PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10432484-2 1999 There is now converging evidence from biochemical, electrophysiological, and behavioral studies that the two major classes of psychedelic hallucinogens, the indoleamines (e.g., LSD) and the phenethylamines (e.g., mescaline), have a common site of action as partial agonists at 5-HT2A and other 5-HT2 receptors in the central nervous system. Phenethylamines 190-205 5-hydroxytryptamine receptor 2A Homo sapiens 277-283 31849671-12 2019 Conclusion: As seen with earlier series investigated, the 4-alkyloxy-substituted 2,5-dimethoxyamphetamines and phenethylamines share some trends with the many other phenethylamine pharmacophore containing compounds, such as when increasing the size of the 4-substituent and increasing the lipophilicity, the affinities at the 5-HT2A/C subtype also increase, and only weak 5-HT2A/C subtype selectivities were achieved. Phenethylamines 111-126 5-hydroxytryptamine receptor 2A Homo sapiens 326-332 31849671-12 2019 Conclusion: As seen with earlier series investigated, the 4-alkyloxy-substituted 2,5-dimethoxyamphetamines and phenethylamines share some trends with the many other phenethylamine pharmacophore containing compounds, such as when increasing the size of the 4-substituent and increasing the lipophilicity, the affinities at the 5-HT2A/C subtype also increase, and only weak 5-HT2A/C subtype selectivities were achieved. Phenethylamines 111-126 5-hydroxytryptamine receptor 2A Homo sapiens 372-378 24244317-11 2013 The new ligands, conformational analysis and docking expand the structure-activity relationships of constrained phenethylamines and contributes towards the development of 5-HT2 receptor subtype-selective ligands. Phenethylamines 112-127 5-hydroxytryptamine receptor 2A Homo sapiens 171-185