PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34156827-2	2021	We recently demonstrated that human viperin (HsVip) catalyzes the conversion of CTP to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP or ddh-synthase), which acts as a chain terminator for virally encoded RNA-dependent RNA polymerases from several flaviviruses.	Cytidine Triphosphate	80-83	radical S-adenosyl methionine domain containing 2	Homo sapiens	36-43	
34156827-7	2021	Furthermore, we define the unique chemical and physical determinants supporting ddh-synthase activity and nucleotide selectivity, including the crystallographic characterization of a fungal viperin-like enzyme that utilizes UTP as a substrate and a cnidaria viperin-like enzyme that utilizes CTP as a substrate.	Cytidine Triphosphate	292-295	radical S-adenosyl methionine domain containing 2	Homo sapiens	258-265	
31917549-1	2020	Viperin is a radical S-adenosylmethionine (SAM) enzyme that inhibits viral replication by converting cytidine triphosphate (CTP) into 3"-deoxy-3",4"-didehydro-CTP and by additional undefined mechanisms operating through its N- and C-terminal domains.	Cytidine Triphosphate	101-122	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7	
33108121-5	2020	This unique role explains why evolution has led to the early emergence in animals of an antiviral immunity enzyme, viperin, that synthesizes a toxic analogue of CTP.	Cytidine Triphosphate	161-164	radical S-adenosyl methionine domain containing 2	Homo sapiens	115-122	
32603630-4	2020	Most recently, however, viperin was demonstrated to catalyze the conversion of cytidine triphosphate (CTP) to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP), a previously unknown ribonucleotide.	Cytidine Triphosphate	79-100	radical S-adenosyl methionine domain containing 2	Homo sapiens	24-31	
32603630-4	2020	Most recently, however, viperin was demonstrated to catalyze the conversion of cytidine triphosphate (CTP) to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP), a previously unknown ribonucleotide.	Cytidine Triphosphate	102-105	radical S-adenosyl methionine domain containing 2	Homo sapiens	24-31	
32061099-2	2020	Recently, it has been reported that the radical-SAM activity of viperin transforms cytidine triphosphate (CTP) to its analogue 3"-deoxy-3",4"-didehydro-CTP (ddhCTP).	Cytidine Triphosphate	83-104	radical S-adenosyl methionine domain containing 2	Homo sapiens	64-71	
32061099-2	2020	Recently, it has been reported that the radical-SAM activity of viperin transforms cytidine triphosphate (CTP) to its analogue 3"-deoxy-3",4"-didehydro-CTP (ddhCTP).	Cytidine Triphosphate	106-109	radical S-adenosyl methionine domain containing 2	Homo sapiens	64-71	
32061099-2	2020	Recently, it has been reported that the radical-SAM activity of viperin transforms cytidine triphosphate (CTP) to its analogue 3"-deoxy-3",4"-didehydro-CTP (ddhCTP).	Cytidine Triphosphate	152-155	radical S-adenosyl methionine domain containing 2	Homo sapiens	64-71	
32061099-2	2020	Recently, it has been reported that the radical-SAM activity of viperin transforms cytidine triphosphate (CTP) to its analogue 3"-deoxy-3",4"-didehydro-CTP (ddhCTP).	Cytidine Triphosphate	152-155	radical S-adenosyl methionine domain containing 2	Homo sapiens	64-71	
32232843-2	2020	Recently, it was found that RSAD2 catalyses transformation of cytidine triphosphate (CTP) to its analogue 3 -deoxy-3 ,4 -didehydro-CTP (ddhCTP).	Cytidine Triphosphate	62-83	radical S-adenosyl methionine domain containing 2	Homo sapiens	28-33	
32232843-2	2020	Recently, it was found that RSAD2 catalyses transformation of cytidine triphosphate (CTP) to its analogue 3 -deoxy-3 ,4 -didehydro-CTP (ddhCTP).	Cytidine Triphosphate	85-88	radical S-adenosyl methionine domain containing 2	Homo sapiens	28-33	
31917549-1	2020	Viperin is a radical S-adenosylmethionine (SAM) enzyme that inhibits viral replication by converting cytidine triphosphate (CTP) into 3"-deoxy-3",4"-didehydro-CTP and by additional undefined mechanisms operating through its N- and C-terminal domains.	Cytidine Triphosphate	124-127	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7	
31917549-2	2020	Here, we describe crystal structures of viperin bound to a SAM analogue and CTP or uridine triphosphate (UTP) and report kinetic parameters for viperin-catalyzed reactions with CTP or UTP as substrates.	Cytidine Triphosphate	76-79	radical S-adenosyl methionine domain containing 2	Homo sapiens	40-47	
31917549-2	2020	Here, we describe crystal structures of viperin bound to a SAM analogue and CTP or uridine triphosphate (UTP) and report kinetic parameters for viperin-catalyzed reactions with CTP or UTP as substrates.	Cytidine Triphosphate	177-180	radical S-adenosyl methionine domain containing 2	Homo sapiens	40-47	
31917549-2	2020	Here, we describe crystal structures of viperin bound to a SAM analogue and CTP or uridine triphosphate (UTP) and report kinetic parameters for viperin-catalyzed reactions with CTP or UTP as substrates.	Cytidine Triphosphate	177-180	radical S-adenosyl methionine domain containing 2	Homo sapiens	144-151	
31917549-3	2020	Viperin orients the C4" hydrogen atom of CTP and UTP similarly for abstraction by a 5"-deoxyadenosyl radical, but the uracil moiety introduces unfavorable interactions that prevent tight binding of UTP.	Cytidine Triphosphate	41-44	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7	
29925952-4	2018	Here we demonstrate that viperin catalyses the conversion of cytidine triphosphate (CTP) to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP), a previously undescribed biologically relevant molecule, via a SAM-dependent radical mechanism.	Cytidine Triphosphate	61-82	radical S-adenosyl methionine domain containing 2	Homo sapiens	25-32	
30872404-7	2019	We show that IRAK1 and TRAF6 increase viperin activity ~10-fold to efficiently catalyze the radical-mediated dehydration of CTP to ddhCTP.	Cytidine Triphosphate	124-127	radical S-adenosyl methionine domain containing 2	Homo sapiens	38-45	
29925952-4	2018	Here we demonstrate that viperin catalyses the conversion of cytidine triphosphate (CTP) to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP), a previously undescribed biologically relevant molecule, via a SAM-dependent radical mechanism.	Cytidine Triphosphate	84-87	radical S-adenosyl methionine domain containing 2	Homo sapiens	25-32