PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26364275-0 2015 Safety and Preliminary Efficacy of the Acetylcholinesterase Inhibitor Huperzine A as a Treatment for Cocaine Use Disorder. huperzine A 70-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 26364275-2 2015 In particular, acetylcholinesterase inhibitors, like huperzine A, may be effective as treatments for cocaine use disorder. huperzine A 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 25766324-7 2015 Blockage of AChE by huperzine A increased the trophic actions as seen in granulosa cells studies. huperzine A 20-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 25875590-4 2015 By this method, the Michaelis constant (Km) of acetylcholinesterase was determined to be 70.60+-0.93muM and Huperzine A as an effective inhibitor of acetylcholinesterase displayed a mixed inhibition with competitive and noncompetitive inhibition behaviors. huperzine A 108-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 25875590-4 2015 By this method, the Michaelis constant (Km) of acetylcholinesterase was determined to be 70.60+-0.93muM and Huperzine A as an effective inhibitor of acetylcholinesterase displayed a mixed inhibition with competitive and noncompetitive inhibition behaviors. huperzine A 108-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 24872501-0 2014 Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds. huperzine A 83-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 24872501-2 2014 To shed light on this puzzle, the enzyme human acetylcholinesterase in its wild-type form and complexed with the inhibitor huperzine A were investigated by various neutron scattering techniques and molecular dynamics simulations. huperzine A 123-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 24890706-2 2014 Therefore, a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives 6a-j were synthesized and investigated for their ability to inhibit the activity of human AChE (hAChE) in comparison with huperzine-A. huperzine A 196-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-175 24611490-8 2014 Interestingly, huperzine A alone exhibited higher efficiency in its binding to the AChE and retained similar orientation irrespective of the polymorphisms since the orientation of Asp74 involved in its binding and trafficking remained unaltered in all protein forms. huperzine A 15-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 24059299-3 2014 Hydrophobic interactions and hydrogen bonds both play an equally important role in the correct positioning of Huperzine-B within the "catalytic site" of AChE to permit docking. huperzine A 110-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 24059299-1 2014 The present study emphasizes the molecular interactions between human brain acetylcholinesterase (AChE) and the natural ligand Huperzine-B and its comparison to "AChE-Tolserine interactions". huperzine A 127-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 24059299-1 2014 The present study emphasizes the molecular interactions between human brain acetylcholinesterase (AChE) and the natural ligand Huperzine-B and its comparison to "AChE-Tolserine interactions". huperzine A 127-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 24059299-5 2014 Such information may aid in the design of versatile AChE-inhibitors, and is expected to aid in safe clinical use of Huperzine-B. huperzine A 116-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 24059299-6 2014 Scope still remains in the determination of the three-dimensional structure of AChE-Huperzine-B complex by X-ray crystallography to validate the described data. huperzine A 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 23399701-2 2013 Huperzine A (HupA) is a selective inhibitor of acetylcholinesterase (AChE) and has been shown to significantly reduce cognitive impairment in animal models of dementia. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 23399701-2 2013 Huperzine A (HupA) is a selective inhibitor of acetylcholinesterase (AChE) and has been shown to significantly reduce cognitive impairment in animal models of dementia. huperzine A 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 23085120-1 2013 Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor. huperzine A 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 23085120-1 2013 Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor. huperzine A 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 21052939-3 2010 The study of AChE inhibitory activity was carried out using the Ellman colorimetric assay with huperzine-A as the positive control drug. huperzine A 95-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 23440190-5 2013 We applied this method to simulate the binding event of the anti-Alzheimer"s disease drug (-)-Huperzine A to its target acetylcholinesterase (AChE). huperzine A 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 23440190-5 2013 We applied this method to simulate the binding event of the anti-Alzheimer"s disease drug (-)-Huperzine A to its target acetylcholinesterase (AChE). huperzine A 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 23440190-8 2013 The method also provides atomic resolution information for the (-)-Huperzine A binding pathway, which may be useful in designing more potent AChE inhibitors. huperzine A 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 23273608-0 2013 Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. huperzine A 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 23273608-1 2013 Four series of novel heterodimers comprised of donepezil and huperzine A (HupA) fragments were designed, synthesized, and evaluated in search of potent acetylcholinesterase (AChE) inhibitors as potential therapeutic treatment for Alzheimer"s disease. huperzine A 74-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 23273608-1 2013 Four series of novel heterodimers comprised of donepezil and huperzine A (HupA) fragments were designed, synthesized, and evaluated in search of potent acetylcholinesterase (AChE) inhibitors as potential therapeutic treatment for Alzheimer"s disease. huperzine A 74-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 23273608-2 2013 Heterodimers comprised of dimethoxyindanone (from donepezil), hupyridone (from HupA), and connected with a multimethylene linker, were identified as potent and selective inhibitors of AChE. huperzine A 79-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 22932810-6 2012 Under the optimum conditions, using Huperzine-A as model inhibitor, K (i) and IC (50) were 0.551 mumol L(-1) and 1.52 mumol L(-1), respectively, for immobilized AChE. huperzine A 36-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 22941287-1 2012 Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer"s disease (AD). huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 22941287-1 2012 Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer"s disease (AD). huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. huperzine A 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. huperzine A 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 23186408-0 2012 Energy landscapes of human acetylcholinesterase and its Huperzine A-inhibited counterpart. huperzine A 56-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 23186408-8 2012 We report here on investigations of the enzyme human acetylcholinesterase, unliganded and in complex with the noncovalent inhibitor Huperzine A, by incoherent neutron scattering. huperzine A 132-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 21185313-3 2011 Huperzine A is a reversible acetylcholinesterase (AChE) inhibitor, its administration results in regionally specific increases in acetylcholine levels in the brain. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 21185313-3 2011 Huperzine A is a reversible acetylcholinesterase (AChE) inhibitor, its administration results in regionally specific increases in acetylcholine levels in the brain. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 20851778-1 2011 UNLABELLED: Binding energy calculations of huperzine A (HUP A) and galanthamine (GAL) to the binding pocket of the acetylcholinesterase enzyme (AChE) were studied. huperzine A 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-142 20851778-1 2011 UNLABELLED: Binding energy calculations of huperzine A (HUP A) and galanthamine (GAL) to the binding pocket of the acetylcholinesterase enzyme (AChE) were studied. huperzine A 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 20452337-2 2010 Several AChE inhibitors, e.g. rivastigmine, galantamine and huperzine are originating from plants, suggesting that herbs could potentially serve as sources for novel AChE inhibitors. huperzine A 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 20452337-2 2010 Several AChE inhibitors, e.g. rivastigmine, galantamine and huperzine are originating from plants, suggesting that herbs could potentially serve as sources for novel AChE inhibitors. huperzine A 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 20737911-2 2010 Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. huperzine A 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 19726199-0 2009 Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives. huperzine A 82-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 19726199-1 2009 By targeting multi-active sites of acetylcholinesterase (AChE), a series of huperzine A (Hup A) derivatives with various aromatic ring groups were designed and synthesized by Schiff reaction. huperzine A 76-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 19726199-1 2009 By targeting multi-active sites of acetylcholinesterase (AChE), a series of huperzine A (Hup A) derivatives with various aromatic ring groups were designed and synthesized by Schiff reaction. huperzine A 76-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 19622237-1 2009 The green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) was investigated for its enhancement effect of huperzine A on inhibiting acetylcholinesterase (AChE). huperzine A 110-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19110209-6 2009 Over the past decade, our group has developed several series of dimeric acetylcholinesterase (AChE) inhibitors derived from tacrine and huperzine A, a unique anti-Alzheimer"s drug originally discovered from a traditional Chinese medicinal plant. huperzine A 136-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 19221692-0 2009 Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer"s disease: an updated meta-analysis. huperzine A 62-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 18555980-10 2008 Preliminary results with human and animal whole blood suggest that 20 microM ethopropazine and 500 nM (-) huperzine A can be used for measuring AChE and BChE activities across species. huperzine A 102-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 18572153-0 2008 Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase. huperzine A 58-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 18572153-1 2008 As part of a phase Ib clinical trial to determine the tolerability and safety of the highly specific acetylcholinesterase (AChE) inhibitor huperzine A, twelve (12) healthy elderly individuals received an escalating dose regimen of huperzine A (100, 200, 300, and 400 microg doses, twice daily for a week at each dose), with three (3) individuals as controls receiving a placebo. huperzine A 139-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 18572153-8 2008 Eluted blood was diluted in buffer, and aliquots taken at various time intervals for AChE and BChE activity measurement to determine the time taken to achieve full return in activity of the free enzyme (dissociation from the active site of AChE by huperzine A), and thus the proportion of AChE that can be protected from soman exposure. huperzine A 248-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 18572153-8 2008 Eluted blood was diluted in buffer, and aliquots taken at various time intervals for AChE and BChE activity measurement to determine the time taken to achieve full return in activity of the free enzyme (dissociation from the active site of AChE by huperzine A), and thus the proportion of AChE that can be protected from soman exposure. huperzine A 248-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 18572153-9 2008 Huperzine A-inhibited red blood cell (RBC) AChE activity was restored almost to the level that was initially inhibited by the drug. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 18572153-10 2008 The increased doses of huperzine A used were well tolerated by these patients and in this ex vivo study sequestered more red blood cell AChE than has been previously demonstrated for pyridostigmine bromide (PB), indicating the potential improved prophylaxis against organophosphate (OP) poisoning. huperzine A 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 18789720-4 2008 For Huperzine A, the linear mixed inhibition of AChE reflected the presence of competitive and noncompetitive components. huperzine A 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 16862548-3 2006 In this study, we investigated the effects of an acetylcholinesterase inhibitor, huperzine A (Hup A), on APP processing and Abeta generation in human embryonic kidney 293 cells transfected with human APP bearing the Swedish mutation (HEK293 APPsw). huperzine A 81-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 17080497-1 2007 Huperzine A is a potent, reversible acetylcholinesterase inhibitor. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 17056129-3 2006 Huperzine A (HupA), a novel alkaloid isolated from a Chinese herb, has neuroprotective effects that go beyond the inhibition of AChE. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 17056129-3 2006 Huperzine A (HupA), a novel alkaloid isolated from a Chinese herb, has neuroprotective effects that go beyond the inhibition of AChE. huperzine A 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 17657601-3 2008 Huperzine A, a potent and reversible inhibitor of acetylcholinesterase that was initially isolated from a Chinese herb, has been found to improve cognitive deficits in a broad range of animal models and has been used for Alzheimer"s disease treatment in China. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 23480140-3 2008 OBJECTIVE: This article reviews the development of novel classes of high affinity AChE inhibitors following a design strategy based on molecular hybridization by stepwise incorporation of different fragments of the known AChE inhibitors (-)-huperzine A and tacrine. huperzine A 237-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 23480140-3 2008 OBJECTIVE: This article reviews the development of novel classes of high affinity AChE inhibitors following a design strategy based on molecular hybridization by stepwise incorporation of different fragments of the known AChE inhibitors (-)-huperzine A and tacrine. huperzine A 237-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 17945434-2 2007 We investigated the effects of the acetylcholinesterase inhibitor, huperzine A (Hup A), on APP processing and Abeta generation in human neuroblastoma SK-N-SH cells overexpressing wild-type human APP695. huperzine A 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 17097792-0 2007 Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge. huperzine A 63-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 14725492-3 2004 The mechanism of action of huperzine A is suggested to be facilitated through the slow reversible inhibition of acetylcholinesterase. huperzine A 27-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 15956816-8 2005 It is also possible that the non-catalytic function of AChE is involved in neuroprotective effects of HupA. huperzine A 102-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 15006409-0 2004 1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative. huperzine A 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 15006409-1 2004 The binding properties of huperzine A (1) with Torpediniforms Nacline acetylcholinesterase (TnAChE) were investigated by (1)H NMR methods. huperzine A 26-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 15006409-5 2004 The experiments give a possible method to use TnAChE to locate the new huperzine A derivatives as AChE inhibitors. huperzine A 71-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 15544504-4 2004 In this review we will describe the development of dimeric AChE inhibitors, from the early observations of high inhibition potency by bis-quaternary inhibitors, to the structure-based design of dimers based on tacrine, huperzine A, galanthamine, and polyamines. huperzine A 219-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 16256090-18 2005 Huperzine A is a plant-derived reversible and selective AChE inhibitor compared to BChE, and is a more potent inhibitor of AChE than PB. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 16256090-18 2005 Huperzine A is a plant-derived reversible and selective AChE inhibitor compared to BChE, and is a more potent inhibitor of AChE than PB. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 16256090-20 2005 Individuals received an increasing dose regimen of huperzine A (final dose 200 microg after 4 weeks), which produced more than 50% inhibition of RBC-AChE. huperzine A 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 16256090-21 2005 Huperzine A was well tolerated by these patients at doses that sequestered more RBC-AChE than PB, and thus warrants further study as a prophylaxis for OP poisoning in addition to Alzheimer"s therapy. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 12173251-7 2002 In this trial with only four primates, huperzine selectively inhibits red cell AChE activity whereas pyridostigmine also inhibits plasma butyrylcholinesterase (BuChE). huperzine A 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 12956931-5 2003 No change in the cytotoxicity of A beta 25-35 was observed when the increased AChE activities were effectively inhibited by huperzine A throughout the 48-h exposure period. huperzine A 124-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 12701885-4 2003 (-) Huperzine A is an inhibitor of AChE and is being considered for the treatment of Alzheimer"s disease. huperzine A 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 12701885-12 2003 (-) Huperzine A inhibited the aryl acylamidase activities of both AChE and BuChE. huperzine A 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 12701885-14 2003 (+/-) Huperzine A inhibited this function in AChE but stimulated BuChE aryl acylamidase suggesting that the (+) enantiomer is a powerful activator of this enzyme activity. huperzine A 6-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 12369981-0 2001 Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer"s disease. huperzine A 8-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 11755146-1 2001 The effect of huperzine A, a reversible and selective acetylcholinesterase inhibitor, on reserpine- or yohimbine-induced spatial working memory deficits in monkeys has been examined using the delayed response task that depends on the integrity of prefrontal cortex. huperzine A 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 12164543-5 2002 Comparatively, huperzine (HUP) is a reversible AChE inhibitor that crosses the blood-brain barrier. huperzine A 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 11863435-2 2002 It is a synthetic hybrid that contains the 4-aminoquinoline substructure of one anti-Alzheimer drug, tacrine, and a carbobicyclic moiety resembling that of another AChE inhibitor, (-)-huperzine A. huperzine A 180-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 12369981-1 2001 Tacrine-huperzine A hybrids (huprines) are a new class of very potent and selective acetylcholinesterase (AChE) inhibitors. huperzine A 8-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 12369981-1 2001 Tacrine-huperzine A hybrids (huprines) are a new class of very potent and selective acetylcholinesterase (AChE) inhibitors. huperzine A 8-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 11101357-0 2000 New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer"s disease. huperzine A 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 10637365-3 2000 These data are summarised from nearly all therapeutically important chemical classes of reversible AChE inhibitors, e.g., derivatives of physostigmine, tacrine, donepezil and huperzine A. Interactions observed from X-ray crystallography between these inhibitors and AChE have also been incorporated and compared with modelling and QSAR results. huperzine A 175-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 10648652-2 2000 Huperzine A, a natural product used in traditional Chinese herbal medicine, and tacrine (Cognex) are among the potent AChE inhibitors used in this treatment, but the search for more selective inhibitors continues. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 10612585-1 1999 The synthesis of huperzine-E2020 combined compound (3) has been accomplished and the activities of 3 and the intermediates 12 and 13 to inhibit the activity of acetylcholinesterase have been measured. huperzine A 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 10602696-1 1999 The binding of the 9-methyl derivative of tacrine-huperzine A hybrid to Torpedo californica acetylcholinesterase (AChE) has been studied by computational methods. huperzine A 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 10602696-8 1999 Overall, the whole of results supports the validity of the putative binding model to explain the binding of tacrine-huperzine A hybrids to AChE. huperzine A 116-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 9398183-2 1997 The Y337 (F330) in mammalian acetylcholinesterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of ligands such as huperzine A, edrophonium, and acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium. huperzine A 157-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 9918593-1 1999 Our previous studies demonstrated that huperzine A, a reversible and selective acetylcholinesterase inhibitor, exerts beneficial effects on memory deficits in various rodent models of amnesia. huperzine A 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 9871590-1 1998 Based on the recently resolved crystal structure of complex (-)-huperzine A-AChE, we simulated the interaction between (-)-huperzine A analogues and AChE using molecular dynamics method. huperzine A 60-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 9871590-1 1998 Based on the recently resolved crystal structure of complex (-)-huperzine A-AChE, we simulated the interaction between (-)-huperzine A analogues and AChE using molecular dynamics method. huperzine A 60-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 9871590-1 1998 Based on the recently resolved crystal structure of complex (-)-huperzine A-AChE, we simulated the interaction between (-)-huperzine A analogues and AChE using molecular dynamics method. huperzine A 119-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 9871590-1 1998 Based on the recently resolved crystal structure of complex (-)-huperzine A-AChE, we simulated the interaction between (-)-huperzine A analogues and AChE using molecular dynamics method. huperzine A 119-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 9871590-2 1998 It was revealed that the methyl group at the three carbon bridge of (-)-huperzine A can form a weak hydrogen bond with the phenol hydroxyl oxygen of Tyr121 and the main-chain oxygen of Gly118 of AChE, respectively. huperzine A 68-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 10520506-0 1999 [Huperzine a: an acetylcholinesterase inhibitor with high pharmacological potential]. huperzine A 1-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 9742217-1 1998 The role of the functional architecture of the human acetylcholinesterase (HuAChE) active centre in accommodating the non-covalent inhibitors tacrine and huperzine A, or the carbamates pyridostigmine and physostigmine, was analysed using 16 mutants of residues lining the active-centre gorge. huperzine A 154-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 9742217-4 1998 Studies with HuAChE mutants carrying replacements at positions 86, 133 and 337 indicate that the orientations of huperzine A and tacrine in the HuAChE complexes in solution are significantly different from those observed in X-ray structures of the corresponding complexes with Torpedo californica AChE (TcAChE). huperzine A 113-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. huperzine A 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. huperzine A 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. huperzine A 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 9521743-9 1998 Direct measurements with the acylation site ligands huperzine A and m-(N,N, N-trimethylammonio)trifluoroacetophenone showed that bound propidium decreased the association rate constants 49- and 380-fold and the dissociation rate constants 10- and 60-fold, respectively, relative to the rate constants for these acylation site ligands with free AChE, in reasonable agreement with the nonequilibrium steric blockade model. huperzine A 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 344-348 8595207-1 1995 Huperzine A, a novel, potent, reversible, and selective acetylcholinesterase (AChE) inhibitor has been expected to be superior to other AChE inhibitors now for the treatment of memory deficits in patients with Alzheimer"s disease. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 8989325-0 1997 Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. huperzine A 73-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 8595207-1 1995 Huperzine A, a novel, potent, reversible, and selective acetylcholinesterase (AChE) inhibitor has been expected to be superior to other AChE inhibitors now for the treatment of memory deficits in patients with Alzheimer"s disease. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 8595207-1 1995 Huperzine A, a novel, potent, reversible, and selective acetylcholinesterase (AChE) inhibitor has been expected to be superior to other AChE inhibitors now for the treatment of memory deficits in patients with Alzheimer"s disease. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 8145739-0 1994 Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase. huperzine A 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 7738603-1 1994 We have performed docking studies with the SYSDOC program on acetylcholinesterase (AChE) to predict the binding sites in AChE of huperzine A (HA), which is a potent and selective, reversible inhibitor of AChE. huperzine A 129-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 7738603-1 1994 We have performed docking studies with the SYSDOC program on acetylcholinesterase (AChE) to predict the binding sites in AChE of huperzine A (HA), which is a potent and selective, reversible inhibitor of AChE. huperzine A 129-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 7738603-1 1994 We have performed docking studies with the SYSDOC program on acetylcholinesterase (AChE) to predict the binding sites in AChE of huperzine A (HA), which is a potent and selective, reversible inhibitor of AChE. huperzine A 129-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 7738604-1 1994 In the preceding paper we reported on a docking study with the SYSDOC program for predicting the binding sites of huperzine A in acetylcholinesterase (AChE) [Pang, Y.-P. and Kozikowski, A.P., J. Comput.-Aided Mol. huperzine A 114-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 7738604-1 1994 In the preceding paper we reported on a docking study with the SYSDOC program for predicting the binding sites of huperzine A in acetylcholinesterase (AChE) [Pang, Y.-P. and Kozikowski, A.P., J. Comput.-Aided Mol. huperzine A 114-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 1766006-0 1991 Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity. huperzine A 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 28788095-4 2017 Another interesting class of AChE inhibitors represents Huprines, designed by merging two fragments of the known AChE inhibitors-THA and (-)-huperzine A. huperzine A 141-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 34966281-8 2021 Furthermore, huperzine A possessed a binding affinity of -8.7 kcal/mol with AChE and interacted within the active site of AChE via H-bonds and hydrophobic interactions. huperzine A 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 34966281-8 2021 Furthermore, huperzine A possessed a binding affinity of -8.7 kcal/mol with AChE and interacted within the active site of AChE via H-bonds and hydrophobic interactions. huperzine A 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 34363318-0 2021 Structural Fractal Analysis of the Active Site of Acetylcholinesterase in Complexes with Huperzine A, Galantamine, and Donepezil. huperzine A 89-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 34445873-4 2021 Three arylated huperzine A analogues (14, 19, and 30) exhibited stronger anti-AChE activity than HPA. huperzine A 15-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 35630613-3 2022 The achieved success of plant-based natural drugs acting as AChE inhibitors, such as galantamine (GAL) from Galanthus genus and huperzine A from Huperzia serrate (approved drug in China), in the treatment of AD, and the fact that natural compounds (NCs) are considered as safer and less toxic compared to synthetic drugs, led us to screen the available NCs (almost 150,000) in the ZINC12 database for AChE inhibitory activity. huperzine A 128-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 31575200-1 2019 This article reports on a frequency domain analysis of quasielastic neutron scattering spectra from free and Huperzine-A-inhibited human acetylcholinesterase, extending a recent time domain analysis of the same experimental data [M. Saouessi et al., J. Chem. huperzine A 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 30101703-5 2019 Plant derived licensed drugs, Galantamine and Huperzine-A were studied extensively due to their AChE inhibitory action for mild to moderate cases of AD. huperzine A 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 29670172-2 2018 These effects were observed upon experimental blockage of the ACh-degrading enzyme (ACH esterase; ACHE), by Huperzine A. huperzine A 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 27900576-3 2017 Although both galantamine and huperzine shared a similar time course profile for acetylcholinesterase inhibition, huperzine was 88 times more potent than galantamine. huperzine A 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 27900576-4 2017 The dose for 50% acetylcholinesterase inhibition (ID50) was 4.1 ug/kg for huperzine, 362 ug/kg for galantamine, and 30.9 ug/kg for pyridostigmine. huperzine A 74-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 27900576-12 2017 Huperzine may be the more promising centrally active reversible acetylcholinesterase inhibitor due to its greater potency and superior safety profile. huperzine A 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 34156230-3 2021 We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A. huperzine A 257-268 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 33930191-0 2021 Promising tacrine/huperzine A- based dimeric AChE inhibitors for neurodegenerative disorders: from relieving symptoms to modifying diseases through multi-target. huperzine A 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 33327436-10 2020 The drug combination of fangchinoline-huperzine A or donepezil synergistically inhibited AChE, having a combination index (CI) < 1 at Fa = 0.5. huperzine A 38-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 32712274-8 2020 Through several well-known molecules (e.g. huperzine) and new examples (tocopherol, trifluoroacetophenone and a 6-methyluracil alkylammonium derivative), we show that slow-binding inhibitors of acetylcholinesterase are promising drugs for treatment of neurological diseases such as Alzheimer disease and myasthenia gravis. huperzine A 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-214 31847089-1 2019 Alkaloids having acetylcholinesterase (AChE) inhibitory activity are commonly found in traditional Chinese medicine (TCM); for example, berberine from Coptis chinensis, galantamine from Lycoris radiata, and huperzine A from Huperzia serrata. huperzine A 207-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 31847089-1 2019 Alkaloids having acetylcholinesterase (AChE) inhibitory activity are commonly found in traditional Chinese medicine (TCM); for example, berberine from Coptis chinensis, galantamine from Lycoris radiata, and huperzine A from Huperzia serrata. huperzine A 207-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 29058298-1 2017 Huperzine A is a potent, reversible, and blood-brain barrier permeable acetylcholinesterase inhibitor. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 27900576-1 2017 Galantamine hydrobromide and (-)huperzine A, centrally active reversible acetylcholinesterase inhibitors, are potentially superior to the current standard, pyridostigmine bromide, as a pretreatment for organophosphorus chemical warfare nerve agent intoxication. huperzine A 29-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 28788095-4 2017 Another interesting class of AChE inhibitors represents Huprines, designed by merging two fragments of the known AChE inhibitors-THA and (-)-huperzine A. huperzine A 141-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. huperzine A 219-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 28110700-4 2017 On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD. huperzine A 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 28110700-4 2017 On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD. huperzine A 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 28110700-4 2017 On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD. huperzine A 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 28110700-4 2017 On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD. huperzine A 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 27605862-2 2016 Huperzine A (HupA), a Traditional Chinese Medicine derived from a genus of clubmosses known as Huperzineserrata, is a powerful AChE inhibitor that has been used as an adjunctive treatment for MDD, but no meta-analysis on HupA augmentation for MDD has yet been reported. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27605862-2 2016 Huperzine A (HupA), a Traditional Chinese Medicine derived from a genus of clubmosses known as Huperzineserrata, is a powerful AChE inhibitor that has been used as an adjunctive treatment for MDD, but no meta-analysis on HupA augmentation for MDD has yet been reported. huperzine A 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. huperzine A 232-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74