PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7531775-9 1995 In accord with the much greater inhibitory potency of chlorpyrifos oxon for AChE than for NTE, clinical reports and experimental studies indicate that OPIDN from acute exposures to chlorpyrifos requires doses well in excess of the LD50, even when followed by repeated doses of the OPIDN potentiator phenylmethanesulfonyl fluoride (PMSF). Chlorpyrifos 54-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 10229710-5 1999 These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban). Chlorpyrifos 190-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 10229710-5 1999 These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban). Chlorpyrifos 204-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 10051415-0 1999 Human red blood cell acetylcholinesterase inhibition as the appropriate and conservative surrogate endpoint for establishing chlorpyrifos reference dose. Chlorpyrifos 125-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 10051415-4 1999 Basing an acceptable level of human exposure (e.g., RfD) on inhibition of RBC AChE provides a significant margin of safety, since it is 12- to 14-fold more sensitive as an indicator of chlorpyrifos exposure than the AChE in the most sensitive relevant neurological tissues (brain or retina). Chlorpyrifos 185-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 10051415-5 1999 Inhibition of RBC AChE activity is consistently exhibited at lower dosages of chlorpyrifos than those required to result in clinical symptoms of OP toxicity, or alterations in cognitive functional responses. Chlorpyrifos 78-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 10051415-7 1999 Thus, inhibition of RBC AChE activity is an appropriate surrogate measurement of chlorpyrifos exposure and provides a conservative endpoint for establishing appropriate margins of safety for both adults and infants. Chlorpyrifos 81-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 9744565-2 1998 The insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (AChE) by CPO, resulting in severe cholinergic toxicity. Chlorpyrifos 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 9744565-2 1998 The insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (AChE) by CPO, resulting in severe cholinergic toxicity. Chlorpyrifos 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 8593081-2 1996 Since chlorpyrifos inhibits acetylcholinesterase, the acetylcholine-innervated ciliated epithelial cultures of frog palate were used as the model. Chlorpyrifos 6-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 7531775-3 1995 Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences. Chlorpyrifos 8-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 7531775-3 1995 Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences. Chlorpyrifos 8-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 7531775-3 1995 Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences. Chlorpyrifos 352-364 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 7531775-3 1995 Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences. Chlorpyrifos 352-364 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 9292287-3 1997 2 Diethylphosphoryl-AChE resulting from intoxications with parathion, chlorpyrifos, chlorfenvinphos, diazinon and other OPs is characterized by slow spontaneous reactivation and low propensity for ageing. Chlorpyrifos 70-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 34818764-5 2022 Chlorpyrifos increased mortality, growth rate and the energy consumed, and reduced the AChE (acetylcholinesterase) activity, the energy available, and the net energy budget (estimated as cellular energy allocation). Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 1711837-6 1991 High AChE inhibition (greater than 90%), however, was measured within hours after dosing because of the higher potency of chlorpyrifos to inhibit this enzyme. Chlorpyrifos 122-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 1711837-7 1991 In vitro studies showed that chlorpyrifos-oxon, the active metabolite of chlorpyrifos, was 10-20 times more active against AChE than against NTE, confirming the clinical observation. Chlorpyrifos 29-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 34818764-5 2022 Chlorpyrifos increased mortality, growth rate and the energy consumed, and reduced the AChE (acetylcholinesterase) activity, the energy available, and the net energy budget (estimated as cellular energy allocation). Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 33930485-0 2021 Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt/beta-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 35294598-1 2022 The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) to account for inter-individual differences in kinetics (HKAF). Chlorpyrifos 126-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-221 35294598-1 2022 The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) to account for inter-individual differences in kinetics (HKAF). Chlorpyrifos 126-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 35572106-4 2022 Chlorpyrifos as an acetylcholinesterase inhibitor controls the enzymatic hydrolysis reaction and further regulates the production of thiocholine that could decompose CoOOH nanoflakes into Co2+, resulting in the fluorescence response of AuNC-based hydrogel. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 34637829-6 2022 Moreover, chlorpyrifos-induced reductions in heat tolerance (CTmax), acetylcholinesterase (AChE) activity and development time were further magnified by the heat spike. Chlorpyrifos 10-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 34637829-6 2022 Moreover, chlorpyrifos-induced reductions in heat tolerance (CTmax), acetylcholinesterase (AChE) activity and development time were further magnified by the heat spike. Chlorpyrifos 10-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 35623791-9 2022 When the bioactivity of AChE was inhibited by the organophosphate pesticides (chlorpyrifos as substrate), the reduced production of thiocholine resulted in a decline in photocurrent. Chlorpyrifos 78-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 35623791-10 2022 Under optimal conditions, the structured AChE/GLD-CS/CdCoS2(2)@Ag/ITO sensing platform was successfully achieved for chlorpyrifos detection. Chlorpyrifos 117-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 35583680-5 2022 In this study, the oxidation of malathion, parathion, and chlorpyrifos by n-bromosuccinimide (NBS) was investigated in an approach combining high-performance thin-layer chromatography (HPTLC) with an AChE-I assay. Chlorpyrifos 58-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 35583680-10 2022 AChE-I effect recoveries in samples from a stormwater retention basin and receiving stream were between 69 and 92% for malathion, parathion, and chlorpyrifos. Chlorpyrifos 145-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 31841723-9 2020 Acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 3,5,6-trichloro-2-pyridinol (TCP-y), specific for Chlorpyrifos, were among the most common biomarkers identified; however, most metabolites found were non-specific. Chlorpyrifos 113-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32290125-1 2020 Chlorpyrifos, an acetylcholinesterase inhibitor (ACI), is one of the most widely used insecticides in the world, and is generally recognized to be a moderate human neurotoxin. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 31841723-9 2020 Acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 3,5,6-trichloro-2-pyridinol (TCP-y), specific for Chlorpyrifos, were among the most common biomarkers identified; however, most metabolites found were non-specific. Chlorpyrifos 113-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32031197-5 2020 In the presence of OPs, the AChE-catalyzed hydrolysis of indoxyl acetate is blocked, and then the silver deposition on the gold electrode declines, leading to a remarkable decrease in the LSV response and, thus producing a large signal output for the ultrasensitive detection of chlorpyrifos, a proof-of-concept OP in this work. Chlorpyrifos 279-291 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 30200437-3 2018 The organophosphate pesticide chlorpyrifos (CPF) primarily exerts toxicity through the inhibition of AChE, which results in excess cholinergic stimulation at the synapse. Chlorpyrifos 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Chlorpyrifos 237-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Chlorpyrifos 237-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Chlorpyrifos 237-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 310-314 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Chlorpyrifos 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Chlorpyrifos 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 31214721-0 2019 Physiologically based kinetic modelling-facilitated reverse dosimetry to predict in vivo red blood cell acetylcholinesterase inhibition following exposure to chlorpyrifos in the Caucasian and Chinese population. Chlorpyrifos 158-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 31214721-2 2019 The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population. Chlorpyrifos 184-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 31214721-2 2019 The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population. Chlorpyrifos 184-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 31214721-2 2019 The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population. Chlorpyrifos 198-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 31214721-2 2019 The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population. Chlorpyrifos 198-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 30200437-3 2018 The organophosphate pesticide chlorpyrifos (CPF) primarily exerts toxicity through the inhibition of AChE, which results in excess cholinergic stimulation at the synapse. Chlorpyrifos 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 30127816-1 2018 Chlorpyrifos (CP), an acetylcholinesterase (AChE) inhibitor, is used throughout the world as an insecticide in agriculture and an eradicating agent for termites around homes. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 26460372-2 2015 The determination of an organophosphate pesticide, chlorpyrifos (CPF), was performed based on the inhibition system of the enzyme acetylcholinesterase bonded to magnetic beads through a biotin-streptavidin complex system. Chlorpyrifos 51-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 26314619-4 2015 We studied two different pesticides, chlorpyrifos and carbaryl, which specifically inhibit acetylcholinesterase (AChE) in the nervous system. Chlorpyrifos 37-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 26314619-4 2015 We studied two different pesticides, chlorpyrifos and carbaryl, which specifically inhibit acetylcholinesterase (AChE) in the nervous system. Chlorpyrifos 37-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 26199915-1 2015 OBJECTIVE: Chlorpyrifos (CP) as an organophosphorus pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2nanoparticle (CNP) and sodium selenite (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated lymphocytes. Chlorpyrifos 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 239-259 26199915-1 2015 OBJECTIVE: Chlorpyrifos (CP) as an organophosphorus pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2nanoparticle (CNP) and sodium selenite (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated lymphocytes. Chlorpyrifos 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 26199915-1 2015 OBJECTIVE: Chlorpyrifos (CP) as an organophosphorus pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2nanoparticle (CNP) and sodium selenite (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated lymphocytes. Chlorpyrifos 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 498-502 26210949-0 2015 Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Chlorpyrifos 32-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 26460372-2 2015 The determination of an organophosphate pesticide, chlorpyrifos (CPF), was performed based on the inhibition system of the enzyme acetylcholinesterase bonded to magnetic beads through a biotin-streptavidin complex system. Chlorpyrifos 65-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 22446730-0 2012 Acetylcholinesterase inhibition dose-response modeling for chlorpyrifos and chlorpyrifos-oxon. Chlorpyrifos 59-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23535398-3 2013 However, we observed long term deficit after acute subcutaneous exposure to Chlorpyrifos (CPF) even when AChE activity is restored. Chlorpyrifos 76-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 23202341-5 2013 Based on the inhibition of pesticides on the AChE activity, using malathion, chlorpyrifos, monocrotophos and carbofuran as model compounds, this biosensor showed a wide range, low detection limit, good reproducibility and high stability. Chlorpyrifos 77-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 23021811-6 2012 The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively. Chlorpyrifos 160-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 23021811-6 2012 The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively. Chlorpyrifos 160-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 22085162-1 2011 We used a hypothesis-based weight-of-evidence (HBWoE) approach to analyze the evidence regarding the hypothesis that chlorpyrifos can cause neurodevelopmental effects below the threshold for inhibition of acetylcholinesterase activity in the nervous system, which is an established mode of action for chlorpyrifos neurotoxicity. Chlorpyrifos 117-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-225 21922192-1 2012 Chlorpyrifos (CPF), an organophosphate pesticide inhibits acetylcholinesterase (AChE) and causes neuromuscular incoordination among children and elderly. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 21922192-1 2012 Chlorpyrifos (CPF), an organophosphate pesticide inhibits acetylcholinesterase (AChE) and causes neuromuscular incoordination among children and elderly. Chlorpyrifos 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 21514354-6 2011 PBPK/PD model simulations estimated that a 4-fold increase or decrease in relative CYP2B6 and CYP2C19 content would produce a 9-22% inhibition in blood AChE activity following exposure of an adult to chlorpyrifos (1000 mug/kg). Chlorpyrifos 200-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 21377346-0 2011 A novel, sensitive, reusable and low potential acetylcholinesterase biosensor for chlorpyrifos based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotubes gel. Chlorpyrifos 82-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 21354413-5 2011 The determination of the inhibition kinetics of pyridostigmine, malaoxon and chlorpyrifos oxon with hAChE in the presence of 5mM DEET resulted in a moderate reduction of the inhibition rate constant k(i). Chlorpyrifos 77-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-105 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 203-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 217-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 368-371 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Chlorpyrifos 34-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-251 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Chlorpyrifos 34-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-257 18076960-0 2008 Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 16838488-0 2006 [Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos]. Chlorpyrifos 201-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 18371683-0 2008 An optical fiber biosensor for chlorpyrifos using a single sol-gel film containing acetylcholinesterase and bromothymol blue. Chlorpyrifos 31-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 18371683-1 2008 An optical fiber biosensor consisting of acetylcholinesterase (AChE) and bromothymol blue (BTB) doped sol-gel film was employed to detect organophosphate pesticide chlorpyrifos. Chlorpyrifos 164-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 18371683-1 2008 An optical fiber biosensor consisting of acetylcholinesterase (AChE) and bromothymol blue (BTB) doped sol-gel film was employed to detect organophosphate pesticide chlorpyrifos. Chlorpyrifos 164-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 18371683-9 2008 A linear calibration curve of chlorpyrifos against the percentage inhibition of AChE was obtained from 0.05 to 2.0mg/L of chlorpyrifos (18-80% inhibition, R(2)=0.9869, n=6). Chlorpyrifos 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 18371683-9 2008 A linear calibration curve of chlorpyrifos against the percentage inhibition of AChE was obtained from 0.05 to 2.0mg/L of chlorpyrifos (18-80% inhibition, R(2)=0.9869, n=6). Chlorpyrifos 122-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 18254274-0 2007 Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX). Chlorpyrifos 162-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. Chlorpyrifos 165-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. Chlorpyrifos 165-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 16838488-6 2006 On the other hand, the known reactivators surpass new substances in the case of chlorpyrifos-inhibited AChE at both concentrations. Chlorpyrifos 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 20021020-2 2006 The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitors of AChE. Chlorpyrifos 94-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 16288867-2 2006 Their potency to reactivate AChE inhibited by insecticide chlorpyrifos was tested in vitro. Chlorpyrifos 58-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 20021020-5 2006 The IC50 values for RBC-AChE were 0.12 muM, 0.25 muM, 0.35 muM, and 4.0 muM for chlorpyrifos, monocrotophos, profenofos, and acephate, respectively. Chlorpyrifos 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 20021020-6 2006 Chlorpyrifos was found to be a more potent inhibitor of AChE followed by the rest of the pesticides used in this study. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 16243090-9 2005 Acetylcholinesterase inhibited by fenthion or dimethoate responded poorly to pralidoxime treatment compared with chlorpyrifos-inhibited acetylcholinesterase. Chlorpyrifos 113-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 15018574-9 2004 The application of the method to infant food in combination with a disposable AChE biosensor enabled detection of chlorpyrifos and parathion at concentrations down to 20 microg/kg within an overall assay time of 95 min. Chlorpyrifos 114-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 16335048-2 2005 Their potency to reactivate AChE inhibited by insecticide chlorpyrifos was tested in vitro. Chlorpyrifos 58-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 11690566-4 2001 The protoxicants chlorpyrifos and parathion produced acetylcholinesterase inhibition after multiple exposures although no inhibition was seen following a single exposure to these agents. Chlorpyrifos 17-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73