PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22164285-0	2011	Balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC.	Cisplatin	73-82	mitogen-activated protein kinase kinase 3	Homo sapiens	25-29	
22164285-5	2011	Interestingly, MKK3 knockdown significantly decreased p38 phosphorylation upon cisplatin exposure and consequently reduced the response to the drug.	Cisplatin	79-88	mitogen-activated protein kinase kinase 3	Homo sapiens	15-19	
22164285-6	2011	Indeed, cisplatin poorly activated MKK3 in resistant cells, while in sensitive cell lines MKK3 showed the opposite pattern in response to the drug.	Cisplatin	8-17	mitogen-activated protein kinase kinase 3	Homo sapiens	35-39	
22164285-10	2011	Altogether, our work provides evidence that MKK3 is the major determinant of p38 MAPK activation in response to cisplatin and, hence, the resistance associated with this MAPK.	Cisplatin	112-121	mitogen-activated protein kinase kinase 3	Homo sapiens	44-48	
22164285-11	2011	Therefore, these data suggest that the balance between both MKK3 and MKK6 could be a novel mechanism which explains the cellular response to cisplatin.	Cisplatin	141-150	mitogen-activated protein kinase kinase 3	Homo sapiens	60-64	
9926932-2	1999	In this study, we found that the DNA-damaging agent cisplatin (cDDP) activated MAP kinase kinase kinase ASK1 and subsequent downstream subgroups of MAP kinase kinase, SEK1 (or MKK4) and MKK3/MKK6, which in turn activated c-Jun N-terminal kinase 1/stress-activated protein kinase (JNK1/SAPK) and p38 MAP kinase prior to caspase family protease activation and the onset of apoptosis in human ovarian carcinoma (OVCAR-3) and human kidney (293T) cells.	Cisplatin	52-61	mitogen-activated protein kinase kinase 3	Homo sapiens	186-190	
9926932-2	1999	In this study, we found that the DNA-damaging agent cisplatin (cDDP) activated MAP kinase kinase kinase ASK1 and subsequent downstream subgroups of MAP kinase kinase, SEK1 (or MKK4) and MKK3/MKK6, which in turn activated c-Jun N-terminal kinase 1/stress-activated protein kinase (JNK1/SAPK) and p38 MAP kinase prior to caspase family protease activation and the onset of apoptosis in human ovarian carcinoma (OVCAR-3) and human kidney (293T) cells.	Cisplatin	63-67	mitogen-activated protein kinase kinase 3	Homo sapiens	186-190