PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21783865-6 2008 Also, carnosine significantly attenuated cisplatin-induced increase in malondialdehyde and decrease in reduced glutathione, and catalase and superoxide dismutase activities in renal cortical homogenates. Cisplatin 41-50 catalase Mus musculus 128-136 15614186-8 2005 The highest activity of CAT was found after incubation with AMD in B16 cells and with Cis-Pt in S91 cells. Cisplatin 86-92 catalase Mus musculus 24-27 17898699-2 2007 We tested the ability of cationized catalase, a catalase derivative, to inhibit nephrotoxicity in cisplatin-treated mice. Cisplatin 98-107 catalase Mus musculus 36-44 17898699-2 2007 We tested the ability of cationized catalase, a catalase derivative, to inhibit nephrotoxicity in cisplatin-treated mice. Cisplatin 98-107 catalase Mus musculus 48-56 17898699-4 2007 Repeated intravenous doses of cationized catalase significantly decreased cisplatin-induced changes in serum creatinine, blood urea nitrogen, nitrite/nitrate levels, lactic dehydrogenase activity, and renal total glutathione and malondialdehyde contents. Cisplatin 74-83 catalase Mus musculus 41-49 17898699-5 2007 In addition, cationized catalase effectively blunted cisplatin-induced proximal tubule necrosis but had no significant effect on the cisplatin-induced inhibition of subcutaneous tumor growth. Cisplatin 53-62 catalase Mus musculus 24-32 17898699-6 2007 Repeated doses of catalase, especially cationized catalase, significantly increased the survival of cisplatin-treated tumor-bearing mice preventing cisplatin-induced acute death. Cisplatin 100-109 catalase Mus musculus 18-26 17898699-6 2007 Repeated doses of catalase, especially cationized catalase, significantly increased the survival of cisplatin-treated tumor-bearing mice preventing cisplatin-induced acute death. Cisplatin 100-109 catalase Mus musculus 50-58 17898699-6 2007 Repeated doses of catalase, especially cationized catalase, significantly increased the survival of cisplatin-treated tumor-bearing mice preventing cisplatin-induced acute death. Cisplatin 148-157 catalase Mus musculus 18-26 17898699-6 2007 Repeated doses of catalase, especially cationized catalase, significantly increased the survival of cisplatin-treated tumor-bearing mice preventing cisplatin-induced acute death. Cisplatin 148-157 catalase Mus musculus 50-58 17898699-7 2007 Our studies suggest that catalase and its derivatives inhibit cisplatin-induced nephrotoxicity, thus improving the efficiency of cisplatin to treat solid tumors. Cisplatin 62-71 catalase Mus musculus 25-33 17898699-7 2007 Our studies suggest that catalase and its derivatives inhibit cisplatin-induced nephrotoxicity, thus improving the efficiency of cisplatin to treat solid tumors. Cisplatin 129-138 catalase Mus musculus 25-33 16889761-11 2007 However the cisplatin induced decline of renal antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities were increased only in the 500 mg/kg vitamins treated groups. Cisplatin 12-21 catalase Mus musculus 103-111 16889761-11 2007 However the cisplatin induced decline of renal antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities were increased only in the 500 mg/kg vitamins treated groups. Cisplatin 12-21 catalase Mus musculus 113-116 12484546-3 2002 In kidney, catalase activity decreased by 47-82% at all time points (24-96 h) of cisplatin treatment, while glutathione S-transferase activity decreased significantly (approximately 24%) mainly at 72 h of treatment. Cisplatin 81-90 catalase Mus musculus 11-19 12565200-4 2003 In cisplatin-treated animals the antioxidant enzymes were activated but the enhancement of HO and CAT was greater in LLC-inoculated mice. Cisplatin 3-12 catalase Mus musculus 98-101 12484546-5 2002 In Dalton lymphoma cells, the activities of glutathione S-transferase, glutathione peroxidase, and catalase decreased very distinctly (approximately 2-5, 2-5 and 5-11 times, respectively) at all time points, but glutathione reductase decreased significantly only at 72 h of cisplatin treatment. Cisplatin 274-283 catalase Mus musculus 99-107 21781737-7 1996 Both SOD and catalase significantly lowered platinum content in the cerebral cortex following cisplatin administration in mice treated with LPS. Cisplatin 94-103 catalase Mus musculus 13-21 33291262-8 2020 Increased expression of nicotinamide adenine dinucleotide phosphate oxidase 4 and decreased expression of manganese superoxide dismutase and catalase after cisplatin treatment were significantly reversed by kahweol. Cisplatin 156-165 catalase Mus musculus 141-149 34710564-10 2021 In the lungs, cisplatin increased the production of hydrogen peroxide, lipid peroxidation, and apoptosis, while decreasing manganese superoxide dismutase, isocitrate dehydrogenase 2, and catalase expression. Cisplatin 14-23 catalase Mus musculus 187-195 28962385-4 2015 The findings show that the combination treatment of mice with ascorbic acid plus cisplatin has much better therapeutic efficacy against murine ascites Dalton"s lymphoma (DL) in comparison to cisplatin alone and this may involve a decrease in reduced glutathione (GSH), catalase activity and increased lipid peroxidation (LPO) in Dalton"s lymphoma tumor cells. Cisplatin 81-90 catalase Mus musculus 269-277 31950223-6 2020 In addition, pantoprazole significantly subsided cisplatin-induced distortion of renal lipid peroxidation marker (MDA), renal superoxide dismutase, and catalase activities and renal reduced glutathione content. Cisplatin 49-58 catalase Mus musculus 152-160 30524274-4 2018 Moreover, biochemical analysis of kidney tissue homogenates showed that cisplatin intoxication was associated with significantly higher (p < 0.05) tissue levels of malondialdehyde (MDA) and lower levels of reduced glutathione and activities of endogenous antioxidant enzymes (glutathione peroxidase, superoxide dismutase, and catalase) in comparison to normal controls. Cisplatin 72-81 catalase Mus musculus 329-337 28962385-8 2015 Therefore, it may be concluded that the increased GSH level, catalase activity and decreased LPO in the tissues, i.e., liver, kidney and testes after combination treatment may be involved in its protective ability against cisplatin-induced tissue toxicities in the host. Cisplatin 222-231 catalase Mus musculus 61-69 22987311-11 2014 Pioglitazone protected against the inhibition of CAT, SOD, GPx, GR and GST activities induced by cisplatin in the kidneys of mice. Cisplatin 97-106 catalase Mus musculus 49-52 22987311-8 2014 Cisplatin exposure induced oxidative stress as indicated by decreased levels of non-enzymatic antioxidant defenses [glutathione (GSH) and ascorbic acid levels] and components of the enzymatic antioxidant defenses [superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx), glutathione reductase (GR) and and glutathione S-transferase(GST) activities)] in renal tissue. Cisplatin 0-9 catalase Mus musculus 242-250 24275644-6 2014 Crocin relieved CDDP-induced oxidative stress by reducing malondialdehyde level and recovering the levels of glutathione and antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. Cisplatin 16-20 catalase Mus musculus 175-183 18644706-6 2008 Cisplatin also induced oxidative stress as indicated by increased lipid peroxidation and decreased levels of reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase in renal tissues. Cisplatin 0-9 catalase Mus musculus 197-205 23108958-10 2013 Treatment with organoselenium compound was also able to restore the renal antioxidant system by modulating the cisplatin induced depleted activities of glutathione S-transferase, thioredoxin reductase, superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione level. Cisplatin 111-120 catalase Mus musculus 224-232 21763304-13 2011 Cisplatin decreased catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes by -47%, -49% and -59%, respectively. Cisplatin 0-9 catalase Mus musculus 20-28 20942565-7 2011 Renal antioxidant defense systems, such as glutathione-S-transferase, glutathione peroxidase, superoxide dismutase, catalase, activities and reduced glutathione level, depleted by cisplatin therapy, were restored to normal by the selenium compound. Cisplatin 180-189 catalase Mus musculus 116-124 22987311-8 2014 Cisplatin exposure induced oxidative stress as indicated by decreased levels of non-enzymatic antioxidant defenses [glutathione (GSH) and ascorbic acid levels] and components of the enzymatic antioxidant defenses [superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx), glutathione reductase (GR) and and glutathione S-transferase(GST) activities)] in renal tissue. Cisplatin 0-9 catalase Mus musculus 252-255 22241628-6 2012 The levels of antioxidant enzymes-superoxide dismutase, catalase and glutathione peroxidase-as well as the glutathione level in the kidney were decreased after cisplatin treatment. Cisplatin 160-169 catalase Mus musculus 56-64