PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11441001-5 2001 Further analysis using RT-PCR and Western blotting showed that c-Myc protein but not its mRNA levels were decreased in response to C(6)-ceramide at 24 h. The effects of ceramide on the c-Myc protein were shown to be due to a reduction in half-life via increased ubiquitination. N-caproylsphingosine 131-144 MYC proto-oncogene, bHLH transcription factor Homo sapiens 63-68 24025258-3 2013 We have investigated the effect of the small chain C6-ceramide, known to be a bioactive tumor suppressor lipid, on I2PP2A function, thereby affecting c-Myc signaling and histone acetylation in cells. N-caproylsphingosine 51-62 MYC proto-oncogene, bHLH transcription factor Homo sapiens 150-155 24025258-6 2013 C6-ceramide inhibits I2PP2A"s upregulation of c-Myc and downregulation of histone acetylation in prostate cancer cells. N-caproylsphingosine 0-11 MYC proto-oncogene, bHLH transcription factor Homo sapiens 46-51 17521618-10 2007 C6-ceramide further diminished protein levels of protooncogenes c-myc (p<0.05) and ODC (p<0.01), which is strictly related to the ability of ceramides to inhibit cell growth in a time- and dose-dependent manner. N-caproylsphingosine 0-11 MYC proto-oncogene, bHLH transcription factor Homo sapiens 64-69