PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33919029-7 2021 In T98G cells exogenous PGE2 increased latent MMP2 gelatinolytic activity. Dinoprostone 24-28 matrix metallopeptidase 2 Homo sapiens 46-50 21792195-6 2011 Capacity of the major product of COX-2, the prostaglandin E2 (PGE(2)), to stimulate the production of the matrix metalloproteinase-2 (MMP-2) and cancer cell invasion were assessed with a zymography gel and invasion chambers. Dinoprostone 44-60 matrix metallopeptidase 2 Homo sapiens 106-132 33788732-10 2021 CONCLUSION: Down-regulation of the COX-2/PGE2 signaling pathway by blue LED irradiation led to reduce expression of MMP-2 and MMP-9, inhibiting the invasiveness of CD133+ colorectal CSC. Dinoprostone 41-45 matrix metallopeptidase 2 Homo sapiens 116-121 27695098-0 2016 Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis. Dinoprostone 59-63 matrix metallopeptidase 2 Homo sapiens 14-40 27695098-8 2016 In vitro study using human endothelial cells showed that prostaglandin E2 (PGE2) significantly increased MMP-2 activity as well as tube formation. Dinoprostone 57-73 matrix metallopeptidase 2 Homo sapiens 105-110 27695098-8 2016 In vitro study using human endothelial cells showed that prostaglandin E2 (PGE2) significantly increased MMP-2 activity as well as tube formation. Dinoprostone 75-79 matrix metallopeptidase 2 Homo sapiens 105-110 27695098-9 2016 Inhibition of COX-2 and/or phosphorylated AKT suppressed MMP-2 activity and endothelial tube formation suggesting involvement of PGE2 in regulation of MMP-2 activity during angiogenesis. Dinoprostone 129-133 matrix metallopeptidase 2 Homo sapiens 57-62 27695098-9 2016 Inhibition of COX-2 and/or phosphorylated AKT suppressed MMP-2 activity and endothelial tube formation suggesting involvement of PGE2 in regulation of MMP-2 activity during angiogenesis. Dinoprostone 129-133 matrix metallopeptidase 2 Homo sapiens 151-156 27695098-13 2016 In conclusion, our study establishes the involvement of MMP-2 activity via COX-2-PGE2-pAKT axis in promoting angiogenesis during endometriosis progression. Dinoprostone 81-85 matrix metallopeptidase 2 Homo sapiens 56-61 27038655-6 2016 In the endometriotic lesions, prostaglandin E2 (PGE2) produced by cyclooxygenase-2 (COX-2), binds to its EP4 receptor (EP4), and via c-Src kinase induces MMPs activation, promoting endometriosis. Dinoprostone 30-46 matrix metallopeptidase 2 Homo sapiens 154-158 27038655-6 2016 In the endometriotic lesions, prostaglandin E2 (PGE2) produced by cyclooxygenase-2 (COX-2), binds to its EP4 receptor (EP4), and via c-Src kinase induces MMPs activation, promoting endometriosis. Dinoprostone 48-52 matrix metallopeptidase 2 Homo sapiens 154-158 32385657-9 2020 A statistically significant, positive correlation was observed between PGE2 -MMP-2, and chemerin-PGE2 in saliva, chemerin and MMP-2 in SF, respectively (p = 0.031, r = 0.382 / p = 0.039, r = 0.366 / p = 0.032, r = 0.379). Dinoprostone 71-75 matrix metallopeptidase 2 Homo sapiens 77-82 30230255-8 2018 Additionally, in smooth muscle cells isolated from human AAA tissues, stimulation of CJ-42794 inhibited PGE2 -induced IL-6 secretion in a dose-dependent manner and decreased PGE2 -induced MMP-2 activity. Dinoprostone 174-178 matrix metallopeptidase 2 Homo sapiens 188-193 29328471-5 2018 The present study was designed to investigate the associations between PGE2 and the PGE2 receptor EP4, and MMPs, RANKL and RUNX2 in PCa, and to define their roles in PCa cell proliferation and invasion in addition to understanding the molecular mechanisms. Dinoprostone 71-75 matrix metallopeptidase 2 Homo sapiens 107-111 29328471-6 2018 The results of western blotting and reverse transcription-quantitative polymerase chain reaction demonstrated that the protein and the mRNA expression levels of MMP-2, MMP-9, RANKL and RUNX2 in PC-3 cells were significantly upregulated by treatment with PGE2, respectively, and knockdown of these proteins blocked PGE2-induced cell proliferation and invasion in PC-3 cells, as determined by Cell Counting Kit-8 and Matrigel invasion assays, respectively. Dinoprostone 254-258 matrix metallopeptidase 2 Homo sapiens 161-166 29328471-6 2018 The results of western blotting and reverse transcription-quantitative polymerase chain reaction demonstrated that the protein and the mRNA expression levels of MMP-2, MMP-9, RANKL and RUNX2 in PC-3 cells were significantly upregulated by treatment with PGE2, respectively, and knockdown of these proteins blocked PGE2-induced cell proliferation and invasion in PC-3 cells, as determined by Cell Counting Kit-8 and Matrigel invasion assays, respectively. Dinoprostone 314-318 matrix metallopeptidase 2 Homo sapiens 161-166 29328471-13 2018 In conclusion, the results of the present study indicate that PGE2 significantly upregulated the mRNA and protein expression levels of the MMP-2, MMP-9, RANKL and RUNX2, and the EP4 receptor was involved in the cell proliferation and invasion of PCa via the cAMP-PKA/PI3K-Akt signaling pathway. Dinoprostone 62-66 matrix metallopeptidase 2 Homo sapiens 139-144 25595899-7 2015 The inhibitory effect of COX-2 depletion on MMPs and the fibronectin/Rac1/cdc42 axis were reversed by co-treatment with PGE2. Dinoprostone 120-124 matrix metallopeptidase 2 Homo sapiens 44-48 23494562-2 2013 Although many aspects of matrix metalloproteinase (MMP2) on tumor invasion have been studied, the exact mechanism of PGE2-induced MMP2 overproduction has not been clearly defined. Dinoprostone 117-121 matrix metallopeptidase 2 Homo sapiens 130-134 23494562-4 2013 Based on the identification of the transcription factor cyclic AMP response element-binding protein (CREB) as an important regulator of MMP2 and Erk phosphorylate CREB at ser133, we hypothesize that CREB may be implicated in the signaling of PGE2 stimulation to MMP2 overproduction via EP1 receptor. Dinoprostone 242-246 matrix metallopeptidase 2 Homo sapiens 136-140 23494562-4 2013 Based on the identification of the transcription factor cyclic AMP response element-binding protein (CREB) as an important regulator of MMP2 and Erk phosphorylate CREB at ser133, we hypothesize that CREB may be implicated in the signaling of PGE2 stimulation to MMP2 overproduction via EP1 receptor. Dinoprostone 242-246 matrix metallopeptidase 2 Homo sapiens 262-266 23494562-5 2013 In the study, we investigated the role of EP1 receptor on PGE2-induced MMP2 expression and delineated the signaling pathway that contributes to EP1 receptor modulation of MMP2 in human cholangiocarcinoma cells. Dinoprostone 58-62 matrix metallopeptidase 2 Homo sapiens 71-75 23494562-6 2013 We found PGE2 or selective EP1 receptor agonist 17-P-T-PGE2-stimulated MMP2 expression and selective EP1 receptor antagonist SC-51322 or EP1 receptor siRNA abrogated PGE2-induced MMP2 expression. Dinoprostone 9-13 matrix metallopeptidase 2 Homo sapiens 71-75 23494562-6 2013 We found PGE2 or selective EP1 receptor agonist 17-P-T-PGE2-stimulated MMP2 expression and selective EP1 receptor antagonist SC-51322 or EP1 receptor siRNA abrogated PGE2-induced MMP2 expression. Dinoprostone 55-59 matrix metallopeptidase 2 Homo sapiens 71-75 23494562-6 2013 We found PGE2 or selective EP1 receptor agonist 17-P-T-PGE2-stimulated MMP2 expression and selective EP1 receptor antagonist SC-51322 or EP1 receptor siRNA abrogated PGE2-induced MMP2 expression. Dinoprostone 55-59 matrix metallopeptidase 2 Homo sapiens 71-75 23494562-9 2013 Our findings suggest that PGE2-enhanced MMP2 expression is, at least in part, mediated through EP1 receptors and calcium signaling pathway-induced CREB phosphorylation in human cholangiocarcinoma cells. Dinoprostone 26-30 matrix metallopeptidase 2 Homo sapiens 40-44 22570740-2 2012 Activation of prostaglandin E(2) (PGE(2)) is known to increase the expression of matrix metalloproteinase (MMP) and the release of inflammatory cytokines, and may thus exacerbate abdominal aortic aneurysm (AAA) formation. Dinoprostone 14-32 matrix metallopeptidase 2 Homo sapiens 107-110 22570740-2 2012 Activation of prostaglandin E(2) (PGE(2)) is known to increase the expression of matrix metalloproteinase (MMP) and the release of inflammatory cytokines, and may thus exacerbate abdominal aortic aneurysm (AAA) formation. Dinoprostone 34-40 matrix metallopeptidase 2 Homo sapiens 107-110 21792195-6 2011 Capacity of the major product of COX-2, the prostaglandin E2 (PGE(2)), to stimulate the production of the matrix metalloproteinase-2 (MMP-2) and cancer cell invasion were assessed with a zymography gel and invasion chambers. Dinoprostone 44-60 matrix metallopeptidase 2 Homo sapiens 134-139 21792195-6 2011 Capacity of the major product of COX-2, the prostaglandin E2 (PGE(2)), to stimulate the production of the matrix metalloproteinase-2 (MMP-2) and cancer cell invasion were assessed with a zymography gel and invasion chambers. Dinoprostone 62-68 matrix metallopeptidase 2 Homo sapiens 106-132 21792195-6 2011 Capacity of the major product of COX-2, the prostaglandin E2 (PGE(2)), to stimulate the production of the matrix metalloproteinase-2 (MMP-2) and cancer cell invasion were assessed with a zymography gel and invasion chambers. Dinoprostone 62-68 matrix metallopeptidase 2 Homo sapiens 134-139 18001719-7 2008 MAIN OUTCOME MEASURE(S): Gene expression pattern and prostaglandin E(2) production and activity of matrix metalloproteinase 2 and matrix metalloproteinase 9. Dinoprostone 53-71 matrix metallopeptidase 2 Homo sapiens 99-125 18699805-4 2008 The objective of this study was to measure the expression of COX-2 and the concentrations of PGE2 and MMP-2, and to investigate the role of COX-2 and PGE2 in airflow limitation mediated by MMP-2, in the pathogenesis of COPD. Dinoprostone 150-154 matrix metallopeptidase 2 Homo sapiens 189-194 18699805-9 2008 Levels of PGE2 were also positively correlated with those of MMP-2 in patients with COPD (r = 0.775, P < 0.01). Dinoprostone 10-14 matrix metallopeptidase 2 Homo sapiens 61-66 18699805-11 2008 CONCLUSIONS: COX-2 and its product PGE2 are not only involved in airway inflammation, but may also contribute to the severity of airflow limitation mediated by MMP-2 during progression of COPD. Dinoprostone 35-39 matrix metallopeptidase 2 Homo sapiens 160-165 20709621-10 2010 Adding extrinsic PGE2 could antagonize the inhibitive effect of celecoxib not only on MMP-2 secretion of Tca8113 cell, but also on invasion and adhesion ability of the cells. Dinoprostone 17-21 matrix metallopeptidase 2 Homo sapiens 86-91 18042549-6 2008 Upon binding to its receptor, PGE(2) initiated an autocrine/paracrine signaling cascade involving the intracellular activation of c-Src, activation of matrix metalloproteinase (predominantly MMP2), which in turn caused the mobilization of membrane-anchored fibroblast growth factor-2 (FGF-2). Dinoprostone 30-36 matrix metallopeptidase 2 Homo sapiens 191-195 16818637-3 2006 We have shown that osteopontin stimulates the activation of protein kinase C alpha/nuclear factor-inducing kinase/nuclear factor-kappaB-dependent signaling cascades that induces COX-2 expression, which in turn regulates the prostaglandin E(2) production, matrix metalloproteinase-2 activation, and tumor progression and angiogenesis. Dinoprostone 224-242 matrix metallopeptidase 2 Homo sapiens 255-281 17038636-10 2006 This effect in turn might contribute to plaque stabilization by inhibiting the biosynthesis of PGE2-dependent MMPs, responsible for plaque rupture. Dinoprostone 95-99 matrix metallopeptidase 2 Homo sapiens 110-114 15120641-5 2004 Exogenous PGE(2) stimulated MMP-2 promoter activity, increased MMP-2 expression, and increased cellular invasiveness. Dinoprostone 10-16 matrix metallopeptidase 2 Homo sapiens 28-33 15492268-11 2004 The mitogen-activated protein kinase kinase inhibitor PD98059 and Ets-1 silencing each abolished PGE(2)-induced increases in MMP-2 expression. Dinoprostone 97-103 matrix metallopeptidase 2 Homo sapiens 125-130 15492268-0 2004 Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2. Dinoprostone 0-16 matrix metallopeptidase 2 Homo sapiens 97-123 15492268-2 2004 Here we tested the hypothesis that the COX-2 product prostaglandin E(2) (PGE(2)) increases cellular invasive potential by inducing matrix metalloproteinase-2 (MMP-2) expression and activity through an extracellular signal-regulated kinase (ERK)/Ets-1-dependent mechanism in pancreatic cancer. Dinoprostone 53-71 matrix metallopeptidase 2 Homo sapiens 131-157 15492268-2 2004 Here we tested the hypothesis that the COX-2 product prostaglandin E(2) (PGE(2)) increases cellular invasive potential by inducing matrix metalloproteinase-2 (MMP-2) expression and activity through an extracellular signal-regulated kinase (ERK)/Ets-1-dependent mechanism in pancreatic cancer. Dinoprostone 53-71 matrix metallopeptidase 2 Homo sapiens 159-164 15492268-2 2004 Here we tested the hypothesis that the COX-2 product prostaglandin E(2) (PGE(2)) increases cellular invasive potential by inducing matrix metalloproteinase-2 (MMP-2) expression and activity through an extracellular signal-regulated kinase (ERK)/Ets-1-dependent mechanism in pancreatic cancer. Dinoprostone 73-79 matrix metallopeptidase 2 Homo sapiens 131-157 15492268-2 2004 Here we tested the hypothesis that the COX-2 product prostaglandin E(2) (PGE(2)) increases cellular invasive potential by inducing matrix metalloproteinase-2 (MMP-2) expression and activity through an extracellular signal-regulated kinase (ERK)/Ets-1-dependent mechanism in pancreatic cancer. Dinoprostone 73-79 matrix metallopeptidase 2 Homo sapiens 159-164 15272234-0 2004 Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes. Dinoprostone 73-89 matrix metallopeptidase 2 Homo sapiens 29-55 15272234-4 2004 IL-1beta-related MMP-2 expression was found to be dependent on prostaglandin E2 (PGE2) production. Dinoprostone 63-79 matrix metallopeptidase 2 Homo sapiens 17-22 15272234-4 2004 IL-1beta-related MMP-2 expression was found to be dependent on prostaglandin E2 (PGE2) production. Dinoprostone 81-85 matrix metallopeptidase 2 Homo sapiens 17-22 15272234-7 2004 Taken together, these results demonstrated that IL-1beta induces MMP-2 expression through the PGE2-dependent mechanism in human chondrocytes. Dinoprostone 94-98 matrix metallopeptidase 2 Homo sapiens 65-70 15120641-5 2004 Exogenous PGE(2) stimulated MMP-2 promoter activity, increased MMP-2 expression, and increased cellular invasiveness. Dinoprostone 10-16 matrix metallopeptidase 2 Homo sapiens 63-68 15120641-7 2004 These data implicated a role for inducible COX-2 and PGE(2) in the regulation of rhabdomyosarcoma cellular invasiveness and MMP-2 activity. Dinoprostone 53-59 matrix metallopeptidase 2 Homo sapiens 124-129 11514380-1 2001 BACKGROUND: Studies have implicated a role for prostaglandin (PG) E(2)-dependent matrix metalloproteinase (MMP) biosynthesis in the rupture of atherosclerotic plaque. Dinoprostone 47-70 matrix metallopeptidase 2 Homo sapiens 107-110 12393872-0 2002 Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. Dinoprostone 20-36 matrix metallopeptidase 2 Homo sapiens 94-120 12393872-5 2002 In contrast, anti-PGE2 decreased EP4 receptor, CD44, and MMP-2 expression in NSCLC cells. Dinoprostone 18-22 matrix metallopeptidase 2 Homo sapiens 57-62 12393872-8 2002 Moreover, MMP-2-AS treatment decreased PGE2-mediated CD44 expression, and CD44-AS treatment decreased MMP-2 expression. Dinoprostone 39-43 matrix metallopeptidase 2 Homo sapiens 10-15 12393872-9 2002 Thus, PGE2-mediated effects through EP4 required the parallel induction of both CD44 and MMP-2 expression because genetic inhibition of either MMP-2 or CD44 expression effectively blocked PGE2-mediated invasion in NSCLC. Dinoprostone 6-10 matrix metallopeptidase 2 Homo sapiens 89-94 12393872-9 2002 Thus, PGE2-mediated effects through EP4 required the parallel induction of both CD44 and MMP-2 expression because genetic inhibition of either MMP-2 or CD44 expression effectively blocked PGE2-mediated invasion in NSCLC. Dinoprostone 6-10 matrix metallopeptidase 2 Homo sapiens 143-148 12393872-9 2002 Thus, PGE2-mediated effects through EP4 required the parallel induction of both CD44 and MMP-2 expression because genetic inhibition of either MMP-2 or CD44 expression effectively blocked PGE2-mediated invasion in NSCLC. Dinoprostone 188-192 matrix metallopeptidase 2 Homo sapiens 89-94 12393872-9 2002 Thus, PGE2-mediated effects through EP4 required the parallel induction of both CD44 and MMP-2 expression because genetic inhibition of either MMP-2 or CD44 expression effectively blocked PGE2-mediated invasion in NSCLC. Dinoprostone 188-192 matrix metallopeptidase 2 Homo sapiens 143-148 12393872-10 2002 These findings indicate that PGE2 regulates COX-2-dependent, CD44- and MMP-2-mediated invasion in NSCLC in an autocrine/paracrine manner via EP receptor signaling. Dinoprostone 29-33 matrix metallopeptidase 2 Homo sapiens 71-76 34093801-9 2021 Lastly, we found that decreased COX-2 protein level affected PGE2 production, leading to lower Bcl-2, Caspase-3, MMP2 and MMP9 expression but higher Bax and E-cadherin expression, which in turn culminated in higher rates of cell death and lower rates of cell migration. Dinoprostone 61-65 matrix metallopeptidase 2 Homo sapiens 113-117