PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33255269-6	2020	Our results showed that MT-III induced biosynthesis of PGE2, PGI2, MCP-1, IL-6 and gene expression of leptin and adiponectin in preadipocytes.	Dinoprostone	55-59	metallothionein 3	Homo sapiens	24-30	
33255269-7	2020	The MT-III-induced PGE2 biosynthesis was dependent on cytosolic PLA2 (cPLA2)-alpha, cyclooxygenases (COX)-1 and COX-2 pathways and regulated by a positive loop via the EP4 receptor.	Dinoprostone	19-23	metallothionein 3	Homo sapiens	4-10	
24718259-5	2014	MT-III caused a marked release of PGE2, PGD2, PGJ2, IL-1beta and IL-10 and increased the number of LDs in WT macrophages.	Dinoprostone	34-38	metallothionein 3	Homo sapiens	0-6	
24718259-7	2014	In MyD88-/- macrophages, MT-III-induced release of PGE2, IL-1beta and IL-10 was abrogated, but release of PGD2 and PGJ2 was maintained.	Dinoprostone	51-55	metallothionein 3	Homo sapiens	25-31	
24808633-9	2014	Altogether, these results show for the first time that the induction of COX-2 protein expression and PGE2 release, which occur via NF-kappaB activation induced by the sPLA2-MT-III in macrophages, are modulated by p38MAPK and PKC, but not by PI3K signaling proteins.	Dinoprostone	101-105	metallothionein 3	Homo sapiens	173-179	
24808633-2	2014	We previously demonstrated that a snake venom sPLA2 named MT-III leads to prostaglandin (PG)E2 biosynthesis in macrophages by inducing the expression of cyclooxygenase-2 (COX-2).	Dinoprostone	74-94	metallothionein 3	Homo sapiens	58-64	
24808633-6	2014	Moreover, MT-III-induced COX-2 protein expression and PGE2 release were attenuated by pretreatment of macrophages with SB202190, and Ly294002, and H-7-dihydro compounds, indicating the involvement of p38MAPK, PI3K, and PKC pathways, respectively.	Dinoprostone	54-58	metallothionein 3	Homo sapiens	10-16