PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33576879-0	2021	Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways.	Niacin	0-6	thymoma viral proto-oncogene 1	Mus musculus	132-135	
33576879-4	2021	The results showed that niacin could activate the AKT/mTOR and ERK signaling pathways and increase phosphorylation of 4EBP1 to promote the synthesis of cell proliferation markers, leading to the dissociation of the Rb-E2F1 complex in mMECs.	Niacin	24-30	thymoma viral proto-oncogene 1	Mus musculus	50-53	
33576879-5	2021	In addition, 0.5% niacin promoted mammary duct development, increased the expression of cyclin D1/D3 and PCNA and activated Akt/mTOR and ERK1/2 in the mammary glands of pubertal mice.	Niacin	18-24	thymoma viral proto-oncogene 1	Mus musculus	124-127	
33576879-6	2021	These results strongly suggest that niacin stimulates mammary gland development in pubertal mice through the Akt/mTOR and ERK1/2 signaling pathways.	Niacin	36-42	thymoma viral proto-oncogene 1	Mus musculus	109-112	
29263047-5	2017	Western blotting was used to detect the activation of the Akt/mTOR signaling pathway and expression of the inflammatory cytokine INF-gamma, in MIN6 cells, following treatments with palmitic acid and palmitic acid+nicotinic acid, or with different concentrations of nicotinic acid and 3-hydroxybutyrate.	Niacin	213-227	thymoma viral proto-oncogene 1	Mus musculus	58-61	
29263047-8	2017	Co-treatment with nicotinic acid, which is an agonist of GPR109A, inhibited the palmitic acid-induced phosphorylation of Akt, mTOR, and p70S6K, as well as the expression of IFN-gamma.	Niacin	18-32	thymoma viral proto-oncogene 1	Mus musculus	121-124	
27799291-7	2016	Importantly, we also found that Niaspan reduces hypermyelination of Vim (vimentin)-/- mice, characterized by increased Nrg1 type III and Akt activation, thus corroborating the hypothesis that Niaspan treatment downregulates Nrg1 type III signaling.	Niacin	32-39	thymoma viral proto-oncogene 1	Mus musculus	137-140	
27799291-7	2016	Importantly, we also found that Niaspan reduces hypermyelination of Vim (vimentin)-/- mice, characterized by increased Nrg1 type III and Akt activation, thus corroborating the hypothesis that Niaspan treatment downregulates Nrg1 type III signaling.	Niacin	192-199	thymoma viral proto-oncogene 1	Mus musculus	137-140	
34141179-0	2021	Curcumin nicotinate suppresses abdominal aortic aneurysm pyroptosis via lncRNA PVT1/miR-26a/KLF4 axis through regulating the PI3K/AKT signaling pathway.	Niacin	9-19	thymoma viral proto-oncogene 1	Mus musculus	130-133	
22536778-4	2012	NAH-mediated increases in the phosphorylation of mitogen-activated protein kinase kinase (MEK)/ERK and AKT/glycogen synthase kinase-3beta (GSK3beta) were also found, which in turn led to the inhibition of MITF expression and then downregulated tyrosinase and tyrosinase-related protein (TRP)-1 expressions.	Niacin	0-3	thymoma viral proto-oncogene 1	Mus musculus	103-106