PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10583023-0 1999 Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin. artemisinin 91-102 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-43 10583023-1 1999 AIMS: The study aimed to identify the specific human cytochrome P450 (CYP450) enzymes involved in the metabolism of artemisinin. artemisinin 116-127 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-68 10583023-1 1999 AIMS: The study aimed to identify the specific human cytochrome P450 (CYP450) enzymes involved in the metabolism of artemisinin. artemisinin 116-127 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-76 10583023-2 1999 METHODS: Microsomes from human B-lymphoblastoid cell lines transformed with individual CYP450 cDNAs were investigated for their capacity to metabolize artemisinin. artemisinin 151-162 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 87-93 10583023-4 1999 The relative contribution of individual CYP450 isoenzymes to artemisinin metabolism in human liver microsomes was evaluated with a tree-based regression model of artemisinin disappearance rate and specific CYP450 activities. artemisinin 61-72 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-46 17521300-10 2007 These results show that intake of artemisinin antimalarials affect the activities of several principal human drug metabolizing CYP450 enzymes. artemisinin 34-45 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 127-133 25363545-0 2014 Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations. artemisinin 121-132 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 24400699-0 2014 Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies. artemisinin 11-22 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-55 21411308-1 2011 Protein engineering of cytochrome P450 monooxygenases (P450s) has been very successful in generating valuable non-natural activities and properties, allowing these powerful catalysts to be used for the synthesis of drug metabolites and in biosynthetic pathways for the production of precursors of artemisinin and paclitaxel. artemisinin 297-308 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 23-38 17521300-0 2007 Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. artemisinin 0-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 44-59 17521300-1 2007 The aim of this study was to investigate which principal human cytochrome P450 (CYP450) enzymes are affected by artemisinin and to what degree the artemisinin derivatives differ with respect to their respective induction and inhibition capacity. artemisinin 112-123 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 63-78 17521300-1 2007 The aim of this study was to investigate which principal human cytochrome P450 (CYP450) enzymes are affected by artemisinin and to what degree the artemisinin derivatives differ with respect to their respective induction and inhibition capacity. artemisinin 112-123 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-86