PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29272001-13 2017 After the intervention of PGE2 and Butaprost, great increases were seen in the cell proliferation rate, invasion capability, and the expression of MMP-9, VEGF, IL-6, and TNF-alpha in EC109 and TE-1 cell strains (p < 0.05), however, the intervention of RNAi could reduce above indexes (p < 0.05). Dinoprostone 26-30 vascular endothelial growth factor A Homo sapiens 154-158 29956615-6 2018 Furthermore, PGE2 shows a healing-promoting effect on gastric ulcers and small intestinal lesions through the up-regulated expression of vascular endothelial growth factor (VEGF) and stimulation of angiogenesis via the activation of EP4 receptors. Dinoprostone 13-17 vascular endothelial growth factor A Homo sapiens 137-171 29956615-6 2018 Furthermore, PGE2 shows a healing-promoting effect on gastric ulcers and small intestinal lesions through the up-regulated expression of vascular endothelial growth factor (VEGF) and stimulation of angiogenesis via the activation of EP4 receptors. Dinoprostone 13-17 vascular endothelial growth factor A Homo sapiens 173-177 33891558-7 2021 Ex vivo activation of human macrophages by ICH-associated stimuli highlighted an important role for HIFs in production of both inflammatory and anti-inflammatory factors, including PGE2, which, in turn, augmented VEGF production. Dinoprostone 181-185 vascular endothelial growth factor A Homo sapiens 213-217 31362785-10 2019 CONCLUSIONS: These results suggest that local ice cryotherapy reduces IL-6, IL-1beta, and VEGF synovial protein levels, mainly in microcrystal-induced arthritis, and potentially through NF-kB and PG-E2-dependent mechanisms. Dinoprostone 196-201 vascular endothelial growth factor A Homo sapiens 90-94 29154474-3 2018 In the present work we studied the effects of PGE2 in immortalized, non-malignant prostate epithelial RWPE-1 cells and found that PGE2 increased cell proliferation, cell migration, and production of vascular endothelial growth factor-A, and activated in vitro angiogenesis. Dinoprostone 130-134 vascular endothelial growth factor A Homo sapiens 199-235 27091669-3 2016 It was recently reported that prostaglandin (PG) E2 induces VEGF release by nasal polyp fibroblasts. Dinoprostone 30-51 vascular endothelial growth factor A Homo sapiens 60-64 29061808-5 2017 PDT also inhibited tubular capillary formation in and invasion by HEC-1-A under VEGF pretreatment, that resulted from down-regulation of VEGFR2, EGFR, Ras homolog gene family/ member A (RhoA) and PGE2. Dinoprostone 196-200 vascular endothelial growth factor A Homo sapiens 80-84 28651842-6 2017 Both HG and exogenous VEGF (80ng/ml) increased PGE2 release, an effect partially reverted by SDX for HG and by AFL for VEGF. Dinoprostone 47-51 vascular endothelial growth factor A Homo sapiens 22-26 28539261-4 2017 Succinate-mediated GPR91 activation upregulates vascular endothelial growth factor (VEGF) through ERK1/2-C/EBP beta (c-Fos) and/or ERK1/2-COX-2/PGE2 signaling pathways, which in turn, leads to the breakdown of blood-retina barriers in these disorders. Dinoprostone 144-148 vascular endothelial growth factor A Homo sapiens 48-82 28539261-4 2017 Succinate-mediated GPR91 activation upregulates vascular endothelial growth factor (VEGF) through ERK1/2-C/EBP beta (c-Fos) and/or ERK1/2-COX-2/PGE2 signaling pathways, which in turn, leads to the breakdown of blood-retina barriers in these disorders. Dinoprostone 144-148 vascular endothelial growth factor A Homo sapiens 84-88 27322147-1 2016 Prostaglandin E-2 (PGE-2) promotes tumor angiogenesis via paracrine secretion of pro-angiogenic growth factors, such as vascular endothelial growth factor (VEGF). Dinoprostone 19-24 vascular endothelial growth factor A Homo sapiens 120-154 27322147-1 2016 Prostaglandin E-2 (PGE-2) promotes tumor angiogenesis via paracrine secretion of pro-angiogenic growth factors, such as vascular endothelial growth factor (VEGF). Dinoprostone 19-24 vascular endothelial growth factor A Homo sapiens 156-160 27322147-2 2016 Since miRNAs regulate several cell processes, including angiogenesis, we sought to determine whether they would influence PGE-2-induced VEGF. Dinoprostone 122-127 vascular endothelial growth factor A Homo sapiens 136-140 27322147-9 2016 Thus, clear evidence for regulating miRNA processing and VEGF output by intrinsic PGE-2 production provides a means to distinguish between aggressive and indolent prostate tumors and suggests a potential target for controlling tumor progression. Dinoprostone 82-87 vascular endothelial growth factor A Homo sapiens 57-61 26926362-0 2016 Prostaglandin E2 possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 59-93 26926362-1 2016 We studied the role of PGE2, its biosynthetic enzymes and its receptors, in regulating the functions of lung fibroblasts through the production of Vascular Endothelial Growth Factor (VEGF) and Interleukin-8 (IL-8) in COPD subjects. Dinoprostone 23-27 vascular endothelial growth factor A Homo sapiens 147-181 26926362-1 2016 We studied the role of PGE2, its biosynthetic enzymes and its receptors, in regulating the functions of lung fibroblasts through the production of Vascular Endothelial Growth Factor (VEGF) and Interleukin-8 (IL-8) in COPD subjects. Dinoprostone 23-27 vascular endothelial growth factor A Homo sapiens 183-187 26926362-6 2016 Low concentrations of synthetic PGE2 increased the release of VEGF in HFL-1, but higher concentrations were needed to induce the release of IL-8. Dinoprostone 32-36 vascular endothelial growth factor A Homo sapiens 62-66 26926362-8 2016 In the airways of COPD subjects, fibroblast-derived PGE2 may regulate angiogenesis and inflammation through the production of VEGF and IL-8 respectively, suggesting that the increase in expression of COX-2, EP2 and EP4 observed in COPD fibroblasts may contribute to steering the role of PGE2 from homeostatic to pro-inflammatory. Dinoprostone 52-56 vascular endothelial growth factor A Homo sapiens 126-130 25446255-10 2015 The study incorporates direct observation on COX-2 promoter and suggests that VIP effect on VEGF may be indirectly mediated by PGE2 after being synthesised by COX-2, thus amplifying the initial signal. Dinoprostone 127-131 vascular endothelial growth factor A Homo sapiens 92-96 26204403-4 2015 It was decided to evaluate the effect of PGE2 on the secretion of VEGF, an inducer of angiogenesis. Dinoprostone 41-45 vascular endothelial growth factor A Homo sapiens 66-70 26250887-7 2016 The role of PGT in mRNA and protein expression of vascular endothelial growth factor (VEGF) was examined in gastric cancer cells stimulated by PGE2 . Dinoprostone 143-147 vascular endothelial growth factor A Homo sapiens 50-84 26250887-7 2016 The role of PGT in mRNA and protein expression of vascular endothelial growth factor (VEGF) was examined in gastric cancer cells stimulated by PGE2 . Dinoprostone 143-147 vascular endothelial growth factor A Homo sapiens 86-90 26295860-3 2015 The pathogenesis of PDP is currently unknown, although an increased secretion of prostaglandin E2 (PGE2), which stimulates the overexpression of vascular endothelial growth factor (VEGF), has been suggested as a major factor. Dinoprostone 81-97 vascular endothelial growth factor A Homo sapiens 145-179 26295860-3 2015 The pathogenesis of PDP is currently unknown, although an increased secretion of prostaglandin E2 (PGE2), which stimulates the overexpression of vascular endothelial growth factor (VEGF), has been suggested as a major factor. Dinoprostone 81-97 vascular endothelial growth factor A Homo sapiens 181-185 26295860-3 2015 The pathogenesis of PDP is currently unknown, although an increased secretion of prostaglandin E2 (PGE2), which stimulates the overexpression of vascular endothelial growth factor (VEGF), has been suggested as a major factor. Dinoprostone 99-103 vascular endothelial growth factor A Homo sapiens 145-179 26295860-3 2015 The pathogenesis of PDP is currently unknown, although an increased secretion of prostaglandin E2 (PGE2), which stimulates the overexpression of vascular endothelial growth factor (VEGF), has been suggested as a major factor. Dinoprostone 99-103 vascular endothelial growth factor A Homo sapiens 181-185 25849942-7 2015 Mechanistic studies indicated that Cox-2 inhibition reduced PGE2-induced migration and proliferation of CAFs via inhibiting phosphorylation of Akt.Hence, Cox-2 inhibition can increase efficacy of anti-angiogenic treatments and our findings might pave the road for clinical investigations of concomitant blockade of Cox-2 and VEGF-signaling. Dinoprostone 60-64 vascular endothelial growth factor A Homo sapiens 325-329 25734181-8 2015 PGE2 maintains high expression of COX-2 and induces angiogenic factors including VEGF and bFGF, causing carcinogenesis. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 81-85 24964992-2 2014 We identified prostaglandin E2 (PGE2) as a soluble tumor-derived angiogenic factor associated with VEGF-independent angiogenesis. Dinoprostone 14-30 vascular endothelial growth factor A Homo sapiens 99-103 25063918-3 2014 Prostaglandin E2 also promotes the healing of intestinal damage by stimulating angiogenesis through the up-regulation of VEGF expression via the activation of EP4 receptors. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 121-125 25110109-0 2014 Helicobacter pylori promotes VEGF expression via the p38 MAPK-mediated COX-2-PGE2 pathway in MKN45 cells. Dinoprostone 77-81 vascular endothelial growth factor A Homo sapiens 29-33 25110109-5 2014 It was also found that prostaglandin E2 (PGE2) and its receptor EP2/EP4 may mediate the upregulation of VEGF in gastric cells exposed to H. pylori. Dinoprostone 23-39 vascular endothelial growth factor A Homo sapiens 104-108 25110109-5 2014 It was also found that prostaglandin E2 (PGE2) and its receptor EP2/EP4 may mediate the upregulation of VEGF in gastric cells exposed to H. pylori. Dinoprostone 41-45 vascular endothelial growth factor A Homo sapiens 104-108 25110109-6 2014 In combination, these results suggest that VEGF expression is regulated by the p38 MAPK COX-2-PGE2-EP2/EP4 pathway in gastric cancer cells induced by H. pylori. Dinoprostone 94-98 vascular endothelial growth factor A Homo sapiens 43-47 25128827-2 2014 Several studies have shown that PGE2 directly induces the growth of colon cancer cells and furthermore promotes tumor angiogenesis by increasing the production of the vascular endothelial growth factor (VEGF). Dinoprostone 32-36 vascular endothelial growth factor A Homo sapiens 167-201 25128827-2 2014 Several studies have shown that PGE2 directly induces the growth of colon cancer cells and furthermore promotes tumor angiogenesis by increasing the production of the vascular endothelial growth factor (VEGF). Dinoprostone 32-36 vascular endothelial growth factor A Homo sapiens 203-207 25128827-9 2014 Finally, stimulation of LS174T cells with PGE2 increased VEGF production which was also prevented by mTORC1 inhibition. Dinoprostone 42-46 vascular endothelial growth factor A Homo sapiens 57-61 27308371-0 2014 Improving VEGF-targeted therapies through inhibition of COX-2/PGE2 signaling. Dinoprostone 62-66 vascular endothelial growth factor A Homo sapiens 10-14 27308371-2 2014 Recent studies suggest that enhanced signaling through a COX-2/PGE2 axis contributes to VEGF-independent tumor angiogenesis. Dinoprostone 63-67 vascular endothelial growth factor A Homo sapiens 88-92 27308371-3 2014 Thus, COX-2/PGE2 inhibition may potentiate VEGF therapies. Dinoprostone 12-16 vascular endothelial growth factor A Homo sapiens 43-47 24953041-2 2014 In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1alpha and VEGF-A through epidermal growth factor receptor (EGFR)-dependent up-regulation of retinoic acid receptor-beta (RARbeta). Dinoprostone 43-59 vascular endothelial growth factor A Homo sapiens 95-101 24953041-2 2014 In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1alpha and VEGF-A through epidermal growth factor receptor (EGFR)-dependent up-regulation of retinoic acid receptor-beta (RARbeta). Dinoprostone 61-65 vascular endothelial growth factor A Homo sapiens 95-101 24953041-8 2014 They also may contribute to new therapeutic approaches based upon the pharmacological control of HIF-1alpha/VEGF-A in the proximal tubule through the modulation of the PGE2/EGFR/MAPK/MSK1/RARbeta pathway. Dinoprostone 168-172 vascular endothelial growth factor A Homo sapiens 108-114 24964992-3 2014 PGE2 production in preclinical breast and colon cancer models was tightly controlled by cyclooxygenase-2 (COX-2) expression, and COX-2 inhibition augmented VEGF pathway blockade to suppress angiogenesis and tumor growth, prevent metastasis, and increase overall survival. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 156-160 24964992-4 2014 These results demonstrate the importance of the COX-2/PGE2 pathway in mediating resistance to VEGF pathway blockade and could aid in the rapid development of more efficacious anticancer therapies. Dinoprostone 54-58 vascular endothelial growth factor A Homo sapiens 94-98 24964992-2 2014 We identified prostaglandin E2 (PGE2) as a soluble tumor-derived angiogenic factor associated with VEGF-independent angiogenesis. Dinoprostone 32-36 vascular endothelial growth factor A Homo sapiens 99-103 23644172-3 2013 In human proximal tubular HK-2 cells, treatment with all-trans retinoic acid or prostaglandin E2 (PGE2) triggers the production of VEGF-A. Dinoprostone 80-96 vascular endothelial growth factor A Homo sapiens 131-137 23701237-8 2013 VEGF and immune modulators, including the transforming growth factor (TGF)-beta1 and prostaglandin E2, secreted from MSCs in fibrin glue significantly increased under inflammatory conditions. Dinoprostone 85-101 vascular endothelial growth factor A Homo sapiens 0-4 23656623-0 2013 Phosphodiesterase-4 inhibition augments human lung fibroblast vascular endothelial growth factor production induced by prostaglandin E2. Dinoprostone 119-135 vascular endothelial growth factor A Homo sapiens 62-96 23656623-3 2013 Prostaglandin E2 (PGE2) stimulates VEGF production from lung fibroblasts via the E-prostanoid (EP)-2 receptor. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 35-39 23656623-3 2013 Prostaglandin E2 (PGE2) stimulates VEGF production from lung fibroblasts via the E-prostanoid (EP)-2 receptor. Dinoprostone 18-22 vascular endothelial growth factor A Homo sapiens 35-39 23644172-3 2013 In human proximal tubular HK-2 cells, treatment with all-trans retinoic acid or prostaglandin E2 (PGE2) triggers the production of VEGF-A. Dinoprostone 98-102 vascular endothelial growth factor A Homo sapiens 131-137 23644172-7 2013 We found that EGFR inhibitor AG1478 prevented the increase in VEGF-A production induced by PGE2- and all-trans retinoic acid. Dinoprostone 91-95 vascular endothelial growth factor A Homo sapiens 62-68 23644172-11 2013 Thus, EGFR transactivation by intracellular PGE2-activated EP receptors results in the sequential activation of RARbeta and HIF-1alpha leading to increased production of VEGF-A and it may be a target for the therapeutic modulation of HIF-1alpha/VEGF-A. Dinoprostone 44-48 vascular endothelial growth factor A Homo sapiens 170-176 23644172-11 2013 Thus, EGFR transactivation by intracellular PGE2-activated EP receptors results in the sequential activation of RARbeta and HIF-1alpha leading to increased production of VEGF-A and it may be a target for the therapeutic modulation of HIF-1alpha/VEGF-A. Dinoprostone 44-48 vascular endothelial growth factor A Homo sapiens 245-251 22378492-12 2012 In conclusion, PGE(2) stimulated hUCB-MSC proliferation through beta-catenin-mediated c-Myc and VEGF expression via Epac/Rap1/Akt and PKA cooperation. Dinoprostone 15-21 vascular endothelial growth factor A Homo sapiens 96-100 23814676-0 2013 Effect of prostaglandin e2 on vascular endothelial growth factor production in nasal polyp fibroblasts. Dinoprostone 10-26 vascular endothelial growth factor A Homo sapiens 30-64 23814676-7 2013 PGE2 significantly increased VEGF production concentration- and time dependently, and VEGF production was regulated by an EP4 receptor. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 29-33 23814676-10 2013 CONCLUSIONS: PGE2 stimulates VEGF production via the EP4 receptor in NPDFs. Dinoprostone 13-17 vascular endothelial growth factor A Homo sapiens 29-33 23656623-5 2013 This study investigates whether phosphodiesterase inhibition modulates the human lung fibroblast VEGF production induced by PGE2. Dinoprostone 124-128 vascular endothelial growth factor A Homo sapiens 97-101 23656623-7 2013 The PDE4 inhibitors roflumilast, roflumilast N-oxide, and rolipram with PGE2 increased VEGF release, as quantified in supernatant media by ELISA. Dinoprostone 72-76 vascular endothelial growth factor A Homo sapiens 87-91 23656623-12 2013 Roflumilast with PGE2 increased VEGF mRNA levels, and the blockade of mRNA synthesis inhibited the augmented VEGF release. Dinoprostone 17-21 vascular endothelial growth factor A Homo sapiens 32-36 23656623-14 2013 These findings demonstrate that PDE4 inhibition can modulate human lung fibroblast VEGF release by PGE2 acting through the EP2 and EP4 receptor-cAMP/PKA signaling pathway. Dinoprostone 99-103 vascular endothelial growth factor A Homo sapiens 83-87 23814676-11 2013 These results indicate that PGE2-induced VEGF production is mediated, at least partially, through cAMP-dependent signaling pathways. Dinoprostone 28-32 vascular endothelial growth factor A Homo sapiens 41-45 22298530-0 2012 Prostaglandin E2 stimulates the production of vascular endothelial growth factor through the E-prostanoid-2 receptor in cultured human lung fibroblasts. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 46-80 22871833-9 2012 CONCLUSIONS: PGE(2) levels are significantly higher in the vitreous of patients with complications from proliferative diabetic retinopathy, and correlate with IP-10 and VEGF. Dinoprostone 13-19 vascular endothelial growth factor A Homo sapiens 169-173 22298530-11 2012 These findings demonstrate that PGE(2) can modulate the release of VEGF by human lung fibroblasts through its actions in the EP2 receptor/PKA pathway. Dinoprostone 32-38 vascular endothelial growth factor A Homo sapiens 67-71 22003899-7 2012 Prostaglandin E(2) affects leukocyte populations and promotes angiogenesis through its effect on estrogen and up regulation of vascular endothelial growth factor (VEGF). Dinoprostone 0-18 vascular endothelial growth factor A Homo sapiens 127-161 22003899-7 2012 Prostaglandin E(2) affects leukocyte populations and promotes angiogenesis through its effect on estrogen and up regulation of vascular endothelial growth factor (VEGF). Dinoprostone 0-18 vascular endothelial growth factor A Homo sapiens 163-167 21980393-4 2011 Lipid mediators in particular arachidonic acid-derived prostaglandin (PG)E2 are regulators of VEGF expression and angiogenesis in colon cancer. Dinoprostone 55-75 vascular endothelial growth factor A Homo sapiens 94-98 21577211-11 2011 Prostaglandin E(2) (PGE(2)) upregulated the expressions of VEGF-A and VEGF-C in cultured macrophages, but not human lymphatic microvascular endothelial cells. Dinoprostone 0-18 vascular endothelial growth factor A Homo sapiens 59-65 21577211-11 2011 Prostaglandin E(2) (PGE(2)) upregulated the expressions of VEGF-A and VEGF-C in cultured macrophages, but not human lymphatic microvascular endothelial cells. Dinoprostone 20-26 vascular endothelial growth factor A Homo sapiens 59-65 21219643-5 2011 COX-2-induced VEGF expression in tumor cells was monitored after treatment with inhibitors of protein kinase C (PKC), PKA, prostaglandin E2 (PGE2), and an activator of PKC. Dinoprostone 123-139 vascular endothelial growth factor A Homo sapiens 14-18 21219643-5 2011 COX-2-induced VEGF expression in tumor cells was monitored after treatment with inhibitors of protein kinase C (PKC), PKA, prostaglandin E2 (PGE2), and an activator of PKC. Dinoprostone 141-145 vascular endothelial growth factor A Homo sapiens 14-18 21219643-8 2011 Inhibitors of PKC and PGE2 attenuated COX-2-induced VEGF expression in NLCSCs, whereas a PKC activator exerted a potentiating effect. Dinoprostone 22-26 vascular endothelial growth factor A Homo sapiens 52-56 21980393-14 2011 Moreover, addition of PGE2 or selective EP2 receptor agonist to activated Caco-2 cells inhibited VEGF production. Dinoprostone 22-26 vascular endothelial growth factor A Homo sapiens 97-101 21980393-15 2011 The autocrine inhibitory role for PGE2 appears to be selective to hypertonic environment since VEGF production induced by exposure to CoCl2 was decreased by inhibition of concomitant PGE2 generation. Dinoprostone 34-38 vascular endothelial growth factor A Homo sapiens 95-99 21980393-15 2011 The autocrine inhibitory role for PGE2 appears to be selective to hypertonic environment since VEGF production induced by exposure to CoCl2 was decreased by inhibition of concomitant PGE2 generation. Dinoprostone 183-187 vascular endothelial growth factor A Homo sapiens 95-99 21980393-17 2011 Also PGE2 plays an inhibitory role on VEGF production by Caco-2 cells exposed to hyperosmotic stress through EP2 activation. Dinoprostone 5-9 vascular endothelial growth factor A Homo sapiens 38-42 19210337-0 2009 Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells. Dinoprostone 25-41 vascular endothelial growth factor A Homo sapiens 57-91 21041985-7 2010 PGE2 also showed a healing-promoting effect on gastric ulcers and intestinal lesions through the activation of EP4 receptors, the effect associated with stimulation of angiogenesis via an increase in VEGF expression. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 200-204 20099472-3 2009 The COX-2-PGE2 pathway has been shown to influence angiogenic factors such as vascular endothelial growth factor (VEGF). Dinoprostone 10-14 vascular endothelial growth factor A Homo sapiens 78-112 20099472-3 2009 The COX-2-PGE2 pathway has been shown to influence angiogenic factors such as vascular endothelial growth factor (VEGF). Dinoprostone 10-14 vascular endothelial growth factor A Homo sapiens 114-118 20692534-8 2010 Finally, LPS/PGE2 generated an arginase-1(+) M2 macrophage that in addition to generating VEGF produced significant quantities of IL-10. Dinoprostone 13-17 vascular endothelial growth factor A Homo sapiens 90-94 20219142-2 2010 PGE1 and PGE2 can increase the production of vascular endothelial growth factor (VEGF), particularly through EP2 and EP4. Dinoprostone 9-13 vascular endothelial growth factor A Homo sapiens 45-79 20219142-2 2010 PGE1 and PGE2 can increase the production of vascular endothelial growth factor (VEGF), particularly through EP2 and EP4. Dinoprostone 9-13 vascular endothelial growth factor A Homo sapiens 81-85 18596194-7 2008 Activation of HIMECs by VEGF resulted in enhanced expression of cyclo-oxygenase-2 (COX-2) mRNA, protein and prostaglandin E(2) (PGE(2)) production. Dinoprostone 108-126 vascular endothelial growth factor A Homo sapiens 24-28 19210337-12 2009 Exogenous prostaglandin E(2), butaprost (an EP2 receptor agonist) and dibutyryl cAMP abolished the inhibitory effect of indomethacin on interleukin-1alpha-induced vascular endothelial growth factor production. Dinoprostone 10-28 vascular endothelial growth factor A Homo sapiens 163-197 19210337-13 2009 CONCLUSION: We suggest that interleukin-1alpha induced vascular endothelial growth factor production via cyclooxygenase-2-derived prostaglandin E(2) in human periodontal ligament cells. Dinoprostone 130-148 vascular endothelial growth factor A Homo sapiens 55-89 19210337-14 2009 The interleukin-1alpha/prostaglandin E(2) pathway might regulate vascular endothelial growth factor production in periodontal lesions. Dinoprostone 23-41 vascular endothelial growth factor A Homo sapiens 65-99 19275959-9 2009 Prostaglandin E(2) (PGE(2)) enhanced the expression of VEGFA, VEGFB, and VEGFC, whereas an adenosine analog (5"-[N-ethylcarboxamido] adenosine [NECA]) increased VEGFA, VEGFC, and VEGFD expression. Dinoprostone 0-18 vascular endothelial growth factor A Homo sapiens 55-60 19275959-9 2009 Prostaglandin E(2) (PGE(2)) enhanced the expression of VEGFA, VEGFB, and VEGFC, whereas an adenosine analog (5"-[N-ethylcarboxamido] adenosine [NECA]) increased VEGFA, VEGFC, and VEGFD expression. Dinoprostone 0-18 vascular endothelial growth factor A Homo sapiens 161-166 17097688-12 2007 Moreover, Cox-2/PGE2/EP/VEGF pathway possibly also contributes to tumor angiogenesis in HCC. Dinoprostone 16-20 vascular endothelial growth factor A Homo sapiens 24-28 18562087-0 2008 Assessment of VEGF-receptor system expression in the porcine endometrial stromal cells in response to insulin-like growth factor-I, relaxin, oxytocin and prostaglandin E2. Dinoprostone 154-170 vascular endothelial growth factor A Homo sapiens 14-18 17685428-3 2008 We found that the stable metabolite of PGI2, 6-keto-PGF(1alpha) and PGE2, induced a concentration-dependent increase in VEGF release by HOBs but not ECs. Dinoprostone 68-72 vascular endothelial growth factor A Homo sapiens 120-124 18261308-11 2007 CONCLUSION: 4(#) siRNA effectively inhibits the expression of COX-2 mRNA and protein the level of PGE2, IL-1beta, IL-6, TNF-alpha, and VEGF in the clear supernatant of the 4(#) group is lowest. Dinoprostone 98-102 vascular endothelial growth factor A Homo sapiens 135-139 17427962-0 2007 Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathway. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 25-59 17427962-1 2007 Prostaglandin E2 (PGE2) has been shown to induce expression of vascular endothelial growth factor (VEGF) and other signaling molecules in several cancers. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 63-97 17427962-1 2007 Prostaglandin E2 (PGE2) has been shown to induce expression of vascular endothelial growth factor (VEGF) and other signaling molecules in several cancers. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 99-103 17427962-1 2007 Prostaglandin E2 (PGE2) has been shown to induce expression of vascular endothelial growth factor (VEGF) and other signaling molecules in several cancers. Dinoprostone 18-22 vascular endothelial growth factor A Homo sapiens 63-97 17427962-1 2007 Prostaglandin E2 (PGE2) has been shown to induce expression of vascular endothelial growth factor (VEGF) and other signaling molecules in several cancers. Dinoprostone 18-22 vascular endothelial growth factor A Homo sapiens 99-103 17427962-7 2007 Treatment of prostate cancer cells with PGE2 (1 nM-10 microM) increased both VEGF secretion and cyclic adenosine monophosphate (cAMP) production. Dinoprostone 40-44 vascular endothelial growth factor A Homo sapiens 77-81 17427962-12 2007 We further demonstrated that the adenylate cyclase activator forskolin and the cAMP anologue 8-bromo-cAMP mimicked the effects of PGE2 on VEGF secretion in PC-3 cells. Dinoprostone 130-134 vascular endothelial growth factor A Homo sapiens 138-142 17427962-14 2007 We conclude that PGE2-induced VEGF secretion in prostate cancer cells is mediated through EP2-, and possibly EP4-, dependent cAMP signaling pathways. Dinoprostone 17-21 vascular endothelial growth factor A Homo sapiens 30-34 17616668-11 2007 Finally, treatment of glioma cell lines with prostaglandin E2, the predominant product of COX-2 activity, results in increased vascular endothelial growth factor expression, thus potentially linking elevations in COX-2 expression with tumor angiogenesis in malignant gliomas. Dinoprostone 45-61 vascular endothelial growth factor A Homo sapiens 127-161 17302909-10 2007 Furthermore, exogenous addition of prostaglandin E2 (PGE2) restored IL-4 inhibition on TGF-beta induced VEGF production. Dinoprostone 35-51 vascular endothelial growth factor A Homo sapiens 104-108 17302909-10 2007 Furthermore, exogenous addition of prostaglandin E2 (PGE2) restored IL-4 inhibition on TGF-beta induced VEGF production. Dinoprostone 53-57 vascular endothelial growth factor A Homo sapiens 104-108 16100286-5 2006 Prostaglandin E2 inhibited the increase in connective tissue growth factor mRNA but augmented the release of vascular endothelial growth factor. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 109-143 16868648-1 2007 Fibroblast-like synoviocytes (FLS) participate in rheumatoid arthritis (RA) chronic synovitis by producing pro-inflammatory cytokines (IL-6, IL-8), growth factors (VEGF) and other inflammatory mediators (PGE2, NO). Dinoprostone 204-208 vascular endothelial growth factor A Homo sapiens 164-168 17035941-3 2006 It induces prostaglandin (PG) E2, which is involved in VEGF release by some normal and tumor cells. Dinoprostone 11-32 vascular endothelial growth factor A Homo sapiens 55-59 17035941-8 2006 Indomethacin exerted a nonsignificant effect on IL-1beta-induced VEGF, and exogenously added PGE2 exhibited a nonsignificant stimulatory effect on VEGF formation. Dinoprostone 93-97 vascular endothelial growth factor A Homo sapiens 147-151 16651031-3 2006 Whereas VEGF-induced tube formation was significantly suppressed by ETYA, an inhibitor of arachidonic acid metabolism, or SU5614, an inhibitor of VEGF-receptor tyrosine kinase, the stimulatory effect of PGE2 was observed in the presence of ETYA or SU5614. Dinoprostone 203-207 vascular endothelial growth factor A Homo sapiens 8-12 16651031-4 2006 Thus, PGE2 counteracted both ETYA- and SU5614-induced blockage of angiogenesis in the presence of VEGF. Dinoprostone 6-10 vascular endothelial growth factor A Homo sapiens 98-102 16651031-5 2006 VEGF induced cyclooxygenase (COX) -2 mRNA expression in HUVECs and increased the PGE2 concentration in the medium. Dinoprostone 81-85 vascular endothelial growth factor A Homo sapiens 0-4 16651031-6 2006 PGE2 treatment enhanced the expression of VEGF mRNA. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 42-46 16651031-7 2006 These findings suggest that PGE2 directly stimulates angiogenesis, apart from VEGF signaling, and further induces VEGF expression in HUVECs. Dinoprostone 28-32 vascular endothelial growth factor A Homo sapiens 114-118 16651031-8 2006 In addition, the effect of VEGF on angiogenesis may be mediated, in part, by PGE2 secretion. Dinoprostone 77-81 vascular endothelial growth factor A Homo sapiens 27-31 16424017-6 2006 Expression of vascular endothelial growth factor A (VEGFA) was rapidly increased by PGE(2) exposure. Dinoprostone 84-90 vascular endothelial growth factor A Homo sapiens 14-50 16424017-6 2006 Expression of vascular endothelial growth factor A (VEGFA) was rapidly increased by PGE(2) exposure. Dinoprostone 84-90 vascular endothelial growth factor A Homo sapiens 52-57 15970595-0 2005 Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites. Dinoprostone 48-64 vascular endothelial growth factor A Homo sapiens 0-34 16332507-1 2006 Vascular endothelial growth factor (VEGF), oncostatin M (OSM), and granulocyte chemotactic protein-2 (GCP-2/CXCL6) are up-regulated in U937 macrophages and peripheral blood macrophages exposed to LPS, beta-adrenergic receptor (beta2-AR) agonists (e.g. zilpaterol, and clenbuterol) and some other agents that induce intracellular cAMP (prostaglandin E2, forskolin, and butyryl cAMP). Dinoprostone 335-351 vascular endothelial growth factor A Homo sapiens 0-34 15970595-1 2005 Prostaglandin E2 (PGE2) can increase endothelial vascular endogrowth factor A (VEGF-A) production but the mechanisms involved are unclear. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 49-77 16038047-0 2005 Effect of c-fos antisense probe on prostaglandin E2-induced upregulation of vascular endothelial growth factor mRNA in human liver cancer cells. Dinoprostone 35-51 vascular endothelial growth factor A Homo sapiens 76-110 16038047-1 2005 AIM: To examine the effect of prostaglandin E2 (PGE2) on the expression of vascular endothelial growth factor (VEGF) mRNA in the human hepatocellular carcinoma (HCC) HepG2 cells and the possible involvement of c-fos protein in this process. Dinoprostone 30-46 vascular endothelial growth factor A Homo sapiens 75-109 16038047-1 2005 AIM: To examine the effect of prostaglandin E2 (PGE2) on the expression of vascular endothelial growth factor (VEGF) mRNA in the human hepatocellular carcinoma (HCC) HepG2 cells and the possible involvement of c-fos protein in this process. Dinoprostone 30-46 vascular endothelial growth factor A Homo sapiens 111-115 16038047-1 2005 AIM: To examine the effect of prostaglandin E2 (PGE2) on the expression of vascular endothelial growth factor (VEGF) mRNA in the human hepatocellular carcinoma (HCC) HepG2 cells and the possible involvement of c-fos protein in this process. Dinoprostone 48-52 vascular endothelial growth factor A Homo sapiens 75-109 16038047-1 2005 AIM: To examine the effect of prostaglandin E2 (PGE2) on the expression of vascular endothelial growth factor (VEGF) mRNA in the human hepatocellular carcinoma (HCC) HepG2 cells and the possible involvement of c-fos protein in this process. Dinoprostone 48-52 vascular endothelial growth factor A Homo sapiens 111-115 16038047-5 2005 RESULTS: Administration of PGE2 resulted in an increased expression of c-fos and VEGF mRNA in HepG2 cells. Dinoprostone 27-31 vascular endothelial growth factor A Homo sapiens 81-85 16038047-7 2005 Whereas, the highest expression level of VEGF mRNA was observed at 6 h (100.5+/-6.1%) after PGE2 treatment, which was significantly higher than that at 0 h (33.2+/-2.4%, P<0.01). Dinoprostone 92-96 vascular endothelial growth factor A Homo sapiens 41-45 16038047-8 2005 C-fos ASO significantly reduced PGE2-induced VEGF mRNA expression in HepG2 cells. Dinoprostone 32-36 vascular endothelial growth factor A Homo sapiens 45-49 16038047-9 2005 CONCLUSION: PGE2 increases the expression and secretion of VEGF in HCC cells by activating the transcription factor c-fos, promotes the angiogenesis of HCC and plays an important role in the pathogenesis of liver cancer. Dinoprostone 12-16 vascular endothelial growth factor A Homo sapiens 59-63 15899904-3 2005 The expression of cyclin D1 and vascular endothelial growth factor was induced by PGE2 in LS-174T cells. Dinoprostone 82-86 vascular endothelial growth factor A Homo sapiens 32-66 15970595-1 2005 Prostaglandin E2 (PGE2) can increase endothelial vascular endogrowth factor A (VEGF-A) production but the mechanisms involved are unclear. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 79-85 15970595-1 2005 Prostaglandin E2 (PGE2) can increase endothelial vascular endogrowth factor A (VEGF-A) production but the mechanisms involved are unclear. Dinoprostone 18-22 vascular endothelial growth factor A Homo sapiens 49-77 15970595-1 2005 Prostaglandin E2 (PGE2) can increase endothelial vascular endogrowth factor A (VEGF-A) production but the mechanisms involved are unclear. Dinoprostone 18-22 vascular endothelial growth factor A Homo sapiens 79-85 15970595-3 2005 PGE2 increased VEGF-A mRNA and protein but not mRNA stability. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 15-21 15970595-4 2005 PGE2 stimulated the activity of a transiently transfected 2068-bp (-2018 to +50) VEGF-A promoter-driven luciferase construct. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 81-87 15970595-5 2005 Functional 5" deletional analysis mapped the PGE2 response element to the 135-bp sequence (-85/+50) of the human VEGF-A promoter. Dinoprostone 45-49 vascular endothelial growth factor A Homo sapiens 113-119 15970595-6 2005 PGE2-induced luciferase activity was reduced in cells transfected with a 135-bp VEGF promoter fragment containing mutated Sp-1 binding sites but not in cells transfected with a construct containing mutated EGR-1 binding sites. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 80-84 15970595-11 2005 These studies suggest that PGE2 increases VEGF transcriptionally and involves the Sp-1 binding site via a cAMP-dependent mechanism involving EP2 and EP4 receptors. Dinoprostone 27-31 vascular endothelial growth factor A Homo sapiens 42-46 15899904-4 2005 Moreover, PGE2 and mutated beta-catenin stimulated the transcription of cyclin D1 and vascular endothelial growth factor in a synergistic fashion. Dinoprostone 10-14 vascular endothelial growth factor A Homo sapiens 86-120 15458923-10 2005 These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway. Dinoprostone 391-395 vascular endothelial growth factor A Homo sapiens 176-180 15995627-0 2005 PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 18-52 15995627-1 2005 AIM: 1) To evaluate the effect of prostaglandin E2 (PGE2) on the regulation of vascular endothelial growth factor (VEGF) expression in gastric MKN28 cells, and 2) to investigate the role of the epidermal growth factor receptor (EGFR) signal transduction pathway in any effect exerted by PGE2 on VEGF expression. Dinoprostone 34-50 vascular endothelial growth factor A Homo sapiens 79-113 15995627-1 2005 AIM: 1) To evaluate the effect of prostaglandin E2 (PGE2) on the regulation of vascular endothelial growth factor (VEGF) expression in gastric MKN28 cells, and 2) to investigate the role of the epidermal growth factor receptor (EGFR) signal transduction pathway in any effect exerted by PGE2 on VEGF expression. Dinoprostone 34-50 vascular endothelial growth factor A Homo sapiens 115-119 15995627-1 2005 AIM: 1) To evaluate the effect of prostaglandin E2 (PGE2) on the regulation of vascular endothelial growth factor (VEGF) expression in gastric MKN28 cells, and 2) to investigate the role of the epidermal growth factor receptor (EGFR) signal transduction pathway in any effect exerted by PGE2 on VEGF expression. Dinoprostone 52-56 vascular endothelial growth factor A Homo sapiens 79-113 15995627-1 2005 AIM: 1) To evaluate the effect of prostaglandin E2 (PGE2) on the regulation of vascular endothelial growth factor (VEGF) expression in gastric MKN28 cells, and 2) to investigate the role of the epidermal growth factor receptor (EGFR) signal transduction pathway in any effect exerted by PGE2 on VEGF expression. Dinoprostone 52-56 vascular endothelial growth factor A Homo sapiens 115-119 15995627-5 2005 RESULTS: PGE2 significantly up-regulated VEGF mRNA and protein expression and increased the activation of EGFR and ERK2. Dinoprostone 9-13 vascular endothelial growth factor A Homo sapiens 41-45 15995627-6 2005 Incubation of MKN28 cells with AG1478 significantly reduced PGE2-induced EGFR activity, ERK2 activity, and VEGF mRNA and protein expression. Dinoprostone 60-64 vascular endothelial growth factor A Homo sapiens 107-111 15995627-8 2005 CONCLUSION: Our data suggested that PGE2 up-regulates VEGF expression in gastric cancer cells via transactivation of EGFR-MAPK signaling pathways, which may be mechanisms underlying the contribution of COX-2 to tumor angiogenesis in gastric cancer. Dinoprostone 36-40 vascular endothelial growth factor A Homo sapiens 54-58 15458923-1 2005 We have previously shown that the cyclooxygenase (COX)-2/PGE2 pathway plays a key role in VEGF production in gastric fibroblasts. Dinoprostone 57-61 vascular endothelial growth factor A Homo sapiens 90-94 15585326-5 2005 The inhibition of TGF-beta-induced VEGF production by DFU was dose-dependent and abolished by exogenous prostaglandin E2. Dinoprostone 104-120 vascular endothelial growth factor A Homo sapiens 35-39 15358633-0 2004 n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. Dinoprostone 82-86 vascular endothelial growth factor A Homo sapiens 17-21 15862289-6 2005 In conclusion, IL-1beta increases VEGF-A secretion by COX-2 derived PGE(2) production whereas TGFbeta uses COX-independent pathways. Dinoprostone 68-74 vascular endothelial growth factor A Homo sapiens 34-40 15864753-9 2005 We found that HIF-1alpha increased concomitantly with VEGF after exogenous PGE2 stimulation to wild-type AGS cells, but this effect was blocked by SC19220, a PGE2 receptor antagonist. Dinoprostone 75-79 vascular endothelial growth factor A Homo sapiens 54-58 15864753-11 2005 Our work supports the COX-2/PGE2/HIF-1alpha/VEGF pathway possibly contributing to tumor angiogenesis in GC. Dinoprostone 28-32 vascular endothelial growth factor A Homo sapiens 44-48 15347673-0 2004 Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion. Dinoprostone 21-37 vascular endothelial growth factor A Homo sapiens 67-101 15347673-4 2004 The use of pharmacological EP agonists and antagonists indicates that ET-1 and PGE2 stimulate VEGF production principally through EP2 and EP4 receptors. Dinoprostone 79-83 vascular endothelial growth factor A Homo sapiens 94-98 15347673-7 2004 These results implicate EP2 and EP4 receptors in the induction of VEGF expression and cell invasiveness by ET-1 and provide a mechanism by which ETAR/ET-1 can promote and interact with PGE2-dependent machinery to amplify its proangiogenic and invasive phenotype in ovarian carcinoma cells. Dinoprostone 185-189 vascular endothelial growth factor A Homo sapiens 66-70 15102673-8 2004 A significant correlation was also found among PGE(2) production, microvessel density, and VEGF expression. Dinoprostone 47-53 vascular endothelial growth factor A Homo sapiens 91-95 15358633-7 2004 Moreover, they inhibited ERK-1 and -2 phosphorylation and HIF-1alpha protein over-expression, critical steps in the PGE(2)-induced signaling pathway leading to the augmented expression of VEGF in colon cancer cells. Dinoprostone 116-122 vascular endothelial growth factor A Homo sapiens 188-192 15353307-3 2004 PGE2 induced by COX-2 exerts several biological properties that may be advantageous for tumorigenesis: 1) Promoting angiogenesis (increased VEGF, bFGF, and PDGF production), 2) Anti-apoptosis mechanism (via increased bcl-2 and Akt activity), 3) Stimulating tumor metastasis (by increasing matrix metalloproteinases) and 4) Decreased immune surveillance (decreased cytokine production and NK activity). Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 140-144 15297183-2 2004 The objective of this study was to investigate the effects of prostaglandin E(2) (PGE(2)) on the expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible transcription factor-1 alpha (HIF-1alpha) genes in epithelial ovarian cancer (EOC) cells. Dinoprostone 62-80 vascular endothelial growth factor A Homo sapiens 111-145 15297183-2 2004 The objective of this study was to investigate the effects of prostaglandin E(2) (PGE(2)) on the expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible transcription factor-1 alpha (HIF-1alpha) genes in epithelial ovarian cancer (EOC) cells. Dinoprostone 62-80 vascular endothelial growth factor A Homo sapiens 147-151 15297183-9 2004 CONCLUSION: PGE(2) is a potent stimulator of VEGF expression in ovarian cancer cells. Dinoprostone 12-17 vascular endothelial growth factor A Homo sapiens 45-49 15044590-6 2004 PGE(2) signaling via the EP2 receptor also promoted the mRNA expression and secretion of vascular endothelial growth factor protein in Ishikawa cells. Dinoprostone 0-6 vascular endothelial growth factor A Homo sapiens 89-123 15102673-14 2004 This interaction is likely to produce a cooperative effect in promoting angiogenesis through PGE(2)-mediated increase in VEGF production. Dinoprostone 93-99 vascular endothelial growth factor A Homo sapiens 121-125 15126502-7 2004 VEGF stimulated prostacyclin and prostaglandin E2 production in DRG cultures that was blocked by inhibitors of cyclooxygenases; the anti-chemorepellent activities of VEGF and PlGF-2 were abrogated by cyclooxygenase inhibitors, and a variety of prostacyclin analogues and prostaglandins strikingly inhibited growth cone collapse. Dinoprostone 33-49 vascular endothelial growth factor A Homo sapiens 0-4 15010822-13 2004 Addition of PGE2 (10 microM) and the stable analog of PGI2, carbaprostacyclin (5 microM), to Hep3B cells also increased VEGF expression. Dinoprostone 12-16 vascular endothelial growth factor A Homo sapiens 120-124 14707101-0 2004 Prostaglandin E2 induces degranulation-independent production of vascular endothelial growth factor by human mast cells. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 65-99 14707101-5 2004 PGE(2) was a very strong inducer of VEGF-A(121/165) production by CBMC and also elevated VEGF-A mRNA expression. Dinoprostone 0-6 vascular endothelial growth factor A Homo sapiens 36-42 14707101-5 2004 PGE(2) was a very strong inducer of VEGF-A(121/165) production by CBMC and also elevated VEGF-A mRNA expression. Dinoprostone 0-6 vascular endothelial growth factor A Homo sapiens 89-95 15550858-4 2004 In addition, it is also known to promote rich micro-vessels within the tumor through up-regulation of prostaglandin E2(PGE2), which can induce vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in cancer cells, and can directly modulate endothelial cell proliferation. Dinoprostone 102-118 vascular endothelial growth factor A Homo sapiens 143-177 15550858-4 2004 In addition, it is also known to promote rich micro-vessels within the tumor through up-regulation of prostaglandin E2(PGE2), which can induce vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in cancer cells, and can directly modulate endothelial cell proliferation. Dinoprostone 102-118 vascular endothelial growth factor A Homo sapiens 178-182 15550858-4 2004 In addition, it is also known to promote rich micro-vessels within the tumor through up-regulation of prostaglandin E2(PGE2), which can induce vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in cancer cells, and can directly modulate endothelial cell proliferation. Dinoprostone 119-123 vascular endothelial growth factor A Homo sapiens 143-177 15550858-4 2004 In addition, it is also known to promote rich micro-vessels within the tumor through up-regulation of prostaglandin E2(PGE2), which can induce vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in cancer cells, and can directly modulate endothelial cell proliferation. Dinoprostone 119-123 vascular endothelial growth factor A Homo sapiens 178-182 12821125-0 2003 PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. Dinoprostone 0-6 vascular endothelial growth factor A Homo sapiens 61-65 12791666-2 2003 Here, we show that prostaglandin E2 (PGE2) mediates the effects of bFGF and VEGF in up-regulating CXCR4 expression on human microvascular endothelial cells (HMECs). Dinoprostone 19-35 vascular endothelial growth factor A Homo sapiens 76-80 12791666-2 2003 Here, we show that prostaglandin E2 (PGE2) mediates the effects of bFGF and VEGF in up-regulating CXCR4 expression on human microvascular endothelial cells (HMECs). Dinoprostone 37-41 vascular endothelial growth factor A Homo sapiens 76-80 12791666-10 2003 These findings indicate that PGE2 is a mediator of VEGF- and bFGF-induced CXCR4-dependent neovessel assembly in vivo and show that angiogenic effects of PGE2 require CXCR4 expression. Dinoprostone 29-33 vascular endothelial growth factor A Homo sapiens 51-55 14678846-22 2003 Since PGE2 is able to increase VEGF synthesis, this may be the link between GC and VEGF decrease. Dinoprostone 6-10 vascular endothelial growth factor A Homo sapiens 31-35 14678846-22 2003 Since PGE2 is able to increase VEGF synthesis, this may be the link between GC and VEGF decrease. Dinoprostone 6-10 vascular endothelial growth factor A Homo sapiens 83-87 12727858-0 2003 Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Dinoprostone 84-100 vascular endothelial growth factor A Homo sapiens 0-34 12727858-5 2003 Inhibition of C-SRC tyrosine kinase activity also blocks PGE(2)-induced HIF-1alpha protein and VEGF mRNA expression without blocking ERK phosphorylation. Dinoprostone 57-63 vascular endothelial growth factor A Homo sapiens 95-99 12107271-4 2002 Pretreatment of HMEC-1 with a selective COX-2 inhibitor, NS-398, abolished VEGF-induced PGE(2) synthesis, suggesting specific up-regulation of COX-2 activity by VEGF in HMEC-1. Dinoprostone 88-94 vascular endothelial growth factor A Homo sapiens 75-79 12601365-9 2003 VEGF up-regulation was accompanied by increased expression of cyclooxygenase type 2 (COX-2) and PGE2 synthesis. Dinoprostone 96-100 vascular endothelial growth factor A Homo sapiens 0-4 12010778-0 2002 Regulation by PGE2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts. Dinoprostone 14-18 vascular endothelial growth factor A Homo sapiens 97-131 11165399-0 2001 Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells. Dinoprostone 0-16 vascular endothelial growth factor A Homo sapiens 60-99 11886167-6 2002 Transforming growth factor-beta1, prostaglandin E2, dexamethasone, and 1,25-dihydroxyvitamin D3 that have been shown to regulate VEGF gene expression in osteoblasts had no effect on HIF-1alpha induction. Dinoprostone 34-50 vascular endothelial growth factor A Homo sapiens 129-133 11556523-9 2001 PGE2 increased in a dose-dependent manner the expression of VEGF in HF but not in HK. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 60-64 11556523-11 2001 CONCLUSIONS: These results indicate different signaling pathways in the PGE2 and UV-induced regulation of VEGF in dermal fibroblasts and epidermal keratinocytes. Dinoprostone 72-76 vascular endothelial growth factor A Homo sapiens 106-110 11556523-0 2001 UV radiation and prostaglandin E2 up-regulate vascular endothelial growth factor (VEGF) in cultured human fibroblasts. Dinoprostone 17-33 vascular endothelial growth factor A Homo sapiens 46-80 11556523-0 2001 UV radiation and prostaglandin E2 up-regulate vascular endothelial growth factor (VEGF) in cultured human fibroblasts. Dinoprostone 17-33 vascular endothelial growth factor A Homo sapiens 82-86 11556523-3 2001 This study was aimed at determining whether UVB/A1 radiation and prostaglandin E2 (PGE2) could modulate the production of VEGF by cultured dermal human fibroblasts (HF) in comparison to keratinocytes (HK). Dinoprostone 65-81 vascular endothelial growth factor A Homo sapiens 122-126 11556523-3 2001 This study was aimed at determining whether UVB/A1 radiation and prostaglandin E2 (PGE2) could modulate the production of VEGF by cultured dermal human fibroblasts (HF) in comparison to keratinocytes (HK). Dinoprostone 83-87 vascular endothelial growth factor A Homo sapiens 122-126 11165399-1 2001 The effects of prostaglandin E2 (PGE2) and vasoactive intestinal peptide (VIP) on vascular endothelial cell growth factor (VEGF) mRNAs were investigated using lung cancer cells. Dinoprostone 15-31 vascular endothelial growth factor A Homo sapiens 82-121 11165399-1 2001 The effects of prostaglandin E2 (PGE2) and vasoactive intestinal peptide (VIP) on vascular endothelial cell growth factor (VEGF) mRNAs were investigated using lung cancer cells. Dinoprostone 15-31 vascular endothelial growth factor A Homo sapiens 123-127 11165399-1 2001 The effects of prostaglandin E2 (PGE2) and vasoactive intestinal peptide (VIP) on vascular endothelial cell growth factor (VEGF) mRNAs were investigated using lung cancer cells. Dinoprostone 33-37 vascular endothelial growth factor A Homo sapiens 82-121 11165399-4 2001 PGE2, VIP and forskolin caused increased VEGF expression in a time- and concentration-dependent manner using NSCLC cell line NCI-H157. Dinoprostone 0-4 vascular endothelial growth factor A Homo sapiens 41-45 11165399-7 2001 Also 1 microM PGE2, 0.1 microM VIP and 50 microM forskolin increased the VEGF mRNA 2.0-, 1.5- and 2.3-fold, respectively, after 4 h. The increase in VEGF mRNA caused by PGE2, VIP and forskolin was inhibited by H-89, a protein kinase A inhibitor. Dinoprostone 14-18 vascular endothelial growth factor A Homo sapiens 73-77 11165399-7 2001 Also 1 microM PGE2, 0.1 microM VIP and 50 microM forskolin increased the VEGF mRNA 2.0-, 1.5- and 2.3-fold, respectively, after 4 h. The increase in VEGF mRNA caused by PGE2, VIP and forskolin was inhibited by H-89, a protein kinase A inhibitor. Dinoprostone 14-18 vascular endothelial growth factor A Homo sapiens 149-153 11165399-7 2001 Also 1 microM PGE2, 0.1 microM VIP and 50 microM forskolin increased the VEGF mRNA 2.0-, 1.5- and 2.3-fold, respectively, after 4 h. The increase in VEGF mRNA caused by PGE2, VIP and forskolin was inhibited by H-89, a protein kinase A inhibitor. Dinoprostone 169-173 vascular endothelial growth factor A Homo sapiens 73-77 11165399-7 2001 Also 1 microM PGE2, 0.1 microM VIP and 50 microM forskolin increased the VEGF mRNA 2.0-, 1.5- and 2.3-fold, respectively, after 4 h. The increase in VEGF mRNA caused by PGE2, VIP and forskolin was inhibited by H-89, a protein kinase A inhibitor. Dinoprostone 169-173 vascular endothelial growth factor A Homo sapiens 149-153 10919714-12 1999 Finally, the effect of COX-2 inhibition on CoCl2-induced VEGF production was reversed by the treatment with exogenous PGE2. Dinoprostone 118-122 vascular endothelial growth factor A Homo sapiens 57-61 10465664-2 1999 The basic carcinogenic processes are: (1) constitutive prostaglandin biosynthesis and formation of mutagenic oxygen and nitrogen free radicals responsible for tumor initiation; (2) PGE-2-induced expression of aromatase and constitutive estrogen biosynthesis which sustains mitogenesis and tumor promotion; and (3) PGE-2-induced expression of vascular endothelial growth factor which stimulates angiogenesis and tumor metastasis. Dinoprostone 181-186 vascular endothelial growth factor A Homo sapiens 342-376 10919714-13 1999 Our data demonstrate that VEGF induction by cobalt chloride-simulated hypoxia is maintained by a concomitant, persistent induction of COX-2 expression and sustained elevation of PGE2 synthesis in a human metastatic prostate cancer cell line, and suggest that COX-2 activity, reflected by PGE2 production, is involved in hypoxia-induced VEGF expression, and thus, modulates prostatic tumor angiogenesis. Dinoprostone 178-182 vascular endothelial growth factor A Homo sapiens 26-30 10919714-13 1999 Our data demonstrate that VEGF induction by cobalt chloride-simulated hypoxia is maintained by a concomitant, persistent induction of COX-2 expression and sustained elevation of PGE2 synthesis in a human metastatic prostate cancer cell line, and suggest that COX-2 activity, reflected by PGE2 production, is involved in hypoxia-induced VEGF expression, and thus, modulates prostatic tumor angiogenesis. Dinoprostone 288-292 vascular endothelial growth factor A Homo sapiens 26-30 9371228-9 1996 Thus, HNSCC-derived VEGF is important in stimulating endothelial cell proliferation, while the antiproliferative effect of TGF-beta and the migration-stimulatory activity of TGF-beta and PGE2 suggest their having a role in the morphogenic processes of angiogenesis. Dinoprostone 187-191 vascular endothelial growth factor A Homo sapiens 20-24 7556649-2 1995 We demonstrate that PGE2 and IL-1 induces the expression of vascular endothelial growth factor (VEGF), a selective angiogenic factor by rheumatoid synovial fibroblast cells. Dinoprostone 20-24 vascular endothelial growth factor A Homo sapiens 60-94 7556649-2 1995 We demonstrate that PGE2 and IL-1 induces the expression of vascular endothelial growth factor (VEGF), a selective angiogenic factor by rheumatoid synovial fibroblast cells. Dinoprostone 20-24 vascular endothelial growth factor A Homo sapiens 96-100 7556649-5 1995 The induction of VEGF expression by PGE2 and interleukin-1 alpha may be an important mechanism in inflammatory angiogenesis. Dinoprostone 36-40 vascular endothelial growth factor A Homo sapiens 17-21 9850741-5 1998 It has been recently shown that cyclooxygenase-2 (Cox-2) is inducible by a variety of stimuli and that eicosanoids, mainly of the PGE2 species, are inducers of basic regulator of angiogenesis, including VEGF/VPF, bFGF, TGF-beta, PDGF, and endothelin-1. Dinoprostone 130-134 vascular endothelial growth factor A Homo sapiens 203-207 7684302-6 1993 Our results reveal that VPF is a potent mediator of plasma leakage which, in the rabbit, depends on a synergistic interaction with arteriolar vasodilators such as prostaglandin E2. Dinoprostone 163-179 vascular endothelial growth factor A Homo sapiens 24-27 34991456-12 2022 In migraine patients, serum levels of NGF and PGE2 positively correlated with headache frequency (NGF: rho = 0.476 and P-value<0.001; PGE2: rho = 0.286 and P-value=0.028), while corresponding levels of BDNF and VEGF did not correlate with headache frequency (BDNF: rho = 0.037 and P-value=0.778; VEGF: rho= -0.025 and P-value=0.850). Dinoprostone 46-50 vascular endothelial growth factor A Homo sapiens 211-215 34991456-12 2022 In migraine patients, serum levels of NGF and PGE2 positively correlated with headache frequency (NGF: rho = 0.476 and P-value<0.001; PGE2: rho = 0.286 and P-value=0.028), while corresponding levels of BDNF and VEGF did not correlate with headache frequency (BDNF: rho = 0.037 and P-value=0.778; VEGF: rho= -0.025 and P-value=0.850). Dinoprostone 46-50 vascular endothelial growth factor A Homo sapiens 296-300