PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15886300-6 2005 HEK293 or A549 lung cancer cells expressing human S-1-P lyase (hSPL) show an increase in sensitivity to cisplatin and carboplatin as predicted from the earlier model studies. Cisplatin 104-113 sphingosine-1-phosphate lyase 1 Homo sapiens 63-67 22122961-4 2011 Recent studies have indicated a synergistic relationship between Cisplatin administration and moderate to high noise level exposure starting between 70-85 dB SPL. Cisplatin 65-74 sphingosine-1-phosphate lyase 1 Homo sapiens 158-161 15886300-8 2005 Studies using inhibitors to specific mitogen-activated protein kinases (MAPK) show that the increased cisplatin sensitivity in the hSPL-overexpressing cells is mediated by p38 and to a lesser extent by c-Jun NH2-terminal kinase MAPKs. Cisplatin 102-111 sphingosine-1-phosphate lyase 1 Homo sapiens 131-135