PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17521300-0	2007	Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.	artemisinin	0-11	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	44-59	
25363545-0	2014	Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations.	artemisinin	121-132	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15	
17521300-10	2007	These results show that intake of artemisinin antimalarials affect the activities of several principal human drug metabolizing CYP450 enzymes.	artemisinin	34-45	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	127-133	
24400699-0	2014	Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.	artemisinin	11-22	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-55	
21411308-1	2011	Protein engineering of cytochrome P450 monooxygenases (P450s) has been very successful in generating valuable non-natural activities and properties, allowing these powerful catalysts to be used for the synthesis of drug metabolites and in biosynthetic pathways for the production of precursors of artemisinin and paclitaxel.	artemisinin	297-308	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	23-38	
17521300-1	2007	The aim of this study was to investigate which principal human cytochrome P450 (CYP450) enzymes are affected by artemisinin and to what degree the artemisinin derivatives differ with respect to their respective induction and inhibition capacity.	artemisinin	112-123	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-78	
17521300-1	2007	The aim of this study was to investigate which principal human cytochrome P450 (CYP450) enzymes are affected by artemisinin and to what degree the artemisinin derivatives differ with respect to their respective induction and inhibition capacity.	artemisinin	112-123	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	80-86	
10583023-0	1999	Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin.	artemisinin	91-102	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-43	
10583023-1	1999	AIMS: The study aimed to identify the specific human cytochrome P450 (CYP450) enzymes involved in the metabolism of artemisinin.	artemisinin	116-127	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	53-68	
10583023-1	1999	AIMS: The study aimed to identify the specific human cytochrome P450 (CYP450) enzymes involved in the metabolism of artemisinin.	artemisinin	116-127	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-76	
10583023-2	1999	METHODS: Microsomes from human B-lymphoblastoid cell lines transformed with individual CYP450 cDNAs were investigated for their capacity to metabolize artemisinin.	artemisinin	151-162	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	87-93	
10583023-4	1999	The relative contribution of individual CYP450 isoenzymes to artemisinin metabolism in human liver microsomes was evaluated with a tree-based regression model of artemisinin disappearance rate and specific CYP450 activities.	artemisinin	61-72	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-46