PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26988982-7 2016 Moreover, IL-17A-induced COX2 and PGE2 production was shown to rely on p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner. Dinoprostone 34-38 mitogen-activated protein kinase 8 Homo sapiens 85-88 26394174-2 2015 P38 and C-jun NH2-terminal kinase (JNK) inhibitors may have a therapeutic effect on endometriosis through regulation of prostaglandin E2 (PGE2)-induced estrogen metabolism. Dinoprostone 120-136 mitogen-activated protein kinase 8 Homo sapiens 8-33 26394174-2 2015 P38 and C-jun NH2-terminal kinase (JNK) inhibitors may have a therapeutic effect on endometriosis through regulation of prostaglandin E2 (PGE2)-induced estrogen metabolism. Dinoprostone 120-136 mitogen-activated protein kinase 8 Homo sapiens 35-38 26394174-2 2015 P38 and C-jun NH2-terminal kinase (JNK) inhibitors may have a therapeutic effect on endometriosis through regulation of prostaglandin E2 (PGE2)-induced estrogen metabolism. Dinoprostone 138-142 mitogen-activated protein kinase 8 Homo sapiens 8-33 26394174-2 2015 P38 and C-jun NH2-terminal kinase (JNK) inhibitors may have a therapeutic effect on endometriosis through regulation of prostaglandin E2 (PGE2)-induced estrogen metabolism. Dinoprostone 138-142 mitogen-activated protein kinase 8 Homo sapiens 35-38 26394174-6 2015 Activation of p38, JNK, ERK 1/2 and ERK 5 MAPKs by PGE2 were observed in ESCs, where PGE2-stimulated aromatase and ERbeta expression mainly through p38 and JNK pathway. Dinoprostone 51-55 mitogen-activated protein kinase 8 Homo sapiens 19-22 26394174-6 2015 Activation of p38, JNK, ERK 1/2 and ERK 5 MAPKs by PGE2 were observed in ESCs, where PGE2-stimulated aromatase and ERbeta expression mainly through p38 and JNK pathway. Dinoprostone 85-89 mitogen-activated protein kinase 8 Homo sapiens 156-159 26394174-7 2015 P38 and JNK inhibition or small interfering RNA knockdown blocked PGE2-induced aromatase and ERbeta expression. Dinoprostone 66-70 mitogen-activated protein kinase 8 Homo sapiens 8-11 26394174-8 2015 PGE2 enhanced binding of downstream p38 and JNK transcription factors activating transcription factor-2 and c-Jun to aromatase and ERB promoter regions in ESCs. Dinoprostone 0-4 mitogen-activated protein kinase 8 Homo sapiens 44-47 26394174-9 2015 Moreover, treatment of endometriosis xenografts with inhibitors of p38 and JNK abrogated PGE2-amplified estradiol synthesis and xenograft growth. Dinoprostone 89-93 mitogen-activated protein kinase 8 Homo sapiens 75-78 26394174-10 2015 CONCLUSIONS: PGE2 activates p38 and JNK signaling pathways, further stimulating c-Jun and activating transcription factor-2 binding to aromatase and ERB promoter regions with elevated estradiol production. Dinoprostone 13-17 mitogen-activated protein kinase 8 Homo sapiens 36-39 26273406-9 2015 Furthermore, PGE2 enhanced alpha7 nAChR expression via activation of c-Jun N-terminal kinase (JNK), phosphatidylinositol 3-kinase (PI3-K), and protein kinase A (PKA) pathways followed by increased c-Jun expression, a critical transcription factor. Dinoprostone 13-17 mitogen-activated protein kinase 8 Homo sapiens 69-92 26059638-8 2015 In addition, PGE2-induced aromatase expression was significantly inhibited by inhibitors of IKK, MEK, JNK, p38 and PKA. Dinoprostone 13-17 mitogen-activated protein kinase 8 Homo sapiens 102-105 26273406-9 2015 Furthermore, PGE2 enhanced alpha7 nAChR expression via activation of c-Jun N-terminal kinase (JNK), phosphatidylinositol 3-kinase (PI3-K), and protein kinase A (PKA) pathways followed by increased c-Jun expression, a critical transcription factor. Dinoprostone 13-17 mitogen-activated protein kinase 8 Homo sapiens 94-97 21859479-7 2011 After administration of inhibitors including LY294002, U0126, SB203580, SP600125 or QNZ, we found that PGE2 treatment up-regulated uPA and MMP-9 expression via JNK1/2 signaling pathway, thus promoting cellular motility in human LoVo cancer cells. Dinoprostone 103-107 mitogen-activated protein kinase 8 Homo sapiens 160-164 21848814-5 2011 In this study we found that EspT induces expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2) an enzyme involved in production of prostaglandin E(2) (PGE2), interleukin (Il)-8 and Il-1beta in U937 human macrophages by activating the nuclear factor kappa-B (NF-kappaB), the extracellular signal-regulated kinases 1 and 2 (Erk1/2) and c-Jun N-terminal kinase (JNK) pathways. Dinoprostone 147-165 mitogen-activated protein kinase 8 Homo sapiens 350-373 21848814-5 2011 In this study we found that EspT induces expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2) an enzyme involved in production of prostaglandin E(2) (PGE2), interleukin (Il)-8 and Il-1beta in U937 human macrophages by activating the nuclear factor kappa-B (NF-kappaB), the extracellular signal-regulated kinases 1 and 2 (Erk1/2) and c-Jun N-terminal kinase (JNK) pathways. Dinoprostone 147-165 mitogen-activated protein kinase 8 Homo sapiens 375-378 21940623-5 2011 We show that PGE2-induced MMP-9 expression is mediated primarily through the EP2/EP4 cAMP protein kinase A (PKA)/PI3K ERK signaling pathway, leading to c-Fos expression, and through JNK-mediated activation of c-Jun in a PKA/PI3K/ERK-independent manner. Dinoprostone 13-17 mitogen-activated protein kinase 8 Homo sapiens 188-191 25909857-6 2015 In addition, the antagonizing effects of aspartic acid against the UVA effects were found to be mediated by reduced production of PGE2 through the inhibition of JNK and p42/44 MAPK. Dinoprostone 130-134 mitogen-activated protein kinase 8 Homo sapiens 161-164 26435723-4 2015 By treatment with PGE2, the chondrocytes apoptosis was significantly increased, the proapoptotic CHOP and JNK were upregulated, the prosurvival GRP78 and XBP1 were downregulated, and GSK-3beta was also upregulated. Dinoprostone 18-22 mitogen-activated protein kinase 8 Homo sapiens 106-109 23788611-7 2013 IL-1beta-stimulated PGE2 production was dependent on the JNK pathway, and chitosan strongly inhibited this response. Dinoprostone 20-24 mitogen-activated protein kinase 8 Homo sapiens 57-60 23788611-10 2013 The present study shows that chitosan exerts a predominantly anti-inflammatory activity by modulating PGE2 levels through the JNK pathway, which may be useful in the prevention or treatment of periodontal inflammation. Dinoprostone 102-106 mitogen-activated protein kinase 8 Homo sapiens 126-129 21859479-0 2011 JNK suppression is essential for 17beta-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. Dinoprostone 59-75 mitogen-activated protein kinase 8 Homo sapiens 0-3 21859479-9 2011 We further observed that 17beta-estradiol treatment inhibited PGE2-induced uPA, MMP-9 and cellular motility by suppressing activation of JNK1/2 in human LoVo cancer cells. Dinoprostone 62-66 mitogen-activated protein kinase 8 Homo sapiens 137-143 19998410-0 2010 PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes. Dinoprostone 0-4 mitogen-activated protein kinase 8 Homo sapiens 49-52 20717968-0 2011 Interaction of profilin-1 and F-actin via a beta-arrestin-1/JNK signaling pathway involved in prostaglandin E(2)-induced human mesenchymal stem cells migration and proliferation. Dinoprostone 94-112 mitogen-activated protein kinase 8 Homo sapiens 60-63 20398340-13 2010 The involvement of the signal pathways JNK and NF-kappaB in the regulation of PGE2 induced by TNFalpha may suggest these two pathways as possible attractive targets in the chronic inflammatory disease periodontitis. Dinoprostone 78-82 mitogen-activated protein kinase 8 Homo sapiens 39-42 21393445-5 2011 The c-Jun N-terminal kinase 1 and p38alpha mitogen activated protein kinases are necessary for PGE(2) activation of aromatase promoters I.3/II; thus, we examined the roles of downstream targets, c-Jun, JunB, JunD, and activating transcription factor 2, in PGE(2)-mediated regulation of aromatase expression in BAF. Dinoprostone 95-101 mitogen-activated protein kinase 8 Homo sapiens 4-29 20717968-8 2011 Together, these experimental data demonstrate that PGE(2) partially stimulates hMSCs migration and proliferation by interaction of Pfn-1 and F-actin via EP2 receptor-dependent beta-arrestin-1/JNK signaling pathways. Dinoprostone 51-57 mitogen-activated protein kinase 8 Homo sapiens 192-195 20398340-10 2010 Inhibitors of JNK and NF-kappaB also decreased the TNFalpha-stimulated up-regulation of mPGES-1 and COX-2 as well as PGE2 production. Dinoprostone 117-121 mitogen-activated protein kinase 8 Homo sapiens 14-17 19998410-7 2010 PGE2 suppressed the phosphorylation of JNK and ERK MAP kinases, but only knockdown of JNK by specific siRNA mimicked the effect of PGE2. Dinoprostone 0-4 mitogen-activated protein kinase 8 Homo sapiens 39-42 19998410-7 2010 PGE2 suppressed the phosphorylation of JNK and ERK MAP kinases, but only knockdown of JNK by specific siRNA mimicked the effect of PGE2. Dinoprostone 131-135 mitogen-activated protein kinase 8 Homo sapiens 86-89 19998410-9 2010 These results demonstrate that PGE2 inhibits IL-1beta-induced MMP-1 and MMP-13 productions via EP4 by suppressing MKK4-JNK MAP kinase-c-JUN pathway. Dinoprostone 31-35 mitogen-activated protein kinase 8 Homo sapiens 119-122 17875734-7 2007 Inhibition or small interfering RNA-mediated knockdown of p38 or JNK1, but not ERK, inhibited PGE(2)- or Bt(2)cAMP + PDA-induced aromatase activity and expression via PI.3/PII. Dinoprostone 94-100 mitogen-activated protein kinase 8 Homo sapiens 65-69 17477350-5 2007 However, Raf-independent regulation of the c-jun N-terminal kinase (JNK) and p38 MAPK cascades is also involved in COX-2 and PGE2 upregulation, with the JNK and p38 pathways exhibiting opposing roles in COX-2 and PGE2 upregulation. Dinoprostone 125-129 mitogen-activated protein kinase 8 Homo sapiens 43-66 17477350-5 2007 However, Raf-independent regulation of the c-jun N-terminal kinase (JNK) and p38 MAPK cascades is also involved in COX-2 and PGE2 upregulation, with the JNK and p38 pathways exhibiting opposing roles in COX-2 and PGE2 upregulation. Dinoprostone 125-129 mitogen-activated protein kinase 8 Homo sapiens 68-71 17477350-5 2007 However, Raf-independent regulation of the c-jun N-terminal kinase (JNK) and p38 MAPK cascades is also involved in COX-2 and PGE2 upregulation, with the JNK and p38 pathways exhibiting opposing roles in COX-2 and PGE2 upregulation. Dinoprostone 125-129 mitogen-activated protein kinase 8 Homo sapiens 153-156 17477350-5 2007 However, Raf-independent regulation of the c-jun N-terminal kinase (JNK) and p38 MAPK cascades is also involved in COX-2 and PGE2 upregulation, with the JNK and p38 pathways exhibiting opposing roles in COX-2 and PGE2 upregulation. Dinoprostone 213-217 mitogen-activated protein kinase 8 Homo sapiens 43-66 17477350-5 2007 However, Raf-independent regulation of the c-jun N-terminal kinase (JNK) and p38 MAPK cascades is also involved in COX-2 and PGE2 upregulation, with the JNK and p38 pathways exhibiting opposing roles in COX-2 and PGE2 upregulation. Dinoprostone 213-217 mitogen-activated protein kinase 8 Homo sapiens 68-71 17477350-5 2007 However, Raf-independent regulation of the c-jun N-terminal kinase (JNK) and p38 MAPK cascades is also involved in COX-2 and PGE2 upregulation, with the JNK and p38 pathways exhibiting opposing roles in COX-2 and PGE2 upregulation. Dinoprostone 213-217 mitogen-activated protein kinase 8 Homo sapiens 153-156 17875734-8 2007 Conversely, overexpression of wild-type p38alpha or JNK1 enhanced PGE(2)-stimulated aromatase expression via PII. Dinoprostone 66-72 mitogen-activated protein kinase 8 Homo sapiens 52-56 17428796-12 2007 Whereas forskolin reduces TGFbeta1-stimulated expression of CCN2/CTGF by 35% and JNK activation in gingival fibroblasts, micromolar PGE(2)-stimulated JNK in gingival fibroblasts and opposes the inhibitory effects of cAMP on CCN2/CTGF expression. Dinoprostone 132-138 mitogen-activated protein kinase 8 Homo sapiens 81-84 17428796-12 2007 Whereas forskolin reduces TGFbeta1-stimulated expression of CCN2/CTGF by 35% and JNK activation in gingival fibroblasts, micromolar PGE(2)-stimulated JNK in gingival fibroblasts and opposes the inhibitory effects of cAMP on CCN2/CTGF expression. Dinoprostone 132-138 mitogen-activated protein kinase 8 Homo sapiens 150-153 15304095-7 2004 In addition, inhibition of ERK or JNK1 reduced the increase of IGF-II-induced prostaglandin E(2) synthesis or cell proliferation. Dinoprostone 78-96 mitogen-activated protein kinase 8 Homo sapiens 34-38 16740977-0 2006 Leptin stimulates proliferation and inhibits apoptosis in Barrett"s esophageal adenocarcinoma cells by cyclooxygenase-2-dependent, prostaglandin-E2-mediated transactivation of the epidermal growth factor receptor and c-Jun NH2-terminal kinase activation. Dinoprostone 131-147 mitogen-activated protein kinase 8 Homo sapiens 217-242 16740977-11 2006 PGE2 stimulated phosphorylation of JNK in an EGF receptor-dependent manner, and activation of the epidermal growth factor receptor required protein kinase C, src, and matrix metalloproteinase activities. Dinoprostone 0-4 mitogen-activated protein kinase 8 Homo sapiens 35-38 15514010-4 2005 The results show that nonselective and COX-1-selective NSAIDs also block activation of the stress kinase c-Jun N-terminal kinase (JNK) and that prostaglandin-E2 (PGE2) reverses this block and enhances TCR-dependent JNK activation. Dinoprostone 144-160 mitogen-activated protein kinase 8 Homo sapiens 215-218 15514010-4 2005 The results show that nonselective and COX-1-selective NSAIDs also block activation of the stress kinase c-Jun N-terminal kinase (JNK) and that prostaglandin-E2 (PGE2) reverses this block and enhances TCR-dependent JNK activation. Dinoprostone 162-166 mitogen-activated protein kinase 8 Homo sapiens 215-218 34267186-4 2021 Mechanistically, PGE2 activates c-Jun N-terminal kinase (JNK), which in turn enables Gli2 to evade ubiquitin-proteasomal degradation by phosphorylating Gli2 at Thr1546. Dinoprostone 17-21 mitogen-activated protein kinase 8 Homo sapiens 32-55 9582321-2 1998 Previously we reported that interleukin-1beta induces activation of JNK/SAPK and p38 MAPK with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 (PGE2) synthesis. Dinoprostone 180-184 mitogen-activated protein kinase 8 Homo sapiens 68-71 9582321-6 1998 These findings suggest that MEKK1 --> SEK1/MKK4 may function as an upstream kinase capable of activating both p38 MAPK and JNK/SAPK with subsequent induction of Cox-2 expression and PGE2 production. Dinoprostone 185-189 mitogen-activated protein kinase 8 Homo sapiens 126-129 9291137-7 1997 The effects of PGE2 and forskolin on Cox-2 and phosphorylation of JNK1 were reversed with the protein kinase A inhibitor H89. Dinoprostone 15-19 mitogen-activated protein kinase 8 Homo sapiens 66-70 34267186-4 2021 Mechanistically, PGE2 activates c-Jun N-terminal kinase (JNK), which in turn enables Gli2 to evade ubiquitin-proteasomal degradation by phosphorylating Gli2 at Thr1546. Dinoprostone 17-21 mitogen-activated protein kinase 8 Homo sapiens 57-60 34267186-5 2021 This study not only presents evidence for understanding the contribution of Hh to colorectal cancers, but also provides a novel molecular portrait underlying how PGE2-activated JNK fine-tunes the evasion of Gli2 from ubiquitin-proteasomal degradation. Dinoprostone 162-166 mitogen-activated protein kinase 8 Homo sapiens 177-180 34267186-6 2021 Therefore, it proposes a rationale for the future evaluation of chemopreventive and selective therapeutic strategies for colorectal cancers by targeting PGE2-JNK-Gli signaling route. Dinoprostone 153-157 mitogen-activated protein kinase 8 Homo sapiens 158-161 34234507-0 2021 Upregulation of COX-2 and PGE2 Induced by TNF-alpha Mediated Through TNFR1/MitoROS/PKCalpha/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts. Dinoprostone 26-30 mitogen-activated protein kinase 8 Homo sapiens 102-108 34234507-13 2021 Conclusion: Our results suggested that TNF-alpha-induced COX-2/PGE2 upregulation is mediated through TNFR1-dependent MitoROS/PKCalpha/p38 MAPK and JNK1/2 cascade to activate FoxO1 binding with the COX-2 promoter in HCFs. Dinoprostone 63-67 mitogen-activated protein kinase 8 Homo sapiens 147-153 31533969-6 2019 The activation of production of PGE2 (due to activation of COX-2 pathway) seems to be dependent on p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner. Dinoprostone 32-36 mitogen-activated protein kinase 8 Homo sapiens 113-116 32553627-0 2020 Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes. Dinoprostone 14-18 mitogen-activated protein kinase 8 Homo sapiens 38-41 32553627-10 2020 These results demonstrated that cell detachment facilitates cytoprotective COX2-mediated PGE2 synthesis via p38/JNK-c-Fos signaling, revealing a possible mechanism that allows resistance against anoikis in floating-cultured 3D MSCs constructs. Dinoprostone 89-93 mitogen-activated protein kinase 8 Homo sapiens 112-115 29891646-5 2018 In vascular smooth muscle cells or aortic segments, PGE2 increased NADPH oxidase expression and activity and reduced mitochondrial membrane potential, effects that were abolished by antagonists of the PGE2 receptors (EP), EP1 and EP3, and by JNK (c-Jun N-terminal kinase) and ERK1/2 (extracellular-signal-regulated kinases 1/2) inhibition. Dinoprostone 52-56 mitogen-activated protein kinase 8 Homo sapiens 242-245 29891646-5 2018 In vascular smooth muscle cells or aortic segments, PGE2 increased NADPH oxidase expression and activity and reduced mitochondrial membrane potential, effects that were abolished by antagonists of the PGE2 receptors (EP), EP1 and EP3, and by JNK (c-Jun N-terminal kinase) and ERK1/2 (extracellular-signal-regulated kinases 1/2) inhibition. Dinoprostone 52-56 mitogen-activated protein kinase 8 Homo sapiens 247-270 27377703-5 2017 PGE2 induced the activation of Src, epidermal growth factor receptor (EGFR), c-Jun NH2 -terminal kinase (JNK), extracellular signal-regulated kinase (Erk), and p38 mitogen activated protein kinase (p38 MAPK). Dinoprostone 0-4 mitogen-activated protein kinase 8 Homo sapiens 105-108 27377703-6 2017 Specific inhibitor and mutagenesis studies showed that Src, EGFR, JNK1/2, and Erk1/2 are involved in PGE2 -induced uPAR expression. Dinoprostone 101-105 mitogen-activated protein kinase 8 Homo sapiens 66-72 27377703-11 2017 To the best of our knowledge, this is the first report that PGE2 -induced uPAR expression, which stimulates invasiveness of human gastric cancer AGS cells, is mediated by the EP2 receptor-dependent Src/EGFR/JNK1/2, Erk1/2/AP-1, and Src/EGFR/JNK1/2, Erk1/2/NF-kappaB cascades. Dinoprostone 60-64 mitogen-activated protein kinase 8 Homo sapiens 207-213 27377703-11 2017 To the best of our knowledge, this is the first report that PGE2 -induced uPAR expression, which stimulates invasiveness of human gastric cancer AGS cells, is mediated by the EP2 receptor-dependent Src/EGFR/JNK1/2, Erk1/2/AP-1, and Src/EGFR/JNK1/2, Erk1/2/NF-kappaB cascades. Dinoprostone 60-64 mitogen-activated protein kinase 8 Homo sapiens 241-247 28054591-11 2017 These observations suggest that JNK1 phosphorylation is necessary for the activation of the MEK/ERK1/2 pathway and the subsequent COX-2 expression for PGE2 release, and p38 independently contributes to the IL-1beta effect in synovial fibroblasts. Dinoprostone 151-155 mitogen-activated protein kinase 8 Homo sapiens 32-36