PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8595642-7 1995 Gemfibrozil was significantly more effective than lovastatin in raising total HDL and HDL3 levels and in lowering the IDL plus VLDL:HDL ratio. Gemfibrozil 0-11 HDL3 Homo sapiens 86-90 7595182-6 1995 RESULTS: Gemfibrozil increased the concentration of HDL cholesterol (+11.1%) because of the rise of HDL3 cholesterol (34.5%, P < 0.01). Gemfibrozil 9-20 HDL3 Homo sapiens 100-104 7595182-11 1995 CONCLUSION: The gemfibrozil-induced elevation of HDL3 and apoA-II may reflect the combined action of LPL, HL and CETP on plasma HDL metabolism. Gemfibrozil 16-27 HDL3 Homo sapiens 49-53 8595642-5 1995 Gemfibrozil significantly decreased triglyceride, very-low-density lipoprotein (VLDL), and intermediate-density lipoprotein (IDL) levels, the total cholesterol:HDL ratio, and the IDL plus VLDL;HDL ratio, and significantly increased levels of HDL, HDL2, and HDL3. Gemfibrozil 0-11 HDL3 Homo sapiens 257-261 8222487-5 1993 These differences may have a physiologic background because the main effect of gemfibrozil is in the stable HDL3 subfraction, rather than in the variable HDL2. Gemfibrozil 79-90 HDL3 Homo sapiens 108-112 7755644-9 1995 Furthermore, gemfibrozil increased HDL cholesterol (P < 0.05) and normalised the elevated HDL2 and HDL3 TG content. Gemfibrozil 13-24 HDL3 Homo sapiens 102-106 8257455-6 1993 Gemfibrozil increased the concentration of HDL cholesterol (P < 0.01), which was due to the rise of HDL3 cholesterol (+16%), while in the placebo group these values remained unchanged. Gemfibrozil 0-11 HDL3 Homo sapiens 103-107 8257455-14 1993 The gemfibrozil-induced elevation of HDL3 and dense HDL subpopulations may reflect the concerted action of LPL, HL and CETP on plasma HDL metabolism. Gemfibrozil 4-15 HDL3 Homo sapiens 37-41 1397665-2 1992 After oral treatment with 450 mg gemfibrozil twice daily for 28 days, triglyceride concentrations were reduced in serum, chylomicrons, VLDL and low-density lipoprotein, and total cholesterol concentrations were reduced in serum, chylomicrons and VLDL, and increased in HDL2 plus HDL3. Gemfibrozil 33-44 HDL3 Homo sapiens 279-283 1613316-3 1992 Gemfibrozil and lovastatin caused primarily similar alterations in HDL components in HDL2 and HDL3 subfractions. Gemfibrozil 0-11 HDL3 Homo sapiens 94-98 1613316-6 1992 Gemfibrozil increased the cholesterol concentrations of HDL2 and HDL3 (p less than 0.05 for both), and lovastatin caused significant increases in HDL2 (p less than 0.05) and HDL3 phospholipids (p less than 0.01). Gemfibrozil 0-11 HDL3 Homo sapiens 65-69 1397665-4 1992 It is concluded that gemfibrozil is effective in lowering triglycerides and cholesterol, particularly in triglyceride-rich particles, and raising the cholesterol content of HDL2 plus HDL3. Gemfibrozil 21-32 HDL3 Homo sapiens 183-187 2073911-6 1990 Ultracentrifuge analysis in a subsample of the cohort revealed that gemfibrozil raised the level of HDL3-cholesterol but had little effect on HDL2-cholesterol. Gemfibrozil 68-79 HDL3 Homo sapiens 100-104 2407250-6 1990 Gemfibrozil increased the level of HDL-cholesterol with the main effect on HDL3-subfraction. Gemfibrozil 0-11 HDL3 Homo sapiens 75-79 2504855-8 1989 Gemfibrozil, in contrast, increased HDL3 cholesterol level by 9% because of an enrichment of HDL3 particles in both free cholesterol and cholesteryl esters and lowered the flotation rate of HDL3 (p less than 0.05). Gemfibrozil 0-11 HDL3 Homo sapiens 36-40 2504855-8 1989 Gemfibrozil, in contrast, increased HDL3 cholesterol level by 9% because of an enrichment of HDL3 particles in both free cholesterol and cholesteryl esters and lowered the flotation rate of HDL3 (p less than 0.05). Gemfibrozil 0-11 HDL3 Homo sapiens 93-97 2504855-8 1989 Gemfibrozil, in contrast, increased HDL3 cholesterol level by 9% because of an enrichment of HDL3 particles in both free cholesterol and cholesteryl esters and lowered the flotation rate of HDL3 (p less than 0.05). Gemfibrozil 0-11 HDL3 Homo sapiens 93-97