased phosphorylation of ERK1/2, which was reversed by an EP4 receptor antagonist, while an EP2 receptor antagonist had no effect. Dinoprostone 21-25 mitogen-activated protein kinase 3 Homo sapiens 78-84 27377703-6 2017 Specific inhibitor and mutagenesis studies showed that Src, EGFR, JNK1/2, and Erk1/2 are involved in PGE2 -induced uPAR expression. Dinoprostone 101-105 mitogen-activated protein kinase 3 Homo sapiens 78-84 27377703-11 2017 To the best of our knowledge, this is the first report that PGE2 -induced uPAR expression, which stimulates invasiveness of human gastric cancer AGS cells, is mediated by the EP2 receptor-dependent Src/EGFR/JNK1/2, Erk1/2/AP-1, and Src/EGFR/JNK1/2, Erk1/2/NF-kappaB cascades. Dinoprostone 60-64 mitogen-activated protein kinase 3 Homo sapiens 215-221 27377703-11 2017 To the best of our knowledge, this is the first report that PGE2 -induced uPAR expression, which stimulates invasiveness of human gastric cancer AGS cells, is mediated by the EP2 receptor-dependent Src/EGFR/JNK1/2, Erk1/2/AP-1, and Src/EGFR/JNK1/2, Erk1/2/NF-kappaB cascades. Dinoprostone 60-64 mitogen-activated protein kinase 3 Homo sapiens 249-255 28740516-0 2017 PGE2 Promotes the Migration of Mesenchymal Stem Cells through the Activation of FAK and ERK1/2 Pathway. Dinoprostone 0-4 mitogen-activated protein kinase 3 Homo sapiens 88-94 28740516-6 2017 Furthermore, MSCs migration induced by PGE2 was blunted by FAK or ERK1/2 inhibitors. Dinoprostone 39-43 mitogen-activated protein kinase 3 Homo sapiens 66-72 28740516-9 2017 In conclusion, our findings reveal EP2-mediated FAK and ERK1/2 activation was essential for MSCs migration induced by PGE2, indicating that activation of EP2 receptor and FAK/ERK pathways may be a promising strategy to accelerate homing efficiency of MSCs, which in turn enhances therapeutic potential of MSCs transplantation. Dinoprostone 118-122 mitogen-activated protein kinase 3 Homo sapiens 56-62 27022132-11 2016 CONCLUSIONS: In GBM, Cox-2-derived PGE2 induces Id1 via EP4-dependent activation of MAPK signaling and the Egr1 transcription factor. Dinoprostone 35-39 mitogen-activated protein kinase 3 Homo sapiens 84-88 27539669-7 2016 Further, SPRY2 knockdown attenuated the AREG-induced COX-2 expression and PGE2 production by inhibiting AREG-activated ERK1/2 signaling. Dinoprostone 74-78 mitogen-activated protein kinase 3 Homo sapiens 119-125 27747963-10 2017 The tumoral cell proliferation induced by PGE2 is related to PKC, ERK 1/2 and MAP Kinase P38 pathways. Dinoprostone 42-46 mitogen-activated protein kinase 3 Homo sapiens 66-73 28054591-4 2017 In the presence of MAPK inhibitors, IL-1beta-induced COX-2 expression and PGE2 release were both attenuated. Dinoprostone 74-78 mitogen-activated protein kinase 3 Homo sapiens 19-23 26261008-14 2015 Knockdown of ERK1 or PI3K p85alpha also attenuated PGE2-induced activation of NF-kappaB in LS-174T cells. Dinoprostone 51-55 mitogen-activated protein kinase 3 Homo sapiens 13-17 26394174-6 2015 Activation of p38, JNK, ERK 1/2 and ERK 5 MAPKs by PGE2 were observed in ESCs, where PGE2-stimulated aromatase and ERbeta expression mainly through p38 and JNK pathway. Dinoprostone 51-55 mitogen-activated protein kinase 3 Homo sapiens 24-31 24561081-8 2014 Collectively, the results indicate that cyclic tensile force activates ERK1/2 and p38 MAP kinase signaling pathways, and induces COX-2 expression, which is responsible for the sequential PGE2 biosynthesis and release, and furthermore, mediates the increase in BMP-2 expression at the transcriptional level. Dinoprostone 187-191 mitogen-activated protein kinase 3 Homo sapiens 71-77 25014275-4 2014 Interestingly, the TLR3 agonist polyinosinic:polycytidylic acid (poly(I:C)) mediated phosphorylation of NF-kappaB and extracellular stress-related kinase 1/2 (ERK1/2), which significantly decreased following PGE2 treatment. Dinoprostone 208-212 mitogen-activated protein kinase 3 Homo sapiens 159-165 24441870-12 2014 Taken together, these results demonstrated that TNF-alpha-induced cPLA2 expression and PGE2 release were mediated through a Jak2/PDGFR/PI3K/Akt/p42/p44 MAPK/Elk-1 pathway in HPAEpiCs. Dinoprostone 87-91 mitogen-activated protein kinase 3 Homo sapiens 148-156 23861370-10 2013 PGE2 stimulated adhesion of porcine trophoblast cells via the estrogen receptor and MEK/MAPK signaling pathway. Dinoprostone 0-4 mitogen-activated protein kinase 3 Homo sapiens 88-92 24416369-12 2014 Moreover, RNO associated with PGE2 reduced CSE+LPS-induced cytokine release, which can happen by occur through of ERK1/2 and JAK/STAT pathways. Dinoprostone 30-34 mitogen-activated protein kinase 3 Homo sapiens 114-120 24092824-0 2013 EGF-like growth factors induce COX-2-derived PGE2 production through ERK1/2 in human granulosa cells. Dinoprostone 45-49 mitogen-activated protein kinase 3 Homo sapiens 69-75 24092824-13 2013 AREG-, BTC-, and EREG-activated ERK1/2 signaling, but not Akt signaling, was required for AREG-, BTC-, and EREG-induced COX-2 expression and PGE2 production. Dinoprostone 141-145 mitogen-activated protein kinase 3 Homo sapiens 32-38 24092824-14 2013 CONCLUSION: AREG, BTC, and EREG induced PGE2 production by upregulating COX-2 expression through ERK1/2 signaling in human granulosa cells. Dinoprostone 40-44 mitogen-activated protein kinase 3 Homo sapiens 97-103 23861370-11 2013 PGE2 induced phosphorylation of MAPK1/MAPK3 through PTGER2 and up-regulated expression of cell adhesion proteins such as focal adhesion kinase and intercellular adhesion molecule-1. Dinoprostone 0-4 mitogen-activated protein kinase 3 Homo sapiens 38-43 22659045-0 2012 Involvement of the MAPK and RhoA/ROCK pathways in PGE2-mediated CCR7-dependent monocyte migration. Dinoprostone 50-54 mitogen-activated protein kinase 3 Homo sapiens 19-23