PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14506174-14	2003	dBG, a weak MGMT inactivator in vitro as compared with BG, was markedly more effective than the latter in enhancing the efficacy of BCNU against pancreatic tumor xenografts.	alpha,alpha-di-n-butylglycine	0-3	O-6-methylguanine-DNA methyltransferase	Mus musculus	12-16	
14506174-15	2003	Both BG and dBG also enhanced the efficacy of TMZ against pancreatic tumors, possibly because of the repression of MGMT, which cannot be achieved with TMZ treatments alone.	alpha,alpha-di-n-butylglycine	12-15	O-6-methylguanine-DNA methyltransferase	Mus musculus	115-119	
10647505-3	2000	O6-Benzyl-2"-deoxyguanosine (dBG), a less effective MGMT inactivator than BG in vitro, is at least as effective as BG in combination with BCNU against tumor xenografts in athymic mice.	alpha,alpha-di-n-butylglycine	29-32	O-6-methylguanine-DNA methyltransferase	Mus musculus	52-56	
10647505-15	2000	The faster and more effective suppression of tumor MGMT by dBG and its greater efficacy, as compared with BGS, also correlates with a more rapid accumulation of BG in blood after dBG than after BGS administration, which results in faster and complete suppression of MGMT in Daov xenografts.	alpha,alpha-di-n-butylglycine	59-62	O-6-methylguanine-DNA methyltransferase	Mus musculus	51-55	
10647505-15	2000	The faster and more effective suppression of tumor MGMT by dBG and its greater efficacy, as compared with BGS, also correlates with a more rapid accumulation of BG in blood after dBG than after BGS administration, which results in faster and complete suppression of MGMT in Daov xenografts.	alpha,alpha-di-n-butylglycine	59-62	O-6-methylguanine-DNA methyltransferase	Mus musculus	266-270	
10647505-16	2000	Thus, metabolism of dBG and BGS to BG appears to be the determining factor for continuous and prolonged suppression of MGMT activity, and that near complete suppression of such activity during and following BCNU administration is required for the higher efficacy of treatments.	alpha,alpha-di-n-butylglycine	20-23	O-6-methylguanine-DNA methyltransferase	Mus musculus	119-123