PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32746845-0	2020	C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway.	N-caproylsphingosine	0-11	AKT serine/threonine kinase 1	Homo sapiens	103-106	
34207464-0	2021	The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway.	N-caproylsphingosine	63-74	AKT serine/threonine kinase 1	Homo sapiens	178-181	
34207464-8	2021	The enhanced cytotoxicity of the targeted combination was mechanistically supported by the downregulation of PI3K/Akt pathway by C6-ceramide, only among the nucleolin-overexpressing cancer cells presenting a basal p-Akt/total Akt ratio lower than 1.	N-caproylsphingosine	129-140	AKT serine/threonine kinase 1	Homo sapiens	114-117	
34207464-8	2021	The enhanced cytotoxicity of the targeted combination was mechanistically supported by the downregulation of PI3K/Akt pathway by C6-ceramide, only among the nucleolin-overexpressing cancer cells presenting a basal p-Akt/total Akt ratio lower than 1.	N-caproylsphingosine	129-140	AKT serine/threonine kinase 1	Homo sapiens	216-219	
34207464-8	2021	The enhanced cytotoxicity of the targeted combination was mechanistically supported by the downregulation of PI3K/Akt pathway by C6-ceramide, only among the nucleolin-overexpressing cancer cells presenting a basal p-Akt/total Akt ratio lower than 1.	N-caproylsphingosine	129-140	AKT serine/threonine kinase 1	Homo sapiens	226-229	
35104605-6	2022	This effect was supported by the downregulation of the PI3K/Akt pathway enabled by C6-ceramide and in contrast with C18-ceramide.	N-caproylsphingosine	83-94	AKT serine/threonine kinase 1	Homo sapiens	60-63	
21193455-4	2011	METHODS: The growth-arresting and pro-apoptotic properties of nanoliposomal C6-ceramide were first evaluated in vitro in human SK-HEP-1 cells by assessing cellular viability, caspase 3/7 activity, annexin-V expression, DNA fragmentation, cell cycle distribution and AKT phosphorylation.	N-caproylsphingosine	76-87	AKT serine/threonine kinase 1	Homo sapiens	266-269	
21193455-7	2011	RESULTS: Nanoliposomal C6-ceramide, but not ghost (no ceramide) nanoliposomes, induced apoptotic cell death of SK-HEP-1 cells in vitro, concomitant with an accumulation of cells in the G2 phase of the cell cycle and decreased phosphorylation of AKT.	N-caproylsphingosine	23-34	AKT serine/threonine kinase 1	Homo sapiens	245-248