PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12576681-0	2003	Up-regulation of MDR1 function and expression by cisplatin in LLC-PK1 cells.	Cisplatin	49-58	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Sus scrofa	17-21	
12576681-3	2003	The growth inhibitory curve of LLC-PK1 cells by paclitaxel was shifted to a higher concentration range by pretreatment with 1 micro M cisplatin for 48 h. The uptake and efflux of Rhodamine123 were significantly reduced and enhanced, respectively, by pretreatment with 1 micro M cisplatin for 48 h. This enhanced efflux was suppressed by the representative MDR1 substrate/inhibitor ciclosporin.	Cisplatin	134-143	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Sus scrofa	356-360	
12576681-4	2003	The expression of MDR1 mRNA was increased by the existence of cisplatin for 48 h. These observations taken together suggested that the transient exposure to cisplatin could cause the up-regulation of MDR1 in LLC-PK1 cells.	Cisplatin	62-71	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Sus scrofa	18-22	
12576681-4	2003	The expression of MDR1 mRNA was increased by the existence of cisplatin for 48 h. These observations taken together suggested that the transient exposure to cisplatin could cause the up-regulation of MDR1 in LLC-PK1 cells.	Cisplatin	62-71	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Sus scrofa	200-204	
12576681-4	2003	The expression of MDR1 mRNA was increased by the existence of cisplatin for 48 h. These observations taken together suggested that the transient exposure to cisplatin could cause the up-regulation of MDR1 in LLC-PK1 cells.	Cisplatin	157-166	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Sus scrofa	18-22	
12576681-4	2003	The expression of MDR1 mRNA was increased by the existence of cisplatin for 48 h. These observations taken together suggested that the transient exposure to cisplatin could cause the up-regulation of MDR1 in LLC-PK1 cells.	Cisplatin	157-166	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Sus scrofa	200-204