PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11441001-2	2001	C(6)-ceramide (20 microm) caused a significant reduction of telomerase activity at 24 h as detected using the telomeric repeat amplification protocol, and this inhibition correlated with decreased telomerase reverse transcriptase (hTERT) protein.	N-caproylsphingosine	0-13	telomerase reverse transcriptase	Homo sapiens	231-236	
15951564-2	2005	The activity of the N-terminal truncated hTERT promoter, lacking the c-Myc recognition (E-box) region but containing multiple Sp1/Sp3 sites, was also significantly inhibited by C6-ceramide, indicating a role for ceramide in the regulation of Sp1/Sp3 function.	N-caproylsphingosine	177-188	telomerase reverse transcriptase	Homo sapiens	41-46	
15951564-4	2005	Treatment with C6-ceramide inhibited the trans-activation function of overexpressed Sp1, whereas it induced the repressor effects of exogenous Sp3 on the hTERT promoter.	N-caproylsphingosine	15-26	telomerase reverse transcriptase	Homo sapiens	154-159	
15951564-6	2005	In contrast, the promoter DNA-binding activity of Sp3 was slightly increased in response to C6-ceramide, resulting in the increased ratio of Sp3/Sp1 on the hTERT promoter, which was concomitant with the reduced recruitment of RNA polymerase II to the promoter.	N-caproylsphingosine	92-103	telomerase reverse transcriptase	Homo sapiens	156-161	
15951564-8	2005	Mechanistically, the data demonstrated that C6-ceramide reduced the acetylation of Sp3 protein and partially blocked the activation of the hTERT promoter by the histone deacetylase inhibitor trichostatin A.	N-caproylsphingosine	44-55	telomerase reverse transcriptase	Homo sapiens	139-144	
11441001-3	2001	Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and Northern blot analyses showed that C(6)-ceramide significantly decreased hTERT mRNA in a time-dependent manner.	N-caproylsphingosine	114-127	telomerase reverse transcriptase	Homo sapiens	152-157