PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27462186-8	2016	Depletion of Top2beta increased the sensitivity of NCH421k cells to replication stress inducing drugs, such as cisplatin, methyl-methanesulfonate, hydrogen peroxide, and temozolomide.	Cisplatin	111-120	DNA topoisomerase II beta	Homo sapiens	13-21	
8759604-0	1996	Gene expression of DNA topoisomerases I, II alpha and II beta and response to cisplatin-based chemotherapy in advanced ovarian carcinoma.	Cisplatin	78-87	DNA topoisomerase II beta	Homo sapiens	19-61	
21793937-10	2012	Finally, Western blot showed that higher expressions of MRP1, LRP, and BCL2 and lower expression of TopoIIbeta were observed in SCC-15/cisplatin cells than in clinical samples.	Cisplatin	135-144	DNA topoisomerase II beta	Homo sapiens	100-110	
21793937-11	2012	CONCLUSION: Our results suggest that the high expressions of MRP1, LRP, and BCL2 and low expression of TOPOIIbeta in patients with tongue carcinoma indicates that intrinsic drug resistance may exist in tongue carcinoma, and is associated with tumor differentiation and cisplatin resistance in tongue carcinoma.	Cisplatin	269-278	DNA topoisomerase II beta	Homo sapiens	103-113