PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29565831-4 2018 Insulin resistance resulting from a high saturated fat diet leads to alterations in lipid cellular intake and accumulation which generate lipotoxic conditions, a key phenomenon in the metabolism of beta-cells. saturated fat 41-54 insulin Homo sapiens 0-7 31675670-1 2019 BACKGROUND: Hepatic insulin resistance can be induced by excess dietary intake of saturated fat. saturated fat 82-95 insulin Homo sapiens 20-27 29495910-7 2018 When young adults consumed a good quality diet (appropriate carbohydrate intakes; high fiber, low saturated fat but protein rich diet), their insulin resistance was decreased. saturated fat 98-111 insulin Homo sapiens 142-149 29193779-1 2018 OBJECTIVE: Diets high in saturated fat induce obesity and insulin resistance and impair insulin access to skeletal muscle, leading to reduced insulin levels at the muscle cell surface available to bind insulin receptors and induce glucose uptake. saturated fat 25-38 insulin Homo sapiens 58-65 29288757-2 2018 When an abundance of glucose and saturated fat enter the cell, impaired blood flow, hypoxia, inflammation and macrophage infiltration in obese adipose tissue may induce oxidative stress and insulin resistance. saturated fat 33-46 insulin Homo sapiens 190-197 29193779-1 2018 OBJECTIVE: Diets high in saturated fat induce obesity and insulin resistance and impair insulin access to skeletal muscle, leading to reduced insulin levels at the muscle cell surface available to bind insulin receptors and induce glucose uptake. saturated fat 25-38 insulin Homo sapiens 88-95 29193779-1 2018 OBJECTIVE: Diets high in saturated fat induce obesity and insulin resistance and impair insulin access to skeletal muscle, leading to reduced insulin levels at the muscle cell surface available to bind insulin receptors and induce glucose uptake. saturated fat 25-38 insulin Homo sapiens 88-95 21193293-2 2012 We aimed to investigate a previously demonstrated saturated fat and carbohydrate interaction for insulin resistance for perilipin (PLIN1), a regulator of adipocyte metabolism. saturated fat 50-63 insulin Homo sapiens 97-104 21193293-4 2012 In multivariable linear regression models, we found an interaction (P < 0.05) between the ratio of saturated fat to carbohydrate intake as a continuous variable and PLIN1 11482G > A for HOMA-IR (homeostasis model assessment of insulin resistance) in women. saturated fat 102-115 insulin Homo sapiens 233-240 21193293-6 2012 By dichotomizing the ratio of saturated fat to carbohydrate intake into high and low, we found significant interaction terms for insulin and HOMA-IR (P < 0.05). saturated fat 30-43 insulin Homo sapiens 129-148 21193293-7 2012 When the ratio of saturated fat to carbohydrate was high, insulin and HOMA-IR were higher in minor allele carriers (P = 0.004 and P = 0.003, respectively), but did not differ when the ratio was low. saturated fat 18-31 insulin Homo sapiens 58-65 21876873-3 2011 Saturated fat intake can also impair insulin sensitivity compared to omega-3 fat, which has the opposite effect due to alterations in cell membranes. saturated fat 0-13 insulin Homo sapiens 37-44 19968905-4 2010 Fat type is also a factor, with evidence suggesting that saturated fat intake is linked to insulin resistance. saturated fat 57-70 insulin Homo sapiens 91-98 16280425-2 2005 OBJECTIVE: Our aim was to determine the effect of adiposity and insulin resistance on the lipoprotein response to diets lower in total and saturated fat than the average American diet (AAD). saturated fat 139-152 insulin Homo sapiens 64-71 20217495-1 2010 High saturated fat intake contributes to insulin resistance, beta-cell failure, and type 2 diabetes. saturated fat 5-18 insulin Homo sapiens 41-48 19932865-7 2009 Among women with insulin concentrations at or greater than the median, we found a statistically significant positive association between intake of saturated fat and ghrelin concentrations, as well as additional statistically significant associations between leptin concentrations and macronutrients not observed among the total cohort. saturated fat 147-160 insulin Homo sapiens 17-24 19083105-6 2009 Fasting insulin and/or glucose were positively associated with body mass index (BMI), height, and dietary total and saturated fat and inversely associated with serum high-density lipoprotein cholesterol (HDL) and dietary available carbohydrates, sucrose, and alcohol. saturated fat 116-129 insulin Homo sapiens 8-15 18092442-4 2007 Specific dietary changes that are appropriate for addressing different aspects of the syndrome include reducing saturated fat intake to lower insulin resistance, reducing sodium intake to lower blood pressure, and reducing high-glycemic-index carbohydrate intake to lower triglyceride levels. saturated fat 112-125 insulin Homo sapiens 142-149 17179917-6 2007 There is an increase in dietary fat intake, particularly saturated fat, in both the developing and Westernized world, which predisposes individuals to become obese and to potentially develop insulin resistance, beta-cell dysfunction and Type 2 diabetes. saturated fat 57-70 insulin Homo sapiens 191-198 15297079-6 2004 Epidemiological evidence and intervention studies clearly show that in humans saturated fat significantly worsen insulin-resistance, while monounsaturated and polyunsaturated fatty acids improve it through modifications in the composition of cell membranes which reflect at least in part dietary fat composition. saturated fat 78-91 insulin Homo sapiens 113-120 15222652-7 2004 Specific dietary changes that are appropriate for addressing different aspects of the syndrome include reducing saturated fat intake to lower insulin resistance, reducing sodium intake to lower blood pressure, and reducing high-glycemic-index carbohydrate intake to lower triglyceride levels. saturated fat 112-125 insulin Homo sapiens 142-149 12933670-2 2003 Substitution of long-chain omega-3 fatty acids for a small percentage of dietary saturated fat prevents insulin resistance in response to high-saturated fat feeding. saturated fat 143-156 insulin Homo sapiens 104-111 11914742-0 2002 Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity. saturated fat 21-34 insulin Homo sapiens 108-115 12933670-2 2003 Substitution of long-chain omega-3 fatty acids for a small percentage of dietary saturated fat prevents insulin resistance in response to high-saturated fat feeding. saturated fat 81-94 insulin Homo sapiens 104-111 12145222-1 2002 OBJECTIVE: Diets high in total and saturated fat are associated with insulin resistance. saturated fat 35-48 insulin Homo sapiens 69-76 12079860-2 2002 In these studies, saturated fat significantly increased insulin resistance, long- and short-chain omega(3) fatty acids significantly improved it, whereas the effects of monounsaturated and omega(6) polyunsaturated fatty acids ranged somewhere in between the two. saturated fat 18-31 insulin Homo sapiens 56-63 11928538-6 2002 In the presence of an insulin-resistance genotype and a westernization of the environment (carbohydrate-rich diet, an increase in saturated fat, low fibre and sedentary lifestyle), a genotype with a high cytokine response will contribute to a worsening of the resistance to insulin and, finally, to type 2 diabetes mellitus and atherosclerosis. saturated fat 130-143 insulin Homo sapiens 274-281 10856515-6 2000 Saturated fat, relative to monounsaturated and polyunsaturated fat, appears to be more deleterious with respect to fat-induced insulin insensitivity. saturated fat 0-13 insulin Homo sapiens 127-134 10421228-1 1999 Epidemiological and experimental studies suggest that a diet rich in saturated fat affects insulin sensitivity. saturated fat 69-82 insulin Homo sapiens 91-98 10889805-5 2000 In this respect, the specific effects of the quality of dietary fat are of great interest, given the considerable evidence in experimental animals that saturated fat in the diet may lead to insulin resistance. saturated fat 152-165 insulin Homo sapiens 190-197 9353601-8 1997 CONCLUSIONS: When the relationship between saturated fat intake and insulin resistance is considered, the possibility exists that dietary modification of fat intake before and during pregnancy may reduce the recurrence rate of GDM. saturated fat 43-56 insulin Homo sapiens 68-75 9701199-8 1998 In summary, our results suggest that the mutation in the apo C-III gene affects insulin response to an OGTT, which could result in reduced sensitivity to insulin, especially when persons consume diets rich in saturated fat. saturated fat 209-222 insulin Homo sapiens 80-87 9701199-8 1998 In summary, our results suggest that the mutation in the apo C-III gene affects insulin response to an OGTT, which could result in reduced sensitivity to insulin, especially when persons consume diets rich in saturated fat. saturated fat 209-222 insulin Homo sapiens 154-161 9591742-1 1998 Results in epidemiological and experimental studies suggest that a diet rich in saturated fat may affect insulin sensitivity. saturated fat 80-93 insulin Homo sapiens 105-112 9021429-1 1997 Saturated fat intake appears to be a risk factor of insulin resistance which is important in the pathogenesis of diabetes and cardiovascular disease. saturated fat 0-13 insulin Homo sapiens 52-59 8739075-3 1996 Excess weight gain linked to high dietary intake of saturated fat is thought to be a major cause of insulin resistance. saturated fat 52-65 insulin Homo sapiens 100-107 7501204-6 1995 Fasting serum insulin correlated with saturated fat intake in female cadets, indicating another health risk factor affected by intakes. saturated fat 38-51 insulin Homo sapiens 14-21 8299435-10 1993 Higher intakes of saturated fat, oleic acid, and linoleic acid were each positively related to higher fasting insulin values. saturated fat 18-31 insulin Homo sapiens 110-117 8299435-12 1993 Only saturated fat intake was significantly associated with 2-h postglucose load insulin level before (P = 0.004) but not after adjustment for obesity. saturated fat 5-18 insulin Homo sapiens 81-88 24394420-5 1995 Both physical inactivity and an energy-dense diet high in saturated fat and fibre-depleted carbohydrate have been shown to increase insulin resistance. saturated fat 58-71 insulin Homo sapiens 132-139 7749056-7 1995 Specifically, obesity--particularly central obesity, physical inactivity, and possibly a low dietary polyunsaturated fat to saturated fat ratio--are major determinants of insulin resistance and hyperinsulinemia, and appear related to colon cancer risk. saturated fat 107-120 insulin Homo sapiens 171-178