PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16794187-4	2006	Consistent with the cell-cycle effects, at a molecular level (Western blots), 2-ME inhibited cyclin D(1) and cyclin B(1) expression; cyclin-dependent kinase (cdk)-1 and cdk-2 activity; and retinoblastoma protein (pRb), extracellular signal-regulated kinase (ERK) 1/2, and Akt phosphorylation.	2-Methoxyestradiol	78-82	cyclin dependent kinase 1	Homo sapiens	133-164	
30797877-0	2019	Upregulated cyclin B1/CDK1 mediates apoptosis following 2-methoxyestradiol-induced mitotic catastrophe: Role of Bcl-XL phosphorylation.	2-Methoxyestradiol	56-74	cyclin dependent kinase 1	Homo sapiens	22-26	
30797877-2	2019	Earlier we showed that 2-methoxyestradiol increases the level and activity of cyclin B1/CDK1, which subsequently induces mitotic prometaphase arrest.	2-Methoxyestradiol	23-41	cyclin dependent kinase 1	Homo sapiens	88-92	
30797877-3	2019	In the present study, we demonstrate that upregulation of cyclin B1/CDK1 is responsible for the increased phosphorylation of the anti-apoptotic proteins Bcl-2 and Bcl-XL in 2-methoxyestradiol-induced, mitotically-arrested cancer cells.	2-Methoxyestradiol	173-191	cyclin dependent kinase 1	Homo sapiens	68-72	
30797877-7	2019	Together, these results indicate that cyclin B1/CDK1 upregulation in cancer cells undergoing 2-methoxyestradiol-induced mitotic catastrophe causes apoptosis via Bcl-XL phosphorylation.	2-Methoxyestradiol	93-111	cyclin dependent kinase 1	Homo sapiens	48-52	
25732194-4	2015	Concomitant treatment of JT/Neo cells with 2-MeO-E2 and the G1/S blocking agent aphidicolin resulted in G1/S arrest and abrogation of all apoptotic events, including Cdk1 activation, phosphorylation of Bcl-2, Mcl-1 and Bim, and ROS accumulation.	2-Methoxyestradiol	43-51	cyclin dependent kinase 1	Homo sapiens	166-170	
25732194-5	2015	The 2-MeO-E2-induced phosphorylation of Bcl-2 family proteins and mitochondrial apoptotic events were suppressed by a Cdk1 inhibitor, but not by an Aurora A kinase (AURKA), Aurora B kinase (AURKB), JNK, or p38 MAPK inhibitor.	2-Methoxyestradiol	4-12	cyclin dependent kinase 1	Homo sapiens	118-122	
25732194-8	2015	These results demonstrate that the apoptogenic effect of 2-MeO-E2 (0.5-1.0 muM) was attributable to mitotic spindle defect-mediated prometaphase arrest, Cdk1 activation, phosphorylation of Bcl-2, Mcl-1, and Bim, and activation of Bak and mitochondria-dependent caspase cascade.	2-Methoxyestradiol	57-65	cyclin dependent kinase 1	Homo sapiens	153-157	
22580043-0	2012	Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol.	2-Methoxyestradiol	136-154	cyclin dependent kinase 1	Homo sapiens	27-31	
17410604-0	2007	In vitro effects of 2-methoxyestradiol on cell morphology and Cdc2 kinase activity in SNO oesophageal carcinoma cells.	2-Methoxyestradiol	20-38	cyclin dependent kinase 1	Homo sapiens	62-66	
12690294-7	2003	Western blot analysis of the G(2)/M regulatory proteins suggests that cdc2 is involved in the cell cycle block by Myt1 phosphorylation following 2-ME treatment.	2-Methoxyestradiol	145-149	cyclin dependent kinase 1	Homo sapiens	70-74	
9018099-3	1996	We investigated the effects of 2-hydroxy-17beta-estradiol, a cell proliferator, and 2-methoxy-17beta-estradiol, a potent inhibitor of cell growth, on the levels and activity of p34(cdc2) and on the levels of PCNA, as well as on protein phosphorylation in MCF-7 cells.	2-Methoxyestradiol	84-110	cyclin dependent kinase 1	Homo sapiens	181-185	
9018099-5	1996	2-Methoxyestradiol caused unscheduled activation of p34(cdc2) in S-phase and decreased levels of p34(cdc2) and PCNA during G2/M.	2-Methoxyestradiol	0-18	cyclin dependent kinase 1	Homo sapiens	56-60	
9018099-5	1996	2-Methoxyestradiol caused unscheduled activation of p34(cdc2) in S-phase and decreased levels of p34(cdc2) and PCNA during G2/M.	2-Methoxyestradiol	0-18	cyclin dependent kinase 1	Homo sapiens	101-105	
11479920-6	2001	We also found an accumulation of phosphorylated cdc2 after 2-ME treatment.	2-Methoxyestradiol	59-63	cyclin dependent kinase 1	Homo sapiens	48-52	
10493943-0	1999	2-methoxyestradiol-induced growth suppression and lethality in estrogen-responsive MCF-7 cells may be mediated by down regulation of p34cdc2 and cyclin B1 expression.	2-Methoxyestradiol	0-18	cyclin dependent kinase 1	Homo sapiens	133-140	
10493943-9	1999	Further, anti-estrogenic effects of 2-ME in these cells can be accounted for by its activation of apoptotic functions, which are correlated with reductions in expression of p34cdc2 and cyclin B1 genes.	2-Methoxyestradiol	36-40	cyclin dependent kinase 1	Homo sapiens	173-180