PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18156630-3 2008 The aim of this investigation was to ascertain whether the anti-fibrotic effects exerted by the angiotensin-converting enzyme inhibitor (ACE-I) perindoprilat on macrophage-conditioned medium (MPCM)-injured human mesangial cells can be modulated by this receptor. perindoprilat 144-157 angiotensin I converting enzyme Homo sapiens 137-140 21411099-5 2011 The angiotensin converting enzyme (ACE) inhibitors, imidaprilat and perindoprilat, enhanced the secretion of endogenous HGF, augmented the TNF-alpha-induced IL-10 secretion and suppressed MCP-1 secretion from AAA tissue. perindoprilat 68-81 angiotensin I converting enzyme Homo sapiens 4-33 21411099-5 2011 The angiotensin converting enzyme (ACE) inhibitors, imidaprilat and perindoprilat, enhanced the secretion of endogenous HGF, augmented the TNF-alpha-induced IL-10 secretion and suppressed MCP-1 secretion from AAA tissue. perindoprilat 68-81 angiotensin I converting enzyme Homo sapiens 35-38 18399693-1 2008 Studies that allow computing values of aqueous proton dissociation constants (pKa), gas phase proton affinities, and the free energy of solvation have been performed for six members of angiotensin-I-converting enzyme (ACE) inhibitor family (captopril, enalaprilat, imidaprilat, ramiprilat, perindoprilat, and spiraprilat). perindoprilat 290-303 angiotensin I converting enzyme Homo sapiens 218-221 12076191-1 2002 Perindopril is a long-acting ACE inhibitor, acting through its only active metabolite perindoprilat. perindoprilat 86-99 angiotensin I converting enzyme Homo sapiens 29-32 14615289-3 2004 The ACE inhibitors ramiprilat and perindoprilat, and the substrate bradykinin (but not angiotensin I), enhanced the activity of ACE-associated CK2 and the phosphorylation of ACE Ser1270 in cultured endothelial cells. perindoprilat 34-47 angiotensin I converting enzyme Homo sapiens 4-7 14615289-3 2004 The ACE inhibitors ramiprilat and perindoprilat, and the substrate bradykinin (but not angiotensin I), enhanced the activity of ACE-associated CK2 and the phosphorylation of ACE Ser1270 in cultured endothelial cells. perindoprilat 34-47 angiotensin I converting enzyme Homo sapiens 128-131 14615289-3 2004 The ACE inhibitors ramiprilat and perindoprilat, and the substrate bradykinin (but not angiotensin I), enhanced the activity of ACE-associated CK2 and the phosphorylation of ACE Ser1270 in cultured endothelial cells. perindoprilat 34-47 angiotensin I converting enzyme Homo sapiens 128-131 12808303-1 2003 Objective of the present study was to investigate the elimination kinetics of quinaprilat and perindoprilat, the active metabolites of angiotensin-converting enzyme (ACE) inhibitors quinapril and perindopril, in hypertensive patients with renal failure under haemodialysis to evaluate the appropriate duration of off-dose of these drugs before starting of low-density lipoprotein (LDL) apheresis. perindoprilat 94-107 angiotensin I converting enzyme Homo sapiens 135-164 12808303-1 2003 Objective of the present study was to investigate the elimination kinetics of quinaprilat and perindoprilat, the active metabolites of angiotensin-converting enzyme (ACE) inhibitors quinapril and perindopril, in hypertensive patients with renal failure under haemodialysis to evaluate the appropriate duration of off-dose of these drugs before starting of low-density lipoprotein (LDL) apheresis. perindoprilat 94-107 angiotensin I converting enzyme Homo sapiens 166-169 16451098-1 2006 Perindopril (Coversyl) is a prodrug ester of perindoprilat, an ACE inhibitor. perindoprilat 45-58 angiotensin I converting enzyme Homo sapiens 63-66 14658015-10 2004 It is concluded that acute ACE inhibition with perindoprilat improves maximal achieved myocardial perfusion in non-hypertensive patients with diabetes and LVH. perindoprilat 47-60 angiotensin I converting enzyme Homo sapiens 27-30 10904025-4 2000 The bradykinin antagonist icatibant (10 mg IV) was coadministered over the first 15 minutes of a 2-hour infusion of the ACE inhibitor perindoprilat (1.5 mg IV). perindoprilat 134-147 angiotensin I converting enzyme Homo sapiens 120-123 11591356-2 2001 Converted from the prodrug ester perindopril, the active diacid perindoprilat is distributed rapidly and extensively, primarily to tissues with high ACE activity. perindoprilat 64-77 angiotensin I converting enzyme Homo sapiens 149-152 11398915-1 2001 UNLABELLED: Perindopril erbumine (perindopril) is a prodrug ester of perindoprilat, an angiotensin converting enzyme (ACE) inhibitor. perindoprilat 69-82 angiotensin I converting enzyme Homo sapiens 87-116 11398915-1 2001 UNLABELLED: Perindopril erbumine (perindopril) is a prodrug ester of perindoprilat, an angiotensin converting enzyme (ACE) inhibitor. perindoprilat 69-82 angiotensin I converting enzyme Homo sapiens 118-121 10904025-5 2000 Perindoprilat inhibited ACE activity and elicited the expected changes in active renin concentration and angiotensin peptides. perindoprilat 0-13 angiotensin I converting enzyme Homo sapiens 24-27 8249053-7 1993 In the case of the assay of zabiciprilat, interference generated by endogenous angiotensin-converting enzyme (ACE) was eliminated by the addition of perindoprilat, another ACE inhibitor. perindoprilat 149-162 angiotensin I converting enzyme Homo sapiens 110-113 9264500-2 1997 We compared the effect of local brachial artery infusions of an ACE inhibitor (perindoprilat) with the effect of placebo (0.9% NaCl) on endogenously mediated (lower body negative pressure [LBNP]) and exogenously mediated (brachial artery infusions of norepinephrine) sympathetic vasoconstriction. perindoprilat 79-92 angiotensin I converting enzyme Homo sapiens 64-67 8070497-8 1994 With perindoprilat a decrease in mean arterial blood pressure and ACE activity, an increase in renin plasma activity and a decrease in aldosterone concentrations were observed compared to the placebo infusion. perindoprilat 5-18 angiotensin I converting enzyme Homo sapiens 66-69 8989118-3 1996 This study was designed to determine whether the ACE inhibitor perindoprilat can restore normal coronary dilative responses in hypertensive patients. perindoprilat 63-76 angiotensin I converting enzyme Homo sapiens 49-52 8572858-0 1995 [Restoration of normal coronary vasomotricity after intravenous infusion of angiotensin converting-enzyme inhibitor (perindoprilat) in hypertensive patients]. perindoprilat 117-130 angiotensin I converting enzyme Homo sapiens 76-105 8249053-7 1993 In the case of the assay of zabiciprilat, interference generated by endogenous angiotensin-converting enzyme (ACE) was eliminated by the addition of perindoprilat, another ACE inhibitor. perindoprilat 149-162 angiotensin I converting enzyme Homo sapiens 172-175 1330941-0 1992 Specific and high affinity binding of perindoprilat, but not of perindopril to blood ACE. perindoprilat 38-51 angiotensin I converting enzyme Homo sapiens 85-88 1657092-1 1991 1 Perindopril is a prodrug which is hydrolysed in vivo to the active metabolite perindoprilat, an angiotensin-converting enzyme inhibitor. perindoprilat 80-93 angiotensin I converting enzyme Homo sapiens 98-127 1576057-1 1992 Perindopril is a non-sulphydryl angiotensin converting enzyme (ACE) inhibitor which requires hydrolysis to its active metabolite, perindoprilat, to produce its effects. perindoprilat 130-143 angiotensin I converting enzyme Homo sapiens 63-66 1327596-6 1992 The higher levels of perindoprilat were associated with a greater inhibition of plasma angiotensin-converting enzyme (ACE) activity in both acute and steady state studies. perindoprilat 21-34 angiotensin I converting enzyme Homo sapiens 87-116 1327596-6 1992 The higher levels of perindoprilat were associated with a greater inhibition of plasma angiotensin-converting enzyme (ACE) activity in both acute and steady state studies. perindoprilat 21-34 angiotensin I converting enzyme Homo sapiens 118-121 1327596-8 1992 The potency of the active diacids in inhibiting plasma ACE activity was perindoprilat greater than cilazaprilat greater than enalaprilat. perindoprilat 72-85 angiotensin I converting enzyme Homo sapiens 55-58 1657093-0 1991 Transpulmonary pharmacokinetics of an ACE inhibitor (perindoprilat) in man. perindoprilat 53-66 angiotensin I converting enzyme Homo sapiens 38-41 1657093-2 1991 The transpulmonary pharmacokinetics of the intravenous diacid ACE inhibitor perindoprilat were studied in 10 male patients undergoing diagnostic cardiac catheterisation for the management of ischaemic heart disease. perindoprilat 76-89 angiotensin I converting enzyme Homo sapiens 62-65 2172371-0 1990 Vascular effects of intravenous infusion of the angiotensin converting enzyme inhibitor perindoprilat. perindoprilat 88-101 angiotensin I converting enzyme Homo sapiens 48-77 2088853-2 1990 In this study we have shown that SH-containing ACE inhibitors (captopril, epicaptopril, zofenopril) are potent FR scavengers at a concentration of 4 x 10(-5) M whereas non-SH ACE inhibitors (enalaprilat, quinaprilat and perindoprilat) have no FR-scavenging activity at this concentration. perindoprilat 220-233 angiotensin I converting enzyme Homo sapiens 47-50 1718688-4 1991 After absorption, perindopril is hydrolysed to the active metabolite, perindoprilat, and with once daily administration adequate 24-hour inhibition of ACE is obtained. perindoprilat 70-83 angiotensin I converting enzyme Homo sapiens 151-154 1817672-1 1991 A new radioimmunoassay (RIA) was developed for the direct measurement of perindoprilate (PT), the active metabolite (diacid) of Perindopril (P), an angiotensin-converting enzyme (ACE) inhibitor. perindoprilat 73-87 angiotensin I converting enzyme Homo sapiens 148-177 1817672-1 1991 A new radioimmunoassay (RIA) was developed for the direct measurement of perindoprilate (PT), the active metabolite (diacid) of Perindopril (P), an angiotensin-converting enzyme (ACE) inhibitor. perindoprilat 73-87 angiotensin I converting enzyme Homo sapiens 179-182 2172371-4 1990 Groups II and III received a continuous intravenous infusion of the angiotensin converting enzyme (ACE) inhibitor perindoprilat at a dose of 1 microgram/kg per min and 2.5 micrograms/kg per min, respectively. perindoprilat 114-127 angiotensin I converting enzyme Homo sapiens 68-97 2172371-4 1990 Groups II and III received a continuous intravenous infusion of the angiotensin converting enzyme (ACE) inhibitor perindoprilat at a dose of 1 microgram/kg per min and 2.5 micrograms/kg per min, respectively. perindoprilat 114-127 angiotensin I converting enzyme Homo sapiens 99-102 2231339-1 1990 Perindopril (P) is a prodrug whose active metabolite perindoprilat (PT) is an antihypertensive agent which acts by inhibition of angiotensin-converting enzyme (ACE). perindoprilat 53-66 angiotensin I converting enzyme Homo sapiens 129-158 2231339-1 1990 Perindopril (P) is a prodrug whose active metabolite perindoprilat (PT) is an antihypertensive agent which acts by inhibition of angiotensin-converting enzyme (ACE). perindoprilat 53-66 angiotensin I converting enzyme Homo sapiens 160-163 2351367-1 1990 Perindopril, an angiotensin converting enzyme (ACE) inhibitor, is converted in vivo to its active diacid metabolite, perindoprilat and to a perindoprilat glucuronide. perindoprilat 117-130 angiotensin I converting enzyme Homo sapiens 47-50 2311339-2 1990 Perindopril is the ester pro-drug of the angiotensin-converting enzyme inhibitor perindoprilat. perindoprilat 81-94 angiotensin I converting enzyme Homo sapiens 41-70 2407493-6 1990 Perindopril is a prodrug which requires de-esterification to perindoprilat for useful ACE inhibition. perindoprilat 61-74 angiotensin I converting enzyme Homo sapiens 86-89 2559190-0 1989 Pharmacokinetics of an ACE inhibitor, S-9780, in man: evidence of tissue binding. perindoprilat 38-44 angiotensin I converting enzyme Homo sapiens 23-26 2559190-1 1989 Pharmacokinetic data from 20-min constant rate infusions of the ACE inhibitor S-9780 1 mg to 16 subjects were studied for evidence of nonlinearity. perindoprilat 78-84 angiotensin I converting enzyme Homo sapiens 64-67 2550045-2 1989 Perindopril, a new ACE inhibitor, is a prodrug requiring conversion into its active form perindoprilat by hydrolysis in the liver. perindoprilat 89-102 angiotensin I converting enzyme Homo sapiens 19-22 2605799-4 1989 After intravenous administration, perindoprilat concentrations show multiexponential decay with a terminal half-life of over 30 hours, associated with sustained inhibition of ACE. perindoprilat 34-47 angiotensin I converting enzyme Homo sapiens 175-178 2605799-6 1989 The therapeutic consequences of these findings are: (1) Binding of perindoprilat to ACE prolongs the hemodynamic effect, giving the option of once daily administration. perindoprilat 67-80 angiotensin I converting enzyme Homo sapiens 84-87 2844467-1 1988 Perindopril is the ester prodrug of the angiotensin converting enzyme inhibitor S-9780. perindoprilat 80-86 angiotensin I converting enzyme Homo sapiens 40-69 2505711-4 1989 After intravenous administration, perindoprilat concentrations show multiexponential decay with a terminal half life of over 30 hours associated with sustained inhibition of ACE. perindoprilat 34-47 angiotensin I converting enzyme Homo sapiens 174-177 2505711-6 1989 The therapeutic consequences of these findings are: binding of perindoprilat to ACE prolongs the haemodynamic effect, giving the option of once daily administration; despite the long terminal elimination half life of the drug, significant accumulation is not a problem during chronic treatment; increased plasma concentrations of active metabolite in the elderly and reduced renal elimination may require reduced doses to be used; further dose adjustment in compensated hepatic cirrhosis is not routinely necessary. perindoprilat 63-76 angiotensin I converting enzyme Homo sapiens 80-83