PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22429849-0	2012	Regulation of interferon pathway in 2-methoxyestradiol-treated osteosarcoma cells.	2-Methoxyestradiol	36-54	interferon alpha 1	Homo sapiens	14-24	
22429849-5	2012	In this report, we have investigated whether interferon (IFN) pathway is involved in 2-ME-induced anti-tumor effects in osteosarcoma cells.	2-Methoxyestradiol	85-89	interferon alpha 1	Homo sapiens	45-55	
22429849-5	2012	In this report, we have investigated whether interferon (IFN) pathway is involved in 2-ME-induced anti-tumor effects in osteosarcoma cells.	2-Methoxyestradiol	85-89	interferon alpha 1	Homo sapiens	57-60	
22429849-7	2012	Transient transfections followed by reporter assays were used for investigating 2-ME effects on IFN-pathway.	2-Methoxyestradiol	80-84	interferon alpha 1	Homo sapiens	96-99	
22429849-9	2012	RESULTS: 2-ME regulates IFN and IFN-mediated effects in osteosarcoma cells.	2-Methoxyestradiol	9-13	interferon alpha 1	Homo sapiens	24-27	
22429849-9	2012	RESULTS: 2-ME regulates IFN and IFN-mediated effects in osteosarcoma cells.	2-Methoxyestradiol	9-13	interferon alpha 1	Homo sapiens	32-35	
22429849-11	2012	2-ME treatment induced IFN-stimulated response element (ISRE) sequence-dependent transcription and gamma-activated sequence (GAS)-dependent transcription in several osteosarcoma cells.	2-Methoxyestradiol	0-4	interferon alpha 1	Homo sapiens	23-26	
22429849-15	2012	CONCLUSIONS: 2-ME treatment triggers the induction and activity of IFN and IFN pathway genes in 2-ME-sensitive osteosarcoma tumor cells but not in 2-ME-resistant normal osteoblasts.	2-Methoxyestradiol	13-17	interferon alpha 1	Homo sapiens	67-70	
22429849-15	2012	CONCLUSIONS: 2-ME treatment triggers the induction and activity of IFN and IFN pathway genes in 2-ME-sensitive osteosarcoma tumor cells but not in 2-ME-resistant normal osteoblasts.	2-Methoxyestradiol	13-17	interferon alpha 1	Homo sapiens	75-78	
22429849-15	2012	CONCLUSIONS: 2-ME treatment triggers the induction and activity of IFN and IFN pathway genes in 2-ME-sensitive osteosarcoma tumor cells but not in 2-ME-resistant normal osteoblasts.	2-Methoxyestradiol	96-100	interferon alpha 1	Homo sapiens	67-70	
22429849-15	2012	CONCLUSIONS: 2-ME treatment triggers the induction and activity of IFN and IFN pathway genes in 2-ME-sensitive osteosarcoma tumor cells but not in 2-ME-resistant normal osteoblasts.	2-Methoxyestradiol	96-100	interferon alpha 1	Homo sapiens	75-78	
22429849-15	2012	CONCLUSIONS: 2-ME treatment triggers the induction and activity of IFN and IFN pathway genes in 2-ME-sensitive osteosarcoma tumor cells but not in 2-ME-resistant normal osteoblasts.	2-Methoxyestradiol	96-100	interferon alpha 1	Homo sapiens	67-70	
22429849-15	2012	CONCLUSIONS: 2-ME treatment triggers the induction and activity of IFN and IFN pathway genes in 2-ME-sensitive osteosarcoma tumor cells but not in 2-ME-resistant normal osteoblasts.	2-Methoxyestradiol	96-100	interferon alpha 1	Homo sapiens	75-78	
22429849-17	2012	Thus, IFN pathways play a role in osteosarcoma and in 2-ME-mediated anti-proliferative effects, and therefore targeted induction of IFN signaling could lead to effective treatment strategies in the control of osteosarcoma.	2-Methoxyestradiol	54-58	interferon alpha 1	Homo sapiens	6-9