PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21304959-4 2011 Catechol-O-methyltransferase (Comt)-deficient pregnant mice have a preeclampsia phenotype that is reversed by exogenous 2-methoxyestradiol (2-ME), an estrogen metabolite generated by COMT. 2-Methoxyestradiol 120-138 catechol-O-methyltransferase Homo sapiens 183-187 21304959-4 2011 Catechol-O-methyltransferase (Comt)-deficient pregnant mice have a preeclampsia phenotype that is reversed by exogenous 2-methoxyestradiol (2-ME), an estrogen metabolite generated by COMT. 2-Methoxyestradiol 140-144 catechol-O-methyltransferase Homo sapiens 183-187 15377160-5 2004 COMT generated two products, 2-methoxyestradiol and 2-hydroxy-3-methoxyestradiol, from 2-OHE(2) but only one product, 4-methoxyestradiol, from 4-OHE(2). 2-Methoxyestradiol 29-47 catechol-O-methyltransferase Homo sapiens 0-4 20606002-2 2010 Recent animal studies showed that placental COMT is involved in the development of placentas and embryos, probably via the formation of 2-methoxyestradiol. 2-Methoxyestradiol 136-154 catechol-O-methyltransferase Homo sapiens 44-48 18469803-7 2008 2-ME ameliorates all pre-eclampsia-like features without toxicity in the Comt(-/-) pregnant mice and suppresses placental hypoxia, hypoxia-inducible factor-1alpha expression and sFLT-1 elevation. 2-Methoxyestradiol 0-4 catechol-O-methyltransferase Homo sapiens 73-77 19809499-2 2009 2-Methoxyestradiol (2ME) is an endogenous estrogen metabolite formed by sequential action of CYP450s and catechol-O-methyltransferase (COMT). 2-Methoxyestradiol 0-18 catechol-O-methyltransferase Homo sapiens 105-133 19809499-2 2009 2-Methoxyestradiol (2ME) is an endogenous estrogen metabolite formed by sequential action of CYP450s and catechol-O-methyltransferase (COMT). 2-Methoxyestradiol 0-18 catechol-O-methyltransferase Homo sapiens 135-139 19809499-2 2009 2-Methoxyestradiol (2ME) is an endogenous estrogen metabolite formed by sequential action of CYP450s and catechol-O-methyltransferase (COMT). 2-Methoxyestradiol 20-23 catechol-O-methyltransferase Homo sapiens 105-133 19809499-2 2009 2-Methoxyestradiol (2ME) is an endogenous estrogen metabolite formed by sequential action of CYP450s and catechol-O-methyltransferase (COMT). 2-Methoxyestradiol 20-23 catechol-O-methyltransferase Homo sapiens 135-139 15507517-9 2005 OR486 and quercetin (COMT inhibitor) blocked the conversion of 2-hydroxyestradiol to 2-methoxyestradiol in CFs. 2-Methoxyestradiol 85-103 catechol-O-methyltransferase Homo sapiens 21-25 12587805-2 2003 2-Hydroxy catecholestrogens are further metabolized by catechol-O-methyltransferase to 2-methoxyestradiol, which is known to be protective against tumor formation. 2-Methoxyestradiol 87-105 catechol-O-methyltransferase Homo sapiens 55-83 12810639-2 2003 Catechol-O-methyltransferase catalyzes the methylation of catechol estrogens to methoxyestrogens (2-MeOE2, 2-OH-3-MeOE2, and 4-MeOE2), which simultaneously lowers the potential for DNA damage and increases the concentration of 2-MeOE2, an antiproliferative metabolite. 2-Methoxyestradiol 98-105 catechol-O-methyltransferase Homo sapiens 0-28 12810639-2 2003 Catechol-O-methyltransferase catalyzes the methylation of catechol estrogens to methoxyestrogens (2-MeOE2, 2-OH-3-MeOE2, and 4-MeOE2), which simultaneously lowers the potential for DNA damage and increases the concentration of 2-MeOE2, an antiproliferative metabolite. 2-Methoxyestradiol 227-234 catechol-O-methyltransferase Homo sapiens 0-28 26450530-1 2016 OBJECTIVE: To evaluate the association between fetal and maternal catechol-O-methyltransferase (COMT) Val158Met and methyl tetrahydrofolate reductase (MTHFR) C677T functional polymorphisms and preeclampsia, examining its influence on placental COMT and in maternal 2-methoxyestradiol (2-ME) plasma levels. 2-Methoxyestradiol 265-283 catechol-O-methyltransferase Homo sapiens 66-94 11701460-1 2001 Catechol-O-methyltransferase (COMT)-mediated methylation of 2-hydroxyestradiol (endogenous estradiol metabolite) to 2-methoxyestradiol (angiogenesis inhibitor) may be responsible for the antimitogenic effects of 2-hydroxyestradiol on vascular smooth muscle cells (VSMCs). 2-Methoxyestradiol 116-134 catechol-O-methyltransferase Homo sapiens 0-28 11701460-1 2001 Catechol-O-methyltransferase (COMT)-mediated methylation of 2-hydroxyestradiol (endogenous estradiol metabolite) to 2-methoxyestradiol (angiogenesis inhibitor) may be responsible for the antimitogenic effects of 2-hydroxyestradiol on vascular smooth muscle cells (VSMCs). 2-Methoxyestradiol 116-134 catechol-O-methyltransferase Homo sapiens 30-34 11559542-2 2001 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metabolite. 2-Methoxyestradiol 198-216 catechol-O-methyltransferase Homo sapiens 0-28 11559542-2 2001 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metabolite. 2-Methoxyestradiol 198-216 catechol-O-methyltransferase Homo sapiens 30-34 11559542-2 2001 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metabolite. 2-Methoxyestradiol 218-225 catechol-O-methyltransferase Homo sapiens 0-28 11559542-2 2001 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metabolite. 2-Methoxyestradiol 218-225 catechol-O-methyltransferase Homo sapiens 30-34 34163140-6 2021 Both preclinical and clinical studies show the decrease in the 2-methoxyestradiol levels in preeclampsia, which may be due to a decrease in estradiol itself along with a decrease in the enzymatic actions of the COMT enzyme. 2-Methoxyestradiol 63-81 catechol-O-methyltransferase Homo sapiens 211-215 2547112-7 1989 The reduction in the number of HeLa cells with abnormal metaphase configurations after exposure to 2-OHE2 plus quinalizarin (an inhibitor of catechol-O-methyltransferase) indicated that the production of 2-MeOE2 is necessary for the formation of abnormal spindles in metaphase. 2-Methoxyestradiol 204-211 catechol-O-methyltransferase Homo sapiens 141-169 28461606-1 2017 Catechol-O-methyltransferase (COMT) metabolizes 2-hydroxyestradiol into 2-methoxyestradiol (2-ME); COMT deficiency has shown to be associated with hypertension in men and preeclampsia, the disease associated with hypersensitivity of pressor response against angiotensin II (Ang II). 2-Methoxyestradiol 72-90 catechol-O-methyltransferase Homo sapiens 0-28 28461606-1 2017 Catechol-O-methyltransferase (COMT) metabolizes 2-hydroxyestradiol into 2-methoxyestradiol (2-ME); COMT deficiency has shown to be associated with hypertension in men and preeclampsia, the disease associated with hypersensitivity of pressor response against angiotensin II (Ang II). 2-Methoxyestradiol 72-90 catechol-O-methyltransferase Homo sapiens 30-34 28461606-1 2017 Catechol-O-methyltransferase (COMT) metabolizes 2-hydroxyestradiol into 2-methoxyestradiol (2-ME); COMT deficiency has shown to be associated with hypertension in men and preeclampsia, the disease associated with hypersensitivity of pressor response against angiotensin II (Ang II). 2-Methoxyestradiol 92-96 catechol-O-methyltransferase Homo sapiens 0-28 28461606-1 2017 Catechol-O-methyltransferase (COMT) metabolizes 2-hydroxyestradiol into 2-methoxyestradiol (2-ME); COMT deficiency has shown to be associated with hypertension in men and preeclampsia, the disease associated with hypersensitivity of pressor response against angiotensin II (Ang II). 2-Methoxyestradiol 92-96 catechol-O-methyltransferase Homo sapiens 30-34 28511459-4 2017 An estradiol metabolite, called 2-Methoxy Estradiol (2-ME), is produced with the help of Catechol-O-Methyltransferase (COMT). 2-Methoxyestradiol 32-51 catechol-O-methyltransferase Homo sapiens 89-117 28511459-4 2017 An estradiol metabolite, called 2-Methoxy Estradiol (2-ME), is produced with the help of Catechol-O-Methyltransferase (COMT). 2-Methoxyestradiol 32-51 catechol-O-methyltransferase Homo sapiens 119-123 28511459-4 2017 An estradiol metabolite, called 2-Methoxy Estradiol (2-ME), is produced with the help of Catechol-O-Methyltransferase (COMT). 2-Methoxyestradiol 53-57 catechol-O-methyltransferase Homo sapiens 89-117 28511459-4 2017 An estradiol metabolite, called 2-Methoxy Estradiol (2-ME), is produced with the help of Catechol-O-Methyltransferase (COMT). 2-Methoxyestradiol 53-57 catechol-O-methyltransferase Homo sapiens 119-123 28511459-15 2017 A lower 2-ME value may indicate COMT not producing enough 2-ME which in turn may cause the pre-eclampsia. 2-Methoxyestradiol 8-12 catechol-O-methyltransferase Homo sapiens 32-36 26450530-1 2016 OBJECTIVE: To evaluate the association between fetal and maternal catechol-O-methyltransferase (COMT) Val158Met and methyl tetrahydrofolate reductase (MTHFR) C677T functional polymorphisms and preeclampsia, examining its influence on placental COMT and in maternal 2-methoxyestradiol (2-ME) plasma levels. 2-Methoxyestradiol 265-283 catechol-O-methyltransferase Homo sapiens 96-100 26450530-1 2016 OBJECTIVE: To evaluate the association between fetal and maternal catechol-O-methyltransferase (COMT) Val158Met and methyl tetrahydrofolate reductase (MTHFR) C677T functional polymorphisms and preeclampsia, examining its influence on placental COMT and in maternal 2-methoxyestradiol (2-ME) plasma levels. 2-Methoxyestradiol 285-289 catechol-O-methyltransferase Homo sapiens 66-94 26450530-1 2016 OBJECTIVE: To evaluate the association between fetal and maternal catechol-O-methyltransferase (COMT) Val158Met and methyl tetrahydrofolate reductase (MTHFR) C677T functional polymorphisms and preeclampsia, examining its influence on placental COMT and in maternal 2-methoxyestradiol (2-ME) plasma levels. 2-Methoxyestradiol 285-289 catechol-O-methyltransferase Homo sapiens 96-100 26450530-11 2016 Homocysteine levels were higher in women with preeclampsia than in normal pregnancies, and were inversely correlated with 2-ME plasma levels, indicating that its altered metabolism may lower COMT activity in vivo. 2-Methoxyestradiol 122-126 catechol-O-methyltransferase Homo sapiens 191-195 26450530-13 2016 However, the preeclamptic patients had elevated homocysteine levels that correlated inversely with 2-ME, indicating that an altered methionine-homocysteine metabolism may contribute to reduce COMT activity in vivo and explain the decreased levels of 2-ME in preeclamptic women. 2-Methoxyestradiol 99-103 catechol-O-methyltransferase Homo sapiens 192-196 22178088-4 2012 2-Methoxyestradiol (2-ME) is formed by the action of catechol-O-methyltransferase (COMT) on 2-hydroxyestradiol. 2-Methoxyestradiol 0-18 catechol-O-methyltransferase Homo sapiens 53-81 25562165-1 2014 BACKGROUND: 2-methoxyestradiol (2-ME), a natural metabolite of 17beta-estradiol, is synthesized by catechol-O-methyltransferase (COMT). 2-Methoxyestradiol 12-30 catechol-O-methyltransferase Homo sapiens 99-127 25562165-1 2014 BACKGROUND: 2-methoxyestradiol (2-ME), a natural metabolite of 17beta-estradiol, is synthesized by catechol-O-methyltransferase (COMT). 2-Methoxyestradiol 12-30 catechol-O-methyltransferase Homo sapiens 129-133 25562165-1 2014 BACKGROUND: 2-methoxyestradiol (2-ME), a natural metabolite of 17beta-estradiol, is synthesized by catechol-O-methyltransferase (COMT). 2-Methoxyestradiol 32-36 catechol-O-methyltransferase Homo sapiens 99-127 25562165-1 2014 BACKGROUND: 2-methoxyestradiol (2-ME), a natural metabolite of 17beta-estradiol, is synthesized by catechol-O-methyltransferase (COMT). 2-Methoxyestradiol 32-36 catechol-O-methyltransferase Homo sapiens 129-133 23456663-5 2013 2-Methoxyestradiol is generated by catechol-O-methyltransferase, an enzyme involved in the metabolic pathway of estrogens. 2-Methoxyestradiol 0-18 catechol-O-methyltransferase Homo sapiens 35-63 26798414-8 2016 C-cancer is associated with less production of 2-methoxy-estradiol resultant of functional polymorphisms of CYP1A1 and COMT, separately. 2-Methoxyestradiol 47-66 catechol-O-methyltransferase Homo sapiens 119-123 22178088-4 2012 2-Methoxyestradiol (2-ME) is formed by the action of catechol-O-methyltransferase (COMT) on 2-hydroxyestradiol. 2-Methoxyestradiol 0-18 catechol-O-methyltransferase Homo sapiens 83-87 22178088-4 2012 2-Methoxyestradiol (2-ME) is formed by the action of catechol-O-methyltransferase (COMT) on 2-hydroxyestradiol. 2-Methoxyestradiol 20-24 catechol-O-methyltransferase Homo sapiens 53-81 22178088-4 2012 2-Methoxyestradiol (2-ME) is formed by the action of catechol-O-methyltransferase (COMT) on 2-hydroxyestradiol. 2-Methoxyestradiol 20-24 catechol-O-methyltransferase Homo sapiens 83-87 22178088-6 2012 Moreover, 2-ME decreases granulosa cell proliferation and steroidogenesis, raising the possibility that ovarian dysfunction associated with PCOS is due, in part, to increased synthesis of 2-ME resulting from increased COMT activity. 2-Methoxyestradiol 10-14 catechol-O-methyltransferase Homo sapiens 218-222 22178088-6 2012 Moreover, 2-ME decreases granulosa cell proliferation and steroidogenesis, raising the possibility that ovarian dysfunction associated with PCOS is due, in part, to increased synthesis of 2-ME resulting from increased COMT activity. 2-Methoxyestradiol 188-192 catechol-O-methyltransferase Homo sapiens 218-222 21531374-2 2011 2-Methoxyoestradiol, a metabolite of COMT, increases human trophoblast invasiveness in vitro under hypoxic conditions, providing further support that decreased COMT expression may have a role in preeclampsia. 2-Methoxyestradiol 0-19 catechol-O-methyltransferase Homo sapiens 37-41 21531374-2 2011 2-Methoxyoestradiol, a metabolite of COMT, increases human trophoblast invasiveness in vitro under hypoxic conditions, providing further support that decreased COMT expression may have a role in preeclampsia. 2-Methoxyestradiol 0-19 catechol-O-methyltransferase Homo sapiens 160-164