PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21193455-4	2011	METHODS: The growth-arresting and pro-apoptotic properties of nanoliposomal C6-ceramide were first evaluated in vitro in human SK-HEP-1 cells by assessing cellular viability, caspase 3/7 activity, annexin-V expression, DNA fragmentation, cell cycle distribution and AKT phosphorylation.	N-caproylsphingosine	76-87	caspase 3	Homo sapiens	175-184	
28858294-5	2018	In this study, we showed that C6 ceramide (an exogenous ceramide supplement, 1.25-40 mumol/L) dose-dependently inhibited the proliferation and promoted the apoptosis in human MM OPM2 cell line, which were associated with elevated caspase 3/9 and PARP cleavage.	N-caproylsphingosine	30-41	caspase 3	Homo sapiens	230-241	
21396934-8	2011	Further, whereas C6-ceramide and cyc A imparted 1.5- and 0-fold increases in caspase 3/7 activity, the combination produced a 3.5-fold increase.	N-caproylsphingosine	17-28	caspase 3	Homo sapiens	77-86	
17596294-9	2007	Apoptosis mediated by C(6)-ceramide at 24 h is significantly reduced by caspase-3 inhibition, which supports cross talk between calpain- and caspase-dependent apoptotic pathways.	N-caproylsphingosine	22-35	caspase 3	Homo sapiens	72-81