PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30483056-4 2018 In this study, we have discovered that tacrine(10)-hupyridone (A10E), a novel acetylcholinesterase (AChE) inhibitor derived from tacrine and huperzine A, could prevent surgery-induced short-term and long-term impairments of recognition and spatial cognition, as evidenced by the novel object recognition test and Morris water maze (MWM) tests, in aged mice. huperzine A 141-152 acetylcholinesterase Mus musculus 78-98 30483056-4 2018 In this study, we have discovered that tacrine(10)-hupyridone (A10E), a novel acetylcholinesterase (AChE) inhibitor derived from tacrine and huperzine A, could prevent surgery-induced short-term and long-term impairments of recognition and spatial cognition, as evidenced by the novel object recognition test and Morris water maze (MWM) tests, in aged mice. huperzine A 141-152 acetylcholinesterase Mus musculus 100-104 24332448-1 2014 Huperzine A (HupA), a natural inhibitor of acetylcholinesterase derived from a plant, is a licensed anti-Alzheimer"s disease (AD) drug in China and a nutraceutical in the United States. huperzine A 0-11 acetylcholinesterase Mus musculus 43-63 29564727-1 2018 Tacrine(10)-hupyridone (A10E) was designed as a dual-binding acetylcholinesterase (AChE) inhibitor from the modification of tacrine and a fragment of huperzine A. huperzine A 150-161 acetylcholinesterase Mus musculus 83-87 24332448-1 2014 Huperzine A (HupA), a natural inhibitor of acetylcholinesterase derived from a plant, is a licensed anti-Alzheimer"s disease (AD) drug in China and a nutraceutical in the United States. huperzine A 13-17 acetylcholinesterase Mus musculus 43-63 24332448-2 2014 In addition to acting as an acetylcholinesterase inhibitor, HupA possesses neuroprotective properties. huperzine A 60-64 acetylcholinesterase Mus musculus 28-48 24649050-2 2013 Huperzine A (HupA) is a reversible inhibitor of AChE and HupA sustained-release microspheres (HSMs) steadily release HupA, resulting in the continual inhibition of AChE activity for 14 days in mice. huperzine A 0-11 acetylcholinesterase Mus musculus 48-52 24649050-2 2013 Huperzine A (HupA) is a reversible inhibitor of AChE and HupA sustained-release microspheres (HSMs) steadily release HupA, resulting in the continual inhibition of AChE activity for 14 days in mice. huperzine A 0-11 acetylcholinesterase Mus musculus 164-168 24649050-2 2013 Huperzine A (HupA) is a reversible inhibitor of AChE and HupA sustained-release microspheres (HSMs) steadily release HupA, resulting in the continual inhibition of AChE activity for 14 days in mice. huperzine A 13-17 acetylcholinesterase Mus musculus 48-52 24649050-2 2013 Huperzine A (HupA) is a reversible inhibitor of AChE and HupA sustained-release microspheres (HSMs) steadily release HupA, resulting in the continual inhibition of AChE activity for 14 days in mice. huperzine A 13-17 acetylcholinesterase Mus musculus 164-168 23403922-0 2013 The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice. huperzine A 15-26 acetylcholinesterase Mus musculus 47-67 23403922-1 2013 The acetylcholinesterase inhibitor (AChEI), huperzine A has been used in the treatment of the cognitive deterioration associated with Alzheimer"s disease (AD). huperzine A 44-55 acetylcholinesterase Mus musculus 4-24 23403922-6 2013 The results revealed that, following a single dose of huperzine A, the AChE activity in the stomach and duodenum were significantly inhibited and the gastrointestinal motility was significantly increased. huperzine A 54-65 acetylcholinesterase Mus musculus 71-75 21289607-1 2011 Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer"s disease (AD) therapy. huperzine A 0-11 acetylcholinesterase Mus musculus 62-82 23022390-1 2012 Huperzine A, a Lycopodium alkaloid produced by Chinese folk herb Huperzia serrata (Lycopodiaceae), has been shown to be a promising agent for the treatment of Alzheimer"s disease due to its potent acetylcholinesterase (AChE) activity, as well its efficacy in the treatment of memory of aged patients. huperzine A 0-11 acetylcholinesterase Mus musculus 197-217 23022390-1 2012 Huperzine A, a Lycopodium alkaloid produced by Chinese folk herb Huperzia serrata (Lycopodiaceae), has been shown to be a promising agent for the treatment of Alzheimer"s disease due to its potent acetylcholinesterase (AChE) activity, as well its efficacy in the treatment of memory of aged patients. huperzine A 0-11 acetylcholinesterase Mus musculus 219-223 23022390-5 2012 The AChE activity was found to be significantly reduced in both the cortex and hippocampus, although this activity was less potent than that of reference inhibitor huperzine A (0.5mg/kg). huperzine A 164-175 acetylcholinesterase Mus musculus 4-8 22969880-2 2012 Steady inhibition of AChE activity was induced by an intramuscular injection of huperizine A (HupA) sustained-release microspheres. huperzine A 94-98 acetylcholinesterase Mus musculus 21-25 21289607-1 2011 Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer"s disease (AD) therapy. huperzine A 0-11 acetylcholinesterase Mus musculus 84-88 21289607-1 2011 Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer"s disease (AD) therapy. huperzine A 13-17 acetylcholinesterase Mus musculus 62-82 21289607-1 2011 Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer"s disease (AD) therapy. huperzine A 13-17 acetylcholinesterase Mus musculus 84-88 17309523-6 2007 The results show that a bolus dose of microsphere-containing huperzine A (at a dose of 300 microg/kg or 600 microg/kg) administered intramuscularly can effectively maintain drug activity and significantly decrease the activity of AChE from day 3 to 14, the strongest effect seen on day 3 and 7. huperzine A 61-72 acetylcholinesterase Mus musculus 230-234 18784370-5 2008 To avoid these treatment complications but safely protect against DFP-induced seizures and other CNS toxicity, we adopted the strategy of administering mice with (i) small doses of huperzine A (HUP), a reversible and long-lasting (half-life approximately 5 h) inhibitor of AChE, and (ii) imidazenil (IMI), a potent positive allosteric modulator of GABA action selective for alpha(5)-containing GABA(A) receptors. huperzine A 181-192 acetylcholinesterase Mus musculus 273-277 17309523-7 2007 Accompanying the reduction of the activity of AChE, microsphere-containing huperzine A (300 microg/kg or 600 microg/kg) remarkably increased transfer latency time and no transfer response on the second trial through mitigating the memory impairments induced by scopolamine as compared to the scopolamine model group. huperzine A 75-86 acetylcholinesterase Mus musculus 46-50 10341665-0 1999 Mouse acetylcholinesterase unliganded and in complex with huperzine A: a comparison of molecular dynamics simulations. huperzine A 58-69 acetylcholinesterase Mus musculus 6-26 15652380-3 2005 In wild-type mice acute reduction of AChE by Huperzine A (1 mg/kg) to the level found in asymptomatic heterozygotes, induced tremors but no respiratory depression, whereas the same dose of Huperzine in heterozygote animals further reduced AChE activity, increased tidal volume (V(T)) and decreased breathing frequency (f(R)). huperzine A 45-56 acetylcholinesterase Mus musculus 37-41 15652380-3 2005 In wild-type mice acute reduction of AChE by Huperzine A (1 mg/kg) to the level found in asymptomatic heterozygotes, induced tremors but no respiratory depression, whereas the same dose of Huperzine in heterozygote animals further reduced AChE activity, increased tidal volume (V(T)) and decreased breathing frequency (f(R)). huperzine A 45-54 acetylcholinesterase Mus musculus 37-41 10341665-1 1999 A 1 ns molecular dynamics simulation of unliganded mouse acetylcholinesterase (AChE) is compared to a previous simulation of mouse AChE complexed with huperzine A (HupA). huperzine A 151-162 acetylcholinesterase Mus musculus 131-135 10423544-0 1999 Molecular dynamics of mouse acetylcholinesterase complexed with huperzine A. huperzine A 64-75 acetylcholinesterase Mus musculus 28-48 10423544-1 1999 Two molecular dynamics simulations were performed for a modeled complex of mouse acetylcholinesterase liganded with huperzine A (HupA). huperzine A 116-127 acetylcholinesterase Mus musculus 81-101 8139389-1 1994 Huperzine A (HUP) is a naturally-occurring, potent, reversible inhibitor of acetylcholinesterase (AChE) that crosses the blood-brain barrier. huperzine A 0-11 acetylcholinesterase Mus musculus 98-102 7849595-3 1994 Inhibition of fetal bovine serum acetylcholinesterase by (-)-Huperzine A was 35-fold more potent than (+)-Huperzine A, with KI values of 6.2 nM and 210 nM, respectively. huperzine A 57-72 acetylcholinesterase Mus musculus 33-53 7849595-3 1994 Inhibition of fetal bovine serum acetylcholinesterase by (-)-Huperzine A was 35-fold more potent than (+)-Huperzine A, with KI values of 6.2 nM and 210 nM, respectively. huperzine A 102-117 acetylcholinesterase Mus musculus 33-53 7849595-4 1994 In addition, (-)-Huperzine A was 88-fold more potent in inhibiting Torpedo acetylcholinesterase than (+)-Huperzine A, with KI values of 0.25 microM and 22 microM, respectively. huperzine A 13-28 acetylcholinesterase Mus musculus 75-95 7849595-8 1994 In contrast, mutation of the conserved Glu 199 residue to Gln in Torpedo acetylcholinesterase produced only a 3-fold increase in KI value for the binding of Huperzine A. huperzine A 157-168 acetylcholinesterase Mus musculus 73-93 34530383-8 2021 Here, we used 6-chlorotacrine and the tetrahydroquinolone moiety of huperzine A to design and synthesize a series of heterodimers that inhibit AChE at nanomolar potency. huperzine A 68-79 acetylcholinesterase Mus musculus 143-147 31402621-2 2019 We previously demonstrated that the reversible acetylcholinesterase inhibitor, Huperzine A, increases seizure resistance in Scn1a mutants. huperzine A 79-90 acetylcholinesterase Mus musculus 47-67