PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34861633-2 2022 In this study, we employed Langmuir monolayers of a mixture of phospholipids and cholesterol (MIX) as models for tumor cell membranes and investigated their interaction with the anticancer drugs cisplatin (CDDP) and doxorubicin (DOX). Cisplatin 195-204 Mix paired-like homeobox Homo sapiens 94-97 34861633-3 2022 We found that both DOX and CDDP expand and affect the elasticity of MIX monolayers, but these effects are hindered when glutathione-s-transferase (GST) and its cofactor glutathione (GSH) are incorporated. Cisplatin 27-31 Mix paired-like homeobox Homo sapiens 68-71 34861633-4 2022 Changes are induced by DOX or CDDP on the polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS) data for MIX/GST/GSH monolayers, thus denoting some degree of interaction that is not sufficient to alter the monolayer mechanical properties. Cisplatin 30-34 Mix paired-like homeobox Homo sapiens 129-132 31353575-6 2019 Furthermore, we demonstrated that MIX enhances antiproliferative effect of common cytostatics: 5-fluorouracil and cisplatin. Cisplatin 114-123 Mix paired-like homeobox Homo sapiens 34-37 31353575-12 2019 Furthermore, activity of the substances combined as MIX to influence antiproliferative potential of commonly used in colon cancer treatment cytostatics, 5-fluorouracil, and cisplatin was verified. Cisplatin 173-182 Mix paired-like homeobox Homo sapiens 52-55