PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11709711-0	2001	Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation.	Singlet Oxygen	26-40	caspase 8	Homo sapiens	73-82	
11709711-2	2001	We have shown previously that caspase-8 and p38 mediate singlet oxygen-induced apoptosis in HL-60 cells.	Singlet Oxygen	56-70	caspase 8	Homo sapiens	30-39	
11709711-3	2001	In this study, we investigated the influence of PKC on regulation of the caspase and p38 pathways initiated by singlet oxygen.	Singlet Oxygen	111-125	caspase 8	Homo sapiens	73-80	
11709711-4	2001	Singlet oxygen induced Fas clustering and subsequent recruitment of FADD and caspase-8.	Singlet Oxygen	0-14	caspase 8	Homo sapiens	77-86	
11709711-6	2001	Surprisingly, under the same conditions PKC activation was still able to prevent singlet oxygen-induced activation of caspase-8 and block its downstream signaling events including cleavage of Bid and caspase-3, decrease in mitochondrial transmembrane potential and release of cytochrome c from mitochondria.	Singlet Oxygen	81-95	caspase 8	Homo sapiens	118-127	
11709711-9	2001	These data indicate that PKC inhibits singlet oxygen-induced apoptosis by blocking activation of caspase-8.	Singlet Oxygen	38-52	caspase 8	Homo sapiens	97-106	
10837470-6	2000	In contrast, blockade of caspase-8 with Ile-Glu-Thr-Asp-fluoromethyl ketone is sufficient to prevent formation of DNA fragments and to inhibit all the above signaling events, with exception of p38 phosphorylation, in both singlet oxygen- and H(2)O(2)-treated cells.	Singlet Oxygen	222-236	caspase 8	Homo sapiens	25-34	
10837470-7	2000	These data suggest that caspase-3 activation is regulated through redundant signaling pathways that involve p38 and caspase-8 acting upstream of Bid during singlet oxygen-induced apoptosis, whereas the activation of caspase-3 by H(2)O(2) is only governed by a caspase-8-mediated apoptotic pathway.	Singlet Oxygen	156-170	caspase 8	Homo sapiens	116-125	
10837470-7	2000	These data suggest that caspase-3 activation is regulated through redundant signaling pathways that involve p38 and caspase-8 acting upstream of Bid during singlet oxygen-induced apoptosis, whereas the activation of caspase-3 by H(2)O(2) is only governed by a caspase-8-mediated apoptotic pathway.	Singlet Oxygen	156-170	caspase 8	Homo sapiens	260-269	
26225731-8	2015	It depended on singlet oxygen-dependent activation of the FAS receptor and caspase-8, followed by caspase-8-mediated enhancement of NOX activity.	Singlet Oxygen	15-29	caspase 8	Homo sapiens	75-84	
10388534-0	1999	Caspase-8 mediates caspase-3 activation and cytochrome c release during singlet oxygen-induced apoptosis of HL-60 cells.	Singlet Oxygen	72-86	caspase 8	Homo sapiens	0-9	
10388534-5	1999	Further studies showed that singlet oxygen induced an increase in caspase-8 activity and a reduction in mitochondrial cytochrome c.	Singlet Oxygen	28-42	caspase 8	Homo sapiens	66-75	
10388534-8	1999	These results suggest that caspase-8 mediates caspase-3 activation and cytochrome c release during singlet oxygen-induced apoptosis in HL-60 cells.	Singlet Oxygen	99-113	caspase 8	Homo sapiens	27-36	
25619142-6	2015	Singlet-oxygen-dependent activation of the FAS receptor and caspase-8 increased superoxide anion generation by NOX1 and amplification of singlet oxygen generation, which allowed singlet-oxygen-dependent inactivation of catalase.	Singlet Oxygen	137-151	caspase 8	Homo sapiens	60-69	
25653236-9	2015	This allows the formation of extracellular singlet oxygen through the reaction between H(2)O(2) and peroxynitrite, amplification through a caspase8-dependent step and subsequent singlet oxygen-mediated inactivation of catalase.	Singlet Oxygen	43-57	caspase 8	Homo sapiens	139-147	
25653236-9	2015	This allows the formation of extracellular singlet oxygen through the reaction between H(2)O(2) and peroxynitrite, amplification through a caspase8-dependent step and subsequent singlet oxygen-mediated inactivation of catalase.	Singlet Oxygen	178-192	caspase 8	Homo sapiens	139-147