PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31697000-1 2020 The iridium half-sandwich complex [Ir(eta5 :kappa1 -C5 Me4 CH2 py)(2-phenylpyridine)]PF6 is highly cytotoxic: 15-250x more potent than clinically used cisplatin in several cancer cell lines. Cisplatin 151-160 sperm associated antigen 17 Homo sapiens 85-88 28814948-7 2017 The cis-[Ru(quin)(dppm)2]PF6 were two to three times more active than the reference metallodrug cisplatin in the MCF-7 and MO59J cell lines. Cisplatin 96-105 sperm associated antigen 17 Homo sapiens 25-28 27235272-1 2016 Herein we report investigation of the interactions between anticancer organoruthenium complexes, [(eta(6)-arene)Ru(en)(Cl)]PF6 (en=ethylenediamine, arene=p-cymene (1) or biphenyl (2)), and the human copper chaperone protein Cox17 by mass spectrometry with cisplatin as a reference. Cisplatin 256-265 sperm associated antigen 17 Homo sapiens 123-126 26825752-9 2016 Cytotoxicity studies on lung cancer cells (A549) and healthy cells (CHL) showed a marked increase in cytotoxicity with the use of gold(III) complexes, and especially [Au(L)B](PF6)2 showed higher cytotoxic and apoptotic features than cisplatin at lower concentrations in cancer cells. Cisplatin 233-242 sperm associated antigen 17 Homo sapiens 175-178 34346447-3 2021 The results revealed that complexes (Cu(L1)Cl)PF6 (1-PF6), (Cu(L2)Cl)ClO4 (2-ClO4) and (Cu(L3)Cl)PF6 (3-PF6) are the most effective, with IC50 values ranging from 1.4 to 6.3 muM, thus exceeding the cytotoxic potential of metallodrug cisplatin (IC50 values ranging from 29.9 to 82.0 muM). Cisplatin 233-242 sperm associated antigen 17 Homo sapiens 46-49 34346447-3 2021 The results revealed that complexes (Cu(L1)Cl)PF6 (1-PF6), (Cu(L2)Cl)ClO4 (2-ClO4) and (Cu(L3)Cl)PF6 (3-PF6) are the most effective, with IC50 values ranging from 1.4 to 6.3 muM, thus exceeding the cytotoxic potential of metallodrug cisplatin (IC50 values ranging from 29.9 to 82.0 muM). Cisplatin 233-242 sperm associated antigen 17 Homo sapiens 53-56 34346447-3 2021 The results revealed that complexes (Cu(L1)Cl)PF6 (1-PF6), (Cu(L2)Cl)ClO4 (2-ClO4) and (Cu(L3)Cl)PF6 (3-PF6) are the most effective, with IC50 values ranging from 1.4 to 6.3 muM, thus exceeding the cytotoxic potential of metallodrug cisplatin (IC50 values ranging from 29.9 to 82.0 muM). Cisplatin 233-242 sperm associated antigen 17 Homo sapiens 97-100 34346447-3 2021 The results revealed that complexes (Cu(L1)Cl)PF6 (1-PF6), (Cu(L2)Cl)ClO4 (2-ClO4) and (Cu(L3)Cl)PF6 (3-PF6) are the most effective, with IC50 values ranging from 1.4 to 6.3 muM, thus exceeding the cytotoxic potential of metallodrug cisplatin (IC50 values ranging from 29.9 to 82.0 muM). Cisplatin 233-242 sperm associated antigen 17 Homo sapiens 104-107 28922506-1 2017 Our study demonstrates that four novel kinetically inert C,N-cyclometalated RuII complexes of the type [Ru(C^N)(N^N)2 ][PF6 ] containing a handle for functionalization on the C^N ligand are very potent cytotoxic agents against several different human cancer cell lines and are up to 400-fold more potent than clinically used cisplatin. Cisplatin 325-334 sperm associated antigen 17 Homo sapiens 120-123